IκBα polymorphisms were associated with increased risk of gastric cancer in a southern Chinese population: a case-control study.

abstract：AIM:The purpose of this study was to investigate whether the flavonoid quercetin can prevent alterations in the behavioral tests and of cholinergic neurotransmission in rats submitted to the ethidium bromide (EB) experimental demyelination model during events of demyelination and remyelination. MAIN METHODS:Wistar rat...

journal_title：Life sciences

authors： Beckmann DV,Carvalho FB,Mazzanti CM,Dos Santos RP,Andrades AO,Aiello G,Rippilinger A,Graça DL,Abdalla FH,Oliveira LS,Gutierres JM,Schetinger MR,Mazzanti A

更新日期：2014-05-17 00:00:00

abstract：:Sexual interactions have multiple effects on oxytocin systems in the brain. In the present study we observed that allowing estrogen-progesterone treated ovariectomized rats to be mounted ten times by a male significantly decreased the density (beta max) of thymic oxytocin receptors. Animals were ovariectomized and aft...

journal_title：Life sciences

authors： Caldwell JD,Walker CH,Pedersen CA,Mason GA

更新日期：1993-01-01 00:00:00

abstract：:Unconjugated bilirubin (UCB), like trifluoperazine (TFP), dibucaine (DBC) and praziquantel (PZQ), induces erythrocyte morphological changes, lysis and lipid exfoliation. In the present study we determined whether TFP, DBC and PZQ toxicity to erythrocytes was potentiated or reverted by UCB. Human erythrocytes were eith...

journal_title：Life sciences

authors： Brito MA,Malheiros SV,Meirelles NC,Brites D

更新日期：2001-07-13 00:00:00

abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...

journal_title：Life sciences

authors： Yanagida M,Gohda E,Yamamoto I

更新日期：1996-01-01 00:00:00

abstract：AIMS:Hypoxia-inducible factor-1α (HIF-1α) is a transcriptional regulator of cellular responses to hypoxic stress. MicroRNAs (miRNAs) play an essential role in hypoxia-mediated cellular responses. Previous studies have identified some let-7 family members as hypoxia-regulated miRNAs (HRMs). In the present study, we aime...

journal_title：Life sciences

authors： Huang CX,Chen N,Wu XJ,He Y,Huang CH,Liu H,Wang WM,Wang HL

更新日期：2017-02-15 00:00:00

abstract：:The participation of the medullary structures in the total respiratory effect of opiates was studied by restricting the access of the delta-agonist D-ala2-D-leu5-enkephalin and the mu-agonist D-ala2-Me-Phe4-Met (O) ol5-enkephalin, to the ventral medullary surface, and by comparing their responses with those induced af...

journal_title：Life sciences

authors： Flórez J,Hurlé MA,Mediavilla A

更新日期：1982-11-15 00:00:00

abstract：:Effects of sophoricoside and its analogs on proinflammatory cytokines have been investigated. Sophoricoside, genistein and orobol exhibited inhibitory effects on IL-5, IL-3, GM-CSF and IL-6 bioactivities. Genistin showed inhibitory effects on IL-5 and IL-3 bioactivities, but did not inhibit GM-CSF and IL-6 bioactiviti...

journal_title：Life sciences

authors： Yun J,Lee CK,Chang IM,Takatsu K,Hirano T,Min KR,Lee MK,Kim Y

更新日期：2000-10-27 00:00:00

abstract：:The effect of cadmium (Cd2+) was studied in vitro on the flavokinase (ATP : riboflavin 5'-phosphotransferase, EC 2.7.1.26) activity purified from rat liver. Cadmium inhibited flavokinase activity in a concentration-dependent manner and the effect was completely reversed by increasing concentration of zinc (Zn2+), indi...

journal_title：Life sciences

authors： Bandyopadhyay D,Chatterjee AK,Datta AG

更新日期：1997-01-01 00:00:00

abstract：:A set of synaptic proteins have been shown to be essential for the life cycle and exocytosis of synaptic vesicles at the nerve terminal. Recently, these proteins have also been identified in certain endocrine cells. Here we analysed the presence and location of some of these synaptic proteins in anterior pituitary cel...

journal_title：Life sciences

authors： Majó G,Aguado F,Blasi J,Marsal J

更新日期：1998-01-01 00:00:00

abstract：:Oxytocin (OT) and arginine-8-vasopressin (AVP) were measured by radioimmunoassay in micropunched hypothalamic neurosecretory nuclei of estrous cycling female Sprague-Dawley rats. In the paraventricular nucleus (PVN): the concentration (pg/microgram protein) of OT was significantly higher in rats in diestrus than durin...

journal_title：Life sciences

authors： Greer ER,Caldwell JD,Johnson MF,Prange AJ Jr,Pedersen CA

更新日期：1986-06-23 00:00:00

abstract：:The object of this study was to develop an assay for platelet activating factor (PAF) in rat plasma, and to utilise this to determine the effects of dietary fish oil on PAF in normotensive and spontaneously hypertensive rats. Measurement of platelet activating factor in blood plasma has proved difficult because of its...

journal_title：Life sciences

authors： Croft KD,Sturm MJ,Codde JP,Vandongen R,Beilin LJ

更新日期：1986-05-19 00:00:00

abstract：:BMP-3b is a novel BMP-3-related protein and its biological functions are unknown. In order to investigate the biological actions of BMP-3b, we constructed a BMP-3b-expressing recombinant adenoviral vector (AxCAKBMP-3b). We show that over expression of BMP-3b stimulated the induction of differentiation and the osteoind...

journal_title：Life sciences

authors： Kaihara S,Bessho K,Okubo Y,Sonobe J,Komatsu Y,Miura M,Miyatake S,Nakao K,Iizuka T

更新日期：2003-02-28 00:00:00

abstract：:The recovery rate of striatal dopamine receptors following blockade by N-ethoxycarbonyl-2-ethoxy-1, 2-dihydroquinoline (EEDQ) in vivo is reduced by 25-35% in striata from senescent Wistar rats when compared to mature counterparts. No differences in binding affinity for [3H]-spiperone were observed for the different ag...

journal_title：Life sciences

authors： Henry JM,Roth GS

更新日期：1984-08-20 00:00:00

abstract：:Active uptake of serotonin (5-hydroxytryptamine, 5-HT) into blood platelets from healthy donors exhibited a lower Vmax value in buffer media than in plasma. Also in plasma ultrafiltrate Vmax was reduced, but it returned to the level measured in plasma upon addition of human serum albumin (40 milligrams) containing fat...

journal_title：Life sciences

authors： Breyer-Pfaff U,Fauss C,Böhne HP

更新日期：1989-01-01 00:00:00

abstract：:During the myocardial protection induced by ischemic preconditioning a reduction in myocardial metabolism occurs due to activation of the A1 adenosine receptors. This study investigates whether preconditioning changes both resting coronary flow and the magnitude of coronary reactive hyperemia and whether A1 adenosine ...

journal_title：Life sciences

authors： Pagliaro P,Penna C,Gattullo D

更新日期：1999-01-01 00:00:00

abstract：:Adult rat offspring earlier exposed to maternally ingested caffeine during both gestation and lactation were observed in an open field following acute administration of diazepam or cyclohexyladenosine. While both drugs reduced measures of locomotion and emotional reactivity, caffeine-exposed rats showed evidence of gr...

journal_title：Life sciences

authors： Fisher CE,Hughes RN

更新日期：1996-01-01 00:00:00

abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...

journal_title：Life sciences

authors： An P,Xie J,Qiu S,Liu Y,Wang J,Xiu X,Li L,Tang M

更新日期：2019-09-01 00:00:00

abstract：:3H-Flunitrazepam (FNZP) binding was examined in a crude membrane fraction obtained from rat interscapular brown adipose tissue (IBAT). A single population of binding sites was apparent with dissociation constant (KD) = 0.47 +/- 0.04 microM and maximal number of binding sites (Bmax) = 31 +/- 5 pmol.mg prot-1. From the ...

journal_title：Life sciences

authors： Gonzalez Solveyra C,Romeo HE,Rosenstein RE,Estevez AG,Cardinali DP

更新日期：1988-01-01 00:00:00

abstract：:The localization of vasoactive intestinal polypeptide (VIP) in the male genitourinary tract was investigated in the rabbit and man by means of radioimmunoassay and immunohistochemistry. In addition, the in vitro effect of VIP upon penile smooth muscle from man, the Vervet monkey, and the rabbit was investigated. Signi...

journal_title：Life sciences

authors： Willis EA,Ottesen B,Wagner G,Sundler F,Fahrenkrug J

更新日期：1983-07-25 00:00:00

abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...

journal_title：Life sciences

authors： Lötsch J,Darimont J,Skarke C,Zimmermann M,Hummel T,Geisslinger G

更新日期：2001-09-28 00:00:00

abstract：AIMS:This study's purpose was to evaluate the effect of ultrasound in air at a frequency of 0.04MHz and an intensity of 50mW/cm2 on neural differentiation of hBM-MSCs in vitro and on neurogenesis in an ischemic stroke model. MATERIALS AND METHODS:hBM-MSCs were exposed to 0.04MHz ultrasound and then compared with no ex...

journal_title：Life sciences

authors： Cho SE,Kim YM,Jeong JS,Seo YK

更新日期：2016-11-15 00:00:00

abstract：AIMS:The purpose of this study was to compare the changes of antihyperalgesic effectiveness of zonisamide (25 and 50 mg/kg), an antiepileptic drug, on the early and late phases of neuropathy and to investigate the role of serotonergic descending inhibitory pain pathways in antihyperalgesic effectiveness of zonisamide i...

journal_title：Life sciences

authors： Bektas N,Arslan R,Ozturk Y

更新日期：2014-01-24 00:00:00

abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...

journal_title：Life sciences

authors： Wu MJ,Lai LW,Lien YH

更新日期：2002-06-21 00:00:00

abstract：:The skin permeabilities of a series of eight salicylates and ten non-steroidal anti-inflammatory drugs were investigated in human subjects. The logarithms of % absorption through intact skin and of n-octanol/water partition coefficients (log P) of the test compounds were plotted against one another, and a parabolic re...

journal_title：Life sciences

authors： Yano T,Nakagawa A,Tsuji M,Noda K

更新日期：1986-09-22 00:00:00

abstract：:Oleuropein (Ole) is the main bioactive phenolic compound present in olive leaves, fruits and olive oil. This molecule has been shown to exert beneficial effects on several human pathological conditions. In particular, recent preclinical and observational studies have provided evidence that Ole exhibits chemo-preventiv...

journal_title：Life sciences

authors： Leto G,Flandina C,Crescimanno M,Giammanco M,Sepporta MV

更新日期：2021-01-01 00:00:00

abstract：:This study examined the protective role of metallothionein (MT) against pulmonary damage caused by acute exposure to metallic mercury (Hg0) vapor using MT-null and wild-type mice. Both strains of mice were exposed to Hg0 at 6.6 to 7.5 mg/m3 for 4 hr each day for 3 consecutive days. This dosing protocol was lethal to o...

journal_title：Life sciences

authors： Yoshida M,Satoh M,Shimada A,Yasutake A,Sumi Y,Tohyama C

更新日期：1999-01-01 00:00:00

abstract：:The interactions of aminoglycoside, 3',4'-dideoxykanamycin B(DKB) with ATP and its related compounds were investigated. ATP, ADP, cyclic AMP and FAD bound to the DKB-conjugated Sepharose 4B column. The binding of DKB to ATP was also confirmed by equilibrium gel filtration. In the acidic pH region, the fluorescence of ...

journal_title：Life sciences

authors： Inaba A,Aramaki Y,Takahashi M,Tsuchiya S

更新日期：1986-10-13 00:00:00

abstract：:When HeLa cells were incubated with tritiated dexamethasone mesylate at 2 degrees C, sodium dodecyl sulfate-polyacrylamide gel electrophoresis of cytosolic and nuclear extracts revealed the presence of two monomeric receptor complex forms with estimated molecular masses of about 98 and 87 kDa. If cells were subjected ...

journal_title：Life sciences

authors： Rossini GP,Malaguti C

更新日期：1992-01-01 00:00:00

abstract：:Cardiovascular effects of the essential oil of Croton zehntneri (EOCZ) were investigated in conscious rats. In these preparations, intravenous (i.v.) injections of EOCZ (1-20 mg kg(-1)) and its main constituents anethole and estragole (both at 1-10 mg kg(-1)) elicited brief and dose-dependent hypotension and bradycard...

journal_title：Life sciences

authors： de Siqueira RJ,Magalhães PJ,Leal-Cardoso JH,Duarte GP,Lahlou S

更新日期：2006-04-11 00:00:00

abstract：:While in vivo electrochemistry has been shown to be useful for discovering new neurophysiological phenomena, there is still considerable controversy about the identity of the compounds being measured and the concentration of those compounds in extracellular fluid in brain. We have found that carbon paste electrodes un...

journal_title：Life sciences

authors： Echizen H,Freed CR

更新日期：1986-07-07 00:00:00