Abstract：
:Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can be due to diabetes-induced hypothyroidism. Thus, we have examined the effect of the thyroid hormone analog diiodothyropropionic acid (DITPA) on calcium-independent outward potassium currents in ventricular myocytes from diabetic rats. Sustained (I(ss)) and fast transient outward (I(tof)) K(+) currents were recorded using the whole-cell configuration of the patch-clamp technique. Myocytes were enzymatically isolated from the free wall of the right ventricle, and the epicardial and endocardial layers of the left ventricle of healthy, diabetic and DITPA-treated diabetic rats. Circulating thyroid hormones were measured by electrochemiluminescence. DITPA-treatment of diabetic rats restored I(tof) and I(ss) current densities in cardiac myocytes from the three regions studied, but did not alter current densities in myocytes of control rats. T(3) and T(4) levels were reduced by diabetes, and DITPA-treatment increased circulating T(3) levels. T(3)-treatment of diabetic rats also restored current densities to control values. However, direct incubation of diabetic myocytes with DITPA did not restore current densities. In summary, DITPA-treatment of diabetic rats restored the potassium current (I(tof) and I(ss)) densities in myocytes from all ventricular regions.
journal_name
Life Scijournal_title
Life sciencesauthors
Ferrer T,Gallego M,Madrigal-Quiñónez R,Torres-Jácome J,Navarro-Polanco R,Cásis O,Sánchez-Chapula JAdoi
10.1016/j.lfs.2006.03.014subject
Has Abstractpub_date
2006-07-24 00:00:00pages
883-9issue
9eissn
0024-3205issn
1879-0631pii
S0024-3205(06)00242-6journal_volume
79pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.06.017
更新日期：2004-11-19 00:00:00
abstract：:The platelet activating factor (PAF) receptor of the guinea pig peritoneal eosinophil was characterized by radioligand ([3H]WEB 2086) binding and measurement of PAF-stimulated membrane GTPase activity. Specific binding of [3H]WEB 2086 was rapid, reversible and saturable, with an equilibrium KD of 20.4 nM at 0 degrees ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90045-5
更新日期：1993-01-01 00:00:00
abstract：:Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways underlying its neurotoxic consequences have not yet been completely explored. Additional...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118020
更新日期：2020-09-15 00:00:00
abstract：:In an attempt to investigate the role of nucleoside transporter function in the hypertensive state, we have compared the binding of [3H]nitrobenzylthioinosine ([3H]NBMPR), a nucleoside transporter probe, in membranes prepared from platelet, renal, pulmonary, cardiac and brain tissues of spontaneously hypertensive rats...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90024-l
更新日期：1990-01-01 00:00:00
abstract：:Uncoupling proteins (UCPs) are supposed to be involved in diet-induced thermogenesis. Their activities are usually elevated by feeding and reduced by fasting in normal animals. To investigate whether fasting affects the expression of UCPs mRNA in brown adipose tissue (BAT) of bilateral ventromedial hypothalamus (VMH)-...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00225-x
更新日期：2003-05-16 00:00:00
abstract：:"Bath salts" is one street name for a family of synthetic cathinones that display pharmacological effects resembling cocaine and commonly abused amphetamines. Despite extensive legislation aimed at the criminalization of bath salts, several designer cathinones are gaining a foothold in the illicit drug scene; for exam...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2013.10.033
更新日期：2014-02-27 00:00:00
abstract：:As a step in the purification and characterization of the glucose transporter from rat skeletal muscle, we have reconstituted glucose transport activity in liposomes. Plasma membranes were prepared from skeletal muscle which display D-glucose reversible binding of cytochalasin B (10 pmol sites/mg protein; KD = 0.3 mic...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90503-0
更新日期：1987-06-15 00:00:00
abstract：:Regulation of glucose-induced oscillations in intracellular Ca2+ concentration ([Ca2+]i) was investigated by using a novel technique, electroporation from an electrolyte-filled capillary, to deliver energy metabolites to the intracellular compartment of mouse islets. Intracellular application of ATP resulted in a nife...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.05.053
更新日期：2005-10-21 00:00:00
abstract：:We studied the effects of arachidonic acid (AA) on Cl secretion across primary cultures of dog tracheal epithelium. Cell sheets showed mean values for baseline short-circuit current (Isc) and transepithelial resistance of 33.8 muA/cm2 and 360 omega.cm2 (n = 44). AA (5 x 10(-5) M) added to both sides increased Isc by 2...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90350-x
更新日期：1992-01-01 00:00:00
abstract：:Experiments were done to examine the analgesic effect of thiorphan alone or in combination with stress in mice. Analgesia was assessed by measuring jump latencies from a 55 degrees C hot plate. Thiorphan exhibited weak analgesic properties evidenced by significant increases in jump latencies only after 300 mg/kg i.p. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90338-1
更新日期：1982-09-20 00:00:00
abstract：AIMS:The role of estrogen in embryo implantation in golden hamster (Mesocricetus auratus) is still ambiguous. In order to clarify it, we investigated the spatial distribution and expression of estrogen receptors, ER-α and ER-β in the uterus of pregnant hamster during peri-implantation period and identified the effect o...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.12.002
更新日期：2017-02-01 00:00:00
abstract：:Imidazole (IMI) (from 18.7 to 300 mg/Kg) i.p. injected in adult rats induced shaking, which was antagonized by both morphine (MOR) and haloperidol (HALO) but not by methysergide (MET). I.p. IMI pretreatment inhibited the penile erections (PE) and stretching and yawning (SY) typically elicited by N-n-propylnorapomorphi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90046-3
更新日期：1985-04-08 00:00:00
abstract：:Hexokinase and glucose-6-phosphate dehydrogenase activities were studied in brain regions after intraventricular injection of kainic acid. Hexokinase activity was decreased by 10-15% in various regions while glucose-6-phosphate dehydrogenase activity remained unaltered. Soluble hexokinase activity, which remained the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90471-m
更新日期：1991-01-01 00:00:00
abstract：:Aim Furowanin A (Fur A) is a flavonoid isolated from Millettia pachycarpa Benth. Studies show its potent anti-neoplastic effects against leukemia cells. The aim of the present study was to determine the potential therapeutic effect of Fur A against colorectal cancer (CRC), and elucidate the underlying mechanism. MATE...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.12.027
更新日期：2019-02-01 00:00:00
abstract：AIMS:Excessive production of nitric oxide (NO) and reactive oxygen species (ROS) in sepsis modulates different cell functions. Since the sepsis severity is associated with the degree of platelet activation, we decided to investigate the role of systemic generation of NO and ROS in modulating the platelet adhesion of li...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.09.004
更新日期：2011-11-21 00:00:00
abstract：:Nitric oxide (NO) is present in the exhaled breath of humans and experimental animals, but its physiologic role and cellular source(s) remain to be determined. Possible sites of origin are pulmonary endothelial cells and/or resident macrophages. Here we have tested the hypothesis that changes in cardiovascular status ...
journal_title：Life sciences
pub_type： 临床试验,杂志文章
doi：10.1016/0024-3205(94)00522-2
更新日期：1994-01-01 00:00:00
abstract：AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.050
更新日期：2018-09-15 00:00:00
abstract：:Two proteolytic activities that convert big ET to ET at neutral pH were identified in solubilized membranes prepared from rat lung. The endothelin-converting activities were partially purified by using A80227 ((2S,3R,4S)-2-([N-acetylcyclohexylalanyl-isoleucyl]amino)-1-(2-nap hthyl)-3,4-dihydroxy-6-methylheptane) coupl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)90033-7
更新日期：1994-01-01 00:00:00
abstract：:Eleven patients with Raynaud's syndrome accompanied by monospecific IgG ANA, nine patients with Raynaud's syndrome in the absence of ANA, and nine normal volunteers were exposed to an ambient cold challenge during which time venous blood was continuously sampled. ANA negative patients were shown to have significantly ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90930-x
更新日期：1983-02-28 00:00:00
abstract：:The process of synaptogenesis has been studied by many investigators to determine the factors which regulate synapse formation. We have used neonatal rabbit retina to investigate the role of the gamma-aminobutyric acid (GABA) neurotransmitter system during development. By utilizing an in vitro incubation treatment of ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90754-3
更新日期：1983-09-05 00:00:00
abstract：AIM:Cadmium is a persistent ubiquitous environmental toxicant that elicits several biological defects on delicate body organs. Growing evidence suggests that cadmium (Cd) may perturb signaling pathways to induce oxidative pancreatitis. Thus, we explored whether hesperidin, a flavonone, could mitigate Cd-induced oxidati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118268
更新日期：2020-10-15 00:00:00
abstract：AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.04.010
更新日期：2011-06-20 00:00:00
abstract：:Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS). These form an environment favourable to oxidative stress. Ethanol ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2007.05.005
更新日期：2007-06-27 00:00:00
abstract：:Ribonucleotide reductase is the rate limiting enzyme of de novo DNA synthesis; its activity is significantly increased in tumor cells related to the proliferation rate. Therefore the enzyme is considered to be an excellent target for cancer chemotherapy. In the present study we tested the in vitro and in vivo antitumo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00305-1
更新日期：1998-01-01 00:00:00
abstract：:Recently, single-dose drug packaging systems, allowing the administration of multiple drugs in a single pill, have become popular for the convenience of the patient. The quality of drugs and an accurate measurement of their photostabilities within this system, however, have not been carefully addressed. Drugs that are...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.033
更新日期：2005-12-12 00:00:00
abstract：:Time-course studies revealed the increased susceptibility of the gastric mucosa to noxious injury in portal hypertension correlates with the level of elevated portal venous pressure and hyperglucagonemia. Whether acute elevation of portal venous pressure by exogenous glucagon aggravates such injury is not known. We te...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(03)00413-2
更新日期：2003-07-18 00:00:00
abstract：:The involvement of atriopeptin in hypertension was investigated in spontaneously hypertensive rats (SHR). It was found that intravenous injection of atriopeptin III (20-80 nmol/kg) markedly decreased the mean arterial pressure in anesthetized SHR in a dose dependent manner. The heart rate was not significantly affecte...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90238-9
更新日期：1986-03-17 00:00:00
abstract：:There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigens specific to T-lympho...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90607-q
更新日期：1992-01-01 00:00:00
abstract：:Chlordimeform (CDM) and demethylchloridimeform (DCDM) mimic the action of octopamine in elevating adenylate cyclase activity in intact nerve cords of the American cockroach, Periplaneta americana. At a concentration of 1 x 10(-5)M, DCDM (13.5x increase within 20 minutes) is a more potent effector of the response than ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90644-6
更新日期：1983-06-27 00:00:00
abstract：:Morphine and oxycodone are potent opioid analgesics most commonly used for the management of moderate to severe acute and chronic pain. Their clinical utility is limited by undesired side effects like analgesic tolerance, dependence, and withdrawal. We have previously demonstrated that endothelin-A (ETA) receptor anta...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2016.01.016
更新日期：2016-08-15 00:00:00
