Atriopeptin and spontaneous hypertension in rats.

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：AIMS:The p53 protein, also called guardian of the genome, has a key role in cell cycle regulation. It is activated under stressful circumstances, such as DNA damage which results in permanent arrest or cell death. The protein is disabled in several types of human cancer due to over-expression of the two regulators, Mdm...

journal_title：Life sciences

authors： Golestanian S,Sharifi A,Popowicz GM,Azizian H,Foroumadi A,Szwagierczak A,Holak TA,Amanlou M

更新日期：2016-01-15 00:00:00

abstract：:We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...

journal_title：Life sciences

authors： Zarzuelo A,Jiménez I,Gámez MJ,Utrilla P,Fernadez I,Torres MI,Osuna I

更新日期：1996-01-01 00:00:00

abstract：:There is some evidence that cardiac rather than circulating insulin-like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of...

journal_title：Life sciences

authors： Jalil JE,Ebensperger R,Meléndez J,Acevedo E,Sapag-Hagar M,González-Jara F,Gálvez A,Pérez-Montes V,Lavandero S

更新日期：1999-01-01 00:00:00

abstract：:The neurological mutant whirler mouse, one of several strains of waltzing mice, may be suitable as an animal model for testing studies relative to hyperkinesis. As in hyperkinetic children, behaviorally the mice are extremely restless, nervous, excitable, irritable and aggressive but also show symptoms of rotation beh...

journal_title：Life sciences

authors： Sackler AM,Weltman AS

更新日期：1985-08-05 00:00:00

abstract：AIMS:A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy and the involved signaling cascade are largely unknown. A previous stud...

journal_title：Life sciences

authors： Shimojo N,Jesmin S,Sakai S,Maeda S,Miyauchi T,Mizutani T,Aonuma K,Kawano S

更新日期：2014-11-24 00:00:00

abstract：:Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches wi...

journal_title：Life sciences

authors： Chakari-Khiavi F,Dolati S,Chakari-Khiavi A,Abbaszadeh H,Aghebati-Maleki L,Pourlak T,Mehdizadeh A,Yousefi M

更新日期：2019-08-15 00:00:00

abstract：:Free radicals induced by cerebral ischemia-reperfusion injury can trigger lipid peroxidation, leading to the production of malondialdehyde (MDA) and 4-hydroxy-2(E)-nonenal (4-HNE). Post-ischemia electroacupuncture (EA) therapy was able to reduce extent of lipid peroxidation. However, the effect of pre-ischemic EA ther...

journal_title：Life sciences

authors： Siu FK,Lo SC,Leung MC

更新日期：2004-07-30 00:00:00

abstract：AIMS:The objectives of this study were to determine the cytokine induction by delta tocotrienol (DT3, a promising radiation countermeasure) and to investigate the role of granulocyte colony-stimulating factor (G-CSF) in its radioprotective efficacy against ionizing radiation in mice. MAIN METHODS:Multiplex Luminex was...

journal_title：Life sciences

authors： Singh VK,Wise SY,Scott JR,Romaine PL,Newman VL,Fatanmi OO

更新日期：2014-03-11 00:00:00

abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...

journal_title：Life sciences

authors： Greggio S,de Paula S,Azevedo PN,Venturin GT,Dacosta JC

更新日期：2014-02-06 00:00:00

abstract：:Danshen, a Chinese herbal medicine has been widely used for the treatment of cardiovascular diseases. Magnesium tanshinoate B (MTB) is an active compound purified from Danshen. The objective of this study was to investigate the effect of MTB on the susceptibility of low density lipoproteins (LDL) to oxidative modifica...

journal_title：Life sciences

authors： O K,Lynn EG,Vazhappilly R,Au-Yeung KK,Zhu DY,Siow YL

更新日期：2001-01-12 00:00:00

abstract：:Although peripheral actions have been shown for the brain-gut peptide, motilin, its localization in the CNS of mammals suggests some physiological role at this site. In the present experiments intracerebroventricular or intrathecal, but not peripheral, administrations of motilin produced a dose-related and naloxone re...

journal_title：Life sciences

authors： Porreca F,Dray A

更新日期：1984-06-25 00:00:00

abstract：AIM:Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced nephrotoxicity (GIN). MAIN METHODS:Male Wistar rats were treated with gentamicin with/out AR ligands (testosterone as agonist and flutamide as antagonist). Megalin expr...

journal_title：Life sciences

authors： Elsakka EGE,Elsisi AM,Mansour OAA,Elsadek BEM,Abd Elaziz AI,Salama SA,Allam S

更新日期：2020-06-15 00:00:00

abstract：AIMS:Clostridium difficile is an important pathogen in nosocomial infections. Although C. difficile toxins are considered to be major virulence factors, pathogenesis of C. difficile associated diseases remains to be determined. In this study, we investigated whether C. difficile flagellin is involved in the pathogenesi...

journal_title：Life sciences

authors： Yoshino Y,Kitazawa T,Ikeda M,Tatsuno K,Yanagimoto S,Okugawa S,Yotsuyanagi H,Ota Y

更新日期：2013-02-27 00:00:00

abstract：:Foscarnet inhibited noradrenaline and calcium-mediated contractions of the isolated perfused tail artery of the rat. When the noradrenaline contractile response was split into two components, where the first was due to the release of calcium from intracellular stores and the second to the influx of calcium from the ex...

journal_title：Life sciences

authors： Paspaliaris V,Mai X,Leaver DD

更新日期：1993-01-01 00:00:00

abstract：AIMS:Although dexamethasone (Dex) is used widely as an anti-inflammatory and immunosuppressive drug, Dex appears to have severe side-effects, including osteoporosis. This study determined the effects of Dex on duodenal and renal expressions of the calcium-processing genes transient receptor potential cation channel, su...

journal_title：Life sciences

authors： Kim MH,Lee GS,Jung EM,Choi KC,Jeung EB

更新日期：2009-07-17 00:00:00

abstract：:Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following...

journal_title：Life sciences

authors： Kogure K,Ishizaki M,Nemoto M,Kuwano H,Tatemoto K,Maruyama Y,Ikarashi Y,Makuuchi M

更新日期：1999-01-01 00:00:00

abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...

journal_title：Life sciences

authors： Cho SE,Kim YM,Jeong JS,Seo YK

更新日期：2016-11-15 00:00:00

abstract：:Mechanisms by which opiates alter neuronal functions, including neuroendocrine functions, are not well defined. We have previously demonstrated that morphine rapidly and transiently increases expression of the proto-oncogene c-fos in the rat caudate-putamen. This regulation of the c-fos gene by morphine may represent ...

journal_title：Life sciences

authors： Chang SL,Harlan RE

更新日期：1990-01-01 00:00:00

abstract：AIMS:Osteosarcoma is one of the most aggressive types of primary bone cancer that responds poorly to radiotherapy frequently. The gene associated with retinoid-interferon mortality (GRIM-19) is a tumor suppressor that mediates cell apoptosis in multiple cancer types. However, the role of GRIM-19 in osteosarcoma and the...

journal_title：Life sciences

authors： Chen W,Liu Q,Fu B,Liu K,Jiang W

更新日期：2018-09-01 00:00:00

abstract：:The mechanism by which benzoate enhances total nitrogen excretion was investigated in-situ and in separated rat renal proximal tubules. Orally administered benzoate augmented NH4+, urea and hippurate excretion 2, 1.9 and 76 fold respectively, as compared to baseline for control. Hippurate had similar effects. Benzoate...

journal_title：Life sciences

authors： Dass PD,Bautista NS,Hardman SH,Lawson LR,Kurtz I

更新日期：1991-01-01 00:00:00

abstract：:Fissistigma oldhamii (Hemsl.) Merr [F. oldhamii], a traditional Chinese herb medicine, is widely used for treating rheumatoid arthritis (RA) in China. Following bioactivity-guided isolation, a representative immunosuppressive compound with low cytotoxicity, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenam...

journal_title：Life sciences

authors： Hu XD,Zhong XG,Zhang XH,Zhang YN,Zheng ZP,Zhou Y,Tang W,Yang Y,Yang YF,Hu LH,Zuo JP

更新日期：2007-12-14 00:00:00

abstract：:The reinforcing effects of cocaine and methylphenidate have been linked to their ability to block dopamine transporters (DAT). Though cocaine and methylphenidate have similar in vitro affinities for DAT the abuse of methylphenidate in humans is substantially lower than of cocaine. To test if differences in in vivo pot...

journal_title：Life sciences

authors： Volkow ND,Wang GJ,Fowler JS,Fischman M,Foltin R,Abumrad NN,Gatley SJ,Logan J,Wong C,Gifford A,Ding YS,Hitzemann R,Pappas N

更新日期：1999-01-01 00:00:00

abstract：AIM:Acute lung injury (ALI) is characterized by alveolar macrophage overactivation and uncontrolled pulmonary inflammation. Mitochondrial damage-associated molecular patterns (MTDs), one type of damage-associated molecular patterns (DAMPs) released from ruptured mitochondrial, can induce inflammation which participates...

journal_title：Life sciences

authors： Peng W,Peng F,Lou Y,Li Y,Zhao N,Shao Q,Chen J,Qian K,Zeng Z,Zhan Y,Jiang R,Liu F

更新日期：2021-01-15 00:00:00

abstract：:Recent studies on the control of adrenal zona glomerulosa function and aldosterone secretion have focussed attention on the role of MSH-like peptides. In particular, at low concentrations, alpha-MSH has a specific stimulatory effect on rat adrenal glomerulosa cells. The synthesis of alpha-MSH analogues which have pote...

journal_title：Life sciences

authors： Vinson GP,Whitehouse BJ,Bateman A,Hruby VJ,Sawyer TK,Darman PS

更新日期：1984-08-06 00:00:00

abstract：AIMS:To assess the relationship between endothelial dysfunction, endothelin 1 (ET-1) plasma levels and subclinical inflammation in primary open angle glaucoma (POAG) patients. MAIN METHODS:We enrolled 40 POAG patients with progressive visual field damage, although well controlled intraocular pressure (IOP) and compare...

journal_title：Life sciences

authors： Cellini M,Strobbe E,Gizzi C,Balducci N,Toschi PG,Campos EC

更新日期：2012-10-15 00:00:00

abstract：:Thirty-seven women, aged 31-78 years, on two separate mornings consumed a decaffeinated beverage to which 6 mg caffeine/kg lean body mass or no caffeine were added. Total urine output of water, calcium, magnesium, sodium, chloride, potassium and creatinine increased in the two hours following caffeine ingestion when c...

journal_title：Life sciences

authors： Bergman EA,Massey LK,Wise KJ,Sherrard DJ

更新日期：1990-01-01 00:00:00

abstract：:The pathogenesis of abdominal aortic aneurysm remains unclear. The aim of the present study was to establish whether isoleucyl-tRNA synthetase (Iars) regulates the differentiation and apoptosis of vascular smooth muscle cells (VSMCs) during the development of abdominal aortic aneurysm (AAA). In addition, the contribut...

journal_title：Life sciences

authors： Li B,Wang Z,Chen R,Hong J,Wu Q,Hu J,Hu Z,Zhang M

更新日期：2019-05-01 00:00:00

abstract：AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...

journal_title：Life sciences

authors： Ding YX,Shi Y,Han WJ,Cui H

更新日期：2016-04-01 00:00:00

abstract：:PD 128907 [4a R, 10 b R-(+)-trans-3, 4, 4a, 10 b - tetrahydro - 4- n -propyl2 H,5H-[1]benzop-yrano[4,3-b]1,4-oxazin-9-ol.], a selective dopamine (DA) D3 receptor agonist ligand exhibits about a 1000-fold selectivity for human D3 receptors (Ki, 1 nM) versus human D2 receptors (Ki, 1183 nM) and a 10000-fold selectivity ...

journal_title：Life sciences

authors： Akunne HC,Towers P,Ellis GJ,Dijkstra D,Wikström H,Heffner TG,Wise LD,Pugsley TA

更新日期：1995-01-01 00:00:00