Magnetically responsive microspheres for the pulsed delivery of insulin.

abstract：:Doxorubicin (DOX) induced cardiotoxicity is a life-threatening side effect of chemotherapy and decreased cardiac function can present years after treatment. Despite the investigation of a broad range of pharmacologic interventions, to date the only drug shown to reduce DOX-related cardiotoxicity in preclinical studies...

journal_title：Life sciences

authors： Zhen J,Yu H,Ji H,Cai L,Leng J,Keller BB

更新日期：2019-12-15 00:00:00

abstract：:Intracerebroventricular (i.c.v.) administration of the neurohypophyseal neuropeptide arginine8-vasopressin (AVP) results in a dose-dependent attenuation of endotoxin-induced fever (EIF) in rats. Specific antagonists of the neuropeptided(CH2)5[Tyr(Me)2]AVP for V1 receptors, d(CH2)5[dlle2lle4]AVP for the V2 receptors an...

journal_title：Life sciences

authors： Kovacs GL,Baars AM,De Wied D

更新日期：1992-01-01 00:00:00

abstract：:C57BL6/J (B6) mice lacking Se-dependent GSH peroxidase 1 and 2 (GPx1/2-DKO) develop mild to moderate ileocolitis around weaning. These DKO mice have a disease resembling human very-early-onset inflammatory bowel disease (VEOIBD), which is associated with mutations in NADPH oxidase genes. Drugs including dexamethasone ...

journal_title：Life sciences

authors： Chu FF,Esworthy RS,Shen B,Gao Q,Doroshow JH

更新日期：2019-12-15 00:00:00

abstract：AIMS:The hypothalamic suprachiasmatic nucleus (SCN), which functions as a circadian pacemaker in mammals, is influenced by melatonin and serotonin. Agomelatine, which acts as an antidepressant and can synchronize disturbed circadian rhythms, displays a unique mechanism of action involving both melatonergic agonist and ...

journal_title：Life sciences

authors： Yang J,Jin HJ,Mocaër E,Seguin L,Zhao H,Rusak B

更新日期：2016-06-15 00:00:00

abstract：:The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compou...

journal_title：Life sciences

authors： Raj P,Louis XL,Thandapilly SJ,Movahed A,Zieroth S,Netticadan T

更新日期：2014-01-30 00:00:00

abstract：:The effects of aporphines and secoaporphines on glucose uptake by isolated intestinal brush-border membrane vesicles (BBMV) or basolateral membrane vesicles (BLMV) and glucose absorption during in situ intestinal perfusion were studied. Of the tested compounds, N-allylsecoboldine was the most potent glucose uptake inh...

journal_title：Life sciences

authors： Lin CJ,Chen CH,Liu FW,Kang JJ,Chen CK,Lee SL,Lee SS

更新日期：2006-06-06 00:00:00

abstract：:The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...

journal_title：Life sciences

authors： Rabkin SW,Klassen SS,Tsang MY

更新日期：2007-08-02 00:00:00

abstract：:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...

journal_title：Life sciences

authors： Surwit RS,Allen LM 3rd,Gilgor RS,Schanberg S,Kuhn C,Duvic M

更新日期：1983-02-28 00:00:00

abstract：:We investigated whether nitric oxide (NO) exposure alters the balance between NO and endothelium-derived hyperpolarizing factor (EDHF) released from rat renal arteries. To produce states of acutely or chronically excessive NO, lipopolysaccharide (LPS) was administered intraperitoneally to rats in a single dose of 4 mg...

journal_title：Life sciences

authors： Kagota S,Yamaguchi Y,Nakamura K,Shinozuka K,Kunitomo M

更新日期：2004-04-16 00:00:00

abstract：AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...

journal_title：Life sciences

authors： Grover GJ,Koetzner L,Wicks J,Gahler RJ,Lyon MR,Reimer RA,Wood S

更新日期：2011-02-28 00:00:00

abstract：:Amylin is co-secreted with insulin from the pancreas of patients with non-insulin dependent diabetes mellitus, and its deposition may contribute to the central nervous system (CNS) manifestations of this disease. Amylin, but not its mRNA, is found in brain, suggesting that CNS amylin is derived from the circulation. T...

journal_title：Life sciences

authors： Banks WA,Kastin AJ,Maness LM,Huang W,Jaspan JB

更新日期：1995-01-01 00:00:00

abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...

journal_title：Life sciences

authors： Paskaloğlu K,Sener G,Kapucu C,Ayanoğlu-Dülger G

更新日期：2004-01-16 00:00:00

abstract：:The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in t...

journal_title：Life sciences

authors： Mangas A,Coveñas R,Geffard K,Geffard M,Marcos P,Insausti R,Dabadie MP

更新日期：2006-08-15 00:00:00

abstract：:The discovery of CB1 and CB2 receptors and of endogenous agonists for these receptors has sparked renewed interest in the therapeutic potential of cannabinoids. This has led to a need for strategies that will provide a better separation of wanted from unwanted effects, particularly for CB1 receptor agonists. Possible ...

journal_title：Life sciences

authors： Pertwee RG

更新日期：1999-01-01 00:00:00

abstract：AIMS:In this study, we investigated the combined effect of Neurotropin® and pregabalin for L5-spinal nerve ligation (L5-SNL) model in rats and thiopental-induced sleep in mice. MAIN METHODS:The left fifth lumbar nerve of rats was tightly ligated with silk sutures under pentobarbital anesthesia. The hindpaw withdrawal ...

journal_title：Life sciences

authors： Okazaki R,Namba H,Yoshida H,Okai H,Taguchi K,Kawamura M

更新日期：2013-03-12 00:00:00

abstract：:We have examined the role of membrane hyperpolarization in mediating vascular hyporeactivity induced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat thoracic aorta ex vivo. The injection of rats with LPS caused a significant fall of blood pressure and a severe vascular hyporeactivity to nore...

journal_title：Life sciences

authors： Chen SJ,Wu CC,Yang SN,Lin CI,Yen MH

更新日期：2000-12-29 00:00:00

abstract：:[3H]ET (etorphine), which is considered either as an "universal" ligand or a mu agonist, interacts with identical affinities KD = 0.33-0.38 nM to hybrid cells and rabbit cerebellum, pure delta and mu-enriched opioid receptor preparations, respectively. In rat brain tissue, [3H]ET binding is inhibited by DAGO (Tyr-D-Al...

journal_title：Life sciences

authors： Delay-Goyet P,Roques BP,Zajac JM

更新日期：1987-08-10 00:00:00

abstract：:The relative distribution of muscarinic and nicotinic cholinergic receptors labeled with [3H]acetylcholine was determined using autoradiography. [3H]Acetylcholine binding to high affinity muscarinic receptors was similar to what has been described for an M-2 distribution: highest levels of binding occurred in the pont...

journal_title：Life sciences

authors： Schwartz RD

更新日期：1986-06-09 00:00:00

abstract：AIMS:Individual susceptibility to develop obesity may impact the development of cardio-metabolic risk factors that lead to obesity-related comorbid conditions. Obesity-prone Osborne-Mendel (OM) rats expressed higher levels of visceral adipose inflammation than obesity-resistant, S5B/Pl (S5B) rats. However, the consumpt...

journal_title：Life sciences

authors： Poret JM,Battle C,Mouton AJ,Gaudet DA,Souza-Smith F,Gardner JD,Braymer HD,Harrison-Bernard L,Primeaux SD

更新日期：2019-04-15 00:00:00

abstract：:This study examined whether there is increased production of oxygen free radicals during chronic renal failure. Rats subjected to 3/4 nephrectomy and sham operated controls were killed after 3 weeks. Lipid extracts of plasma and renal tissue were examined by HPLC and kidney specimens were also analyzed by EPR spectros...

journal_title：Life sciences

authors： Trachtman H,Wilson D,Rao PS

更新日期：1992-01-01 00:00:00

abstract：:There is evidence that senescence affects neurotransmission at different levels. In particular, this review summarizes the studies on age-dependent modifications in protein phosphorylation, which represents the final pathway in the action of transmitters and hormones at neuronal level. Cyclic AMP-dependent protein kin...

journal_title：Life sciences

authors： Magnoni MS,Govoni S,Battaini F,Trabucchi M

更新日期：1991-01-01 00:00:00

abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...

journal_title：Life sciences

authors： Czech DA,Stein EA,Blake MJ

更新日期：1983-08-22 00:00:00

abstract：:The effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue was investigated and compared with other a-adrenergic antagonists. Moxisylyte produced a concentration-dependent relaxation of a norepinephrine-induced (1 x 10(-5) M) contraction of the corpus cavernosum tissue. Pretreatment with ...

journal_title：Life sciences

authors： Imagawa A,Kimura K,Kawanishi Y,Tamura M

更新日期：1989-01-01 00:00:00

abstract：:The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly ...

journal_title：Life sciences

authors： Libro R,Bramanti P,Mazzon E

更新日期：2016-08-01 00:00:00

abstract：:Nitric oxide (NO) is present in the exhaled breath of humans and experimental animals, but its physiologic role and cellular source(s) remain to be determined. Possible sites of origin are pulmonary endothelial cells and/or resident macrophages. Here we have tested the hypothesis that changes in cardiovascular status ...

journal_title：Life sciences

authors： Bauer JA,Wald JA,Doran S,Soda D

更新日期：1994-01-01 00:00:00

abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...

journal_title：Life sciences

authors： Lötsch J,Darimont J,Skarke C,Zimmermann M,Hummel T,Geisslinger G

更新日期：2001-09-28 00:00:00

abstract：:The influence of oral administration of rare earth element cerium (Ce) was studied in relation to metallothionein (MT) and glutathione (GSH) content in the organs of ICR mice, which were administered heavy metal cadmium (Cd) for comparison. Male ICR mice were divided into 9 groups: 1 control group, 4 cerium groups and...

journal_title：Life sciences

authors： Kawagoe M,Hirasawa F,Cun Wang S,Liu Y,Ueno Y,Sugiyama T

更新日期：2005-07-08 00:00:00

abstract：:The profile of endogenous opioid peptides in the peptide-rich fraction obtained from a homogenate of an ACTH-secreting human pituitary tumor is presented. Gradient RP-HPLC is used to separate the mixture into peptide constituents. A preparation of opioid receptors is used in a radioreceptor assay with ethorphine - a r...

journal_title：Life sciences

authors： Desiderio DM,Cezayirli RC,Fridland G,Robertson JT,Sacks H

更新日期：1985-11-11 00:00:00

abstract：:The antinociceptive and temperature responses to morphine were compared in male and female rats from two different strains. Males of both the Sprague-Dawley and Wistar-Furth strains were slightly more responsive to the acute actions of morphine than were females of the same strain. However, Wistar-Furth animals requir...

journal_title：Life sciences

authors： Kasson BG,George R

更新日期：1984-04-23 00:00:00

abstract：:Changes in neuroendocrine function have been shown to occur in diabetic animals. The aim of the present study was to examine both the prolactin (PRL) and corticosterone (CORT) responses to a short period of restraint stress after the animals had been made diabetic for six weeks. The streptozotocin - induced diabetic r...

journal_title：Life sciences

authors： Ratner A,Pasternack LB,Weiss GK

更新日期：1991-01-01 00:00:00