Abstract：
:Aim Doxorubicin (Dox) is one of the most cardiotoxic anti-cancerous drug that is widely used for broad-range of cancers. There is an urgent need for developing cardio-oncological therapeutic interventions. Natural products having both anti-cancerous potential as well as cardioprotective effects may hold a great potential in this regard. Curcuma longa (an Indian herb) polyphenols including curcumin, and well known for its anti-oxidative and anti-cancerous potential was used in the present study for its synergistic effect on cancer cells and cardiomyocytes. MATERIAL AND METHODS:Preliminary dose dependent analysis for cell viability was conducted by MTT and trypan blue assays where the effects of curcumin and Dox on cancer cell progression and cardiotoxicity were studied. Microscopic studies were done to analyse the morphological alterations of cells followed by intracellular ROS production studies by NBT and DCFH-DA assays. Apoptotic cellular death was studied by caspase activity and Annexin/PI FACS analysis. TUNEL assay was done followed by expression analysis of different cellular death biomarkers by quantitative real-time PCR. KEY FINDINGS:We observed that dose dependent cardiotoxicity of Dox can be significantly minimized by supplementing it with curcumin. Curcumin supplementation exaggerates oxidative stress and apoptosis leading to cancer cell death by modulating pro- and anti-apoptotic biomarkers. SIGNIFICANCE:The combination treatment with curcumin results in achieving the desired anti-cancerous effect of Dox without compromising its activity and hence, reduces the possibility of its dose mediated cardiotoxic effects. Hence, curcumin holds a great potential for cardio-oncological therapeutic interventions.
journal_name
Life Scijournal_title
Life sciencesauthors
Jain A,Rani Vdoi
10.1016/j.lfs.2018.05.021subject
Has Abstractpub_date
2018-07-15 00:00:00pages
97-106eissn
0024-3205issn
1879-0631pii
S0024-3205(18)30278-9journal_volume
205pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.025
更新日期：2006-07-04 00:00:00
abstract：:Nitric oxide is involved in a countless number of physiological processes and is known to have cytoprotective as well as cytotoxic effects. Increased knowledge about the multifaceted role of nitric oxide in a variety of disease states has led to the design of multiple treatment strategies involving the nitric oxide sy...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2003.08.029
更新日期：2004-02-20 00:00:00
abstract：:This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.042
更新日期：2006-02-09 00:00:00
abstract：AIMS:To establish the differential cytoprotective activity against arsenic (As) toxicity of the flavonoids silymarin (S), which is without protective effects on cancer cells, and quercetin (Q). Arsenic (As) has a paradoxical biomedical role: it causes oxidative damage to normal cells leading to death or malignant trans...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.07.007
更新日期：2010-08-28 00:00:00
abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)01090-4
更新日期：1998-01-01 00:00:00
abstract：AIMS:Ganoderma lucidum, a traditional Chinese medicine, is well known as a modulator of functions of the immune system as well as an anti-tumour agent. However, its active compounds and their molecular mechanisms of action are not well established. GLIS, a proteoglycan isolated from the fruiting body of G. lucidum, sti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.09.026
更新日期：2010-11-20 00:00:00
abstract：:An increase in natural killer (NK) cell activity can be conditioned with a one trial learning paradigm to demonstrate the interaction between the central nervous system (CNS) and the immune system. In order to demonstrate learning possibilities during 'non-conscious' state, mice were anesthetized with a ketamin/rompun...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90573-8
更新日期：1992-01-01 00:00:00
abstract：:Urine flow, osmolality, concentrations of sodium and potassium were measured every 10 min for 24 hours in 6 female dogs, whose sleep-wake stages were monitored electrographically. Experiments were conducted under hydration and progressive dehydration conditions. Visual examination and spectral analysis revealed signif...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90718-4
更新日期：1982-12-13 00:00:00
abstract：AIMS:The heterodimerization of angiotensin II receptors (AT1R and AT2R) with adiponectin receptor AdipoR1 and AdipoR2 may instigate high glucose (HG)-induced renal tubulointerstitial injury. This study examined the effect of telmisartan on diabetic nephropathy (DN) and its underlying mechanism. MAIN METHODS:Diabetes w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.01.044
更新日期：2019-03-15 00:00:00
abstract：:Four Rhesus monkeys were subjected to daily administration of 2.5 mg of tetrahydrocannabinol (THC)/kg body wt, after establishing the norms for complete blood count, T- and B-cell concentrations, and the dose response of thymidine incorporation after PHA stimulation. THC was administered daily for 3 weeks, the treatme...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90642-7
更新日期：1982-01-04 00:00:00
abstract：:Autophagy is an essential mechanism of cellular degradation, a way to protect the cells under stress conditions, such as deprivation of nutrients, growth factors and cellular damage. However, in normal physiology autophagy plays a significant role in cancer cells. Current research is in progress to understand how auto...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118184
更新日期：2020-10-15 00:00:00
abstract：:To determine how protein kinase C (PKC) activity influences properties of the tetrodotoxin-resistant sodium current (TTX-R I(Na)) in neonatal rat nodose ganglion (NG) neurons, we assessed the effects of phorbol,-12-myristate,13-acetate (PMA), one of the PKC activators, and staurosporine, one of the PKC inhibitors, on ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.053
更新日期：2005-11-19 00:00:00
abstract：AIMS:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inf...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.08.064
更新日期：2018-10-01 00:00:00
abstract：:A mechanism of antidepressant activity of beta-amyrin palmitate was studied using the forced swimming method in mice. Beta-amyrin palmitate (10 mg/kg) reduced the increase in the duration of immobility induced by tetrabenazine (100 and 200 mg/kg), but showed no effect on that in mice treated with alpha-methyl-para-tyr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90220-w
更新日期：1993-01-01 00:00:00
abstract：:We investigated the mechanism mediating cholinergic control of cell-to-cell adhesion of human epidermal keratinocytes (KC) by non-neuronal acetylcholine produced by KC themselves. We first measured cholinergic effects on the expression of desmoglein (Dsg) 1 and 3 in KC using the semi-quantitative immunofluorescence an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00087-0
更新日期：2003-03-28 00:00:00
abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117220
更新日期：2020-02-01 00:00:00
abstract：:The hypothermia induced by apomorphine, a mixed dopamine (DA) agonist in male Swiss-Webster mice, was not blocked by the selective D-1 antagonist SCH 23390 but was completely blocked by the selective D-2 antagonists haloperidol, sulpiride and YM-09151-2. The selective D-1 agonist SKF 38393 did not elicit hypothermic r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90515-2
更新日期：1988-01-01 00:00:00
abstract：:A simple and sensitive method using high performance liquid chromatography with fluorometric detection has been developed for the identification and quantitation of the endogeneous tryptamine metabolites, indoleacetic acid (IAA) and tryptophol (TOL) in the normal mouse brain. The limits of sensitivity are 5pg for both...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90744-0
更新日期：1983-11-14 00:00:00
abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.11.011
更新日期：2005-04-01 00:00:00
abstract：:As the relationship between emotional behavior and electrocardiographic (ECG) change induced by hypothalamic stimulation is poorly understood, eighty-four points in various areas within the hypothalamus in conscious cats were stimulated electrically through chronically implanted electrodes, the objective being to clar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90494-1
更新日期：1985-03-18 00:00:00
abstract：:Although exposure to broad band (0.2-20 MHz) electromagnetic fields (EMF) is part of the treatment of several diseases, little is known as to their effects on myocardial protein expression and resistance to ischemia-reperfusion (I/R). We exposed Sprague-Dawley rats to either high (H, 10 min/day at 200 V/m, 36.1 microT...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.12.033
更新日期：2004-09-03 00:00:00
abstract：:Alpha adrenergic agonists and antagonists as clonidine, guanfacine, yohimbine, phenylephrine and prazosin inhibited the [3H]-QNB binding to rat brain cortex muscarinic acetylcholine receptor (mAChR, M-1 subtype), heart (M-2 subtype) and parotid gland homogenate (M-3 subtype) in a dose-dependent competitive fashion. Ki...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90436-u
更新日期：1990-01-01 00:00:00
abstract：:The effect of wortmannin (WT), an inhibitor of myosin light chain kinase (MLCK) as well as PI3-kinase, on catecholamine (CA) secretion in the perfused rat adrenal medulla was studied. After a 35-min application of 10 microM WT, secretory response to repetitive stimulation with 30 mM extracellular K+ was reduced to 30%...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00842-0
更新日期：2000-10-13 00:00:00
abstract：:Oxidative stress induced cell injury is reported to contribute to the pathogenesis of cerebral ischemia. Reactive oxygen species such as hydrogen peroxide (H2O2) and superoxide radical along with nitric oxide and peroxynitrite generated during ischemia-reperfusion injury, causes the overactivation of poly (ADP-ribose)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.034
更新日期：2006-11-10 00:00:00
abstract：:We studied the effect of thapsigargin on intracellular calcium levels ([Ca2+]i) measured by fura-2 fluorimetry in Madin Darby canine kidney (MDCK) cells. Thapsigargin elevated [Ca2+]i dose dependently with an EC50 of approximately 0.15 microM. The Ca2+ signal consisted of a slow rise, a gradual decay and a plateau. De...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00561-x
更新日期：1999-01-01 00:00:00
abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90536-2
更新日期：1983-01-01 00:00:00
abstract：AIMS:To explore the role of chemokine CC motif ligand 2 (CCL2) in spatial memory and cognition impairment, and the underlying mechanisms focused on inflammatory, glutamate metabolistic and apoptotic- associated mRNA expression. MATERIALS AND METHODS:Stereotaxic surgery was performed here to establish a rat model by bi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117828
更新日期：2020-08-15 00:00:00
abstract：:The effects of leucine- and methionine-enkephalin, opiate peptides, on Ca2+ efflux from cultured bovine adrenal chromaffin cells were examined. These enkephalins stimulated the efflux of 45Ca2+ from cells in a concentration-dependent manner (10(-8) M-10(-6) M). Leucine-enkephalin did not increase the intracellular fre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00493-2
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.119004
更新日期：2021-01-06 00:00:00
abstract：:Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactiviti...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00873-0
更新日期：2000-10-27 00:00:00
