Abstract：
:Opiate addiction could involve a change in the binding of endogenous antiopiates. A candidate for such a role is Tyr-MIF-1 (Tyr-Pro-Leu-Gly-NH2), a brain peptide that can antagonize exogenous and endogenous opiates and bind to opiate receptors. Its primary action, however, may be through its own binding site in brain, which we now report is altered by chronic administration of morphine. Rats given morphine pellets had reduced binding of both iodinated and tritiated Tyr-MIF-1 on day 5, when substantial tolerance is evident. In contrast, mu and delta opiate receptors were increased. Acute injection of an analgesic dose of morphine did not reduce Tyr-MIF-1 binding, indicating that chronic administration is required for the change. These findings open new approaches to the study of addiction by focusing on antiopiate activity.
journal_name
Life Scijournal_title
Life sciencesauthors
Zadina JE,Kastin AJ,Ge LJ,Gulden H,Bungart KJdoi
10.1016/0024-3205(89)90617-6subject
Has Abstractpub_date
1989-01-01 00:00:00pages
555-61issue
8eissn
0024-3205issn
1879-0631pii
0024-3205(89)90617-6journal_volume
44pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:The platelet activating factor (PAF) receptor of the guinea pig peritoneal eosinophil was characterized by radioligand ([3H]WEB 2086) binding and measurement of PAF-stimulated membrane GTPase activity. Specific binding of [3H]WEB 2086 was rapid, reversible and saturable, with an equilibrium KD of 20.4 nM at 0 degrees ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90045-5
更新日期：1993-01-01 00:00:00
abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90638-7
更新日期：1986-06-23 00:00:00
abstract：:There is no satisfactory assay procedure of PAF in human whole blood in terms of sensitivity, reproducibility and simplicity. This is due to coexisting lipids from plasma and cellular membranes which inhibit measurement of PAF in various assay procedures, including bioassay. In the present study, an attempt was made t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00701-2
更新日期：1994-01-01 00:00:00
abstract：:The important immunological activities of Thymosin alpha 1 (T alpha 1), a peptide derived from the thymus, led to its use in combination therapies in cancer patients. Prothymosin alpha (ProT alpha) is a highly acidic polypeptide, first isolated as the putative precursor of T alpha 1. However ProT alpha is now known to...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00157-9
更新日期：1996-01-01 00:00:00
abstract：AIMS:As of the 28th April 2020, the COVID-19 pandemic has infiltrated over 200 countries and affected over three million confirmed people. We review different biomarkers to evaluate if they are able to predict clinical outcomes and correlate with the severity of COVID-19 disease. METHODS:A systematic review of the lit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117788
更新日期：2020-08-01 00:00:00
abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficien...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00377-3
更新日期：1996-01-01 00:00:00
abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118847
更新日期：2021-02-01 00:00:00
abstract：:The mammalian pineal gland synthesizes melatonin in a circadian manner, peaking during the dark phase. This synthesis is primarily regulated by sympathetic innervations via noradrenergic fibers, but is also modulated by many peptidergic and hormonal systems. A growing number of studies reveal a complex role for melato...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.10.016
更新日期：2008-01-02 00:00:00
abstract：AIM:Irisin, the adipomyokine, released mainly by exercised muscles, participate in the browning of adipose tissue and contribute to the restriction of insulin resistance and diabetes mellitus 2 development. Because of the limited reports describing the effect of irisin on inflammation and immunocompetent cells activati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.03.011
更新日期：2017-05-01 00:00:00
abstract：:The challenge of discovering new, urgently needed anti-TB drugs from natural sources requires a truly interdisciplinary research. Cutting-edge mycobacteriology and innovative natural products chemistry tools have to be developed and employed in tandem, in order to meet these demands. The present review provides cross-...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.09.004
更新日期：2005-12-22 00:00:00
abstract：:We administered intravenous adenosine to 11 neonatal rabbits. Adenosine depressed respiration in 10 of 11 rabbits. For the group as a whole the adenosine-induced respiratory depression was highly significant (p less than 0.001). After aminophylline administration to the same animals the respiratory effect of intraveno...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90248-7
更新日期：1987-01-05 00:00:00
abstract：:The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90457-1
更新日期：1986-09-01 00:00:00
abstract：:Preconditioning (PC) is a potential approach to myocardial protection. We hypothesize that brief ischemia or adenosine given prior to an extended period of warm ischemia may prevent myocardial stunning by altering myocardial metabolism. Using a global ischemia model, 19 dogs were subjected to no PC(control), two episo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.08.037
更新日期：2007-10-13 00:00:00
abstract：:The effects of cannabinoid receptor agonists WIN 55,212-2, delta9-tetrahydrocannabinol (delta9-THC), arachidonoylethanolamide (anandamide) and palmitoylethanolamide on lipopolysaccharide (LPS) -induced bronchopulmonary inflammation in mice were investigated. WIN 55,212-2 and delta9-THC induced a concentration-dependen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00324-5
更新日期：1998-01-01 00:00:00
abstract：:Intravenous (i.v.) or intrarenal arterial (i.r.a.) injection of big endothelin-1 (big ET-1) (1.6 nmol/kg) in anesthetized rats produced a significant increase in mean arterial pressure (MAP), a decrease in renal blood flow (RBF) and an increase in renal vascular resistance (RVR). Although the pressor responses to big ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90067-1
更新日期：1994-01-01 00:00:00
abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90536-2
更新日期：1983-01-01 00:00:00
abstract：:To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90026-4
更新日期：1994-01-01 00:00:00
abstract：:We find a significantly lower level of specific [3H]nicotine binding in the fetal rat forebrain of 20 day gestational age as compared to adult rat tissue, and a progressive increase in the [3H]nicotine binding in the early neonatal forebrain, reaching adult level at 14-28 days of age. The maximal binding sites (Bmax) ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90057-3
更新日期：1986-02-17 00:00:00
abstract：:The inhibitory activity of methylguanidine, guanidine and their precursors, creatine and creatinine, on both the neuronal constitutive and lung inducible isoforms of nitric oxide synthase were examined in this study. Methylguanidine and guanidine (0.01-3 mM) significantly (P<0.01) inhibited in a concentration-dependen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00673-5
更新日期：1997-01-01 00:00:00
abstract：:To understand the leptin's action on hypothalamic arcuate nucleus (ARC), Ca2+/calmodulin (CaM)-dependent response in leptin-treated rat ARC was investigated. The in vitro phosphorylation of ARC extracts from leptin-treated rats did not respond to CaM. Although CaM-dependent protein kinase II activity was not affected ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00460-3
更新日期：1998-01-01 00:00:00
abstract：UNLABELLED:Isolation of meiotic arrested oocytes from mammalian ovaries involves a resumption of the meiosis. Studying the effect of FSH on this process it was found that doses up to of 0.1 IU/ml did not maintain the meiotic arrest in hamster oocytes in pre-antral follicles during static incubation conditions. However,...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90045-0
更新日期：1994-01-01 00:00:00
abstract：AIM:This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats. MAIN METHODS:The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. Th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.05.006
更新日期：2011-07-18 00:00:00
abstract：:Corticotropin releasing factor (CRF), one of the major effectors of stress, plays a major role in the natural course of drug addiction by accelerating the acquisition of psychostimulant self-administration and increasing incentive motivation for the drug itself and for drug-associated stimuli. Stress-induced CRF is al...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2009.11.005
更新日期：2010-01-02 00:00:00
abstract：AIMS AND METHODS:We previously reported that angiotensin II (AngII) restores the vascular reactivity diminished by hemorrhagic shock. In this study, we investigated whether the beneficial effects of AngII are related to regulation of gap junctions (GJs) and connexin43 (Cx43), and the implication of MAPK signaling and m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.11.019
更新日期：2019-01-01 00:00:00
abstract：:Simultaneously drawn arterial and forearm venous levels of free and sulfate conjugated epinephrine and norepinephrine were measured in 8 subjects in order to study the role of skeletal muscle in catecholamine sulfation. A sensitive radioenzymatic assay was used. The average free epinephrine level was 46% lower in veno...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90758-5
更新日期：1982-11-29 00:00:00
abstract：BACKGROUND:The emergence of SARS-CoV-2 pandemic has upset health systems around the world and caused immeasurable losses and costs. Until a vaccine will become available, the recommended prevention measures remain physical distancing and enhanced hygiene. METHODS AND FINDINGS:The proteic structure external to the viru...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118801
更新日期：2021-01-15 00:00:00
abstract：AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.050
更新日期：2018-09-15 00:00:00
abstract：:We have confirmed that hypoxia elicits a substantial rise in blood choline levels in young adult rats. An intravenous infusion of tracer quantities of [2H4]-Ch, serial measurements of blood [2H0]-Ch and [2H4]-Ch, and a simple pharmacokinetic model were used to assess the bidirectional flux of choline between the centr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00191-9
更新日期：1996-01-01 00:00:00
abstract：:The pressor effect of hemoglobin-based blood substitutes is due partly to their capacity to scavenge nitric oxide (NO), a potent vasodilator. NO also appears to modulate the release of norepinephrine (NE) from sympathetic nerve endings in some blood vessels. Thus studies were designed to determine if contraction occur...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00269-x
更新日期：1996-01-01 00:00:00
abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2004.05.034
更新日期：2004-11-05 00:00:00
