Spectral and inhibitory interactions of (+/-)-3,4-methylenedioxyamphetamine (MDA) and (+/-)-3,4-methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes.

abstract：:The renal hemodynamic and tubular effects of ANF were investigated using the Sperber technique in chickens. This technique takes advantage of the unique portal circulation of the avian kidney and permits direct access to the renal peritubular space independent of renal arterial blood flow and glomerular filtration. In...

journal_title：Life sciences

authors： Springate JE,Fildes RD,Hong SK,Feld LG,Acara M

更新日期：1987-03-09 00:00:00

abstract：AIMS:Cortisol is a glucocorticoid in mammals, but has both gluco- and mineralocorticoid activities in teleost fish. Our previous in vivo studies on osmoregulatory esophagi of euryhaline fish showed that epithelial apoptosis for the simple epithelium in seawater and cell proliferation for the stratified epithelium in fr...

journal_title：Life sciences

authors： Takagi C,Takahashi H,Kudose H,Kato K,Sakamoto T

更新日期：2011-01-31 00:00:00

abstract：:Several antihistamines were evaluated for their ability to interact with sigma, muscarinic and histaminic H1 binding sites in rat brain preparations. All of the antihistamines were able to interact with the sigma site, as well as the other two sites. In addition, tripelennamine was found to elicit sigma-like behaviors...

journal_title：Life sciences

authors： Gray NM,Contreras PC,Allen SE,Taylor DP

更新日期：1990-01-01 00:00:00

abstract：:Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactiviti...

journal_title：Life sciences

authors： Yun J,Lee CK,Chang IM,Takatsu K,Hirano T,Min KR,Lee MK,Kim Y

更新日期：2000-10-27 00:00:00

abstract：:Based on our earlier animal study, we became interested to investigate if thromboxane A2 (TXA2) is involved in angiotensin converting enzyme (ACE) induced cough in man. To 11 patients with hypertension, who had developed cough induced by ACE inhibitors, a TXA2 synthetase inhibitor, ozagrel was given for 1 to 2 months ...

journal_title：Life sciences

authors： Umemura K,Nakashima M,Saruta T

更新日期：1997-01-01 00:00:00

abstract：:Alpha(1)-adrenergic receptors are one of the three subfamilies of G protein coupled receptors activated by epinephrine and norepinephrine to control important functions in many target organs. Three human subtypes (alpha(1A), alpha(1B), alpha(1D)) are derived from separate genes and are highly homologous in their trans...

journal_title：Life sciences

authors： Hague C,Chen Z,Uberti M,Minneman KP

更新日期：2003-12-12 00:00:00

abstract：:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo pr...

journal_title：Life sciences

authors： Molchan SE,Hill JL,Minichiello M,Vitiello B,Sunderland T

更新日期：1994-01-01 00:00:00

abstract：AIMS:The roles of miR-141 in various types of cancers and inflammatory bowel diseases are researched, whereas, little information about its function in lung inflammation is available. This study was designed to explore the effect of miR-141 on inflammation injury in WI-38 cells, possibly providing basis for targeted th...

journal_title：Life sciences

authors： Quan B,Zhang H,Xue R

更新日期：2019-01-01 00:00:00

abstract：:The purpose of this present study was to develop a method for stimulation of acid secretion by the isolated perfused rat stomach. Rat stomachs were perfused in situ via the abdominal aorta and celiac axis with Krebs-Ringer bicarbonate buffer in the presence or absence of 10% ovine erythrocytes. The gastric lumen was p...

journal_title：Life sciences

authors： Short GM,Wolfe MM,McGuigan JE

更新日期：1984-06-18 00:00:00

abstract：:The effect of the repeated or continuous administration of an analog of GH releasing factor (GH-RF), D-Tyr-1, D-Ala-2, Nle-27, GH-RF(1-29)-NH2 (DBO-29), on the subsequent response to this peptide was investigated in pentobarbital-anesthetized male rats. A sc administration of this analog induced a greater and more pro...

journal_title：Life sciences

authors： Karashima T,Olsen D,Schally AV

更新日期：1987-06-22 00:00:00

abstract：:The regulation of the production of platelet-derived growth factor (PDGF) and the influence of high glucose concentration, eicosapentaenoic acid (EPA) were studied in cultured human umbilical vein endothelial cells (HUE). The PDGF production of HUE increased markedly depending on glucose concentration. However, EPA (3...

journal_title：Life sciences

authors： Mizutani M,Okuda Y,Suzuki S,Sawada T,Soma M,Yamashita K

更新日期：1995-01-01 00:00:00

abstract：:Pulmonary surfactant release from lamellar bodies in alveolar type II cells in response to exogenous and circulating catecholamines is well documented but sympathetic influences from direct nerve stimulation are not as extensively studied. In order to study sympathetic nerve influence on release, ultrastructure of typ...

journal_title：Life sciences

authors： Crittenden DJ,Alexader LA,Beckman DL

更新日期：1994-01-01 00:00:00

abstract：AIMS:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered to be one of the most promising candidates in research on treatments for cancer, including renal cell carcinoma (RCC). However, many cells are resistant to TRAIL-induced apoptosis which limits the potential application of TRAIL in ...

journal_title：Life sciences

authors： Ou YC,Li JR,Kuan YH,Raung SL,Wang CC,Hung YY,Pan PH,Lu HC,Chen CJ

更新日期：2014-04-01 00:00:00

abstract：:Although the understanding of migraine pathophysiology is still incomplete, there seems to be little doubt that dilatation of cranial blood vessels, including meningeal arteries, is involved in the headache phase of migraine. Since calcitonin gene-related peptide (CGRP) has been implicated in this vasodilatation, the ...

journal_title：Life sciences

authors： Gupta S,Mehrotra S,Avezaat CJ,Villalón CM,Saxena PR,Maassenvandenbrink A

更新日期：2006-06-13 00:00:00

abstract：:The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with alpha-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amin...

journal_title：Life sciences

authors： Dyck LE

更新日期：1987-02-09 00:00:00

abstract：:Despite considerable progressions, cardiovascular disease (CVD) is still one of the major causes of mortality around the world, indicates an important and unmet clinical need. Recently, extensive studies have been performed on the role of inflammatory factors as either a major or surrogate factor in the pathophysiolog...

journal_title：Life sciences

authors： Soroureddin Z,Nouri-Vaskeh M,Maleki M,Baghbanzadeh A,Hajiasgharzadeh K,Taban Sadeghi M,Baradaran B

更新日期：2020-07-15 00:00:00

abstract：:Glucocorticoid receptors (GR) are ubiquitous molecules and are present also in the hippocampus and in several other nervous and immune tissues. Peripheral blood mononuclear cells (PBMCs) are a good model for studies of GR in humans. Glucocorticoids are important for maintaining cellular and humoral homeostasis and are...

journal_title：Life sciences

authors： Grasso G,Lodi L,Lupo C,Muscettola M

更新日期：1997-01-01 00:00:00

abstract：:Alpha-adrenergic receptors may play an important role in regulating vascular tone and reactivity. To study alpha-adrenergic receptors in blood vessels, we have developed a method to characterize and quantitate alpha-adrenergic receptors in a particulate fraction of individual rabbit aortas using the high specific acti...

journal_title：Life sciences

authors： Tsujimoto G,Bristow MR,Hoffman BB

更新日期：1984-02-13 00:00:00

abstract：:Elevated total homocysteine concentrations and obesity are both associated with an increased risk of cardiovascular disease. However, previous studies of weight reduction on serum homocysteine concentrations have obtained inconsistent reports. We investigated the effect of folic acid supplementation on serum homocyste...

journal_title：Life sciences

authors： Sheu WH,Chin HM,Lee WJ,Wan CJ,Su HY,Lang HF

更新日期：2005-03-18 00:00:00

abstract：:Previous studies indicated that exogenous dopamine and its agonists directly regulated mitogen-induced immune cell proliferation. In this study, we further investigated role of endogenous dopamine in immune cell growth. Haloperidol, a general antagonist for dopamine receptors, could reduce the cell growth rate of T ce...

journal_title：Life sciences

authors： Tsao CW,Lin YS,Cheng JT

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:Most hepatocellular carcinoma cases are diagnosed at late stages of the disease, which makes it the second cause of cancer mortality worldwide. For advanced-stage patients, chemotherapeutic drugs are the best treatment option; however, their adverse effects and high cost are still major obstacles for effecti...

journal_title：Life sciences

authors： Mahmoud YI,Shehata AMM,Fares NH,Mahmoud AA

更新日期：2021-01-15 00:00:00

abstract：:The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus in vitro has been investigated. Of the compounds tested, only trans-[(NO)(P(OEt)3)(NH3)4Ru](PF6)3 (1-2.5 mM) exerted a strong facilitatory action on the population spik...

journal_title：Life sciences

authors： Wieraszko A,Clarke MJ,Lang DR,Lopes LG,Franco DW

更新日期：2001-02-16 00:00:00

abstract：:Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...

journal_title：Life sciences

authors： Xu K,Xiwen Liu,Ren G,Yin D,Guo S,Zhao Y

更新日期：2019-12-15 00:00:00

abstract：:The effects of delta 9-THC and other cannabinoids on cAMP levels in synaptosomes from mouse brains were investigated in order to determine whether cannabinoids produced their behavioral effects through alterations in adenylate cyclase. delta 9-THC (0.01-10 microM) did not significantly alter basal cAMP levels, whereas...

journal_title：Life sciences

authors： Little PJ,Martin BR

更新日期：1991-01-01 00:00:00

abstract：:Tumor angiogenesis and lymphangiogenesis are key features of tumor progression and metastasis. The role of tumor cells-derived factors in the promotion of associated angiogenesis and lymphangiogenesis is much studied and, no doubt, very important for the understanding of cancer progression. This review aims to present...

journal_title：Life sciences

authors： Gomes FG,Nedel F,Alves AM,Nör JE,Tarquinio SB

更新日期：2013-02-07 00:00:00

abstract：:Protein phosphorylation is a key posttranslational modification mechanism controlling the conformation and activity of many proteins. Increasing evidence has implicated an essential role of phosphorylation by several major protein kinases in promoting and maintaining opioid tolerance. We review some of the most recent...

journal_title：Life sciences

authors： Wang ZJ,Wang LX

更新日期：2006-09-27 00:00:00

abstract：:Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...

journal_title：Life sciences

authors： Zhao S,Chu Y,Zhang Y,Zhou Y,Jiang Z,Wang Z,Mao L,Li K,Sun W,Li P,Jia S,Wang C,Xu A,Loomes K,Tang S,Wu D,Hui X,Nie T

更新日期：2019-04-01 00:00:00

abstract：AIMS:Previous study demonstrated that Ginsenoside Rd. (GS-Rd) could improve cognitive and memory function in animal model of Alzheimer's disease. This study was aimed to investigate whether GS-Rd could improve non-amyloidogenic pathway by activating estrogen receptor (ER). MAIN METHODS:10mg/kg GS-Rd in ovariectomy (OV...

journal_title：Life sciences

authors： Yan X,Hu G,Yan W,Chen T,Yang F,Zhang X,Zhao G,Liu J

更新日期：2017-01-01 00:00:00

abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...

journal_title：Life sciences

authors： Wei Z,Hao Y,Yu H,Shi L,Jing X,Zhang X,Liu N,Li T,Zhang X,Yuan F

更新日期：2020-09-15 00:00:00

abstract：AIM:Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was aimed to explore the effects of nicotine on human pancreatic stellate cells (hPSCs) and...

journal_title：Life sciences

authors： Li Z,Zhang X,Jin T,Hao J

更新日期：2020-02-15 00:00:00