Determination of endogeneous indoleacetic acid and tryptophol in mouse brain by high performance liquid chromatography with fluorometric detection.

abstract：:In vitro studies showed that organophosphate insecticides have different IC50 values (i.e., concentration of inhibitor required to inhibit 50% enzyme activity) for acetylcholinesterases (AChE's) from different species. Since previous reports indicated that the binding of active cholinesterase inhibitors to non-critica...

journal_title：Life sciences

authors： Wang C,Murphy SD

更新日期：1982-07-12 00:00:00

abstract：:Rats were exposed for ten months to 60 ppm of lead (Pb, as acetate) in drinking water to further assess cardiovascular effects of chronic Pb exposure. At the end of the treatment, mean blood Pb was 3.1+/-0.3 microg/dL in the control rats and 22.8+/-1.2 microg/dL in the Pb-exposed rats (means+/-SE, n=12 in each group);...

journal_title：Life sciences

authors： Carmignani M,Volpe AR,Boscolo P,Qiao N,Di Gioacchino M,Grilli A,Felaco M

更新日期：2000-12-15 00:00:00

abstract：:Pitavastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor that is used for suppressing cholesterol biosynthesis. Previously, we have reported that pitavastatin induces the activation of endothelial nitric oxide synthase (eNOS) and increases nitric oxide (NO) production in vascular endothelial cells (...

journal_title：Life sciences

authors： Wang J,Tokoro T,Matsui K,Higa S,Kitajima I

更新日期：2005-03-25 00:00:00

abstract：:To characterize the mechanism of the analgesic action of H1 antihistaminics the effects of a new, highly selective agonist, 2-(3-trifluoromethylphenyl)histamine dihydrogenmaleate (FMPH), and of the better known H1 agonist, 2-thiazolylethylamine (2-TEA), were studied on pain threshold by means of three different kinds ...

journal_title：Life sciences

authors： Malmberg-Aiello P,Lamberti C,Ipponi A,Bartolini A,Schunack W

更新日期：1998-01-01 00:00:00

abstract：AIM:Intra-myocardial injection of adult bone marrow-derived stem cells (MSC) has recently been proposed as a therapy to repair damaged cardiomyocytes after acute myocardial infarction (AMI). PGI(2) has vasodilatation effects; however, the effects of combining both MSC and PGI(2) therapy on AMI have never been evaluated...

journal_title：Life sciences

authors： Lian WS,Cheng WT,Cheng CC,Hsiao FS,Chen JJ,Cheng CF,Wu SC

更新日期：2011-02-28 00:00:00

abstract：:We investigated lithium-induced changes in norepinephrine (NE) catabolism. NE and its major metabolites 3-methoxy-4-hydroxyphenylglycol (MHPG) and 3,4-dihydroxyphenyl glycol (DHPG), ions such as lithium (Li(+)), magnesium (Mg(2+)), and potassium (K(+)) were measured in rat plasma and cerebral cortex using an HPLC meth...

journal_title：Life sciences

authors： Sastre E,Nicolay A,Bruguerolle B,Portugal H

更新日期：2005-07-01 00:00:00

abstract：AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...

journal_title：Life sciences

authors： Yamanashi K,Kinugawa S,Fukushima A,Kakutani N,Takada S,Obata Y,Nakano I,Yokota T,Kitaura Y,Shimomura Y,Anzai T

更新日期：2020-06-01 00:00:00

abstract：AIMS:The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthe...

journal_title：Life sciences

authors： Ahishali B,Kaya M,Orhan N,Arican N,Ekizoglu O,Elmas I,Kucuk M,Kemikler G,Kalayci R,Gurses C

更新日期：2010-11-20 00:00:00

abstract：:In situ radioligand binding and quantitative autoradiography have been used to measure the density of striatal D1-like, D2-like, and GABAA receptors in rats treated with haloperidol at 0.01 or 0.1 mg/kg/ day or chlorpromazine, olanzapine or clozapine at 0.1 or 1.0 mg/kg/day for 1, 3 or 7 months. [3H]SCH23390 binding t...

journal_title：Life sciences

authors： Dean B,Hussain T,Scarr E,Pavey G,Copolov DL

更新日期：2001-08-03 00:00:00

abstract：:High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on t...

journal_title：Life sciences

authors： Jatlow P,Elsworth JD,Bradberry CW,Winger G,Taylor JR,Russell R,Roth RH

更新日期：1991-01-01 00:00:00

abstract：:Ribonucleotide reductase is the rate limiting enzyme of de novo DNA synthesis; its activity is significantly increased in tumor cells related to the proliferation rate. Therefore the enzyme is considered to be an excellent target for cancer chemotherapy. In the present study we tested the in vitro and in vivo antitumo...

journal_title：Life sciences

authors： Fritzer-Szekeres M,Novotny L,Romanova D,Göbl R,Sedlak J,Vachalkova A,Rauko P,Elford HL,Szekeres T

更新日期：1998-01-01 00:00:00

abstract：AIM:The study is aimed at evaluating the chemosensitization and apoptotic effect of aglycone rich extracts of dietary phytoestrogens (derived from soybean and flaxseed) on estrogen receptor positive, MCF-7 and estrogen receptor negative, MDA-MB-231 cells. The extracts show potent activity on both the cell lines, hence,...

journal_title：Life sciences

authors： Dutta S,Kharkar PS,Sahu NU,Khanna A

更新日期：2017-09-15 00:00:00

abstract：:The antinociceptive and temperature responses to morphine were compared in male and female rats from two different strains. Males of both the Sprague-Dawley and Wistar-Furth strains were slightly more responsive to the acute actions of morphine than were females of the same strain. However, Wistar-Furth animals requir...

journal_title：Life sciences

authors： Kasson BG,George R

更新日期：1984-04-23 00:00:00

abstract：:The present study was designed to investigate the effects of chronic administration of the alcoholic extract of Terminalia arjuna (TAAE) bark on isoproterenol induced myocardial injury. The TAAE was administered orally to Wistar albino rats (150-200 g) in three different doses, by gastric gavage [3.4 mg/kg: (T1), 6.75...

journal_title：Life sciences

authors： Karthikeyan K,Bai BR,Gauthaman K,Sathish KS,Devaraj SN

更新日期：2003-10-10 00:00:00

abstract：:In primary cultured bovine adrenal chromaffin cells (BACC), pituitary adenylate cyclase activating polypeptide 1-38 (PACAP) produced a dose related increase in tyrosine hydroxylase (TH) Vmax when measured 48 hours after the beginning of the treatment; a significant increase was observed with 0.5 nM and the maximal ind...

journal_title：Life sciences

authors： Rius RA,Guidotti A,Costa E

更新日期：1994-01-01 00:00:00

abstract：:Three continuous cell lines isolated from small cell carcinoma of the lung (SCCL) have been examined for their ability to take up and metabolize the biogenic amine precursors, L-DOPA and 5-hydroxytryptophane (5-HTP). In two of the three lines formaldehyde-induced fluorescence (FIF) and mass-spectrographic analysis ind...

journal_title：Life sciences

authors： Pettengill OS,Bacopoulos NG,Sorenson GD

更新日期：1982-04-19 00:00:00

abstract：:Increase of intracellular reactive oxygen species (ROS) has been proposed to cause endothelial injury, and oxidized LDL (oxLDL) actions are associated with an early increase of ROS. Estrogen protects vascular cells partly via its antioxidant effects and by preventing lipid peroxidation. However, whether it can inhibit...

journal_title：Life sciences

authors： Yen CH,Hsieh CC,Chou SY,Lau YT

更新日期：2001-12-14 00:00:00

abstract：:We have evaluated the effect of intraperitoneal (I.P.) injection of human recombinant interferon-2alpha (IFN-alpha) on Bleomycin-induced pulmonary injury in hamsters. Pulmonary injury was induced by a single intratracheal (I.T.) instillation of Bleomycin (Bleo). Six groups of male Syrian hamsters were treated as follo...

journal_title：Life sciences

authors： Berkman N,Goldstein RH,Breuer R

更新日期：1997-01-01 00:00:00

abstract：:We used a sensitive and specific radioimmunoassay for acetylcholine (ACh), and detected significant amounts of ACh in the blood of various mammals, including humans. About 60% of human blood ACh was localized in mononuclear leukocytes. Human leukemic T-cell lines, used as T-lymphocyte models, contained both ACh and ch...

journal_title：Life sciences

authors： Kawashima K,Fujii T,Watanabe Y,Misawa H

更新日期：1998-01-01 00:00:00

abstract：:The effect of nimodipine on nitric oxide synthase (NOS) activities in brains in transient focal cerebral ischemia rats, in cultured mouse neurons and astroglial cells and bovine brain capillary endothelial cells (BCECs) was investigated. The administration of nimodipine (3 mg.kg(-1), p.o., twice a day, for 3 days) bef...

journal_title：Life sciences

authors： Zhu D,Li R,Liu G,Hua W

更新日期：1999-01-01 00:00:00

abstract：:5-Bromo-2'-deoxyuridine (BrdU) has been recently found to enhance adrenal glucocorticoid secretion in rats. Since BrdU-labeling is today the most employed technique for assessing cell proliferation, we have investigated whether this side-effect of BrdU may influence mitotic activity (as evaluated by metaphase-arrested...

journal_title：Life sciences

authors： Malendowicz LK,Nussdorfer GG,Trejer M

更新日期：1997-01-01 00:00:00

abstract：:To establish a simple and sensitive quantitation of leukotriene B4 (LTB4), we developed a radioreceptor assay (RRA) using a highly specific [3H]leukotriene B4[( 3H]LTB4) binding to a guinea pig spleen homogenate. The assay detected LTB4 levels as low as 0.12 pmol per tube. Fifty percent inhibition of bound [3H]LTB4 wa...

journal_title：Life sciences

authors： Kohi F,Agrawal DK,Cheng JB,Bewtra A,Townley RG,Olesch JW

更新日期：1988-01-01 00:00:00

abstract：:Recent studies in animals have demonstrated that the steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3A5P), is a potent analgesic when given intracerebroventricularly. Several studies in humans report that spinal steroids are effective in the treatment of chronic low-back pain when given in combination with morphine....

journal_title：Life sciences

authors： Winfree CJ,Coombs DW,DeLeo JA,Colburn RW

更新日期：1992-01-01 00:00:00

abstract：AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...

journal_title：Life sciences

authors： Yang J,Jin HJ,Mocaër E,Seguin L,Zhao H,Rusak B

更新日期：2016-06-15 00:00:00

abstract：AIMS:Studies indicate that the pattern of shear stress determines the direction of endothelial progenitor cells (EPCs) differentiation. However, the mechanism remains largely unknown. Herein, we try to identify the role of oscillatory shear stress (OSS) in the transdifferentiation of EPCs into mesenchymal cells and the...

journal_title：Life sciences

authors： Gao Y,Cui X,Wang M,Zhang Y,He Y,Li L,Li H,Zhang X,Cheng M

更新日期：2020-07-15 00:00:00

abstract：:Opiate addiction could involve a change in the binding of endogenous antiopiates. A candidate for such a role is Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), a brain peptide that can antagonize exogenous and endogenous opiates and bind to opiate receptors. Its primary action, however, may be through its own binding site in brain,...

journal_title：Life sciences

authors： Zadina JE,Kastin AJ,Ge LJ,Gulden H,Bungart KJ

更新日期：1989-01-01 00:00:00

abstract：:These experiments were designed to test the hypothesis that cyclosporine A (CSA) inhibits renin secretion and stimulates renal prostaglandin E2 (PGE2) release in vitro. In rat renal cortical slices incubated at 37 degrees C in a buffered and oxygenated physiological saline solution containing 4 mM KCl, CSA concentrati...

journal_title：Life sciences

authors： Churchill PC,Rossi NF,Ellis VR,Churchill MC,McDonald FD

更新日期：1990-01-01 00:00:00

abstract：:Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders. This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic...

journal_title：Life sciences

authors： Moss DE,Manderscheid PZ,Montgomery SP,Norman AB,Sanberg PR

更新日期：1989-01-01 00:00:00

abstract：:We examined the effects of cyrneine A, a novel diterpene isolated from the mushroom Sarcodon cyrneus, on morphology of rat pheochromocytoma cells (PC12). In response to cyrneine A, PC12 cells extended their neurites, an effect partially blocked by the extracellular signal-regulated kinase (ERK) kinase inhibitor PD9805...

journal_title：Life sciences

authors： Obara Y,Hoshino T,Marcotullio MC,Pagiotti R,Nakahata N

更新日期：2007-04-10 00:00:00

abstract：:When HeLa cells were incubated with tritiated dexamethasone mesylate at 2 degrees C, sodium dodecyl sulfate-polyacrylamide gel electrophoresis of cytosolic and nuclear extracts revealed the presence of two monomeric receptor complex forms with estimated molecular masses of about 98 and 87 kDa. If cells were subjected ...

journal_title：Life sciences

authors： Rossini GP,Malaguti C

更新日期：1992-01-01 00:00:00