Abstract：
:The present study was undertaken to examine whether there was a time-dependent change in the toxic effects of amikacin, an aminoglycoside, on renal functions. Male Wistar rats were maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Amikacin (1.2 g/kg) was injected intraperitoneally to animals at 4 am, 10 am, 4 pm or 10 pm. Glomerular function estimated by creatinine clearance (Clcr) and tubular function estimated by urinary excretion of a loop diuretic, furosemide, which was excreted in urine mainly by tubular secretion, were determined before and 24 hours after amikacin injection. The values of these parameters were reduced by amikacin at each observation point. The magnitude of these decrements was greatest at 4 pm both for Clcr and urinary furosemide excretion. These results suggest that the toxic effects of amikacin on renal glomerular and tubular functions vary with its time of administration.
journal_name
Life Scijournal_title
Life sciencesauthors
Fujimura A,Sudoh T,Ebihara Adoi
10.1016/0024-3205(94)00647-4subject
Has Abstractpub_date
1994-01-01 00:00:00pages
367-72issue
5eissn
0024-3205issn
1879-0631pii
0024-3205(94)00647-4journal_volume
55pub_type
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