The role of oxygen free radicals in the development of chronic renal failure.

abstract：AIMS:Active immunization with human vascular endothelial growth factor (hVEGF) vaccines provides a therapeutic option instead of bevacizumab therapy. However, the immunity to self-molecule is difficult to elicit due to immune tolerance. A bioactive peptide of two tandem repeats of mHSP70407-426 (M2) has exhibited poten...

journal_title：Life sciences

authors： Xu M,Zhang Y,Dong W,Jiang L,Zhang J,Yu P,Xie S,Zhou L

更新日期：2018-05-15 00:00:00

abstract：:The distribution of thiamine-immunoreactive structures was studied in the brain of the monkey using an indirect immunoperoxidase technique. Fibers containing thiamine, but no thiamine-immunoreactive cell bodies, were found. The highest density of fibers containing thiamine was observed in the pulvinar nucleus and in t...

journal_title：Life sciences

authors： Mangas A,Coveñas R,Geffard K,Geffard M,Marcos P,Insausti R,Dabadie MP

更新日期：2006-08-15 00:00:00

abstract：:Tobacco smoke exposure has been shown to inhibit brain and platelet MAO B in animals and in humans. Though the mechanism(s) responsible for MAO B inhibition are not known, studies in rodents have shown that nicotine administration does not inhibit brain MAO B. In this study we investigated whether brain MAO B is also ...

journal_title：Life sciences

authors： Fowler JS,Volkow ND,Logan J,Pappas N,King P,MacGregor R,Shea C,Garza V,Gatley SJ

更新日期：1998-01-01 00:00:00

abstract：:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular fo...

journal_title：Life sciences

authors： Evans SF,Medbak S,Hinds CJ,Tomlin SJ,Varley JG,Rees LH

更新日期：1984-04-09 00:00:00

abstract：:Recent studies suggest that the time of day at which food is consumed dramatically influences clinically-relevant cardiometabolic parameters (e.g., adiposity, insulin sensitivity, and cardiac function). Meal feeding benefits may be the result of daily periods of feeding and/or fasting, highlighting the need for improv...

journal_title：Life sciences

authors： Brewer RA,Collins HE,Berry RD,Brahma MK,Tirado BA,Peliciari-Garcia RA,Stanley HL,Wende AR,Taegtmeyer H,Rajasekaran NS,Darley-Usmar V,Zhang J,Frank SJ,Chatham JC,Young ME

更新日期：2018-03-15 00:00:00

abstract：:Tissue copper levels of brindled (Mobr) mice and normal litter-mates after single and repeated dosing with CuCl2 and/or D-penicillamine are examined, together with a study of the cytosol distribution of copper after CuCl2 treatment. The results confirm that the mutant mouse kidney is capable of extensive copper accumu...

journal_title：Life sciences

authors： Hunt DM,Port AE

更新日期：1982-08-02 00:00:00

abstract：:The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of common drug transporters that mediate the efflux and uptake of drugs, respectively, and play an important role in the absorption, distribution, metabolism and excretion of drugs in vivo. Rheumatoid arthritis (RA) is an autoimmune d...

journal_title：Life sciences

authors： Gao J,Wang C,Wei W

更新日期：2021-01-08 00:00:00

abstract：:In human tumors changes in angiogenesis and expression of extracellular matrix-degrading enzymes occur simultaneously during invasion and metastasis. Tissues from 20 biopsies of human neuroblastoma (NB) were investigated immunohistochemically by using an antibody against factor VIII to determine their microvessel numb...

journal_title：Life sciences

authors： Ribatti D,Surico G,Vacca A,De Leonardis F,Lastilla G,Montaldo PG,Rigillo N,Ponzoni M

更新日期：2001-01-26 00:00:00

abstract：:Synaptic mechanisms were studied ex vivo in the aged rat hippocampus, using a slice preparation and intracellular electrophysiological recordings of the CA1 pyramidal neurons. A dramatic depression of the slow cholinergic excitatory postsynaptic potential (EPSP) and of the slow, GABAB-mediated inhibitory postsynaptic ...

journal_title：Life sciences

authors： Krzywkowski P,Potier B,Billard JM,Dutar P,Lamour Y

更新日期：1996-01-01 00:00:00

abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

journal_title：Life sciences

authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

更新日期：2015-09-15 00:00:00

abstract：:This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on langua...

journal_title：Life sciences

authors： Normando VMF PhD,Dias ÁRN Me,da Silva ALSE Lic,da Silva Pinto D PhD,de Souza Santos MC PhD,Rodrigues CL Lic,de Oliveira EM PhD,de Souza Filho LEC Me,de Brito Vieira W Esp,Andriolo RB PhD,Sousa RCM PhD,Falcão LFM PhD,Quaresma JAS

更新日期：2020-09-01 00:00:00

abstract：AIMS:The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential roles in intercellular crosstalk. Here, it is proposed that tumor cell-derived exosomes could function as vehicles to deliver exogenous miRNA-155 into DCs, f...

journal_title：Life sciences

authors： Asadirad A,Hashemi SM,Baghaei K,Ghanbarian H,Mortaz E,Zali MR,Amani D

更新日期：2019-02-15 00:00:00

abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...

journal_title：Life sciences

authors： Tsukamoto I,Taya K,Watanabe G,Sasamoto S

更新日期：1986-07-14 00:00:00

abstract：:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined ...

journal_title：Life sciences

authors： Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

更新日期：1995-01-01 00:00:00

abstract：:The aim of the present work was to study whether physiological doses of melatonin (1nM) modified DNA synthesis in MCF-7 human breast cancer cells. Exponentially growing MCF-7 cells were incubated for 24 h with thymidine (2mM) for blocking mitosis and synchronizing the cell division cycle. Synchronization was assessed ...

journal_title：Life sciences

authors： Cos S,Fernández F,Sánchez-Barceló EJ

更新日期：1996-05-24 00:00:00

abstract：:The conversion of beta-carotene to retinal and the succeeding metabolic process of the retinal leading to production of retinol and retinyl esters are the prerequisite for the utilization of beta-carotene as a provitamin A. These processes are participated by beta-carotene cleavage enzyme, retinal reductase and retino...

journal_title：Life sciences

authors： Tajima S,Goda T,Takase S

更新日期：1999-01-01 00:00:00

abstract：:The multidrug transporter MDR1 (P-glycoprotein)-mediated interaction between digoxin and 29 antihypertensive drugs of various types was examined by using the MDR1 overexpressing LLC-GA5-COL150 cells, which were established by transfecting MDR1 cDNA into porcine kidney epithelial LLC-PK1 cells. These cells construct mo...

journal_title：Life sciences

authors： Takara K,Kakumoto M,Tanigawara Y,Funakoshi J,Sakaeda T,Okumura K

更新日期：2002-02-15 00:00:00

abstract：:The colchicine-induced accumulation of vasopressin (AVP) and oxytocin (OXT) has recently been applied to estimate the synthesis and turnover rates for these neuropeptides in whole rat hypothalamus. In the present studies, this pharmacologic procedure has been examined as a potential method for estimating hypothalamic ...

journal_title：Life sciences

authors： Liu B,Kwok RP,Fernstrom JD

更新日期：1991-01-01 00:00:00

abstract：:Salicylate displaces phenytoin from protein binding leading to an increase in free phenytoin concentration. We observed unexpected decreases in free phenytoin concentration in the presence of salicylate. Serum pools containing no phenytoin or salicylate were supplemented with the same concentrations of phenytoin. Then...

journal_title：Life sciences

authors： Biddle DA,Wells A,Dasgupta A

更新日期：2000-01-01 00:00:00

abstract：AIMS:Morus, a member of the family Moraceae and commonly known as the mulberry, comprises a pharmaceutically important plant group whose major constituents are the moracins. Moracin derivatives have received great attention because they exhibit a diverse range of biological functionalities. However, no studies have con...

journal_title：Life sciences

authors： Seong SH,Ha MT,Min BS,Jung HA,Choi JS

更新日期：2018-10-01 00:00:00

abstract：:The influence of stressful experiences on the development of vacuous chewing movements (VCM) was investigated in non-medicated rats. After an initial baseline period one group of rats was housed in a noisy environment while another group was housed in quiet surroundings. The development of VCM was recorded during a 16...

journal_title：Life sciences

authors： Glenthøj B,Hemmingsen R

更新日期：1991-01-01 00:00:00

abstract：:Effects of 1-methyl-4-phenylpyridine(MPP+), a putative neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), on the contents of dopamine were examined in the various regions of the rat brain. Under anesthesia with pentobarbital sodium and flunitrazepam, MPP+ 150 micrograms/rat was intracerebrove...

journal_title：Life sciences

authors： Okada M,Yokotani K,Yamashita M,Ikeda H,Osumi Y

更新日期：1989-01-01 00:00:00

abstract：AIMS:MicroRNA-1 (miR-1) has been demonstrated as a tumor-suppressive miRNA, which shows a down-regulated pattern in several human malignancies including hepatocellular carcinoma (HCC). However, the pathophysiologic roles of miR-1 and their mechanisms in HCC tumorigenesis are still not totally elucidated. MAIN METHODS:...

journal_title：Life sciences

authors： Li D,Yang P,Li H,Cheng P,Zhang L,Wei D,Su X,Peng J,Gao H,Tan Y,Zhao Z,Li Y,Qi Z,Rui Y,Zhang T

更新日期：2012-10-05 00:00:00

abstract：:A heterogeneous particulate fraction of mouse brain homogenates binds NRDC 157 (3-phenoxybenzyl [1R, cis]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate), a potent pyrethroid insecticide, stereospecifically and with high affinity. Stereospecific binding is a minor component of total binding (2.8%); the remai...

journal_title：Life sciences

authors： Soderlund DM,Ghiasuddin SM,Helmuth DW

更新日期：1983-07-18 00:00:00

abstract：:P-glycoprotein (P-gp) is found to play a very significant role in intestinal and biliary transport of irinotecan and its active metabolite, SN-38. This makes P-gp inhibition a logical strategy for improving irinotecan's oral efficacy and reducing its toxicity. The objective of the present study was to identify the mos...

journal_title：Life sciences

authors： Bansal T,Awasthi A,Jaggi M,Khar RK,Talegaonkar S

更新日期：2008-08-15 00:00:00

abstract：:This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observe...

journal_title：Life sciences

authors： Brown-Croyts LM,Caton PW,Radecki DT,McPherson SL

更新日期：2000-06-30 00:00:00

abstract：:Kinetics of activation of the NADPH oxidase in a fully soluble cell-free system from phorbol myristate acetate (PMA)-stimulated human neutrophils were investigated. In a cell-free system in which Mg2+ and sodium dodecyl sulfate, an anionic detergent required for the activation of NADPH oxidase are contained, cytosol p...

journal_title：Life sciences

authors： Umeki S

更新日期：1990-01-01 00:00:00

abstract：:Hydrolysis of fragments of the C-terminal and mid-portions of parathyroid hormone (PTH) by a phosphoramidon-insensitive metallo-endopeptidase, previously purified by us from the microvillar membranes of rat kidney, and by the microvillar membranes of rat kidney themselves were investigated using a reverse-phase HPLC, ...

journal_title：Life sciences

authors： Yamaguchi T,Fukase M,Kido H,Sugimoto T,Katunuma N,Chihara K

更新日期：1994-01-01 00:00:00

abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

journal_title：Life sciences

authors： Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

更新日期：1995-03-03 00:00:00

abstract：AIMS:Prior work suggests that ischemic preconditioning increases the level of CD39 in the heart and contributes to cardiac protection. Therefore, we examined if targeted cardiac expression of CD39 protects against myocardial injury. MAIN METHODS:Mice with cardiac-specific expression of human CD39 (αMHC/hCD39-Tg) were ...

journal_title：Life sciences

authors： Smith SB,Xu Z,Novitskaya T,Zhang B,Chepurko E,Pu XA,Wheeler DG,Ziolo M,Gumina RJ

更新日期：2017-06-15 00:00:00