Abstract：
:The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respiratory symptoms. With the increase in confirmed cases, however, the infection symptoms turn to be diverse with secondary or first clinical symptoms relating to damage of the cardiovascular system and changes of myocardial enzyme spectrum, cardiac troponin I, electrocardiogram, cardiac function. The occurrence of extra-pulmonary manifestations, including immediately and long-term damage, means that the overall health burden caused by SARS-CoV-2 infection may be under-estimated because COVID-19 patients developed cardiovascular system injury are more likely to become serious. The factors such as directly pathogen-mediated damage to cardiomyocytes, down-regulated angiotensin-converting enzyme 2 (ACE2) expression, excessive inflammatory response, hypoxia and adverse drug reaction, are closely related to the occurrence and development of the course of COVID-19. In combination with recently published medical data of patients having SARS-CoV-2 infection and the latest studies, the manifestations of damage to cardiovascular system by COVID-19, possible pathogenic mechanisms and advances of the treatment are proposed in this article.
journal_name
Life Scijournal_title
Life sciencesauthors
Peng W,Wu H,Tan Y,Li M,Yang D,Li Sdoi
10.1016/j.lfs.2020.118496subject
Has Abstractpub_date
2020-12-01 00:00:00pages
118496eissn
0024-3205issn
1879-0631pii
S0024-3205(20)31249-2journal_volume
262pub_type
杂志文章,评审相关文献
LIFE SCIENCES文献大全abstract：:In canine renal tubular cells, the effect of Y-24180, a presumed specific platelet activating factor (PAF) receptor antagonist, on intracellular Ca(2+) concentration ([Ca(2+)](i)) was measured by using fura-2 as a Ca(2+)-sensitive fluorescent probe. Y-24180 (0.1-10 microM) caused a rapid and sustained [Ca(2+)](i) rise...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.09.033
更新日期：2004-01-02 00:00:00
abstract：:The opiate antagonist naloxone was found to block nitrous oxide analgesia in a stereospecific fashion. Using a modified hotplate test in mice, the (-)-enantiomer of naloxone (which has a KD of approximately 1 nM for opiate receptors) antagonized the analgesic actions of nitrous oxide in a dose-dependent (2.5-20 mg/kg)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90381-0
更新日期：1989-01-01 00:00:00
abstract：BACKGROUND:Quercetin is a major flavonoid in various plants. It possesses the multiple pharmacological actions like vascular integrity and regulatory action of the blood-brain barrier. AIMS:The present study is focused on evaluating the role of solid lipid nanoparticle of quercetin in pentylenetetrazole (PTZ) induced ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.03.010
更新日期：2018-04-15 00:00:00
abstract：:In order to explore the effect of neonatal androgen administration on oocyte quality, ovulation induction and in vitro fertilization (IVF) were performed in androgen-sterilized mice. Androgen sterilized mice were produced by the subcutaneous injection of testosterone propionate (TP) at 5 days of age and ovulation indu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00745-4
更新日期：1994-01-01 00:00:00
abstract：:Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by symptoms that include social communication impairments, interaction deficits, and repetitive and stereotyped behaviors. Recent studies have suggested that imbalanced cytokine levels are associated with impaired behavioral outcomes in ind...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116930
更新日期：2019-11-15 00:00:00
abstract：:The metabolism and disposition of N-hydroxy-3,4-methylenedioxyamphetamine (N-OH MDA) was studied by utilizing rat liver slices as well as by intravenous pharmacokinetic studies in rats. In the liver slice experiments, N-OH MDA (16 micrograms/ml) was incubated with rat liver slices and the disappearance of N-OH MDA and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00726-8
更新日期：1994-01-01 00:00:00
abstract：:Pitavastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor that is used for suppressing cholesterol biosynthesis. Previously, we have reported that pitavastatin induces the activation of endothelial nitric oxide synthase (eNOS) and increases nitric oxide (NO) production in vascular endothelial cells (...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.12.003
更新日期：2005-03-25 00:00:00
abstract：:Methotrexate was found to stimulate asparagine synthetase activity in vivo by approximately six-fold in rat liver. The maximum effect of methotrexate on hepatic asparagine synthetase activity was observed sixteen hours after intraperitoneal injection of the drug. Cycloheximide, like methotrexate, is a protein synthesi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90524-0
更新日期：1982-03-22 00:00:00
abstract：:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90258-8
更新日期：1983-12-05 00:00:00
abstract：AIMS:A bridging ligand 2,4,6-pyridine tricarboxylic acid (H(3)ptc) and its manganese(II) complex [Mn(Hptc)(phen)(OH)]n(Hptc=2,4,6-pyridine tricarboxylic acid, phen=1,10-phenanthroline) have been synthesized and characterized. MAIN METHODS:The interaction with DNA (HeLa and KB) was carried out by fluorescence spectrum ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.01.006
更新日期：2012-04-09 00:00:00
abstract：:Short-chain fatty acids (SCFA) are produced by fermentation of water-soluble fiber by anaerobic bacteria in the large bowel. Fiber-rich diets decrease the risk of developing inflammatory bowel disease (IBD) and butyrate enemas are effective as a therapy in some patients. Crohn's disease, one form of IBD, appears to in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00490-9
更新日期：2003-08-15 00:00:00
abstract：AIMS:To evaluate potential agents of therapeutic value in tissue inflammation, we studied norcantharidin (NCTD) and its derivatives for their effects on immune responses of human peripheral blood mononuclear cells (PBMC) in vitro. MAIN METHODS:PBMC proliferation was evaluated by tritiated thymidine uptake method. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.020
更新日期：2009-02-13 00:00:00
abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00117-3
更新日期：1997-01-01 00:00:00
abstract：:The effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice has been studied. After the mice were on diets containing added ascorbic acid for two months, the activities of ascorbic acid synthesizing enzymes in the mouse liver homogenates were measured using L-gulono-gamma-lactone as a substra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90421-9
更新日期：1989-01-01 00:00:00
abstract：:In the CNS, dopamine (DA) is a recognized neurotransmitter as well as a precursor for norepinephrine (NE) and epinephrine (EPI). In contrast to the CNS, DA has been assumed to be only a precursor in peripheral tissues. There is now, however, considerable evidence to support the hypothesis that it may function as a neu...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(83)90827-5
更新日期：1983-04-11 00:00:00
abstract：AIM:Up-regulation of inflammasome proteins was reported in dystrophin-deficient muscles. However, it remains to be determined whether inflammasome activation plays a role in the pathogenesis of Duchenne muscular dystrophy. This study was therefore set out to investigate whether genetic disruption of the inflammasome pa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118069
更新日期：2020-09-15 00:00:00
abstract：:Anti-cancer and anti-angiogenesis effects of green tea catechins have been demonstrated. It has been found that chemical modification of tea catechins improves their biological activities. We examined the chemical modification of epicatechin enhanced anti-cancer and anti-angiogenic effects. Epicatechin conjugated with...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.01.049
更新日期：2007-04-03 00:00:00
abstract：:A simple procedure has been developed for the large scale purification of fetal bovine serum acetylcholinesterase (AChE) (EC 3.1.1.7). The procedure involves two steps: batch adsorption of the AChE from 250 L of serum onto a procainamide affinity Sepharose 4B gel; and analytical procainamide affinity chromatography of...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90530-8
更新日期：1986-07-21 00:00:00
abstract：:A previous communication from this laboratory reported that brain uptake of libenzapril, a small polar molecule, was enhanced in chronic hypertension (1). The objective of this investigation was to determine if this was a more generalized phenomenon. Therefore, experiments were undertaken to examine the effect of chro...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90033-y
更新日期：1993-01-01 00:00:00
abstract：AIMS:Endothelin A receptor (ET(A)R) and epidermal growth factor receptor (EGFR) cross-talk enhances the metastatic potential of epithelial ovarian cancer (EOC) cells activating different pathways, including β-catenin signalling. Here, we evaluated β-catenin as one of ET(A)R/EGFR downstream pathway in the invasive behav...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.03.023
更新日期：2012-10-15 00:00:00
abstract：AIMS:Benidipine is a dihydropyridine (DHP) derived Ca2+ antagonist, can block triple Ca2+ channels (L, N, and T). It has been used as a safety anti-hypertensive drug because of its long-acting relaxant effect on vascular smooth muscle (VSM). However, whether benidipine has similar pharmacological actions in airway smoo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.04.036
更新日期：2019-06-15 00:00:00
abstract：:Using in vivo microdialysis and flow-injection, we evaluated the production of nitric oxide (NO) in the striatum and substantia nigra of freely moving rats in response to challenge doses of L-dihydroxyphenylalanine (L-DOPA) by measuring the NO metabolite levels of nitrate and nitrite. The dopamine and 3,4-dihydroxyphe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00275-6
更新日期：1998-01-01 00:00:00
abstract：:In an effort to obtain highly potent glucagon antagonists, we have investigated glucagon (1) structure-function relationships utilizing the following design principles: (1) structural changes known to lead to partial agonist activities; (2) conformational restrictions; (3) changes in the conformational probabilities o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90513-3
更新日期：1993-01-01 00:00:00
abstract：:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) into blood platelets from healthy donors exhibited a lower Vmax value in buffer media than in plasma. Also in plasma ultrafiltrate Vmax was reduced, but it returned to the level measured in plasma upon addition of human serum albumin (40 milligrams) containing fat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90361-5
更新日期：1989-01-01 00:00:00
abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2010.06.001
更新日期：2010-07-17 00:00:00
abstract：:Actinomycin D was found to block binding of a monoclonal antibody to nucleolar phosphoprotein 37/5.2 (B23) when incubated either simultaneously with or prior to addition of the antibody. Daunorubicin had no significant blocking activity of this antigen-antibody reaction. In comparative studies with a monoclonal antibo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90275-3
更新日期：1984-10-22 00:00:00
abstract：:A laboratory mouse can be partially restrained by placing it inside a cage with its tail protruding through a hole in one wall and taped to a surface outside of the cage. The mouse maintains enough mobility to perform an operant response yet its movements are limited to the extent that electrical or chemical stimulati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90164-3
更新日期：1982-11-15 00:00:00
abstract：:Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo pr...
journal_title：Life sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0024-3205(94)00629-6
更新日期：1994-01-01 00:00:00
abstract：:Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.050
更新日期：2006-02-09 00:00:00
abstract：:The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes throughout development and adult life. Growing evidences have suggested that deregulation of the Wnt canonical pathway could be involved in the pathogenesis of neurodegenerative diseases. The Wnt canonical signaling is a pathway tightly ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2016.06.024
更新日期：2016-08-01 00:00:00
