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High glucose increases platelet-derived growth factor production in cultured human vascular endothelial cells and preventive effects of eicosapentaenoic acids.

Abstract：

:The regulation of the production of platelet-derived growth factor (PDGF) and the influence of high glucose concentration, eicosapentaenoic acid (EPA) were studied in cultured human umbilical vein endothelial cells (HUE). The PDGF production of HUE increased markedly depending on glucose concentration. However, EPA (3 x 10(-4)M) markedly inhibited PDGF production [27.5 mM glucose group: 123 +/- 3% of control (5.5 mM glucose group), 27.5 mM glucose+EPA group: 104 +/- 5% of control]. These results suggested that a high glucose concentration and a high osmotic pressure-induced increase in PDGF production is involved in the development and progression of diabetic macroangiopathy. As eicosapentaenoic acid inhibits the PDGF production induced by high glucose concentration in HUE, use of this agent may exhibit anti-arteriosclerotic effects.

journal_name

Life Sci

journal_title

Life sciences

authors

Mizutani M,Okuda Y,Suzuki S,Sawada T,Soma M,Yamashita K

doi

10.1016/0024-3205(95)00261-4

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

PL31-5

issue

2

eissn

0024-3205

issn

1879-0631

pii

0024320595002614

journal_volume

57

pub_type

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