Vasoactive intestinal polypeptide (VIP) as a putative neurotransmitter in penile erection.

abstract：:Morning urine samples were assayed for human EGF (hEGF) in 137 non-insulin dependent diabetic patients with normal serum creatinine and beta 2-microglobulin levels. Serving as controls, 80 age- and sex-matched healthy subjects were also examined. A significant positive correlation between hEGF excretion and the level ...

journal_title：Life sciences

authors： Kawaguchi M,Kamiya Y,Ito J,Fujii T,Hayakawa F,Sakuma N,Fujinami T

更新日期：1993-01-01 00:00:00

abstract：AIMS:Oxidative stress emerges after reperfusion of an organ following an ischemic period and results in tissue damage. In the heart, an amplified generation of reactive oxygen species and a significant Ca(2+) accumulation cause ventricular arrhythmias and mitochondrial dysfunction. This occurs in consequence of increas...

journal_title：Life sciences

authors： Hernández-Esquivel L,Pavón N,Buelna-Chontal M,González-Pacheco H,Belmont J,Chávez E

更新日期：2014-02-06 00:00:00

abstract：:Salicylate displaces phenytoin from protein binding leading to an increase in free phenytoin concentration. We observed unexpected decreases in free phenytoin concentration in the presence of salicylate. Serum pools containing no phenytoin or salicylate were supplemented with the same concentrations of phenytoin. Then...

journal_title：Life sciences

authors： Biddle DA,Wells A,Dasgupta A

更新日期：2000-01-01 00:00:00

abstract：AIMS:We recently reported that acute exposure to nicotine vasodilates the renal vasculature of male rats via facilitation of endothelial nitric oxide synthase (eNOS). In this study, we investigated whether this effect of nicotine is sexually dimorphic and the role of estrogen in modulating the nicotine effect. MAIN ME...

journal_title：Life sciences

authors： el-Mas MM,el-Gowilly SM,Gohar EY,Ghazal AR,Abdel-Rahman AA

更新日期：2011-01-17 00:00:00

abstract：AIMS:Amino acids, especially branched chain amino acids (BCAAs), have important regulatory roles in protein synthesis. Recently studies revealed that BCAAs protect against ischemia/reperfusion (I/R) injury. We studied the signaling pathway and mitochondrial function affecting a cardiac preconditioning of BCAAs. MAIN M...

journal_title：Life sciences

authors： Satomi S,Morio A,Miyoshi H,Nakamura R,Tsutsumi R,Sakaue H,Yasuda T,Saeki N,Tsutsumi YM

更新日期：2020-03-15 00:00:00

abstract：:A sensitive method for quantitation of beta-endorphin in biological fluids and tissues using ELISA methodology has been developed. This assay is sensitive to as low as 30 picograms of beta-endorphin per measurement and can be carried out in approximately 5 hours. The determination of antibody titer levels to beta-endo...

journal_title：Life sciences

authors： Sarma JM,Houghten RA

更新日期：1983-01-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors have been shown to inhibit intimal thickening following balloon catheterization of rat carotid arteries. To assess the role of the renin-angiotensin pathway and the angiotensin type-I (AT1) receptor in this effect, the nonpeptide Ang II antagonist losartan (DuP 753) or vehicle ...

journal_title：Life sciences

authors： Kauffman RF,Bean JS,Zimmerman KM,Brown RF,Steinberg MI

更新日期：1991-01-01 00:00:00

abstract：:Administration of ovine-prolactin (O-PRL) stimulated Ca2+ uptake in isolated duodenal cells prepared from vitamin D-deficient rats. The time course of this effect was biphasic: uptake activity reached a peak in 2.5 hrs followed by a decrease at 5 hrs to original levels. This stimulatory effect of O-PRL was observed in...

journal_title：Life sciences

authors： Balakir RA,Cheng L,Sacktor B,Liang CT

更新日期：1990-01-01 00:00:00

abstract：:The effect of diabetes mellitus on serum cholesterol and aortic microsomal prostanoid synthesis was studied in cholesterol fed male Lewis rats. Normal, diabetic and diabetic rats treated with pancreatic islets were divided into three diet subgroups, control diet, control +2% cholesterol for 8 weeks and control +2% cho...

journal_title：Life sciences

authors： Myers SI,Bartula L,Linzel M,Phan T,Jung PJ,Merrell RC

更新日期：1990-01-01 00:00:00

abstract：AIMS:Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin sensitivity; however, the underlying mechanism remains unknown. In this study...

journal_title：Life sciences

authors： Xu D,Wang L,Jiang Z,Zhao G,Hassan HM,Sun L,Fan S,Zhou Z,Zhang L,Wang T

更新日期：2018-09-15 00:00:00

abstract：:Two recently isolated peptides, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), are highly selective micro-opioid receptor agonists with analgesic actions in the tail-flick test. To further assess the analgesic properties of these peptides, the effects of endomorphin-1, endomorphin-2, and ...

journal_title：Life sciences

authors： Soignier RD,Vaccarino AL,Brennan AM,Kastin AJ,Zadina JE

更新日期：2000-07-14 00:00:00

abstract：AIMS:Schisandra is a good choice in Traditional Chinese Medicine for the therapy of cardiovascular diseases, but whether it contains a or some specific component (s) responsible these effects are still unclear. In the present study, we explored whether Schisantherin A (SCA) causes vasorelaxation in isolated rat thoraci...

journal_title：Life sciences

authors： Yang S,Xu Z,Lin C,Li H,Sun J,Chen J,Wang C

更新日期：2020-03-15 00:00:00

abstract：:Specific binding sites for atrial natriuretic peptide have been identified in membrane of the phaeochromocytoma cell line PC12. Scatchard analysis of binding studies revealed a Kd of 794 pM and a density (Bmax) of 254 fmol/mg protein. Hormones unrelated to ANP such as angiotensin II, bradykinin and arginine-8-vasopres...

journal_title：Life sciences

authors： Boumezrag A,Lyall F,Dow JA

更新日期：1988-01-01 00:00:00

abstract：:Involvement of cyclic AMP-dependent protein kinase in the desensitization of GABAB receptor expressed in Xenopus oocytes was studied. GABA produced an outward current in the presence of bicuculline, under voltage-clamp conditions. Baclofen mimicked the effect of GABA, thereby indicating that the response to GABA in th...

journal_title：Life sciences

authors： Yoshimura M,Yoshida S,Taniyama K

更新日期：1995-11-17 00:00:00

abstract：:The purpose of this study was to explore the feasibility of utilizing the granatanol: N-methyl [9-azabicyclo (3.3.1) nonane] 3-alpha-ol as the terminal group in a series of new bisquaternary azabicycyclic diester-type neuromuscular blocking agents. Fifty two bisquaternary ammonium derivatives of several dicarboxylic a...

journal_title：Life sciences

authors： Gyermek L,Lee C,Cho YM,Nguyen N

更新日期：2006-07-04 00:00:00

abstract：AIMS:Skeletal muscle diseases have become to be the most common complication in patients with type 2 diabetic mellitus (T2DM). However, the effective therapies against skeletal muscle diseases are not yet available. Sulforaphane (SFN) is an organic isothiocyanate found in cruciferous plants. Our aim was to explore whet...

journal_title：Life sciences

authors： Wang M,Pu D,Zhao Y,Chen J,Zhu S,Lu A,Liao Z,Sun Y,Xiao Q

更新日期：2020-08-15 00:00:00

abstract：:Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of d...

journal_title：Life sciences

authors： Khot V,Chavan-Gautam P,Joshi S

更新日期：2015-05-15 00:00:00

abstract：:A phase 1, randomized, double-blind, placebo-controlled, dose escalation study of the purine derivative, AIT-082 (Neotrofin, NeoTherapeutics) was conducted in mild Alzheimer's disease (AD) patients to evaluate multiple-dose safety, tolerability, and pharmacokinetics. Possible short-term effects of AIT-082 on cognition...

journal_title：Life sciences

authors： Grundman M,Capparelli E,Kim HT,Morris JC,Farlow M,Rubin EH,Heidebrink J,Hake A,Ho G,Schultz AN,Schafer K,Houston W,Thomas R,Thal LJ,Alzheimer's Disease Cooperative Study.

更新日期：2003-06-20 00:00:00

abstract：:The regulation of G protein-coupled receptor expression is important in the physiology of an organism and can occur at any of the steps between gene transcription to turnover of the receptor protein itself. Agonist stimulation causes receptor desensitization, which is characterized by a rapid reduction in response to ...

journal_title：Life sciences

authors： Heck DA,Bylund DB

更新日期：1998-01-01 00:00:00

abstract：AIMS:Fenofibrate (FF) is commonly used clinically as a lipid-lowering drug, but whether it participates in endoplasmic reticulum (ER) stress and decreases inflammation in skeletal muscle is still unknown. The aim of this study is to determine whether FF treatment reduces insulin resistance (IR) by alleviating ER stress...

journal_title：Life sciences

authors： Dai F,Jiang T,Bao YY,Chen GJ,Chen L,Zhang Q,Lu YX

更新日期：2016-07-15 00:00:00

abstract：AIMS:Right ventricular failure (RVF) varies significantly from the more common left ventricular failure (LVF). This study was undertaken to determine potential molecular pathways that are important in human right ventricular (RV) function and may mediate RVF. MATERIALS AND METHODS:We analyzed mRNA of human non-failing...

journal_title：Life sciences

authors： Williams JL,Cavus O,Loccoh EC,Adelman S,Daugherty JC,Smith SA,Canan B,Janssen PML,Koenig S,Kline CF,Mohler PJ,Bradley EA

更新日期：2018-03-01 00:00:00

abstract：AIMS:The study aimed to investigate whether IL-23 is amplified in monocyte subsets of MP pneumonia and to determine its relevant pathway. MATERIALS AND METHODS:We firstly analyze the IL-23p19 expression in monocyte subgroups in MP pneumonia patients and healthy controls subjects by using flow cytometry. Then, we also ...

journal_title：Life sciences

authors： Wang Z,Bao H,Liu Y,Wang Y,Qin J,Yang L

更新日期：2020-10-01 00:00:00

abstract：:The neuropeptide substance P (SP) is a mediator of neurogenic inflammation. Also, beta-amyloid protein (beta AP) can directly activate the cell types involved in inflammatory processes. The relationship between SP and beta AP on their biological actions has attracted much interest. SP is trophic in neuronal cells and ...

journal_title：Life sciences

authors： Takenouchi T,Munekata E

更新日期：1995-01-01 00:00:00

abstract：:The low Km GTPase displayed an apparent Km value of 0.2-0.4 microM in P2 fractions from whole mouse brain. The activity of this enzyme ranged from 102 (pmols of GTP hydrolysed per micrograms of protein per min) in the striatum to 39 in the pons-medulla oblongata. Intermediate values were found in other structures, 74-...

journal_title：Life sciences

authors： Martínez-Peña Y,Garzón J

更新日期：1993-01-01 00:00:00

abstract：:Incubation of racemic methylenedioxyamphetamine (MDA) or methylenedioxymethamphetamine (MDMA) with rat hepatic microsomes, in the presence of NADPH, generated a spectrally observed inhibitory complex with cytochrome P-450. The complex inhibited product formation from MDA and MDMA as well as other P-450 dependent react...

journal_title：Life sciences

authors： Brady JF,Di Stefano EW,Cho AK

更新日期：1986-10-20 00:00:00

abstract：:Diabetes Mellitus (DM) can produce an increase in the cardiac action potential duration and QT interval that can be associated with sudden death. These cardiac effects are due to a region-specific decrease in repolarizing outward K(+) currents. Some authors have suggested that the proarrhythmic effects of diabetes can...

journal_title：Life sciences

authors： Ferrer T,Gallego M,Madrigal-Quiñónez R,Torres-Jácome J,Navarro-Polanco R,Cásis O,Sánchez-Chapula JA

更新日期：2006-07-24 00:00:00

abstract：:Fish oil is rich in the long chain n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA); typically these fatty acids constitute 20 to 25 g/100 g total fatty acids in fish oil. Feeding rodents diets rich in fish oil has been shown to decrease lymphocyte proliferation and natural ki...

journal_title：Life sciences

authors： Peterson LD,Thies F,Sanderson P,Newsholme EA,Calder PC

更新日期：1998-01-01 00:00:00

abstract：:Losartan, a recently developed nonpeptide angiotensin II (Ang II) receptor antagonist, was administered orally to 10-week-old spontaneously hypertensive rats (SHR) for 2 weeks. Cardiac weight and tissue Ang II, as well as plasma renin activity (PRA) and Ang II, were determined. Treatment with Losartan (10 mg/kg per da...

journal_title：Life sciences

authors： Mizuno K,Tani M,Hashimoto S,Niimura S,Sanada H,Watanabe H,Ohtsuki M,Fukuchi S

更新日期：1992-01-01 00:00:00

abstract：:Exposure to Cd(2+) via inhalation or intratracheal instillation results in pulmonary edema, which is followed by the influx of leukocytes, the proliferation of type II pneumocytes and eventual scarring and fibrotic changes. While the general toxic effects of Cd(2+) in the lung have been well characterized, the specifi...

journal_title：Life sciences

authors： Pearson CA,Lamar PC,Prozialeck WC

更新日期：2003-01-31 00:00:00

abstract：AIMS:Osteosarcoma is one of the most aggressive types of primary bone cancer that responds poorly to radiotherapy frequently. The gene associated with retinoid-interferon mortality (GRIM-19) is a tumor suppressor that mediates cell apoptosis in multiple cancer types. However, the role of GRIM-19 in osteosarcoma and the...

journal_title：Life sciences

authors： Chen W,Liu Q,Fu B,Liu K,Jiang W

更新日期：2018-09-01 00:00:00