Increased acidic phospholipids in rat brain membranes after chronic ethanol administration.

Abstract:

:Two types of plasma membranes isolated from rat brain cortex were used to study the membrane-perturbing properties of ethanol. Rats administered ethanol in the form of a liquid diet showed an increase in levels of phosphatidylserines, phosphatidylinositols and phosphatidic acids as compared to controls. The results present evidence that chronic ethanol treatment results in an increase in the acidic phospholipids in brain membranes. This type of membrane modification may have important implications for the function of membrane transport enzymes such as (Na+, K+)-ATPase, which also increases in activity upon chronic ethanol administration.

journal_name

Life Sci

journal_title

Life sciences

authors

Sun GY,Huang HM,Lee DZ,Sun AY

doi

10.1016/0024-3205(84)90512-5

subject

Has Abstract

pub_date

1984-11-19 00:00:00

pages

2127-33

issue

21

eissn

0024-3205

issn

1879-0631

pii

0024-3205(84)90512-5

journal_volume

35

pub_type

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