Abstract：
:Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G protein-coupled estrogen receptor (GPER) mediates beneficial actions in the cardiovascular system. Our goal was to prevent and regress the hypertrophy by the activation of GPER in neonatal cardiac myocytes (NRCM) and SHR male rats. Aldosterone increased the neonatal cardiomyocytes cell surface area after 48 h of incubation. The aldo-induced hypertrophy was blocked by the mineralocorticoid receptor (MR) inhibitor Eplererone or the reduction of MR expression by siRNA. The activation of GPER by the agonist G-1 totally prevented the increase surface area by Ald. The transfection of neonatal rat cardiac myocytes with a siRNA against GPER or the incubation with GPER blockers G-15 and G-36 inhibited the protection of G-1. The significant increase of cell surface area after 48 h of incubation with Ald was totally regressed in 24 h by the presence of G-1, indicating that the activation of GPER not only prevent the hypertrophy but also regress the hypertrophy when it is already established. In the in vivo model, G-1 or Vehicle was constantly infused via the minipump to SHR. The reduction of the hypertrophy by G-1 was evident by the cross-sectional area, BNP and ANP markers and by echocardiography. In this studied we demonstrated that the activation of GPER prevented and regressed the hypertrophy induced by Ald in NRCM and regressed hypertrophy in SHR rats.
journal_name
Life Scijournal_title
Life sciencesauthors
Di Mattia RA,Mariángelo JIE,Blanco PG,Jaquenod De Giusti C,Portiansky EL,Mundiña-Weilenmann C,Aiello EA,Orlowski Adoi
10.1016/j.lfs.2019.117211subject
Has Abstractpub_date
2020-02-01 00:00:00pages
117211eissn
0024-3205issn
1879-0631pii
S0024-3205(19)31139-7journal_volume
242pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Vascular endothelial cells have been found to produce a relaxant mediator, identified as nitric oxide (NO) and implicated in numerous physiological functions. Subsequently, there has been an intensive search for accurate and specific detection methods to measure biological NO production. In the present study, we compa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00661-9
更新日期：1997-01-01 00:00:00
abstract：:Electroshock induced seizures in the rat enhanced high affinity specific Na+ independent binding of 3H-gamma aminobutyric acid (GABA) to frozen, Triton X-100 treated cerebral synaptic membranes 30 minutes after exposures to electroshock, although no change in 3H GABA binding was observed in similarly treated preparati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90756-1
更新日期：1982-11-29 00:00:00
abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90827-5
更新日期：1983-04-11 00:00:00
abstract：AIM:Betel-nut, a popular masticatory among Southeast Asian populations is a class I carcinogen, previously associated with dyslipidemia and aberrant lipid metabolism, and is reported to be used more frequently by females, than males. This study investigates the potential of repurposing the anti-diabetic drug, vildaglip...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118870
更新日期：2021-02-01 00:00:00
abstract：:Two breeds of rats, Charles River Wistar [Crl(Wi)Br.] and HSD Wistar [Wistar per LATI (Budapest) Br.], with remarkable difference in learning performance were selected. The rats were trained in the shuttle box with 100 trials per day and the number of conditioned avoidance responses (CARs), the escape failures (EFs) t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00037-9
更新日期：1996-01-01 00:00:00
abstract：AIMS:This study aims to explore the effect and underlying mechanism of zoledronic acid (ZA) on the incidence of thyroid cancer (TC) tumorigenesis. MATERIALS AND METHODS:Human mononuclear cells THP-1 were differentiated into M2-like tumor associated macrophages (TAMs) by incubation with PMA followed by additional incub...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117925
更新日期：2020-09-01 00:00:00
abstract：:Information concerning the cellular localization of dopamine receptor subtypes in the nucleus accumbens (NAcc) was obtained using receptor autoradiographic analysis. Unilateral, stereotaxic injection of the axon-sparing neurotoxin, quinolinic acid, into the NAcc resulted in a prominent loss of dopamine D1 receptors (a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90609-f
更新日期：1991-01-01 00:00:00
abstract：:Almost all diabetic complications are known to be associated with vascular dysfunctions of different tissues. Oxidative stress, on the other hand, has been implicated in the pathogenesis of diabetes mellitus. Therefore in the present study we have investigated the correlation between redox status and oxidative stress ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00662-3
更新日期：2003-10-03 00:00:00
abstract：:Cannabinoid agonists such as Delta9-tetrahydrocannabinol (THC) produce a wide range of pharmacological effects both in the central nervous system and in the periphery. One of the most striking features of cannabinoids such as THC is the magnitude to tolerance that can be produced upon repetitive administration of this...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2005.05.005
更新日期：2005-08-19 00:00:00
abstract：:Six diterpenes (three clerodanes, two abietanes and one rosane) were tested for interactions with the cyclooxygenase and 5-lipoxygenase pathways of arachidonate metabolism and for effects of nitric oxide production. Two abietane diterpenes, aethiopinone and 11,12-dihydroxy-6-oxo-8,11,13-abietatriene and the rosane lag...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01402-3
更新日期：2001-12-07 00:00:00
abstract：:Aluminum (Al) is thought to be a risk factor for neurodegenerative disorders, but the molecular mechanism has been not clarified yet. In this study, we examined how a transport system handled transport of Al citrate, the major Al species in brain, and effect of Al citrate treatment on expression of the transporter and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.12.048
更新日期：2006-05-30 00:00:00
abstract：:P75(NTR) is a common neurotrophin receptor which binds all neurotrophins with similar affinities and has been shown to be capable of mediating programmed cell death. In this study, we investigated effects of the antipsychotic drugs (APDs) haloperidol, clozapine, quetiapine, and risperidone on p75(NTR) mRNA levels in P...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.039
更新日期：2006-07-04 00:00:00
abstract：:Guinea pig ileum longitudinal muscle/myenteric plexus preparations contain functional mu- and kappa-opioid receptors. A preparation with blocked kappa receptors was obtained by pretreating guinea pigs with 0.1-10.0 mg/kg intraperitoneal doses of a new kappa-selective affinity label, DIPPA (2-(3,4-dichlorophenyl)-N-met...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00076-3
更新日期：1997-01-01 00:00:00
abstract：AIMS:Various investigations have demonstrated the protective capacity of general anesthetics as neuroprotective agents. The effects of propofol against ischemia are known to reside in its antioxidant properties and its GABAergic activity. Other aromatic alcohols have also been reported as able to protect neurons agains...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.03.005
更新日期：2017-04-15 00:00:00
abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.12.014
更新日期：2011-02-14 00:00:00
abstract：:The roles of capsaicin-sensitive sensory nerves (CPSN), endogenous nitric oxide (NO), sulfhydryls (SHs), prostaglandins (PGs) in the gastroprotection by momordin Ic, an oleanolic acid oligoglycoside isolated from the fruit of Kochia scoparia (L.) SCHRAD., on ethanol-induced gastric mucosal lesions were investigated in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00241-6
更新日期：1999-01-01 00:00:00
abstract：:Electrically evoked release of dopamine from the caudate nucleus is reduced by the dopamine receptor agonists, apomorphine and bromocriptine, and facilitated by neuroleptic drugs, which act as dopamine autoreceptor antagonists. The potencies of chlorpromazine, fluphenazine, levomepromazine and their hydroxy-metabolite...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90088-9
更新日期：1990-01-01 00:00:00
abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.10.017
更新日期：2014-02-06 00:00:00
abstract：:The effects of leucine- and methionine-enkephalin, opiate peptides, on Ca2+ efflux from cultured bovine adrenal chromaffin cells were examined. These enkephalins stimulated the efflux of 45Ca2+ from cells in a concentration-dependent manner (10(-8) M-10(-6) M). Leucine-enkephalin did not increase the intracellular fre...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00493-2
更新日期：1999-01-01 00:00:00
abstract：:Chronic cocaine abuse has been associated with cerebrovascular pathology. This is likely to reflect its vasoactive effects; cocaine produces vasoconstriction and reduces cerebral blood flow. We propose that cerebrovascular pathology in chronic cocaine abusers would result in abnormal BOLD [blood oxygenation level depe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00548-4
更新日期：2003-08-29 00:00:00
abstract：:The antinociceptive effect of the benzomorphan class of opioid analgesics have been difficult to measure utilizing some of the standard animal pain models. This may be due, in part, to the sedative and/or motor effects associated with these drugs. In addition, it has been proposed that the major site of action for dru...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90270-5
更新日期：1986-01-06 00:00:00
abstract：AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible u...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.11.018
更新日期：2016-01-01 00:00:00
abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90218-g
更新日期：1990-01-01 00:00:00
abstract：:Amyloid beta-protein (A beta), the major protein of cerebrovascular and plaque amyloid in Alzheimer disease, is considered a primary factor in the pathology of this disease. The effect of synthetic A beta (1-40) on the activity of protein kinase C (PKC) was studied with histones for a substrate in a mixed micellar ass...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90328-9
更新日期：1991-01-01 00:00:00
abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.08.029
更新日期：2016-11-15 00:00:00
abstract：AIMS:The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.04.041
更新日期：2018-06-15 00:00:00
abstract：:Puromycin is an experimental anti-tumor antibiotic acting through inhibition of protein synthesis. Because of its untoward side effects (as inner ear and renal lesions) the antibiotic was not approved for clinical trials. The mechanism underlying the organ specificity of the side effect is not understood. In view of t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.070
更新日期：2005-06-17 00:00:00
abstract：:The feasibility of visualizing the heterogeneity of benzodiazepine (BDZ) receptors in the brain of living baboons was investigated using Positron Emission Tomography. Ethyl 8-fluoro-5,6-dihydro-5-methyl 6-oxo-4H-imidazo (1,5-a) (1, 4) benzodiazepine-3-carboxylate (RO 15 1788) labelled by carbon 11 (11C-RO 15 1788) was...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90363-7
更新日期：1985-04-29 00:00:00
abstract：:Effects of hexamethonium (C6) on the excitability of sympathetic ganglion cells were examined by means of intracellular recording. When DC currents were injected, high concentrations of C6 significantly augmented the repetitive firing of the cells without any change in threshold voltage for initiation of the spike. Th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90324-8
更新日期：1985-06-17 00:00:00
abstract：:Animal studies suggest nicotine and cannabinoids may significantly enhance the therapeutic value of neuroleptics in motor disorders. This was recently demonstrated in humans by the finding that chewing nicotine gum produced striking relief from tics and other symptoms of Tourette syndrome not controlled by neuroleptic...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(89)90444-x
更新日期：1989-01-01 00:00:00
