Respiratory responses to opiates applied to the medullary ventral surface.

abstract：AIM:Pancreatic stellate cells (PSCs) are the main functional cells leading to pancreatic fibrosis. Nicotine is widely considered as an independent risk factor of pancreatic fibrosis, but the mechanism is still unclear. Our study was aimed to explore the effects of nicotine on human pancreatic stellate cells (hPSCs) and...

journal_title：Life sciences

authors： Li Z,Zhang X,Jin T,Hao J

更新日期：2020-02-15 00:00:00

abstract：:Ventricular hypertrophy is a risk factors for arrhythmias, ischemia and sudden death. It involves cellular modifications leading to a pathological remodeling and is associated with heart failure. The activation of the G protein-coupled estrogen receptor (GPER) mediates beneficial actions in the cardiovascular system. ...

journal_title：Life sciences

authors： Di Mattia RA,Mariángelo JIE,Blanco PG,Jaquenod De Giusti C,Portiansky EL,Mundiña-Weilenmann C,Aiello EA,Orlowski A

更新日期：2020-02-01 00:00:00

abstract：:Early induction of VEGF was studied in liver, kidney and lung of spontaneously diabetic rats. Western blot analysis, northern hybridization were applied to show the expression of VEGF in different organs. Radiolabelled hypoxia responsive element (HRE) and cAMP responsive element (CRE) oligonucleotides were assayed by ...

journal_title：Life sciences

authors： Braun L,Kardon T,Reisz-Porszasz ZS,Banhegyi G,Mandl J

更新日期：2001-10-12 00:00:00

abstract：:The conversion of lyso-platelet activating factor (lyso-PAF) to PAF in cultured paranasal sinus mucosa obtained from normal human subjects was studied. The PAF concentration in the medium was determined after addition of lyso-PAF. PAF became detectable at 10 minutes after the addition of 10(-8)M lyso-PAF, and reached ...

journal_title：Life sciences

authors： Inoue H,Ganbo T,Hisamatsu K,Ishida H

更新日期：1993-01-01 00:00:00

abstract：:MicroRNAs plays important role in the development of myocardial infarction (MI). The aim of this study was to analyze whether miR-429 has effect on the process of autophagy in myocardial anoxia/reoxygenation (AR) or ischemia/reperfusion (IR) injury and explore the underlying mechanism. The results showed that miR-429 ...

journal_title：Life sciences

authors： Zhu Q,Hu F

更新日期：2019-10-15 00:00:00

abstract：:Human T-cell lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic, and HAM/TSP...

journal_title：Life sciences

authors： Fuzii HT,da Silva Dias GA,de Barros RJ,Falcão LF,Quaresma JA

更新日期：2014-05-28 00:00:00

abstract：:The effects of capsaicin on cellular growth and intracellular calcium mobilization were examined in human cervical carcinoma derivation, HeLa cells. Capsaicin inhibited cellular growth and increased intracellular calcium level in HeLa cells. This capsaicin-induced intracellular calcium concentration rise was blocked b...

journal_title：Life sciences

authors： Takahata K,Chen X,Monobe K,Tada M

更新日期：1999-01-01 00:00:00

abstract：AIMS:Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid receptor 1 (CB1R) located in the nucleus accumbens (NAc) plays a critical role in morphine-induced conditioning. Therefore, the main objective of this study was to...

journal_title：Life sciences

authors： Sadeghi-Adl M,Sadat-Shirazi MS,Shahini F,Akbarabadi A,Khalifeh S,Borzabadi S,Nasehi M,Zarrindast MR

更新日期：2020-11-01 00:00:00

abstract：AIMS:Fructose administration induces hepatic oxidative stress, insulin resistance, inflammatory and metabolic changes. We tested their potential pathogenic relationship and whether these alterations can be prevented by R/S-α-lipoic acid. MAIN METHODS:Wistar rats received during 21days a commercial diet or the same die...

journal_title：Life sciences

authors： Castro MC,Massa ML,Arbeláez LG,Schinella G,Gagliardino JJ,Francini F

更新日期：2015-09-15 00:00:00

abstract：:In situ radioligand binding and quantitative autoradiography have been used to measure the density of striatal D1-like, D2-like, and GABAA receptors in rats treated with haloperidol at 0.01 or 0.1 mg/kg/ day or chlorpromazine, olanzapine or clozapine at 0.1 or 1.0 mg/kg/day for 1, 3 or 7 months. [3H]SCH23390 binding t...

journal_title：Life sciences

authors： Dean B,Hussain T,Scarr E,Pavey G,Copolov DL

更新日期：2001-08-03 00:00:00

abstract：:The effects of 14-day physical exercise or iloprost treatment (0.5-2 ng/Kg/min) on endogenous nitric oxide production and neutrophil adhesion were evaluated in 20 patients with peripheral arterial occlusive disease (Fontaine Stage II). Peripheral venous blood samples and 4-h urine samples were collected before, immedi...

journal_title：Life sciences

authors： Arosio E,Cuzzolin L,De Marchi S,Minuz P,Degan M,Crivellente F,Zannoni M,Benoni G

更新日期：1999-01-01 00:00:00

abstract：:Chlorin e(6) and its derivatives are promising sensitizers for photodynamic therapy (PDT). In order to compare the photodynamic effects of 8 novel derivatives of chlorin e(6) and to explore some mechanisms of their effects at the cellular level, we studied PDT-induced changes in bioelectric activity of crayfish mechan...

journal_title：Life sciences

authors： Uzdensky AB,Dergacheva OY,Zhavoronkova AA,Reshetnikov AV,Ponomarev GV

更新日期：2004-03-12 00:00:00

abstract：AIM:The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular...

journal_title：Life sciences

authors： Peixoto P,Aires RD,Lemos VS,Bissoli NS,Santos RLD

更新日期：2017-08-15 00:00:00

abstract：AIMS:microRNA-96 (miR-96) is considered as a tumor suppressor in multiple malignancies. Some studies have indicated that EZRIN could be regulated by the miR-96 in several kinds of cancer cells. However, the function of miR-96 in human osteosarcoma has not been investigated intensively so far. In this study, we mainly e...

journal_title：Life sciences

authors： Yao Q,Pei Y,Zhang X,Xie B

更新日期：2018-06-15 00:00:00

abstract：:The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...

journal_title：Life sciences

authors： Volpato KC,Menegaz D,Leite LD,Barreto KP,de Vilhena Garcia E,Silva FR

更新日期：2004-01-23 00:00:00

abstract：:To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg intraperi...

journal_title：Life sciences

authors： Katoh J,Taniguchi H,Ogura M,Miyamoto K,Kasuga M,Okada Y

更新日期：1994-01-01 00:00:00

abstract：:Phencyclidine hydrochloride (PCP) was tested for its ability to alter a variety of immune effector and regulatory functions in vitro. B6C3F1 murine splenic lymphocytes or elicited peritoneal macrophages were cultured in vitro with medium only or medium containing 10(-10)-10(-4) M PCP. Macrophages cultured with or with...

journal_title：Life sciences

authors： Thomas PT,House RV,Bhargava HN

更新日期：1993-01-01 00:00:00

abstract：:Cold acclimation increases the thermogenic capacity of brown adipose tissue (BAT) and this is associated with both a general hypertrophy of the tissue and a selective increase in the proportion of a specific 32,000 molecular weight, GDP-binding protein in the mitochondrial membrane. This protein regulates the activity...

journal_title：Life sciences

authors： Young P,Wilson S,Arch JR

更新日期：1984-03-19 00:00:00

abstract：:The aim was to investigate the suppressive effect of bicyclol on hepatic fibrosis induced by dimethylnitrosamine (DMN) in mice and the mechanism of its action. Hepatic fibrosis was established by intraperitoneal injection of 8 mg kg(-1) day(-1) on three consecutive days of each week for 4 or 5 weeks. In the prophylact...

journal_title：Life sciences

authors： Hu QW,Liu GT

更新日期：2006-07-04 00:00:00

abstract：:Muscarinic receptors on epithelial cells mediate intestinal secretion, while those in intestinal smooth muscle mediate motility. Experiments were carried out to determine whether the muscarinic receptors mediating each of these two functions in intestinal tissue might be associated with differences in the way agonist ...

journal_title：Life sciences

authors： Tien XY,Wahawisan R,Wallace LJ,Gaginella TS

更新日期：1985-05-20 00:00:00

abstract：:Insulin remains a predominant life-saving medication for type 1 and type 2 Diabetes Mellites. Natural insulin secretion limits the fluctuation of the narrow and high surge of blood glucose levels. However, imitating the same by external insulin remains a challenge as a variety of insulin analogs (rapid acting, short a...

journal_title：Life sciences

authors： Sharma AK,Taneja G,Kumar A,Sahu M,Sharma G,Kumar A,Sardana S,Deep A

更新日期：2019-02-15 00:00:00

abstract：AIMS:Alterations in the expression of antioxidant enzymes are associated with changes in cancer cell sensitivity to chemotherapeutic drugs (menadione and β-lapachone). Mechanisms of acquisition of resistance to pro-oxidant drugs were investigated using a model of oxidative stress-resistant MCF-7 breast cancer cells (Re...

journal_title：Life sciences

authors： Glorieux C,Sandoval JM,Dejeans N,Ameye G,Poirel HA,Verrax J,Calderon PB

更新日期：2016-01-15 00:00:00

abstract：:Male, adult mice of the Binghamton heterogeneous stock received one of two doses of ethanol (1.0 g/kg or 2.0 g/kg in saline) alone or in combination with the calcium (Ca2+) slow channel blocker, verapamil (5.45 mg/kg in 25% v/v ethanol in saline). Hypothermic responses and motor incoordination were assessed in terms o...

journal_title：Life sciences

authors： Johnston JE,Draski LJ,Molina JC,Burright RG,Reynoso G,Calendrillo BA,Isaacson RL

更新日期：1986-12-01 00:00:00

abstract：:The stability of epidermal growth factor (EGF) in the gastrointestinal humen of 3-day-old suckling and 45-day-old weaned pigs was examined by incubating iodine labeled recombinant human EGF (hEGF) in the gastrointestinal fluids at 37 degrees C and monitoring the generation of acid soluble radioactivity. Chromatographi...

journal_title：Life sciences

authors： Shen WH,Xu RJ

更新日期：1996-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia worldwide. β-amyloid peptide (Aβ) is currently assumed to be the main cause of synaptic dysfunction and cognitive impairments in AD, but the molecular signaling pathways underlying its neurotoxic consequences have not yet been completely explored. Additional...

journal_title：Life sciences

authors： Amidfar M,de Oliveira J,Kucharska E,Budni J,Kim YK

更新日期：2020-09-15 00:00:00

abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...

journal_title：Life sciences

authors： Akaike A,Sasa M,Takaori S

更新日期：1983-06-06 00:00:00

abstract：:This study was designed to determine whether the increase in atriopeptin secretion induced by an intravenous infusion of norepinephrine is mediated directly by adrenergic receptor stimulation or indirectly by the associated increase in atrial pressure. Norepinephrine was infused at 0.5 microgram.kg-1.min-1 for 30 min ...

journal_title：Life sciences

authors： Zhu JL,Leadley RJ Jr,Geer PG,Wang BC,Goetz KL

更新日期：1990-01-01 00:00:00

abstract：:In 6-[18F]fluoro-L-dopa (Fdopa)/positron emission tomography (PET) studies, carbidopa pretreatment increases the Fdopa bioavailability to the brain and enhances the intensity of striatal PET images. Different PET research teams have used various carbidopa doses and routes of administration in non-human primate studies...

journal_title：Life sciences

authors： Chan GL,Doudet DJ,Dobko T,Hewitt KA,Schofield P,Pate BD,Ruth TJ

更新日期：1995-01-01 00:00:00

abstract：:The metabolism of haloperidol (HP) to the potentially neurotoxic pyridinium species, HPP+ and RHPP+, has been demonstrated in humans. In vitro studies in microsomes harvested from various animal species indicate that the tetrahydropyridines, HPTP and RHPTP, could be intermediates in this pathway. However, this has not...

journal_title：Life sciences

authors： Avent KM,Riker RR,Fraser GL,Van der Schyf CJ,Usuki E,Pond SM

更新日期：1997-01-01 00:00:00

abstract：:The effects of C-reactive protein (CRP), the prototypical acute-phase reactant were studied on human polymorphonuclear leukocytes (PMNL) challenged with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF). CRP at 8-64 micrograms/ml concentrations inhibited degranulation and superoxide p...

journal_title：Life sciences

authors： Filep J,Földes-Filep E

更新日期：1989-01-01 00:00:00