Magnesium ion: a possible physiological regulator of aldosterone production.

abstract：:Responses to synthetic human adrenomedullin, a novel hypotensive peptide localized in several organ systems, including the lung, and the carboxy terminal 15-52 amino acid fragment of adrenomedullin (ADM15-52) were investigated in the pulmonary vascular bed of the intact-chest cat. Under constant flow conditions when b...

journal_title：Life sciences

authors： Cheng DY,DeWitt BJ,Wegmann MJ,Coy DH,Bitar K,Murphy WA,Kadowitz PJ

更新日期：1994-01-01 00:00:00

abstract：:The ATP-binding cassette (ABC) and solute carrier (SLC) transporter families consist of common drug transporters that mediate the efflux and uptake of drugs, respectively, and play an important role in the absorption, distribution, metabolism and excretion of drugs in vivo. Rheumatoid arthritis (RA) is an autoimmune d...

journal_title：Life sciences

authors： Gao J,Wang C,Wei W

更新日期：2021-01-08 00:00:00

abstract：:The relative affinities of nortriptyline (NT) and its 10-hydroxymetabolites to rat brain muscarinic acetylcholine receptors have been determined by competition with 3H-quinuclidinyl benzilate binding. It is shown that the major NT metabolite, E-10-OH-NT, has only 1/18 the affinity of NT for the muscarinic receptor. Si...

journal_title：Life sciences

authors： Wägner A,Ekqvist B,Bertilsson L,Sjöqvist F

更新日期：1984-09-24 00:00:00

abstract：AIMS:Coronavirus disease 2019 (COVID-19) has appeared in Wuhan, China but the fast transmission has led to its widespread prevalence in various countries, which has made it a global concern. Another concern is the lack of definitive treatment for this disease. The researchers tried different treatment options which are...

journal_title：Life sciences

authors： Hosseini FS,Amanlou M

更新日期：2020-10-01 00:00:00

abstract：:The influence of oral administration of rare earth element cerium (Ce) was studied in relation to metallothionein (MT) and glutathione (GSH) content in the organs of ICR mice, which were administered heavy metal cadmium (Cd) for comparison. Male ICR mice were divided into 9 groups: 1 control group, 4 cerium groups and...

journal_title：Life sciences

authors： Kawagoe M,Hirasawa F,Cun Wang S,Liu Y,Ueno Y,Sugiyama T

更新日期：2005-07-08 00:00:00

abstract：:Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory...

journal_title：Life sciences

authors： Bastaki S,Aravindhan S,Ahmadpour Saheb N,Afsari Kashani M,Evgenievich Dorofeev A,Karoon Kiani F,Jahandideh H,Beigi Dargani F,Aksoun M,Nikkhoo A,Masjedi A,Mahmoodpoor A,Ahmadi M,Dolati S,Namvar Aghdash S,Jadidi-Niaragh F

更新日期：2021-02-01 00:00:00

abstract：:We investigated the involvement of alpha 1-adrenoceptor subtypes in the positive chronotropic response to norepinephrine (NE) in neonatal rat cardiac myocytes at day 3 of culture. The cardiac myocytes at day 3 of culture exhibited a dose-dependent positive chronotropic response to NE in the presence of propranolol, a ...

journal_title：Life sciences

authors： Kimura H,Kawana S,Kanaya N,Sakano S,Miyamoto A,Ohshika H

更新日期：1994-01-01 00:00:00

abstract：:Recently, 4.4'-bis(1-p-carboxyphenyl-3-methyl-5-dydroxyl)-pyrazol (DRD156) has been developed as a new sensitive reagent that reacts specifically with singlet oxygen. The specificity of DRD156 for singlet oxygen in a biomimetic solution (micellar solution) and the effects of its coexistence with other reagent were exa...

journal_title：Life sciences

authors： Nishide N,Miyoshi N

更新日期：2002-12-06 00:00:00

abstract：:Human histiocytic lymphoma cells (U-937) undergo similar differentiation when incubated with the phorbol ester 12-0-tetradecanoyl phorbol-13-acetate (TPA) and 1,25-dihydroxycholecalciferol. In this action, TPA somehow implicates calcium-sensitive and phospholipid-dependent protein kinase (protein kinase C), which is r...

journal_title：Life sciences

authors： Mezzetti G,Bagnara GP,Monti MG,Pernecco Casolo L,Bonsi L,Brunelli MA

更新日期：1987-05-25 00:00:00

abstract：:1-Aminocyclopropane carboxylic acid (ACPC), a partial agonist of the glycine site on the NMDA receptor, prevents tolerance to the mu opioid morphine and the delta ligand [D-Pen2,D-Pen5]enkephalin (DPDPE) when co-administered with the opioid. In contrast, ACPC does not significantly influence tolerance to the kappa1 op...

journal_title：Life sciences

authors： Kolesnikov YA,Maccechini ML,Pasternak GW

更新日期：1994-01-01 00:00:00

abstract：:Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...

journal_title：Life sciences

authors： Van der Krogt JA,Koot-Gronsveld E,Van den Berg CJ

更新日期：1983-08-15 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：:We previously reported the discovery and partial characterization of bovine atrial granule serine proteinase, a candidate processing enzyme of pro-atrial natriuretic factor, which is associated with atrial granule membranes. We now report the physicochemical properties of electrophoretically homogeneous enzyme purifie...

journal_title：Life sciences

authors： Wypij DM,Harris RB

更新日期：1992-01-01 00:00:00

abstract：:A single intravenous injection of alloxan in mice induced hyperglycemia in a dose dependent fashion. This diabetogenic action of alloxan was prevented by a single intraperitoneal injection of the alpha 2-adrenergic agonists, i.e. oxymetazoline, clonidine or epinephrine 40 min prior to the injection of alloxan. The alp...

journal_title：Life sciences

authors： Nakadate T,Nakaki T,Yamamoto S,Kato R

更新日期：1983-02-14 00:00:00

abstract：:Kappa (kappa) opioid agonists induce a water diuresis and inhibit vasopressin (AVP) secretion. Hypothalamic and neurohypophysial sites have both been implicated in the response. The present study was designed to ascertain if kappa-agonist inhibition of osmotically-stimulated AVP secretion is associated with parallel c...

journal_title：Life sciences

authors： Rossi NF,Kim JK,Summers SN,Schrier RW

更新日期：1997-01-01 00:00:00

abstract：AIMS:Obesity is not only associated with metabolic diseases but is also a symptom of menopause in women. To date, there are no effective drugs for the management of obesity, and it is important to find new agents with fewer side effects, for the treatment of obesity. This study aimed to determine the anti-obesity effec...

journal_title：Life sciences

authors： Tsai YC,Leu SY,Chen SY,Kung CW,Lee YM,Liu YP,Yen MH,Cheng PY

更新日期：2019-09-01 00:00:00

abstract：:We produced thiamine-deficient (TD) mice by TD diet treatment. The growth curve of mice on TD feeding was sharply increased until on the 10th day and subsequently the body weight gradually decreased. The mortality rate in mice was about 67% on the 30th day after the start of TD feeding. We performed the forced swimmin...

journal_title：Life sciences

authors： Nakagawasai O,Tadano T,Hozumi S,Taniguchi R,Tan-No K,Esashi A,Niijima F,Kisara K

更新日期：2001-07-27 00:00:00

abstract：:The effects of chronic treatment with piracetam (100 mg/Kg) plus choline (100 mg/Kg) on rabbits' hippocampal electrical activity and behavior have been studied. Animals were exposed to a neutral environment, in the absence of any external stimulus, and then to an object and a stuffed sparrow-hawk. Results show a drug ...

journal_title：Life sciences

authors： Fontani G,Grazzi F,Meucci M

更新日期：1984-09-10 00:00:00

abstract：:Catalase, glutathione peroxidase and superoxide dismutase enzymes were determined after administering dexamethasone. Catalase increased its activity over six times (0.388 U/mg DNA) the normal rate, while glutathione peroxidase caused 3 times an increase one hour after dexamethasone injection. Superoxide dismutase incr...

journal_title：Life sciences

authors： José HJ,Berenice SG,Cecilia VR

更新日期：1997-01-01 00:00:00

abstract：:Bacitracin (BAC) U.S.P., obtained in the form of sterile powder, elicits dose-dependent and non-tachyphylactic contractions of the rabbit isolated aorta and of other rabbit vessels. The use of several pharmacologic antagonists suggests that BAC is a 5-hydroxytryptamine mimetic in aortic strips, since the antibiotic is...

journal_title：Life sciences

authors： deBlois D,Bouthillier J,Marceau F

更新日期：1990-01-01 00:00:00

abstract：:This paper gives a short account of the mechanisms regulating choline production. Although choline is absorbed from the GI tract and biosynthesized in the liver, its subsequent metabolism to choline esters and phospholipids seems to dominate in importance as to its regulatory role in maintaining a constant source of f...

journal_title：Life sciences

authors： Freeman JJ

更新日期：1996-01-01 00:00:00

abstract：:In order to understand the mechanism of increasing body fat in perimenopausal and postmenopausal women, an ovariectomy-induced obesity model was used to study the role of leptin. In this investigation, a long-term study lasted for 13 weeks was conducted to monitoring the change of serum leptin level in rats after the ...

journal_title：Life sciences

authors： Chu SC,Chou YC,Liu JY,Chen CH,Shyu JC,Chou FP

更新日期：1999-01-01 00:00:00

abstract：:Muscarinic agonists elicit contraction in the standard guinea pig ileum bioassay through activation of M3 muscarinic receptors that are also linked to phosphoinositide hydrolysis. Surprisingly, the most abundant muscarinic receptor in the ileum is the M2 which causes a specific inhibition of cyclic AMP accumulation el...

journal_title：Life sciences

authors： Ehlert FJ,Thomas EA

更新日期：1995-01-01 00:00:00

abstract：UNLABELLED:Acute exercise is a stress stimulus that may cause cell damage through the activation of the toll-like receptor (TLR)4 pathway, resulting in the translocation of nuclear factor kappa B (NF-κB) into the cell nucleus and the upregulation of inflammatory genes. Nonsteroidal anti-inflammatory drugs, such as dicl...

journal_title：Life sciences

authors： Barcelos RP,Bresciani G,Rodriguez-Miguelez P,Cuevas MJ,Soares FA,Barbosa NV,González-Gallego J

更新日期：2016-03-01 00:00:00

abstract：:The temperature effects of naloxone and naltrexone (1-30 mg/kg) were examined in well habituated male rats. These drugs had a similar time course and potency, producing a dose-dependent hypothermia followed several hours later by a hyperthermia. A subsequent study found that not only did 30 mg/kg of naloxone or naltre...

journal_title：Life sciences

authors： Eikelboom R

更新日期：1987-03-16 00:00:00

abstract：:The present investigation examined the correlation between the regulation of mucosal prostaglandin (PG) biosynthesis and the release of the neuropeptide substance P (SP) in rat stomachs by indomethacin, a cyclooxygenase inhibitor. When given subcutaneously at the dose of 5 mg/kg, indomethacin reduced mucosal biosynthe...

journal_title：Life sciences

authors： Ko JK,Tang F,Cho CH

更新日期：1997-01-01 00:00:00

abstract：:Two types of plasma membranes isolated from rat brain cortex were used to study the membrane-perturbing properties of ethanol. Rats administered ethanol in the form of a liquid diet showed an increase in levels of phosphatidylserines, phosphatidylinositols and phosphatidic acids as compared to controls. The results pr...

journal_title：Life sciences

authors： Sun GY,Huang HM,Lee DZ,Sun AY

更新日期：1984-11-19 00:00:00

abstract：:P120-catenin (P120) was known to function in adhesion between cells and signal transduction in many types of cells. In this study, we investigated the expression and role of P120 in pulmonary fibrosis and transforming growth factor beta (TGF-β) mediated lung fibroblast-to-myofibroblast differentiation (fibroblast diff...

journal_title：Life sciences

authors： Zhang Y,Jiao H,Wu Y,Sun X

更新日期：2019-08-01 00:00:00

abstract：AIMS:Metformin is an insulin sensitizing agent with beneficial effects in diabetic patients on glycemic levels and in the cardiovascular system. We examined whether the metabolic changes and the vascular dysfunction in monosodium glutamate-induced obese non-diabetic (MSG) rats might be improved by metformin. MAIN METH...

journal_title：Life sciences

authors： Lobato NS,Filgueira FP,Hagihara GN,Akamine EH,Pariz JR,Tostes RC,Carvalho MH,Fortes ZB

更新日期：2012-01-30 00:00:00

abstract：:While attempting to delineate the reason for the reported extreme variability of beta-endorphin-like immunoreactivity (beta-ir) in human plasma (eg., nondetectable to 1 ng/ml) by standard radioimmunoassay, we noted that a substantial portion of circulating beta-ir was associated with erythrocytes. That erythrocyte ass...

journal_title：Life sciences

authors： Fisher A,Comly M,Do R,Tamarkin L,Ghazanfari AF,Mukherjee AB

更新日期：1984-05-07 00:00:00