Estrogen dependence of the renal vasodilatory effect of nicotine in rats: role of α7 nicotinic cholinergic receptor/eNOS signaling.

abstract：AIMS:Chemerin has been recently identified as a vasoactive adipokine implicated in blood pressure regulation. In this context, we evaluated whether chemerin could influence pulmonary vasoreactive response. MATERIALS AND METHODS:Vascular reactivity to chemerin and to phenylephrine, serotonin and endothelin-1 after chem...

journal_title：Life sciences

authors： Hanthazi A,Jespers P,Vegh G,Degroot GN,Springael JY,Lybaert P,Dewachter L,Mc Entee K

更新日期：2019-08-15 00:00:00

abstract：:The present study was undertaken to examine whether there was a time-dependent change in the toxic effects of amikacin, an aminoglycoside, on renal functions. Male Wistar rats were maintained under conditions of light from 7 am to 7 pm and dark from 7 pm to 7 am. Amikacin (1.2 g/kg) was injected intraperitoneally to a...

journal_title：Life sciences

authors： Fujimura A,Sudoh T,Ebihara A

更新日期：1994-01-01 00:00:00

abstract：AIMS:Nanoparticles (NPs)-based drugs have been recently introduced to improve the efficacy of current therapeutic strategies for the treatment of cancer; however, the molecular mechanisms by which a NP interacts with cellular systems still need to be delineated. Here, we utilize the autophagic potential of TiO2 NPs for...

journal_title：Life sciences

authors： Azimee S,Rahmati M,Fahimi H,Moosavi MA

更新日期：2020-05-01 00:00:00

abstract：:Examination was made of the effects of 17 synthetic and naturally occurring flavonoids on human lymphocyte proliferation in the presence of concanavalin A as a mitogen. Twelve of the flavonoids examined were mono-hydroxy or methoxy derivatives. The mitogen-induced response of lymphocytes was evaluated from the extent ...

journal_title：Life sciences

authors： Hirano T,Oka K,Kawashima E,Akiba M

更新日期：1989-01-01 00:00:00

abstract：:Over the past few years, it has been reported that physical and psychological stress elevate plasma interleukin-6 (IL-6), and that neural cells can produce IL-6 and have receptors for IL-6 (IL-6R). However, it is unknown whether IL-6 plays a role in regulating the functions of neural cells in response to stress. We de...

journal_title：Life sciences

authors： Shizuya K,Komori T,Fujiwara R,Miyahara S,Ohmori M,Nomura J

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA). DESIGN AND METHODS:We investigated the serum enzyme activity and concentration of PON1 and their relationship with serum lipids, high-density lipoprotein (HDL) parameters, and acute phase reac...

journal_title：Life sciences

authors： Tanimoto N,Kumon Y,Suehiro T,Ohkubo S,Ikeda Y,Nishiya K,Hashimoto K

更新日期：2003-05-09 00:00:00

abstract：:Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano...

journal_title：Life sciences

authors： Nishihata T,Higuchi T

更新日期：1984-01-30 00:00:00

abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...

journal_title：Life sciences

authors： Tsuchiya M,Niijima-Yaoita F,Yoneda H,Chiba K,Tsuchiya S,Hagiwara Y,Sasaki K,Sugawara S,Endo Y,Tan-No K,Watanabe M

更新日期：2014-05-08 00:00:00

abstract：:Stimulation of the preganglionic trunk of the ipsilateral superior cervical sympathetic ganglion with square wave electrical pulses produced secretion from the main excretory duct of the rabbit lacrimal gland. The secretion was inhibited by propranolol (1 mg/kg) and metoprolol (10 mg/kg) but not by phenoxybenzamine (2...

journal_title：Life sciences

authors： Tangkrisanavinont V

更新日期：1984-06-11 00:00:00

abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...

journal_title：Life sciences

authors： Hou YC,Hsiu SL,Ching H,Lin YT,Tsai SY,Wen KC,Chao PD

更新日期：2005-01-21 00:00:00

abstract：AIMS:Second-generation antipsychotic drugs (SGAs) have a high risk for serious metabolic side-effects including dyslipidemia. This study aimed to investigate the acute effects of oral olanzapine treatment on the expression of genes for fatty acid and cholesterol biosynthesis in rats. MAIN METHODS:Female Sprague-Dawley...

journal_title：Life sciences

authors： Liu X,Deng C,Cao S,Gong J,Wang BC,Hu CH

更新日期：2015-05-01 00:00:00

abstract：:Since moderate hyperhomocysteinemia is an independent risk factor for vascular disease by mean of its oxidant effect and glutathione plays a main role as intracellular redox-regulating agent, we have studied for the first time the total intracellular content of homocysteine in aging. Plasma homocysteine concentration,...

journal_title：Life sciences

authors： Hernanz A,Fernández-Vivancos E,Montiel C,Vazquez JJ,Arnalich F

更新日期：2000-08-04 00:00:00

abstract：:The effects of two benzodiazepine derivatives (diazepam, 0.5-1 mg/kg; alprazolam, 1.25-2.5 mg/kg) on ultrasonic calling elicited in adult rats by unavoidable aversive stimuli (footshocks) were investigated. The results show that either diazepam or alprazolam affected the duration of ultrasonic calls. In particular, a ...

journal_title：Life sciences

authors： Cuomo V,Cagiano R,De Salvia MA,Maselli MA,Renna G,Racagni G

更新日期：1988-01-01 00:00:00

abstract：:Two proteolytic activities that convert big ET to ET at neutral pH were identified in solubilized membranes prepared from rat lung. The endothelin-converting activities were partially purified by using A80227 ((2S,3R,4S)-2-([N-acetylcyclohexylalanyl-isoleucyl]amino)-1-(2-nap hthyl)-3,4-dihydroxy-6-methylheptane) coupl...

journal_title：Life sciences

authors： Chiou WJ,Shiosaki K,Tasker AS,Wu-Wong JR

更新日期：1994-01-01 00:00:00

abstract：AIMS:This study aims to identify by a molecular genetic approach potential targets in mast cells at which 1,4-benzodiazepines may cause their inhibitory effect on mast cell activity. MAIN METHODS:Gene expression analyses with microarray gene chip and/or quantitative PCR were performed using 1,4-benzodiazepine-treated ...

journal_title：Life sciences

authors： Haenisch B,Huber M,Wilhelm T,Steffens M,Molderings GJ

更新日期：2013-03-14 00:00:00

abstract：AIMS:The beneficial effects of cannabinoid type 2 receptor (CB2R) activation have been verified in various tissue repair processes. Our recent study revealed CB2R activation promotes myogenesis partly through Nrf2 signaling in a mouse skeletal muscle ischemia-reperfusion (IR) injury model. Other relevant mechanisms nee...

journal_title：Life sciences

authors： Jiang P,Wang L,Zhang M,Zhang M,Wang C,Zhao R,Guan D

更新日期：2020-09-01 00:00:00

abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...

journal_title：Life sciences

authors： Atarashi K,Matsuoka H,Takagi M,Sugimoto T

更新日期：1989-01-01 00:00:00

abstract：:Previous studies have paid little attention to the anticonvulsant effect of anticholinergic drugs that act on both muscarinic (M) and nicotinic (N) receptors during soman-induced seizures. Therefore, with the establishment of a soman-induced seizures model in rats, this study evaluated the efficacy in preventing soman...

journal_title：Life sciences

authors： Wang YA,Zhou WX,Li JX,Liu YQ,Yue YJ,Zheng JQ,Liu KL,Ruan JX

更新日期：2005-11-26 00:00:00

abstract：:Cloned human MCF-7 breast tumor cells were prevented from proliferating when grown in charcoal-dextran stripped human female serum (CDFHS)-supplemented media (40% and 10%); this inhibition was maximally cancelled by estradiol-17, cisTamoxifen, and Metabolite E, whereas Tamoxifen, N-desmethylTamoxifen and Metabolite Y ...

journal_title：Life sciences

authors： Sonnenschein C,Papendorp JT,Soto AM

更新日期：1985-07-29 00:00:00

abstract：:The impact of low level lead exposure on human central nervous system function is a major public health concern. This study addresses the inhibition of the cation pump enzyme Na, K-ATPase by low level lead. Human brain tissue was obtained at autopsy and frozen until use. Brain homogenates were preincubated with PbCl2 ...

journal_title：Life sciences

authors： Bertoni JM,Sprenkle PM

更新日期：1991-01-01 00:00:00

abstract：:The density of bovine peripheral-type benzodiazepine receptors (PBR) in four tissues was highest in adrenal cortex. The adrenal cortex PBR cofractionated with a mitochondrial membrane marker enzyme and could be solubilized with intact ligand binding properties using digitonin. The membrane bound and soluble mitochondr...

journal_title：Life sciences

authors： Parola AL,Laird HE 2nd

更新日期：1991-01-01 00:00:00

abstract：:High performance liquid chromatography combined with either single quad or triple quad mass spectral detectors (LC/MS) was used to measure the brain distribution of receptor occupancy tracers targeting dopamine D2, serotonin 5-HT2A and neurokinin NK-1 receptors using the ligands raclopride, MDL-100907 and GR205171, re...

journal_title：Life sciences

authors： Chernet E,Martin LJ,Li D,Need AB,Barth VN,Rash KS,Phebus LA

更新日期：2005-12-12 00:00:00

abstract：:Since Oct-1 is a ubiquitous DNA binding protein shown to play an important role in regulating cell proliferation and possess structural characteristics consistent with a nitric oxide (NO) target, we studied NO regulation of the DNA binding activity of Oct-1 in the A7R5 vascular smooth muscle cell (VSMC) line. Two NO d...

journal_title：Life sciences

authors： Liu XK,Abernethy DR,Andrawis NS

更新日期：1998-01-01 00:00:00

abstract：:Promoter methylation is an important mechanism of regulating E-cadherin expression. Methylation-specific PCR (MSP) assay was done to evaluate the promoter methylation status of E-cadherin gene in primary tumor samples from 23 cases of Chinese women with invasive ductal breast cancers. Western blotting assay was employ...

journal_title：Life sciences

authors： Hu XC,Loo WT,Chow LW

更新日期：2002-08-09 00:00:00

abstract：AIMS:The progressive accumulation of beta-amyloid peptide (Abeta), in the form of senile plaques, has been recognized as one of the major causes of Alzheimer's disease (AD) pathology. Increased production of Abeta and the aggregation of Abeta to oligomers have been reported to trigger neurotoxicity, oxidative damage an...

journal_title：Life sciences

authors： Sul D,Kim HS,Lee D,Joo SS,Hwang KW,Park SY

更新日期：2009-02-27 00:00:00

abstract：:Morphine and the enkephalin-like peptide FK 33-824 given i.p. to rats potently inhibit gastrointestinal transit of a charcoal test meal, the doses inhibiting transit by 50% being respectively about 10 and 1 microgram/kg. These intestinal effects are opiate-specific, locally elicited and presumably involve the same act...

journal_title：Life sciences

authors： Manara L,Bianchi G,Fiocchi R,Notarnicola A,Peracchia F,Tavani A

更新日期：1982-09-20 00:00:00

abstract：AIM:Diabetic nephropathy (DN) is a leading cause of end-stage renal disease, and thus, the ability of antidiabetic drugs to ameliorate renal microvascular disease may be as important as their ability to control blood glucose. Therefore, we investigated the reno-protective effect of the antidiabetic drugs, Sitagliptin a...

journal_title：Life sciences

authors： Ali SM,Khalifa H,Mostafa DK,El Sharkawy A

更新日期：2016-05-15 00:00:00

abstract：:Neuroblastoma x glioma hybrid cells NG 108-15 were chronically treated with opioid agonists and tested for their development of "tolerance" as evaluated by the loss of inhibitory activity of opioids upon cAMP-accumulation. Desensitization was dose-dependent and non-competitive and highly selective, since the activity ...

journal_title：Life sciences

authors： Wüster M,Costa T,Gramsch C

更新日期：1983-01-01 00:00:00

abstract：:Clinical trials with muscarinic agonists or acetylcholine esterase inhibitors for the treatment of Alzheimer's dementia have shown disappointing or equivocal results. An alternative treatment of this disease is the development of drugs which enhance the release of acetylcholine. It is believed, that of the five muscar...

journal_title：Life sciences

authors： Doods HN,Quirion R,Mihm G,Engel W,Rudolf K,Entzeroth M,Schiavi GB,Ladinsky H,Bechtel WD,Ensinger HA

更新日期：1993-01-01 00:00:00

abstract：:Although the understanding of migraine pathophysiology is still incomplete, there seems to be little doubt that dilatation of cranial blood vessels, including meningeal arteries, is involved in the headache phase of migraine. Since calcitonin gene-related peptide (CGRP) has been implicated in this vasodilatation, the ...

journal_title：Life sciences

authors： Gupta S,Mehrotra S,Avezaat CJ,Villalón CM,Saxena PR,Maassenvandenbrink A

更新日期：2006-06-13 00:00:00