Abstract:
:Specific binding sites for atrial natriuretic peptide have been identified in membrane of the phaeochromocytoma cell line PC12. Scatchard analysis of binding studies revealed a Kd of 794 pM and a density (Bmax) of 254 fmol/mg protein. Hormones unrelated to ANP such as angiotensin II, bradykinin and arginine-8-vasopressin did not complete for the binding sites. Of the ANP-related peptides which competed for the binding sites, the following order of affinity was established; rANP (8-33) greater than rANP (28 amino acid) greater than rat atrial peptide fragment (13-28) greater than a-hANP (28 amino acid) greater than atrial peptide fragment (1-11) greater than atriopeptin I.
journal_name
Life Scijournal_title
Life sciencesauthors
Boumezrag A,Lyall F,Dow JAdoi
10.1016/0024-3205(88)90577-2subject
Has Abstractpub_date
1988-01-01 00:00:00pages
2035-42issue
24eissn
0024-3205issn
1879-0631pii
0024-3205(88)90577-2journal_volume
43pub_type
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