Abstract:
AIMS:Doxorubicin is a widely used anthracycline derivative anticancer drug. Unfortunately, the clinical use of doxorubicin has the serious drawback of cardiotoxicity. In this study, we investigated whether baicalein, a bioflavonoid, can prevent doxorubicin-induced cardiotoxicity in vivo and we delineated the possible underlying mechanisms. MAIN METHODS:Male BALB/c mice were treated with either intraperitoneal doxorubicin (15 mg/kg divided into three equal doses for 15 days) and/or oral baicalein (25 and 50 mg/kg for 15 days). Serum markers of cardiac injury, histology of heart, parameters related to myocardial oxidative stress, apoptosis and inflammation were investigated. KEY FINDINGS:Treatment with baicalein reduced doxorubicin-induced elevation of serum creatine kinase-MB isoenzyme (CK-MB), lactate dehydrogenase (LDH), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels and ameliorated the histopathological damage. Baicalein restored the doxorubicin-induced decrease in both enzymatic and non-enzymatic myocardial antioxidants and increased the myocardial expression of nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1). Further studies showed that baicalein could inverse the Bax/Bcl-2 ratio, suppress doxorubicin-induced p53, cleaved caspase-3 and PARP expression and prevented doxorubicin-induced DNA damage. Baicalein treatment also interferes with doxorubicin-induced myocardial NF-κB signaling through inhibition of IκBα phosphorylation and nuclear translocation of p65 subunit. Doxorubicin elevated iNOS and nitrites levels were also significantly decreased in baicalein treated mice. However, we did not find any significant change (p>0.05) in the myocardial TNF-α and IL-6 levels in control and treated animals. SIGNIFICANCE:Our finding suggests that baicalein might be a promising molecule for the prevention of doxorubicin-induced cardiotoxicity.
journal_name
Life Scijournal_title
Life sciencesauthors
Sahu BD,Kumar JM,Kuncha M,Borkar RM,Srinivas R,Sistla Rdoi
10.1016/j.lfs.2015.11.018subject
Has Abstractpub_date
2016-01-01 00:00:00pages
8-18eissn
0024-3205issn
1879-0631pii
S0024-3205(15)30081-3journal_volume
144pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Incubation of racemic methylenedioxyamphetamine (MDA) or methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes, in the presence of NADPH, generated a spectrally observed inhibitory complex with cytochrome P-450. The complex inhibited product formation from MDA and MDMA as well as other P-450 dependent react...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90551-5
更新日期:1986-10-20 00:00:00
abstract::The number of GABAergic neurons as determined by GAD immunocytochemistry and total neurons as determined from Nissl preparations were counted and classified at the light microscopic level in the inferior colliculus (IC) of the genetically epilepsy prone rat (GEPR) and the non-epileptic Sprague-Dawley (SD) strain of ra...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(86)90457-1
更新日期:1986-09-01 00:00:00
abstract::Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G protein-coupled estrogen receptor (GPER) mediates beneficial actions in the cardiovascular system. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.117211
更新日期:2020-02-01 00:00:00
abstract::A sensitive and specific radioimmunoassay for substance P has been developed and its full characterisation is described. The assay was used to investigate the stability of substance P in tissue in order to establish the optimal conditions of tissue storage for maximal recovery of the peptide. The results indicate unex...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90211-4
更新日期:1983-02-07 00:00:00
abstract::Current therapy for type 1 diabetes mellitus involves a daily regimen of multiple subcutaneous or intramuscular injections of recombinant human insulin. To achieve long-term insulin delivery in vivo, we investigated the applicability of cytomedical therapy using beta TC6 cells or MIN6 cells, both of which are murine p...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01724-1
更新日期:2002-08-30 00:00:00
abstract::We have recently demonstrated that the hypertensinogenic and natriuretic actions of ACTHI-39 can be found in a non-steroidogenic fragment of ACTH, ACTH4-10. These effects of ACTH or ACTH4-10 may be due to their ability to act as weak agonists of gamma MSH. gamma MSH is found in the 16K N-terminus of pro-opiocortin, an...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90197-3
更新日期:1985-02-25 00:00:00
abstract::Long non-coding RNA (LncRNA) involved in types of physiological insults and diseases via regulating the responses of complex molecular, including cerebral ischemia-reperfusion (I/R) injury. LncRNA SNHG16 played a potential role in ketamine-induced neurotoxicity. In this study, we utilized an in vitro cell model of I/R...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117778
更新日期:2020-08-01 00:00:00
abstract:AIMS:The aim of this study was to investigate the effects of a mood stabilizer lamotrigine (LMG) on learning and memory processes using Morris water maze (MWM), modified elevated plus maze (mEPM) and passive avoidance (PA) tests. MAIN METHODS:Balb-c mice were used. LMG were injected (20; 40mg/kg, intraperitoneal, i.p....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2012.09.020
更新日期:2012-12-17 00:00:00
abstract::The expression of the corticotropin-releasing hormone (CRH) gene and the arginine vasopressin (AVP) gene in the hypothalamus examined in bilateral nephrectomized rats by in situ hybridization histochemistry. The expression of the CRH gene was significantly increased in the parvocellular part of the paraventricular nuc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)02287-7
更新日期:2002-12-20 00:00:00
abstract:AIMS:Acute respiratory distress syndrome (ARDS) is characterized by acute hypoxemia with diffuse alveolar damage and increased pulmonary microvascular permeability. Honokiol (HKL), the principal active ingredient of Chinese herb magnolia officinalis, protected the lung of experimental ARDS models via attenuation of inf...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.08.064
更新日期:2018-10-01 00:00:00
abstract::Among hepatic diseases, cholestatic ductopenic cholangiopathies are poorly studied, and they are rarely given the importance they deserve, especially considering their high incidence in clinical practice. Although cholestatic ductopenic cholangiopathies have different etiologies and pathogenesis, all have the same tar...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.12.044
更新日期:2019-02-01 00:00:00
abstract::It has been reported that while bacteria and higher plants possess two different pathways for the biosynthesis of putrescine, via ornithine decarboxylase (ODC) and arginine decarboxylase (ADC); the fungi, like animals, only use the former pathway. We found that contrary to the earlier reports, two of the phytopathogen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90317-2
更新日期:1989-01-01 00:00:00
abstract::TNF production has been studied in peritoneal macrophages and splenic T cells of Arctic Yakutian ground squirrel (Citellus Undulatus Pallas) in hibernating and awake animals in winter and in prehibernating autumn as well as in active euthermic spring-summer animals. A high level of TNF production in macrophages of gro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(00)00698-6
更新日期:2000-01-01 00:00:00
abstract::We evaluated whether fish oil or vitamin E administration affected ethanol-induced changes in membrane ATPases. Male Wistar rats (225-250 g) were fed, through a gastric tube a liquid diet containing fish oil (25% of calories) and ethanol for one month. Another group of animals was given supplemental vitamin E (300 u/k...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00545-1
更新日期:1994-01-01 00:00:00
abstract::Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)90100-7
更新日期:1994-01-01 00:00:00
abstract::Many persistent pesticides have been implicated in reproductive and developmental adverse effects, in man and wildlife. It has been hypothesized that these so-called xeno-hormones could upset the endocrine system function by binding to human estrogen receptor alpha and beta (ERalpha, beta) and thus be responsible for ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2006.03.023
更新日期:2006-08-15 00:00:00
abstract::The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro-L-arginine (NOARG; 8 mg/kg) ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00226-9
更新日期:1997-01-01 00:00:00
abstract:AIMS:The roles of miR-141 in various types of cancers and inflammatory bowel diseases are researched, whereas, little information about its function in lung inflammation is available. This study was designed to explore the effect of miR-141 on inflammation injury in WI-38 cells, possibly providing basis for targeted th...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.11.056
更新日期:2019-01-01 00:00:00
abstract::Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90248-5
更新日期:1983-08-15 00:00:00
abstract::Of primary interest for every enzyme is the identification of its physiological substrates. However, the vast structural diversity of endogenous metabolites, coupled with the overlapping activities of numerous enzymes, makes it difficult to deduce the identity of natural substrates for a given enzyme based on in vitro...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.05.019
更新日期:2005-08-19 00:00:00
abstract::Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.09.032
更新日期:2007-11-30 00:00:00
abstract:AIM:The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination. MAIN METHODS:Wistar rat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.03.033
更新日期:2014-05-17 00:00:00
abstract::An animal model of haloperidol-induced tardive dyskinesia was studied in relation to the dietary manipulation of tryptophan and its effect on the movement disorder. This study showed a significant negative behavioral response to the neuroleptic drug, haloperidol. Increased dietary tryptophan (1.0 vs. 0.3%) significant...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(87)90602-3
更新日期:1987-10-05 00:00:00
abstract::beta-Adrenergic agonists used in therapy of premature labor and asthma cross the placenta and can affect development of the fetal nervous system. In the current study, pregnant rats were given 10 mg/kg of terbutaline on gestational days 17, 18 and 19 and adrenergic receptor binding capabilities examined in brain regio...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90440-3
更新日期:1990-01-01 00:00:00
abstract::The temporal relationship of changes in cAMP and cGMP to oocyte maturation was examined in proestrous hamsters (day 4). The first series of experiments showed, in normal cycling hamsters, an increase in cAMP and a decrease in cGMP at 1400 h shortly after the rise in LH with oocyte maturation beginning at 1800 h. When ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90726-9
更新日期:1983-10-24 00:00:00
abstract::The effects of central administration of two serotonin receptor agonists, 8-OH-DPAT and mCPP, on tuberoinfundibular dopaminergic (TIDA) neuron activity and serum prolactin (PRL) levels in ovariectomized, estrogen-treated rats were determined. 8-OH-DPAT dose-dependently (0.1-10 microgram/rat, icv) stimulated serum PRL ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00077-x
更新日期:1996-01-01 00:00:00
abstract::S-adenosylmethionine and adenosine levels in the rat pineal gland were determined by high-performance liquid chromatography after fractionation of the pineal extracts. The concentration of S-adenosylmethionine follows a circadian rhythm and is about three times higher during the day (2.5 nmol/gland) than the night (1....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90253-4
更新日期:1984-08-06 00:00:00
abstract::Definition of the physiological and pharmacological properties of primary afferent neurons by the use of capsaicin and its analogues (e.g. resiniferatoxin) has represented one of the most active areas of research of the last decade (1-4 for reviews). In the past 3 years many important advancements have been made in th...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(91)90169-c
更新日期:1991-01-01 00:00:00
abstract::Plants are potentially important for novel therapeutic drug leads, but the slowness of conventional methods for investigation of plants limits enthusiasm in the pharmaceutical industry. To overcome some of the drawbacks, we have applied high throughput pharmacological screening (HTPS) to crude plant extracts. Using a ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.09.013
更新日期:2005-12-22 00:00:00
abstract::We aimed to study the alterations in serum homocysteine levels and endothelium-dependent and -independent vascular relaxant responses in adjuvant-induced arthritis of the rat and to determine the effects of vitamin E administration on these changes. Arthritis was induced by a single intradermal injection of Freund's c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(02)01700-9
更新日期:2002-06-14 00:00:00