Abstract：
:We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabetic rats, a marked antidiabetic activity was achieved. This effect was evidenced by a significant decrease in glycemia levels (> 50%), a 2.5-fold increase in insulin blood levels and an increase in body and pancreas weight, compared to the diabetic control group.
journal_name
Life Scijournal_title
Life sciencesauthors
Zarzuelo A,Jiménez I,Gámez MJ,Utrilla P,Fernadez I,Torres MI,Osuna Idoi
10.1016/0024-3205(96)00231-7subject
Has Abstractpub_date
1996-01-01 00:00:00pages
2311-6issue
25eissn
0024-3205issn
1879-0631pii
0024320596002317journal_volume
58pub_type
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