Abstract：
:The effect of diabetes mellitus on serum cholesterol and aortic microsomal prostanoid synthesis was studied in cholesterol fed male Lewis rats. Normal, diabetic and diabetic rats treated with pancreatic islets were divided into three diet subgroups, control diet, control +2% cholesterol for 8 weeks and control +2% cholesterol diet for 16 weeks. Serum glucose levels were elevated three-fold in the diabetic group compared to normal. Treatment with islets restored serum glucose to normal levels in diabetic rats. The 2% cholesterol diet did not significantly alter serum glucose levels in any of the groups. Body weights in the diabetic group were significantly lower than normal or diabetic rats treated with islets. Feeding 2% cholesterol for 16 weeks significantly increased weight in normal and islet treated diabetic rats but not in the diabetic group. Aortic microsomal prostanoid synthesis was similar in all experimental groups with 6-keto-PGF1 alpha (PGI2 metabolite) being the major product synthesized in all groups. Aortic microsomal prostanoid levels were not altered by the 2% cholesterol diet. Serum cholesterol levels increased 14-fold in the diabetic group which returned to the normal level in the diabetic animals treated with islets. These data show that diabetes does not alter aortic microsomal prostanoid levels in the rat. However, diabetes significantly increased serum cholesterol levels which were reversed by islet transplantation.
journal_name
Life Scijournal_title
Life sciencesauthors
Myers SI,Bartula L,Linzel M,Phan T,Jung PJ,Merrell RCdoi
10.1016/0024-3205(90)90620-7subject
Has Abstractpub_date
1990-01-01 00:00:00pages
587-94issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(90)90620-7journal_volume
47pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:We have investigated the effect of calcitonin (CT) on adenylate cyclase in membranes from different rat brain areas. Salmon calcitonin (sCT) dose-dependently inhibited the enzyme activity in midbrain, hypothalamus, medulla, pons and caudate nucleus, but was ineffective in adenohypophysis. The inhibitory effect was enh...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90404-2
更新日期：1986-12-08 00:00:00
abstract：:CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.06.026
更新日期：2008-08-29 00:00:00
abstract：BACKGROUND:Coronavirus disease 2019 (COVID-19) has become a severe public health problem around the globe. Various epidemiological, statistical, and laboratory-based studies have shown that the role of temperature and other environmental factors has important influence in the transmission of coronaviruses. Scientific r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119093
更新日期：2021-01-18 00:00:00
abstract：:Responses to synthetic human adrenomedullin, a novel hypotensive peptide localized in several organ systems, including the lung, and the carboxy terminal 15-52 amino acid fragment of adrenomedullin (ADM15-52) were investigated in the pulmonary vascular bed of the intact-chest cat. Under constant flow conditions when b...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00246-0
更新日期：1994-01-01 00:00:00
abstract：:Recent studies in animals have demonstrated that the steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3A5P), is a potent analgesic when given intracerebroventricularly. Several studies in humans report that spinal steroids are effective in the treatment of chronic low-back pain when given in combination with morphine....
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90095-7
更新日期：1992-01-01 00:00:00
abstract：:We have evaluated the effect of intraperitoneal (I.P.) injection of human recombinant interferon-2alpha (IFN-alpha) on Bleomycin-induced pulmonary injury in hamsters. Pulmonary injury was induced by a single intratracheal (I.T.) instillation of Bleomycin (Bleo). Six groups of male Syrian hamsters were treated as follo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00332-9
更新日期：1997-01-01 00:00:00
abstract：:DHEA improves insulin sensitivity and has anti-obesity effect in animal models and men. However, the molecular mechanisms by which DHEA improves insulin action have not been clearly understood. In the present study, we examined the protein levels and phosphorylation state of insulin receptor (IR), IRS-1 and IRS-2, the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.06.017
更新日期：2004-11-19 00:00:00
abstract：:The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90026-8
更新日期：1991-01-01 00:00:00
abstract：:Bradykinin receptor stimulation results in G-protein-coupled phospholipase activation, initiating protein kinase C (PKC) stimulation and cytosolic free Ca2+ concentration ([Ca2+]i) rises as signalling pathways. Using Rb+ as a tracer for K+, we have studied the mechanisms involved in bradykinin-stimulated Rb+ influx in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00530-9
更新日期：1996-01-01 00:00:00
abstract：:Using a ligation method, rat rectal epithelium was exposed to 2% sodium salicylate, and light and electron microscopic methods were used to assay for: 1) permeability of the epithelium to a marker dye, trypan blue, and 2) damage expressed in terms of disruption of the epithelial surface. Rectal mucosa was exposed to s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90656-2
更新日期：1983-09-12 00:00:00
abstract：AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.08.013
更新日期：2012-10-05 00:00:00
abstract：AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.01.003
更新日期：2013-03-28 00:00:00
abstract：:Amino acid and reduced glutathione (GSH) levels in substantia nigra (SN) as well as striatal monoamine levels were measured in acetyl-L-carnitine (ALCar) treated and control Swiss-Webster mice. ALCar, L carnitine, or saline were administered i.p. to mice for 5 days and mice were decapitated 24 hours following the last...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90319-0
更新日期：1988-01-01 00:00:00
abstract：:The development of the specific uptake of dopamine in the rat striatum during the early postnatal period is compared with the ontogenetic changes of the specific binding of (3H)GBR 12783 to the site of uptake inhibition. During maturation, the increase in the specific binding of (3H)GBR 12783 parallels the increase in...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90563-8
更新日期：1989-01-01 00:00:00
abstract：UNLABELLED:Limited clinical and experimental studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit gastric cancer growth. However, the mechanisms involved are not completely understood and cannot be explained by COX-2 inhibition alone. MAPK signaling pathway is essential for cell proliferation...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01411-4
更新日期：2001-11-09 00:00:00
abstract：:Dopaminergic agents ameliorate experimentally induced gastroduodenal mucosal injury, but there is no information about their effect on small intestinal mucosa. We studied the effect of L-dopa and related substances on indomethacin-induced intestinal ulceration in the rat. Ulceration was produced by s.c. injection of 3...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90517-s
更新日期：1992-01-01 00:00:00
abstract：:Substrate stiffness is essential for cell functions, but the mechanisms by which cell sense mechanical cues are still unclear. Here we show that the frequency and the amplitude of spontaneous Ca2+ oscillations were greater in chick cardiomyocytes cultured on the stiff substrates than that on the soft substrates. The s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116802
更新日期：2019-10-15 00:00:00
abstract：:Previous in vitro evidence suggests that adrenaline causes K influx in skeletal muscle by stimulating a ouabain sensitive Na/K ATPase membrane pump. However in rabbits, adrenaline induced hypokalaemia was not significantly altered by pretreatment with digoxin (50 micrograms/kg). Rats were infused with adrenaline or sa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90258-x
更新日期：1987-01-05 00:00:00
abstract：:In rat brain microvessels, tetrahydroaminoacridine (THA) caused a significant inhibition of both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities, in a dose-dependent manner. THA resulted to be a more potent inhibitor of BuChE than AChE. Lineweaver-Burk plots showed that Km (app) and V were alt...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90553-f
更新日期：1993-01-01 00:00:00
abstract：:miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.117865
更新日期：2020-09-01 00:00:00
abstract：:The present study was to test whether the recently described endogenous ligand for the cannabinoid receptor; arachidonyl-ethanolamide (anandamide, ANA), may produce similar effects on pregnancy as the main psychoactive component of marihuana: delta9-tetrahydrocannabinol (THC) in rats. ANA, THC (0.02 mg/kg i.p./day, re...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00296-8
更新日期：1997-01-01 00:00:00
abstract：:Coxsackievirus B3 (CVB3) is a major pathogen for acute and chronic viral myocarditis. The aim of this study was to investigate the antiviral effects of sophoridine, an alkaloid extracted from Chinese medicinal herb, Sophora flavescens, against CVB3, and the underlying pharmacokinetics. First, we determined the antivir...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.09.034
更新日期：2006-03-20 00:00:00
abstract：:The in vitro oxidative hemolysis of human red blood cells (RBCs) was used as a model to study the free radical-induced damage of biological membranes and the protective effect of flavonols and their glycosides (FOHs), i.e., myricetin (MY), quercetin (Q), morin (MO), kaempferol (K), rutin (R), quercetin galactopyranosi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.10.009
更新日期：2006-04-18 00:00:00
abstract：:The risk of atherosclerosis (AS) ascends among post-menopausal women, while current hormone replacement therapy exerts several adverse effects. Alisol B 23-acetate (AB23A), a tetracyclic triterpenoid isolated from the rhizome of Alisma orientale, was reported to show multiple physiological activities, including regula...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118030
更新日期：2020-10-01 00:00:00
abstract：:The effect of the Type I benzodiazepine (BDZ) receptor agonist, CL 218,872, on convulsions generated by low doses of methyl beta-carboline-3-carboxylic acid ( MBCC ), bicuculline, picrotoxin and pentylenetetrazole (PTZ) in mice was examined. Low doses of CL 218,872 enhanced the convulsions produced by all agents excep...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90321-7
更新日期：1984-05-28 00:00:00
abstract：UNLABELLED:The present study was conducted to examine whether melatonin impairs serotonin (5HT) release and uptake in rat platelets. Exposure of platelet-rich plasma samples (PRP) to melatonin induced a concentration-dependent inhibition of 5HT uptake and the value of IC50 was 1.3 x 10(-3) M. We have also investigated ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90261-z
更新日期：1993-01-01 00:00:00
abstract：:The induction of aldose reductase (AR) mRNA expression and its activity by glucose were investigated in fetal rat aortic smooth muscle (A10) cells. The increase in the expression of AR mRNA was observed at 6 h, and reached a maximum (2.3 fold) at 12 h after exposure to 80 mM glucose. On the other hand, increase in AR ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90480-d
更新日期：1992-01-01 00:00:00
abstract：:Resveratrol, a polyphenolic substance found in grape skin, is proposed to account in part for the protective effect of red wine in the cardiovascular system. The aim of the present study is to investigate the action and possible mechanisms of resveratrol-produced regulation of plasma glucose in normal and diabetic rat...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.02.002
更新日期：2007-04-10 00:00:00
abstract：:[3H]A-69024 has been prepared as a radioligand for studying the dopamine D1 receptor. [3H]A-69024 binds to rat striatal membranes with a KD = 14.3 +/- 3.2 nM (mean +/- SEM; n = 3) and Bmax = 63.5 +/- 12.8 fmol/mg wet tissue (1.8 +/- 0.3 pmol/mg protein). This ligand binds to only one site with a Hill coefficient close...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)02212-2
更新日期：1995-01-01 00:00:00
abstract：:High concentrations of cocaethylene (EC), the ethyl ester of benzoylecgonine, were measured in the blood of individuals who had concurrently used cocaine and ethanol. Since the powerful reinforcing effects of cocaine appear to be dependent on inhibition of dopamine reuptake in brain, we compared the effects of EC on t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90217-y
更新日期：1991-01-01 00:00:00
