Effect of moxisylyte hydrochloride on isolated human penile corpus cavernosum tissue.

abstract：:Utilizing a nine amino-acid (Asp-Glu-Leu-Tyr-Pro-Leu-Glu-Val-Glu) non-enkephalin containing fragment of Peptide F from the pro-enkephalin molecule, a radioimmunoassay was developed. Extraction of bovine, rat, and guinea pig adrenomedullary preparations demonstrated this fragment to be present and apparently partially ...

journal_title：Life sciences

authors： Alessi N,Taylor L,Akil H

更新日期：1982-10-18 00:00:00

abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...

journal_title：Life sciences

authors： Czech DA,Stein EA,Blake MJ

更新日期：1983-08-22 00:00:00

abstract：:Neem seed preparations contain not only azadirachtin as the active insect antifeedant or growth regulator but also a variety of their limonoids, some of which are cytotoxic to N1E-115 neuroblastoma (mouse), 143B.TK- osteosarcoma (human) and Sf9 (insect) cultured cell lines. The most potent of these limonoids is nimbol...

journal_title：Life sciences

authors： Cohen E,Quistad GB,Casida JE

更新日期：1996-01-01 00:00:00

abstract：AIMS:Dysfunction of the Hippo-Yes-Associated Protein (YAP) signaling pathway is known to be associated with hepatocellular carcinoma (HCC). Evodiamine (Evo), a plant-derived bioactive alkaloid, exerts inhibitory effects on cancer. However, the precise influence of Evo on HCC and its potential effects on Hippo-YAP signa...

journal_title：Life sciences

authors： Zhao S,Xu K,Jiang R,Li DY,Guo XX,Zhou P,Tang JF,Li LS,Zeng D,Hu L,Ran JH,Li J,Chen DL

更新日期：2020-06-15 00:00:00

abstract：:XY99-5038 is a preparation from a specific formula provided by Dr. Yan Xin, a renowned Traditional Chinese Medicine specialist. This formulation has proven to be effective without side effects but has not been studied under rigorous laboratory conditions. In order to investigate the role of XY99-5038 in protecting neu...

journal_title：Life sciences

authors： Xin Y,Fong YT,Wolf G,Wolf D,Cao W

更新日期：2001-06-08 00:00:00

abstract：:The aim of the present study was to assess the effects of peanut (Arachis hypogaea L.) shell extracts (PSE) on lipases and to evaluate its potential development for the treatment of obesity. The peanut shells were extracted in 95% ethanol, and the extracts were screened for inhibitory effects on pancreatic lipase (PL)...

journal_title：Life sciences

authors： Moreno DA,Ilic N,Poulev A,Raskin I

更新日期：2006-05-08 00:00:00

abstract：:Voltage clamp recordings of GH3/B6 pituitary cells reveal the presence of non linear steady state membrane properties at the level of the resting potential (about -41 mV). Clamping the cells to potentials more depolarized than -60 mV is associated with a potential dependent increase in membrane conductance and membran...

journal_title：Life sciences

authors： Dufy B,Barker JL

更新日期：1982-05-31 00:00:00

abstract：:Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds...

journal_title：Life sciences

authors： Harris DW,Baker CA,Saneii HH,Johnson GA

更新日期：1985-08-19 00:00:00

abstract：:Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by ...

journal_title：Life sciences

authors： Berrens L,de la Cuadra B,Gallego MT

更新日期：1997-01-01 00:00:00

abstract：:Tissue copper levels of brindled (Mobr) mice and normal litter-mates after single and repeated dosing with CuCl2 and/or D-penicillamine are examined, together with a study of the cytosol distribution of copper after CuCl2 treatment. The results confirm that the mutant mouse kidney is capable of extensive copper accumu...

journal_title：Life sciences

authors： Hunt DM,Port AE

更新日期：1982-08-02 00:00:00

abstract：:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...

journal_title：Life sciences

authors： Inoue H,Ganbo T,Hisamatsu K,Ishida H

更新日期：1993-01-01 00:00:00

abstract：:Oxidative stress has been implicated to play an important role in the pathogenesis of diabetic neuropathy, which is the most common complication of diabetes mellitus affecting more than 50% of diabetic patients. In the present study, we have investigated the effect of U83836E [(-)-2-((4-(2,6-Di-1-pyrrolidinyl-4-pyrimi...

journal_title：Life sciences

authors： Sayyed SG,Kumar A,Sharma SS

更新日期：2006-07-17 00:00:00

abstract：:Palytoxin induced increases in cytosolic Ca2+ and tension, which were dependent on external Ca2+, and depolarized the membrane in endothelium-denuded porcine coronary arteries. When the endothelium was present, however, these effects were greatly inhibited, suggesting that some factors from endothelium inhibited the p...

journal_title：Life sciences

authors： Ishii K,Ito KM,Ikeda M,Uemura D,Ito K

更新日期：1997-01-01 00:00:00

abstract：:Acute renal injury (AKI) is a risk factor for the development of hypertension, which involves oxidative stress, changes in Na+ handling, and the intrarenal renin-angiotensin-aldosterone system (RAAS) as underlying mechanisms. We investigated in rats whether renal ischemia-reperfusion (IR) leads to changes in the proxi...

journal_title：Life sciences

authors： Lima NKS,Farias WRA,Cirilo MAS,Oliveira AG,Farias JS,Aires RS,Muzi-Filho H,Paixão ADO,Vieira LD

更新日期：2021-02-01 00:00:00

abstract：AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...

journal_title：Life sciences

authors： Stein T,Tonussi CR

更新日期：2020-12-01 00:00:00

abstract：:To investigate the changes in the FSH receptor and the activin receptor during sexual maturation in rat testes, we examined the mRNA levels of the receptors by Northern blot analysis. With a full length rat activin receptor cRNA probe in this study, Northern blot analysis revealed two activin receptor mRNAs (6Kb and 3...

journal_title：Life sciences

authors： Ito I,Minegishi T,Hasegawa Y,Shinozaki H,Nakamura K,Igarashi S,Nakamura M,Miyamoto K,Ibuki Y

更新日期：1993-01-01 00:00:00

abstract：:Digoxin-like immunoreactive factors (DLIFs) in serum may represent endogenous cardiotropic agents. We determined if blood levels of these endogenous factors changed during prolonged strenuous exercise. Total and loosely protein-bound (LPB) DLIF were measured by radioimmunoassay in the serum of nine healthy subjects du...

journal_title：Life sciences

authors： Valdes R Jr,Hagberg JM,Vaughan TE,Lau BW,Seals DR,Ehsani AA

更新日期：1988-01-01 00:00:00

abstract：AIMS:In myocardial ischemia-reperfusion (MI/R) injury, impaired autophagy function worsens cardiomyocyte death. AMP-activated protein kinase (AMPK) is a heterotrimeric protein that plays an important role in cardioprotection and myocardial autophagic function. AMPKα1 and α2 are localized primarily in the cytoplasm and ...

journal_title：Life sciences

authors： Wang Y,Yang Z,Zheng G,Yu L,Yin Y,Mu N,Ma H

更新日期：2019-05-15 00:00:00

abstract：:When HeLa cells were incubated with tritiated dexamethasone mesylate at 2 degrees C, sodium dodecyl sulfate-polyacrylamide gel electrophoresis of cytosolic and nuclear extracts revealed the presence of two monomeric receptor complex forms with estimated molecular masses of about 98 and 87 kDa. If cells were subjected ...

journal_title：Life sciences

authors： Rossini GP,Malaguti C

更新日期：1992-01-01 00:00:00

abstract：:CCK-octapeptide (CCK-8) (EC50 = 0.5 nM), in the presence of Li+, increased 3H-inositol phosphate (IP) accumulation in guinea pig gastric glands prelabeled with 3H-inositol. CCK-8 desulfate, human gastrin I and pentagastrin were much less potent than CCK-8. Antagonists of CCK receptors such as proglumide, dibutyryl-c-G...

journal_title：Life sciences

authors： Chang RS,Lotti VJ,Chen TB

更新日期：1985-03-11 00:00:00

abstract：:Methyl beta-carboline-3-carboxylate (beta-CCM) and flumazenil (Ro15-1788) are known to be respectively an inverse agonist and an antagonist of the central benzodiazepine-receptor. Surprisingly, these two drugs have shown a similar enhancing effect in a negatively reinforced multiple-trial brightness discrimination tas...

journal_title：Life sciences

authors： Raffalli-Sebille MJ,Chapouthier G

更新日期：1991-01-01 00:00:00

abstract：:The vascular endothelium is recognized as a barrier between blood and blood vessel wall. The abnormality of vascular endothelium is critical for atherosclerosis, hypertension and diabetes. Oxidative stress, inflammation, obesity, hyperlipidemia and insulin resistance are major contributors to endothelial dysfunction i...

journal_title：Life sciences

authors： Sun HJ,Hou B,Wang X,Zhu XX,Li KX,Qiu LY

更新日期：2016-12-15 00:00:00

abstract：:The biosynthesis of phospholipids during differentiation of normal and dystrophic muscle cells was studied using [32Pi] added to primary culture media. Labeled phosphatides were separated by two-dimensional thin-layer chromatography, exposing the plates to HCl vapors between solvents to cleave the alk-1-enyl bonds. Ph...

journal_title：Life sciences

authors： Leskawa KC,Erwin RE,Hogan EL

更新日期：1986-01-13 00:00:00

abstract：:Acute effect of streptozotocin-induced diabetes on several parameters of glucose metabolism was investigated in thymus lymphocytes (thymocytes). The cells from diabetics rats accumulated in vitro about 2-fold more fructose 2,6-bisphosphate (Fru-2, 6-P2) in the presence of increasing glucose concentration than cells fr...

journal_title：Life sciences

authors： Moreno-Aurioles VR,Montaño R,Conde M,Bustos R,Sobrino F

更新日期：1996-01-01 00:00:00

abstract：:Hyperglycemia and/or hypoinsulinemia have been found to inhibit L-ascorbic acid cellular transport. The resultant decrease in intracellular ascorbic acid may de-inhibit aryl sulfatase B and increase degradation of sulfated glycosaminoglycans (sGAG). This could lead to a degeneration of the extracellular matrix and res...

journal_title：Life sciences

authors： Fay MJ,Bush MJ,Verlangieri AJ

更新日期：1990-01-01 00:00:00

abstract：:Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of d...

journal_title：Life sciences

authors： Khot V,Chavan-Gautam P,Joshi S

更新日期：2015-05-15 00:00:00

abstract：:Insulin binding and 3-0-Methylglucose transport have been studied in erythrocyte- and reticulocyte-enriched fractions of blood cells in order to determine if the increased number of insulin binding sites in reticulocytes is associated with a glucose transport response to insulin. In these experiments rabbit reticulocy...

journal_title：Life sciences

authors： Albert SG

更新日期：1982-07-19 00:00:00

abstract：:Several recent reports indicate that patients with Huntington's Disease (HD) may manifest membrane abnormalities in a wide variety of cells including peripheral blood lymphocytes. In this study, flow cytometry is used in conjunction with the fluorescent membrane probe, 8-anilino-1-naphthalene sulfonate (ANS), to exami...

journal_title：Life sciences

authors： Gollin SM,Leary JF,Shoulson I,Doherty RA

更新日期：1985-02-18 00:00:00

abstract：:Clinical data indicate that hydroalcoholic extracts of Hypericum perforatum might be as valuable as conventional antidepressants in mild-to-moderate depression, with fewer side effects. One clinical trial using two extracts with different hyperforin contents indicated it as the main active principle responsible for th...

journal_title：Life sciences

authors： Mennini T,Gobbi M

更新日期：2004-07-16 00:00:00

abstract：:Clinical reports suggest that EGFR-mutated lung cancer usually respond significantly towards small molecule tyrosine kinase inhibitors. Same studies also report the eventual development of acquired resistance within a median time interval of 9 to 14months. One of the major mechanisms involved in this acquired resistan...

journal_title：Life sciences

authors： Singh PK,Silakari O

更新日期：2017-10-01 00:00:00