Receptor-like stereospecific binding of a pyrethroid insecticide to mouse brain membranes.

abstract：AIMS:The aim of this study was to investigate the molecular mechanism underlying preterm white matter injury (WMI) via the identification and functional analysis of differentially expressed long non-coding RNAs (lncRNAs) and mRNAs. MAIN METHODS:A neonatal rat model of preterm WMI was established by ligating the common...

journal_title：Life sciences

authors： Wang D,Ye X,Xie H,Liu Y,Xu Y,Wang Y,Zhou Y,Zhou N,Wang J

更新日期：2020-08-15 00:00:00

abstract：:Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can...

journal_title：Life sciences

authors： Ferrer T,Gallego M,Madrigal-Quiñónez R,Torres-Jácome J,Navarro-Polanco R,Cásis O,Sánchez-Chapula JA

更新日期：2006-07-24 00:00:00

abstract：:Anti-cancer and anti-angiogenesis effects of green tea catechins have been demonstrated. It has been found that chemical modification of tea catechins improves their biological activities. We examined the chemical modification of epicatechin enhanced anti-cancer and anti-angiogenic effects. Epicatechin conjugated with...

journal_title：Life sciences

authors： Matsubara K,Saito A,Tanaka A,Nakajima N,Akagi R,Mori M,Mizushina Y

更新日期：2007-04-03 00:00:00

abstract：:Lesions of the serotonergic afferents to the hippocampus, by fimbrial transection or by 5,7-dihydroxytryptamine treatment, produce an increase in the Bmax of [3H]WB4101 to its nanomolar affinity binding site, with no effect on its picomolar affinity binding site or on [3H]prazosin binding. The nanomolar site is seroto...

journal_title：Life sciences

authors： Morrow AL,Norman AB,Battaglia G,Loy R,Creese I

更新日期：1985-11-18 00:00:00

abstract：:Momordin II, a ribosome-inactivating protein from Momordica charantia seeds, was purified by a procedure involving a series of chromatographies on S-Sepharose, Sephadex G-50, CM-Sepharose, and Red Sepharose columns. Highly purified momordin II inhibited cell-free protein synthesis, released adenine from rat liver ribo...

journal_title：Life sciences

authors： Valbonesi P,Barbieri L,Bolognesi A,Bonora E,Polito L,Stirpe F

更新日期：1999-01-01 00:00:00

abstract：:This investigation examines the role of Angiotensin II in renal hemodynamic functions during acute unilateral ureteral obstruction (UUO) in a dog model. An electro magnetic flow probe was utilized to assess renal blood flow while the arteriovenous extraction technique of technetium 99m DTPA was utilized for the assess...

journal_title：Life sciences

authors： Katzberg RW,DiMarco PL,Morris TW,Harnish PP,Graves RF,Merguerian PA,Ventura JA,Proskin HM

更新日期：1988-01-01 00:00:00

abstract：:Gastric mucosal lipid peroxide levels, based on the amounts of thiobarbituric acid reacting substances, increased soon after oral application of absolute ethanol. On the other hand, gastric mucosal nonprotein sulfhydryl levels slightly but significantly decreased. Administration of 20% ethanol, a mild irritant which c...

journal_title：Life sciences

authors： Mizui T,Doteuchi M

更新日期：1986-06-09 00:00:00

abstract：:We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...

journal_title：Life sciences

authors： Ikegishi Y,Tawata M,Aida K,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:To elucidate the pharmacological profile of P2X receptors and the probable expression of P2Y receptors in otic ganglion neurons from 17-day-old rats, single neurons were enzymatically isolated and maintained in tissue culture for up to 30 h. Whole-cell voltage-clamp recording was carried out at a holding potential of ...

journal_title：Life sciences

authors： Ma B,Yu LH,Fan J,Ni X,Burnstock G

更新日期：2008-08-01 00:00:00

abstract：:Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have ...

journal_title：Life sciences

authors： Cherng JY,Shih MF

更新日期：2006-02-09 00:00:00

abstract：AIMS:The aim of this study was to evaluate the antinociceptive (acute assays) and anti-inflammatory (chronic assays) effects of kramecyne (KACY), a peroxide isolated from Krameria cytisoides. MAIN METHODS:The antinociceptive activity of KACY was evaluated using the hot plate, acetic acid and formalin tests. The effect...

journal_title：Life sciences

authors： Alonso-Castro AJ,Zavala-Sánchez MA,Pérez-Ramos J,Sánchez-Mendoza E,Pérez-Gutiérrez S

更新日期：2015-01-15 00:00:00

abstract：:In experiments on conscious rats it was found that preliminary microinjection of 100 nl 100 microM glutamic acid to the rostral commissural part of the solitary tract nucleus or to the caudal ventrolateral medulla increased a rise in colonic temperature induced by systemically applied endotoxin (3 microg/kg Escherichi...

journal_title：Life sciences

authors： Koulchitsky SV,Levkovets VS,Tchitchkan DN,Soltanov VV,Kulchitsky VA

更新日期：1999-01-01 00:00:00

abstract：:Synthetic nitric oxide donors are known to protect the gastric mucosa from damage and dietary nitrate is known to release NO in the stomach. Mast cells have been found to be involved in gastric mucosal damage in humans or in rodents, and recent studies have pointed out the possibility of nitric oxide from endogenous o...

journal_title：Life sciences

authors： Larauche M,Buéno L,Fioramonti J

更新日期：2003-08-08 00:00:00

abstract：:The effect of brief inhalation of carbon dioxide (CO2) was studied in a conflict situation (Vogel test) in the rat. This treatment, which inhibits gamma-aminobutyric acid (GABA)-mediated transmission in rat brain and induces anxiety and panic attacks in humans, elicited a proconflict effect. Exposure of rats for 1 min...

journal_title：Life sciences

authors： Cuccheddu T,Floris S,Serra M,Porceddu ML,Sanna E,Biggio G

更新日期：1995-03-10 00:00:00

abstract：:The pigeon crop-sac is a well-known target organ of prolactin (PRL). Pukac and Horseman (Endocrinology 114: 1718, 1984) reported that injections of the hormone caused changes in the expression of several specific proteins in that organ. We investigated the possibility that measuring the amounts of three of these prote...

journal_title：Life sciences

authors： Lebovic DI,Nicoll CS

更新日期：1992-01-01 00:00:00

abstract：:The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the intestine in the enterohepatic circulation of bile acids. In the present study, we showed that S-8921 could dose-dependently inhibit the uptake of [3H] taurocholate in the COS7 cell line which constitutively expresses hamste...

journal_title：Life sciences

authors： Hara S,Higaki J,Higashino K,Iwai M,Takasu N,Miyata K,Tonda K,Nagata K,Goh Y,Mizui T

更新日期：1997-01-01 00:00:00

abstract：:An in vitro perifusion system was used to investigate the effects of GnRH stimulation on LH, ACTH, and immunoreactive beta-endorphin (i beta-END) release from ovariectomized (1 week) rat anterior hemipituitaries. Either 0, 8 or 80 nM GnRH was administered as a 15 min pulse followed 30 min later by a prolonged 45 min i...

journal_title：Life sciences

authors： Gambacciani M,Yen SS,Rasmussen DD

更新日期：1988-01-01 00:00:00

abstract：:Using a ligation method, rat rectal epithelium was exposed to 2% sodium salicylate, and light and electron microscopic methods were used to assay for: 1) permeability of the epithelium to a marker dye, trypan blue, and 2) damage expressed in terms of disruption of the epithelial surface. Rectal mucosa was exposed to s...

journal_title：Life sciences

authors： Sithigorngul P,Burton P,Nishihata T,Caldwell L

更新日期：1983-09-12 00:00:00

abstract：:The potential photoaffinity ligand 14-beta-(o-nitro, p-azido)-cinnamoyl-amino-N-cyclopropylmethylnormorphinone (NAM) and its derivative NOM, lacking the p-azido function, were synthesised and their opiate receptor activity determined in isolated tissue preparations. The ligands showed slow receptor kinetics. NAM was a...

journal_title：Life sciences

authors： Peers EM,Rance MJ,Barnard EA,Haynes AS,Smith CF

更新日期：1983-01-01 00:00:00

abstract：:Effects of 1-methyl-4-phenylpyridine(MPP+), a putative neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP), on the contents of dopamine were examined in the various regions of the rat brain. Under anesthesia with pentobarbital sodium and flunitrazepam, MPP+ 150 micrograms/rat was intracerebrove...

journal_title：Life sciences

authors： Okada M,Yokotani K,Yamashita M,Ikeda H,Osumi Y

更新日期：1989-01-01 00:00:00

abstract：:Calcium entry from extracellular space to acetylcholine (ACh)-sensitive internal stores was investigated in beta-escin permeabilized bovine tracheal smooth muscle. Cyclopiazonic acid (CPA), a selective inhibitor of the sarcoplasmic reticulum (SR) calcium pump, and nifedipine, both inhibited the refilling, and inhibiti...

journal_title：Life sciences

authors： Qian Y,Bourreau JP

更新日期：1999-01-01 00:00:00

abstract：:Antinuclear antibodies (ANA) development was studied in male guinea pigs in response to chronic treatment with procainamide, hydralazine, acetanilide or caffeine. Acetanilide and caffeine have not previously been associated with ANA induction. Fifty-one weanling Hartley guinea pigs were divided into five groups which ...

journal_title：Life sciences

authors： Robinson CJ,Balazs T

更新日期：1982-01-11 00:00:00

abstract：:An increase in the weight of the thyroid gland, accompanied by reductions in uptake and release of 1311, serum T3 and reverse T3 concentrations and an increase in serum TSH concentration, occurs during the development of renal hypertension in rats. Renal function, as assessed by BUN, serum and urinary creatinine conce...

journal_title：Life sciences

authors： Fregly MJ,Threatte RM

更新日期：1982-02-15 00:00:00

abstract：:DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are ...

journal_title：Life sciences

authors： Zhou Q,You C,Zheng C,Gu Y,Gu H,Zhang R,Wu H,Sun B

更新日期：2018-08-01 00:00:00

abstract：:Calcium spirulan (Ca-SP) is a novel sulfated polysaccharide isolated from a blue-green alga Spirulina platensis. Ca-SP inhibits thrombin by activation of heparin cofactor II. Therefore, it could serve as an origin of anti-atherogenic medicines. Since maintenance of vascular endothelial cell monolayers is important for...

journal_title：Life sciences

authors： Kaji T,Fujiwara Y,Inomata Y,Hamada C,Yamamoto C,Shimada S,Lee JB,Hayashi T

更新日期：2002-03-08 00:00:00

abstract：:Formation of etretinate, ethyl ester of acitretin, can be confirmed in vitro and in vivo using acitretin as the substrate. Etretinate was identified by LC/MS. The in vitro incubation was performed using rat and human liver 12,000 g supernatant, and the in vivo experiment was conducted in rats after oral dosing of acit...

journal_title：Life sciences

authors： Chou RC,Wyss R,Huselton CA,Wiegand UW

更新日期：1991-01-01 00:00:00

abstract：:Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments. Inert gas narcosis induces a decrease of the dopamine release at the striatum level, structure involved in the regulation of the extrapyram...

journal_title：Life sciences

authors： Balon N,Risso JJ,Blanc F,Rostain JC,Weiss M

更新日期：2003-05-02 00:00:00

abstract：:Two-dimensional and line-scan analyses of the early phase Ca2+ transients in rat cardiomyocytes were performed with a rapid-scanning laser confocal microscope and fluo-3 to elucidate the mechanism of activation of Ca2+ release from the sarcoplasmic reticulum in atrial myocytes which lack a well developed T-tubular net...

journal_title：Life sciences

authors： Tanaka H,Masumiya H,Sekine T,Kase J,Kawanishi T,Hayakawa T,Miyata S,Sato Y,Nakamura R,Shigenobu K

更新日期：2001-12-28 00:00:00

abstract：AIMS:Serotonergic neurons and amino acid neurons are involved in the central nervous control of lower urinary tract function. We investigated the role of the serotonergic system in the central regulation of micturition, as well as the relationship between serotonergic neurons and amino acid neurons in the lumbosacral c...

journal_title：Life sciences

authors： Kadekawa K,Nishijima S,Sugaya K,Miyazato M,Saito S

更新日期：2009-10-07 00:00:00

abstract：:The infection epidemic event of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was formally declared a pandemic by World Health Organization on March 11th, 2020. Corona Virus Disease 2019 (COVID-19) is caused by SARS-CoV-2, a new type of coronavirus, which has high contagion and mainly causes respira...

journal_title：Life sciences

authors： Peng W,Wu H,Tan Y,Li M,Yang D,Li S

更新日期：2020-12-01 00:00:00