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Tyrosine metabolism in users of oral contraceptives.

Abstract：

:Brain noradrenaline takes part in the regulation of several brain functions. The formation of brain noradrenaline depends on brain tyrosine (Tyr) levels, which associates with the ratio in plasma of Tyr to other large, neutral amino acids (LNAA). Tyr metabolism has been studied in users of the new generation combined oral contraceptives (OC) and comparable controls at the follicular, mid-cycle, and luteal phases of the menstrual cycle. OC users showed significantly increased plasma Tyr transaminase activity, and significantly decreased plasma Tyr and Tyr/LNAA levels at mid-cycle and luteal phase, whereas plasma total 3-methoxy-4-hydroxyphenylglycol (MHPG) was not affected. Following an oral protein load, the area under the curve in plasma of Tyr and Tyr/LNAA in OC users at the luteal phase were 43% and 29%, respectively, of control levels. The results suggest that the decreased Tyr availability to the brain in OC users may result in a substrate-limited reduction of brain noradrenaline formation, which, secondarily, may contribute to disturbances of mood, coping mechanisms, and appetite in susceptible subjects.

journal_name

Life Sci

journal_title

Life sciences

authors

Møller SE,Maach-Møller B,Olesen M,Madsen B,Madsen P,Fjalland B

doi

10.1016/0024-3205(94)00502-j

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

687-95

issue

9

eissn

0024-3205

issn

1879-0631

pii

002432059400502J

journal_volume

56

pub_type

临床试验,杂志文章,随机对照试验

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