Alcohol-induced oxidative stress.

abstract：:Besides an isomer of the cardenolide ouabain, a material with a similar HPLC retention time as ouabain but cross-reactivating with antibodies against the bufadienolide proscillaridin A and inhibiting the sodium pump is known to circulate in human blood plasma (B. SICH et al., Hypertension 27, 1073-1078 (1996).). The c...

journal_title：Life sciences

authors： Li S,Eim C,Kirch U,Lang RE,Schoner W

更新日期：1998-01-01 00:00:00

abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...

journal_title：Life sciences

authors： Tsukamoto I,Taya K,Watanabe G,Sasamoto S

更新日期：1986-07-14 00:00:00

abstract：:This paper demonstrates marked differences between blood levels and those in the CSF for three anterior pituitary peptide hormones, prolactin, luteinizing hormone (LH) and adrenocorticotrophin (ACTH) in the rhesus monkey. CSF levels of endogenous prolactin (measured by radioimmunoassay) are about 20% of those in the b...

journal_title：Life sciences

authors： Dubey AK,Herbert J,Martensz ND,Beckford U,Jones MT

更新日期：1983-04-18 00:00:00

abstract：:Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-...

journal_title：Life sciences

authors： Matera MG,D'agostino B,Cardone M,Calderaro V,Rossi F

更新日期：1995-02-17 00:00:00

abstract：:The effects of exposure to ionizing radiation on the nociceptive thresholds of CF-1 mice were examined. Significant increases in thermal response latencies, indicative of analgesia were observed after exposure to either high or low doses of radiation. However, the onset of analgesia occurred significantly more rapidly...

journal_title：Life sciences

authors： Teskey GC,Kavaliers M

更新日期：1984-10-08 00:00:00

abstract：:In this study, we have focused our investigation of the facts whether co-administration of a NMDA antagonist dextromethorphan (DM) with morphine during pregnancy and throughout lactation could prevent the adverse effects associated with chronic morphine administration in rat offspring. Adult female Sprague-Dawley rats...

journal_title：Life sciences

authors： Tao PL,Yeh GC,Su CH,Wu YH

更新日期：2001-10-05 00:00:00

abstract：AIMS:Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid receptor 1 (CB1R) located in the nucleus accumbens (NAc) plays a critical role in morphine-induced conditioning. Therefore, the main objective of this study was to...

journal_title：Life sciences

authors： Sadeghi-Adl M,Sadat-Shirazi MS,Shahini F,Akbarabadi A,Khalifeh S,Borzabadi S,Nasehi M,Zarrindast MR

更新日期：2020-11-01 00:00:00

abstract：:Recent studies have indicated that Ginsenoside Rb1, one of the major components of ginseng root, may play an important role in protecting cells from damage. Here, we investigated the neuroprotective activity of Rb1 after hypoxic injury in young rats. About 50% animals were dead by exposing hypoxic condition three time...

journal_title：Life sciences

authors： Park JK,Namgung U,Lee CJ,Park JO,Jin SH,Kwon OB,Ko SR,Kim SW,Kang EJ,Ko JH,Lee SM,Kim DH,Won MH

更新日期：2005-01-14 00:00:00

abstract：:Effects of baicalein and wogonin, the major flavonoids of Scutellariae radix, on cytochrome P450 (CYP), UDP-glucuronosyl transferase (UGT), and glutathione S-transferase (GST) were studied in C57BL/6J mice. One-week treatment of mice with a liquid diet containing 5 mM baicalein resulted in 29%, 14%, 36%, 28%, and 46% ...

journal_title：Life sciences

authors： Ueng YF,Shyu CC,Lin YL,Park SS,Liao JF,Chen CF

更新日期：2000-09-22 00:00:00

abstract：:Extracts of brain and heart from rats at birth and postnatal days 2 and 10 were evaluated for naltrexone following maternal injection of 50 mg/kg opioid antagonist throughout gestation. Samples were prepared by ultrafiltration, lyophilized, reconstituted in mobile phase, and separated by reversed-phase high performanc...

journal_title：Life sciences

authors： Zagon IS,Hurst WJ,McLaughlin PJ

更新日期：1998-01-01 00:00:00

abstract：:We administered a series of alpha-blocking drugs to the nucleus reticularis lateralis (NRL) of the medulla oblongata, the main site for the hypotensive action of clonidine. These experiments were performed on pentobarbital anaesthetized cats. Drugs were injected through a needle which was stereotaxically inserted. Pra...

journal_title：Life sciences

authors： Bousquet P,Feldman J

更新日期：1987-03-16 00:00:00

abstract：:In order to estimate the intestinal stability of ebiratide [H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8-NH2], a novel adrenocorticotropic hormone (ACTH) analogue, after oral administration, the hydrolytic properties of ebiratide were determined in the rat small intestinal fluid and mucosal homogenates. Ebiratide was extr...

journal_title：Life sciences

authors： Okagawa T,Fujita T,Murakami M,Yamamoto A,Shimura T,Tabata S,Kondo S,Muranishi S

更新日期：1994-01-01 00:00:00

abstract：:In the course of investigating the binding of imipramine to soluble cellular fractions from brain and leukocytes using equilibrium dialysis, an artifactual binding component was produced. On Scatchard and double-reciprocal plots of the data, the component appeared as a homogenous population of sites displaying a bindi...

journal_title：Life sciences

authors： Cullen EI,Medzihradsky F

更新日期：1983-07-11 00:00:00

abstract：AIMS:To investigate the roles of neutrophil alkaline phosphatase (NAP) in the migration, reactive oxygen species (ROS) generation and apoptosis of neutrophils. MAIN METHODS:NAP was overexpressed in neutrophil-like differentiated HL-60 cells via transfecting coding sequence of NAP by lentivirus. NAP overexpression in H...

journal_title：Life sciences

authors： Li H,Zhao Y,Li W,Yang J,Wu H

更新日期：2016-07-15 00:00:00

abstract：:An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension. Captopril produced a fall in mean arterial pre...

journal_title：Life sciences

authors： Mohara O,Masuyama Y

更新日期：1991-01-01 00:00:00

abstract：:The temporal relationship of changes in cAMP and cGMP to oocyte maturation was examined in proestrous hamsters (day 4). The first series of experiments showed, in normal cycling hamsters, an increase in cAMP and a decrease in cGMP at 1400 h shortly after the rise in LH with oocyte maturation beginning at 1800 h. When ...

journal_title：Life sciences

authors： Hubbard CJ

更新日期：1983-10-24 00:00:00

abstract：:Nitric oxide (NO) plays an important role in glucose and lipid metabolism. We previously reported that NO synthesis inhibitors, such as NG-nitro-L-arginine methyl ester (L-NAME), deteriorate insulin sensitivity and lipid metabolism, while the addition of L-arginine reverses this deterioration. L-arginine is a precurso...

journal_title：Life sciences

authors： Kawano T,Nomura M,Nisikado A,Nakaya Y,Ito S

更新日期：2003-10-24 00:00:00

abstract：:Brown adipose tissue (BAT) has multiple functions in the human body, including the production of heat and increasing energy consumption. However, BAT is also related to many kinds of diseases, such as obesity and metabolic disorders. The progression of such diseases occurs at the cellular level, and thus, imaging tech...

journal_title：Life sciences

authors： Gu J,Wang X,Yang H,Li H,Wang J

更新日期：2020-05-15 00:00:00

abstract：:Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can...

journal_title：Life sciences

authors： Ferrer T,Gallego M,Madrigal-Quiñónez R,Torres-Jácome J,Navarro-Polanco R,Cásis O,Sánchez-Chapula JA

更新日期：2006-07-24 00:00:00

abstract：AIMS:Coronavirus disease 2019 (COVID-19) has appeared in Wuhan, China but the fast transmission has led to its widespread prevalence in various countries, which has made it a global concern. Another concern is the lack of definitive treatment for this disease. The researchers tried different treatment options which are...

journal_title：Life sciences

authors： Hosseini FS,Amanlou M

更新日期：2020-10-01 00:00:00

abstract：AIMS:Smooth muscle cells (SMCs) play a role in medial vascular calcification, which can be stimulated by high levels of serum phosphate and inflammatory mediators. The aim of this study was to investigate whether mitogen-activated protein kinases (MAPKs) (p38 MAPK, ERK1/2, and JNK) and protein kinase A (PKA) can partic...

journal_title：Life sciences

authors： Toita R,Otani K,Kawano T,Fujita S,Murata M,Kang JH

更新日期：2018-09-15 00:00:00

abstract：:The effect of prior incubation with a single concentration of isoproterenol (10(-4) M) for 2 hours at 37 degrees C on isoproterenol-stimulated cyclic AMP accumulation in intact lymphocytes from young, old and subjects with Alzheimer's disease was studied. In lymphocytes from all three subjects groups prior incubation ...

journal_title：Life sciences

authors： Oppenheim G,Mintzer J,Halperin Y,Eliakim R,Stessman J,Ebstein RP

更新日期：1984-10-22 00:00:00

abstract：AIM:MicroRNAs (miRNAs) function as oncogenes or tumor suppressors in an extensive variety of human cancers, including prostate cancer (PCa). Herein, the aim of this study is to investigate the effect of miR-381 on autophagy and apoptosis of PCa cells through the reelin (RELN)-mediated the PI3K/AKT/mTOR signaling pathwa...

journal_title：Life sciences

authors： Liao W,Zhang Y

更新日期：2020-08-01 00:00:00

abstract：:The aim of the present work was to study the effects of various durations of fasting (12, 24 and 72 hours) on brown adipose tissue (BAT) thermogenic parameters--cytrochrome-c-oxidase (COX) activity, GDP-binding activity and uncoupling protein (UCP1) content--and also on morphological features of different mitochondria...

journal_title：Life sciences

authors： Gianotti M,Clapés J,Lladó I,Palou A

更新日期：1998-01-01 00:00:00

abstract：:We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...

journal_title：Life sciences

authors： Kimura H,Kawana S,Kanaya N,Sakano S,Miyamoto A,Ohshika H

更新日期：1994-01-01 00:00:00

abstract：:Involvement of T-type voltage dependent Ca2+ channels (VDCCs) on morphine antinociception, in the development of tolerance and dependence to morphine, and naloxone-precipitated abstinence syndrome in morphine dependent mice was examined by using mibefradil, a T-type VDCCs blocker. Mice were rendered tolerant and depen...

journal_title：Life sciences

authors： Dogrul A,Zagli U,Tulunay FC

更新日期：2002-06-28 00:00:00

abstract：:Immunoreactive atrial natriuretic peptide (ir-ANP) was measured in the follicular fluid of pig ovarian follicle, and rabbit ovarian homogenates and perfusates using a specific radioimmunoassay (RIA). Serial dilution curves made with the extracts of follicular fluid, ovarian homogenates and perfusates using SepPak C18 ...

journal_title：Life sciences

authors： Kim SH,Cho KW,Seul KH,Ryu H,Koh GY

更新日期：1989-01-01 00:00:00

abstract：:A series of studies were conducted to determine the effects of leucine-(leu-) enkephalin and methionine-(met-) enkephalin on perfusion pressure. These experiments utilized isolated perfused femoral arterial preparations in pentobarbital-anesthetized cats. The enkephalins were administered intraarterially into the femo...

journal_title：Life sciences

authors： Moore RH 3rd,Dowling DA

更新日期：1982-10-11 00:00:00

abstract：:Release of alpha-MSH from the pars intermedia melanotrope cells of Xenopus laevis is regulated by various classical neurotransmitters and neuropeptides. We have examined the effect of two of these regulatory substances, the neurotransmitter GABA and the CRF-related peptide sauvagine, on the adenylate cyclase system of...

journal_title：Life sciences

authors： Jenks BG,van Zoest ID,de Koning HP,Leenders HJ,Roubos EW

更新日期：1991-01-01 00:00:00

abstract：:CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities. ...

journal_title：Life sciences

authors： Nakayama K,Nitto T,Inoue T,Node K

更新日期：2008-08-29 00:00:00