Abstract:
:Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficient RBCs to Ca(2+)-induced vesiculation is not due to ATP depletion. The remnant G6PD-deficient RBCs following vesiculation are more sensitive to complement-mediated hemolysis than control normal RBCs. A strong positive correlation exists between the level of Ca(2+)-induced vesiculation and the extent of complement mediated hemolysis.
journal_name
Life Scijournal_title
Life sciencesauthors
Tsai KJ,Shih LY,Hung IJ,Huang SW,Wei JS,Liu TZ,Chiu DTdoi
10.1016/0024-3205(96)00377-3subject
Has Abstractpub_date
1996-01-01 00:00:00pages
867-76issue
10eissn
0024-3205issn
1879-0631pii
0024320596003773journal_volume
59pub_type
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