Abstract:
AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility in experimental ChC. MAIN METHODS:Wistar rats were subjected to a 9-week treadmill running training and challenged with Trypanosoma cruzi. Control animals remained sedentary. Physical and metabolic performance, cardiac morphology, cytokines, chemokines, nitric oxide, oxidative tissue damage, cardiomyocyte morphology and contractility were analyzed. KEY FINDINGS:Exercise training was efficient to improve physical performance and anaerobic threshold in trained animals. By increasing cardiac and serum levels of cytokines (TNF-α, IFN-γ, and IL-6), chemokines (MCP-1 and CX3CL1), the myocardial activity catalase and superoxide dismutase, and reducing lipid and protein oxidation in cardiac tissue, exercise training seem to be a beneficial strategy to mitigate the progression and severity of Chagas-associated cardiomyopathy. SIGNIFICANCE:The protective adaptations to the host triggered by exercise training contributed to reduce cardiac parasitism, inflammation, fibrosis and cardiomyocytes atrophy. Although exercise training does not affect nitric oxide levels in cardiac tissue from infected animals, this strategy enhanced the efficiency of endogenous antioxidant mechanisms, restricting oxidative tissue damage with positive repercussions to cardiomyocytes biomechanics in rats.
journal_name
Life Scijournal_title
Life sciencesauthors
Novaes RD,Gonçalves RV,Penitente AR,Bozi LH,Neves CA,Maldonado IR,Natali AJ,Talvani Adoi
10.1016/j.lfs.2016.03.053subject
Has Abstractpub_date
2016-05-01 00:00:00pages
210-9eissn
0024-3205issn
1879-0631pii
S0024-3205(16)30203-Xjournal_volume
152pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract::Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(88)90319-0
更新日期:1988-01-01 00:00:00
abstract::In vivo benzodiazepine receptor binding has generally been studied by "ex vivo" techniques. In this investigation, we identify the conditions where [3H]-Ro 15-1788 labels benzodiazepine receptors by true "in vivo" binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homoge...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90505-3
更新日期:1985-07-29 00:00:00
abstract::Salicylate displaces phenytoin from protein binding leading to an increase in free phenytoin concentration. We observed unexpected decreases in free phenytoin concentration in the presence of salicylate. Serum pools containing no phenytoin or salicylate were supplemented with the same concentrations of phenytoin. Then...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00572-x
更新日期:2000-01-01 00:00:00
abstract::A heterogeneous particulate fraction of mouse brain homogenates binds NRDC 157 (3-phenoxybenzyl [1R, cis]-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropanecarboxylate), a potent pyrethroid insecticide, stereospecifically and with high affinity. Stereospecific binding is a minor component of total binding (2.8%); the remai...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90385-5
更新日期:1983-07-18 00:00:00
abstract::Mitochondrial dysfunction caused by calcium overload is a vital factor for mediating cardiomyocyte death following ischemia/reperfusion (I/R) injury. The stromal interactive molecule 2 (STIM2) is a calcium sensor protein that regulates the store-operated calcium entry (SOCE). Whereas, whether STIM2 is associated with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2019.116560
更新日期:2020-04-15 00:00:00
abstract::Even though conventional systemic doses of cimetidine and other histamine H(2) antagonists display minimal brain penetration, central nervous system (CNS) effects (including seizures and analgesia) have been reported after administration of these drugs in animals and man. To test the hypothesis that cimetidine-like dr...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2004.05.020
更新日期:2004-10-08 00:00:00
abstract:AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.12.002
更新日期:2017-02-01 00:00:00
abstract::In situ radioligand binding and quantitative autoradiography have been used to measure the density of striatal D1-like, D2-like, and GABAA receptors in rats treated with haloperidol at 0.01 or 0.1 mg/kg/ day or chlorpromazine, olanzapine or clozapine at 0.1 or 1.0 mg/kg/day for 1, 3 or 7 months. [3H]SCH23390 binding t...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01214-0
更新日期:2001-08-03 00:00:00
abstract::2',6'-Dimethyl substitution of the Tyr(1) residue of opioid agonist peptides and deletion of the positively charged N-terminal amino group or its replacement with a methyl group has recently been shown to represent a general structural modification to convert opioid peptide agonists into antagonists. This conversion r...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(03)00389-8
更新日期:2003-06-27 00:00:00
abstract::Swim therapy in the form of moderate physical activity has general health benefits. Regular exercise prevents the progression of chronic diseases affecting the different bodily systems. The metabolic alterations associated with following such lifestyle remain not fully understood. The aim of the present study was to e...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.118516
更新日期:2020-12-01 00:00:00
abstract:AIMS:The clinical utilization of the combinations of all-trans-retinoic acid (RA) with antiestrogens, which present synergism of action in breast cancer, has been limited by RA adverse effects, including hepatotoxicity, which may be related with mitochondrial damage. This work evaluated the effects of RA alone and in c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.05.027
更新日期:2013-07-30 00:00:00
abstract::In order to determine the effect of relaxin and estradiol on collagen and noncollagen synthesis by mammary gland fibroblasts, fibroblasts isolated from guinea pig mammary glands were grown on plastic or Cytodex-3 collagen coated microcarriers. On plastic, estradiol (600 pg/ml) increased the incorporation of tritiated ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90460-0
更新日期:1984-11-26 00:00:00
abstract::The compound (+)-MR200 [(+)-methyl (1R,2S)-2-{[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate] is a sigma ligand with increased affinity and selectivity compared to the structurally related ligand haloperidol. From the results of a previous study on the modulation of a systemically ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2005.10.005
更新日期:2006-04-18 00:00:00
abstract::Thirty-seven women, aged 31-78 years, on two separate mornings consumed a decaffeinated beverage to which 6 mg caffeine/kg lean body mass or no caffeine were added. Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when c...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90616-y
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2020.117759
更新日期:2020-08-01 00:00:00
abstract:AIMS:Solid lipid nanoparticles (SLNs) conjugated with surface 83-14 monoclonal antibody (8314MAb) and anti-epithelial growth factor receptor (AEGFR) were synthesized and applied to permeate the blood-brain barrier (BBB) and inhibit the growth of glioblastoma multiforme (GBM). MAIN METHODS:8314MAb and AEGFR were crossl...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2016.01.025
更新日期:2016-02-01 00:00:00
abstract::The concept of food has expanded beyond its traditional role of survival and hunger satisfaction, to include a role in the prevention and treatment of disease. Polyphenols are classes of compounds that are synthesized by plants to serve a wide variety of functions including growth pollination and defense. These compou...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2013.12.011
更新日期:2014-01-30 00:00:00
abstract::Semi-purified dog kidney Na+,K+-ATPase cross-linked with ovalbumin was used in batch-wise affinity chromatography for the detection of endogenous Na+,K+-ATPase inhibitor in human plasma and urine. Ammonium acetate 1 M washed off the endogenous inhibitor from the immobilized enzyme. The inhibitory activity of the eluat...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90562-4
更新日期:1985-05-06 00:00:00
abstract::We used in vitro quantitative autoradiography to investigate changes in neurotransmitter receptor binding, including muscarinic cholinergic, PCP, GABAA, benzodiazepine, D1 and 5-HT2A receptor, in the brains of aged rats, compared with such binding in young rats. Scatchard analysis revealed that the maximal number of b...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00320-3
更新日期:1994-01-01 00:00:00
abstract::Protein tyrosine phosphorylation is prevalent throughout the nervous system. It has been implicated to play an important role in the development and maintenance of neuronal functions. In the past few years significant advances have been made in our understanding of the molecular mechanisms of synapse formation and syn...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/0024-3205(95)02118-3
更新日期:1995-01-01 00:00:00
abstract::Thymic hormones have immunomodulatory effects on T cells and hence have been used clinically to restore the immunity of immunodeficient patients as well as to enhance the cellular immunity of cancer patients. Prothymosin alpha, which is a member of the thymic hormone family, has recently been suggested to act as a nuc...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00882-5
更新日期:1997-01-01 00:00:00
abstract:AIMS:To examine the effects of metoprolol on expression of myocardial inflammatory cytokines and myocardial function in rats following coronary microembolization (CME). MAIN METHODS:Male rats were randomly assigned to receive either sham-operation (control group), CME plus saline (CME group), or CME plus metoprolol (m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.03.012
更新日期:2011-06-06 00:00:00
abstract::The Thirteenth International Conference on Endothelin (ET-13) was held from September 8-11, 2013 in Tokyo, Japan chaired by Noriaki Emoto, Kobe Pharmaceutical University, Japan, and Takashi Miyauchi, University of Tsukuba, Japan and held on the Tokyo Campus of Tsukuba University. The International Conferences on Endot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2014.09.020
更新日期:2014-11-24 00:00:00
abstract::Using electric eel acetylcholinesterase (AChE) which was either membrane-bound (AChEm) or solubilized (AChEs), similar kinetics were seen in the absence of inhibitor or in the presence of edrophonium, trimethylammonium ion or paraoxon. Thus, both forms of the enzyme appear to behave similarly toward various inhibitors...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(84)90593-9
更新日期:1984-01-16 00:00:00
abstract::We investigated the mechanism by which glucose refeeding can reverse the enhancement of glycolysis caused by glucose starvation. Human fibroblasts were deprived of glucose for 18 hr and then refed for 1 hr with either (a) medium from sister glucose-starved cultures (controls), (b) fresh, glucose-containing medium (fre...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(89)90057-x
更新日期:1989-01-01 00:00:00
abstract::In this study, we evaluated whether butein can inhibit the effects of tumor necrosis factor alpha (TNF-alpha), an inflammatory mediator, in intestinal epithelial HT-29 cells. Butein significantly inhibited TNF-alpha-induced interleukin 8 (IL-8) secretion and mRNA expression. Moreover, butein suppressed the expression ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.09.024
更新日期:2007-11-10 00:00:00
abstract:AIM:Diabetic nephropathy is the leading cause of end stage renal disease in developed countries throughout the world. The imbalance between the production of reactive oxygen species (ROS) and the antioxidant defense system is the main problem that is responsible for the progression of diabetic kidney disease. In this s...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.04.018
更新日期:2015-08-15 00:00:00
abstract::The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respira...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2020.118496
更新日期:2020-12-01 00:00:00
abstract::Diabetic retinopathy, a common secondary complication of diabetes mellitus, involves extensive damage to the retinal microvasculature. Retina, being a susceptible target, is highly prone to hyperglycemia-induced molecular damages. PPAR receptor, chiefly gamma subtype, mediates numerous responses related to glucose met...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2016.03.054
更新日期:2016-05-15 00:00:00
abstract::In the present study the formation of thrombin-antithrombin-complexes (TAT) during incubation of thrombin (0.89, 4.5, 8.9 nmol/l) and antithrombin (4.6 micromol/l) on the surface of cultured human EC, derived from different parts of the circulation, and on the surface of human vessel segments was studied. In the absen...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(98)00416-0
更新日期:1998-01-01 00:00:00