Nifedipine inhibits the activation of inflammatory and immune reactions in viral myocarditis.

abstract：AIMS:Opioid addiction is associated with long-term adaptive changes in the brain that involve protein expression. The carboxyl-terminal of the μ opioid receptor (MOR-C) is important for receptor signal transduction under opioid treatment. However, the proteins that interact with MOR-C after chronic morphine exposure re...

journal_title：Life sciences

authors： Zhou P,Jiang J,Dong Z,Yan H,You Z,Su R,Gong Z

更新日期：2015-12-15 00:00:00

abstract：:Muscarinic receptors can be pharmacologically classified into 3 types at the present time, however, five genes for the receptor have been identified. The muscarinic receptor types have unique antagonist selectivity, distribution and are linked to specific second messenger systems. The interaction between the muscarini...

journal_title：Life sciences

authors： Mei L,Roeske WR,Yamamura HI

更新日期：1989-01-01 00:00:00

abstract：AIMS:RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS. MAIN METHODS:RNA sequence profiles and CNV data of 255 STS patie...

journal_title：Life sciences

authors： Wang X,Han Y,Li J,Hong D,Xue Z,Huang H,Du Z,Hou Y,Li H,Li H,Liao H,Xie X,Ding C

更新日期：2021-01-15 00:00:00

abstract：:The effects of the cannabinoid receptor agonist Win 55,212-2 and of the competitive cannabinoid receptor antagonist SR 141716A on the electrically-evoked peristalsis of isolated distal colon of mouse were studied. Intraluminal pressure, longitudinal displacement, ejected fluid volume and changes in morphology of exter...

journal_title：Life sciences

authors： Mancinelli R,Fabrizi A,Del Monaco S,Azzena GB,Vargiu R,Colombo GC,Gessa GL

更新日期：2001-05-25 00:00:00

abstract：:Aim Determine changes in the expressions of the ion channel-TRPV1-and neuropeptides-NKA, NKB, calcitonin gene-related peptide (CGRP), and SP-in 14-, 21-, and 42-day-old rats after inhaling 1.5% and 2.6% sevoflurane. MAIN METHODS:A small in-house inhalation anesthesia chamber was designed to allow 14-, 21-, and 42-day...

journal_title：Life sciences

authors： Liu D,Yuan J,Fei X,Zhu Y,Zhou Y,Zhang C,Dong L,Zhu Z

更新日期：2020-05-15 00:00:00

abstract：AIMS:Wistar-Kyoto rats (HA-WKY) kept in the author's laboratory showed higher levels of serum adiponectin (approximately 4-fold) compared with Wistar-Kyoto/Izm rats (WKY/Izm), a WKY standard strain, at 6weeks old. In a preliminary study, HA-WKY but not WKY/Izm showed hyperinsulinemia and severe hypercholesterolemia whe...

journal_title：Life sciences

authors： Inoue T,Takemori K,Yamamoto K,Ito H

更新日期：2010-02-27 00:00:00

abstract：AIMS:Dyslipidemia-associated diabetic retinopathy is featured by macular edema and retinal angiogenesis. This study investigated the in vitro lipotoxicity of free fatty acids and their modulatory roles in regulation of autophagy and angiogenic factor production in cultured human retinal pigment epithelium (RPE) ARPE-19...

journal_title：Life sciences

authors： Chang YC,Lin CW,Chang YS,Chen PH,Li CY,Wu WC,Kao YH

更新日期：2020-10-15 00:00:00

abstract：:Chlorella, a type of unicellular fresh water algae, has been a popular foodstuff in Japan and Taiwan. Studies have shown the hypoglycemic effects of Chlorella in alloxan-induced and Streptozocin (STZ)-induced diabetic animals. However, the mechanisms by which Chlorella treatment affects blood glucose homeostasis have ...

journal_title：Life sciences

authors： Cherng JY,Shih MF

更新日期：2006-02-09 00:00:00

abstract：BACKGROUND:The prevalence and mortality of the outbreak of the COVID-19 pandemic show marked geographic variation. The presence of several subtypes of the coronavirus and the genetic differences in the populations could condition that variation. Thus, the objective of this study was to propose variants in genes that en...

journal_title：Life sciences

authors： Vargas-Alarcón G,Posadas-Sánchez R,Ramírez-Bello J

更新日期：2020-11-01 00:00:00

abstract：:This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was reveal...

journal_title：Life sciences

authors： Lim YS,So HS,Kim MS,Moon G,Won JH,Baek SW,Moon SR,Yang SH,Kim BJ,Ko CB,Park R

更新日期：2002-10-04 00:00:00

abstract：:In Madin-Darby canine kidney (MDCK) cells, the effect of 2-O-methyl PAF, an inactive analogue of platelet activating factor (PAF), on intracellular Ca2+ concentration ([Ca2+]i) was measured by using the Ca2+-sensitive fluorescent dye fura-2. 2-O-methyl PAF (> or = 15 microM) caused a rapid rise of [Ca2+]i in a concent...

journal_title：Life sciences

authors： Yeh JH,Huang CJ,Lee JH,Hsu SS,Chen JS,Cheng HH,Chang HT,Huang JK,Chung HM,Mei-Yin Y,Jan CR

更新日期：2005-06-03 00:00:00

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：AIMS:Osteoclasts, the unique bone-resorbing polykaryons, are responsible for many bone-destructive diseases, such as osteoporosis and rheumatoid arthritis. Hence, the regulation of osteoclast formation is considered a potential therapeutic approach for these diseases. In this study, we investigated the effect of a nove...

journal_title：Life sciences

authors： Kim HJ,Yoon KA,Lee MK,Kim SH,Lee IK,Kim SY

更新日期：2012-11-02 00:00:00

abstract：:Dialyzed aqueous extracts of plant pollen are widely used in the clinical practice of allergy for diagnostic and therapeutic purposes. The present investigation shows that such allergenic extracts are capable of consuming complement in every human serum, independent of the clinical condition. Complement is engaged by ...

journal_title：Life sciences

authors： Berrens L,de la Cuadra B,Gallego MT

更新日期：1997-01-01 00:00:00

abstract：:The circadian rhythm of 6-sulphatoxymelatonin (aMT6s) excretion has been determined in male and female rats at 3 weeks and at 2, 8, 14 and 20 months of age. All animals have a pronounced circadian pattern of aMT6s excretion under a 12 hour dark: 12 hour light cycle. A significant increase in aMT6s excretion is observe...

journal_title：Life sciences

authors： Yie SM,Liu GY,Johansson E,Brown C,Brown GM

更新日期：1992-01-01 00:00:00

abstract：:The beta-endorphin, met5-enkephalin-arg6-phe7 (MEAP) and met5-enkephalin (ME) changes related to age and diurnal rhythms were studied in various regions of rat brain and in the pituitary by specific radioimmunoassays. The contents of MEAP, met5-enkephalin and beta-endorphin were higher in the pituitary of old rats (18...

journal_title：Life sciences

authors： Tang F,Tang J,Chou J,Costa E

更新日期：1984-08-27 00:00:00

abstract：:The aim of the present study was to observe the effect of repeated subcutaneous (sc) injections of low doses of ketamine for the treatment of acute inflammatory pain in a complete Freund's adjuvant-induced monoarthritic pain model in rats. The results show: (1) sc injection of ketamine at a dose of 2 mg x kg(-1) or 10...

journal_title：Life sciences

authors： Wang Y,Huang C,Cao Y,Han JS

更新日期：2000-06-08 00:00:00

abstract：:Rats were submitted to 110 dB white noise exposure for 1, and 6 hours and brain alpha 1, beta 1 and benzodiazepine receptor binding was evaluated with selective ligands. An increase in cerebral benzodiazepine receptor (CBR) concentration, without any significant change in affinity constant, occurred after the 6 h trea...

journal_title：Life sciences

authors： Breschi MC,Martini C,Scatizzi R,Cristofani R,Giannaccini G,Martinotti E,Lucacchini A

更新日期：1995-01-01 00:00:00

abstract：AIMS:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered to be one of the most promising candidates in research on treatments for cancer, including renal cell carcinoma (RCC). However, many cells are resistant to TRAIL-induced apoptosis which limits the potential application of TRAIL in ...

journal_title：Life sciences

authors： Ou YC,Li JR,Kuan YH,Raung SL,Wang CC,Hung YY,Pan PH,Lu HC,Chen CJ

更新日期：2014-04-01 00:00:00

abstract：:Both in men and rats, most of the ethanol ingested at a low dose is metabolized before it reaches the systemic circulation. Oxidation of ethanol (mainly in the stomach) accounts for the bulk of this effect. This "first pass" metabolism (FPM) may be viewed as a barrier which protects against the systemic toxicity of et...

journal_title：Life sciences

authors： Julkunen RJ,Di Padova C,Lieber CS

更新日期：1985-08-12 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic interactions between simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, and diltiazem, a calcium antagonist, were investigated in 7 male and 4 female patients with hypercholesterolemia and hypertension. The patients were given, for one in a three con...

journal_title：Life sciences

authors： Watanabe H,Kosuge K,Nishio S,Yamada H,Uchida S,Satoh H,Hayashi H,Ishizaki T,Ohashi K

更新日期：2004-12-03 00:00:00

abstract：:This study examined whether there is increased production of oxygen free radicals during chronic renal failure. Rats subjected to 3/4 nephrectomy and sham operated controls were killed after 3 weeks. Lipid extracts of plasma and renal tissue were examined by HPLC and kidney specimens were also analyzed by EPR spectros...

journal_title：Life sciences

authors： Trachtman H,Wilson D,Rao PS

更新日期：1992-01-01 00:00:00

abstract：AIMS:Lithium is a common mood stabilizer to treat bipolar disorder. It has a narrow window of therapeutic action and its mechanism of action and possible side effects are still not fully understood. Lithium is a potent inhibitor of glycogen synthase kinase 3β (GSK-3β). Previous studies indicated that lithium can induce...

journal_title：Life sciences

authors： Tsui MM,Tai WC,Wong WY,Hsiao WL

更新日期：2012-09-24 00:00:00

abstract：:Recent studies in animals have demonstrated that the steroid, 3 alpha-hydroxy-5 alpha-pregnan-20-one (3A5P), is a potent analgesic when given intracerebroventricularly. Several studies in humans report that spinal steroids are effective in the treatment of chronic low-back pain when given in combination with morphine....

journal_title：Life sciences

authors： Winfree CJ,Coombs DW,DeLeo JA,Colburn RW

更新日期：1992-01-01 00:00:00

abstract：:Adenylate cyclase activity in isolated rat liver plasma membranes was inhibited by NADH in a concentration-dependent manner. Half-maximal inhibition of adenylate cyclase was observed at 120 microM concentration of NADH. The effect of NADH was specific since adenylate cyclase activity was not altered by NAD+, NADP+, NA...

journal_title：Life sciences

authors： Nair BG,Patel TB

更新日期：1991-01-01 00:00:00

abstract：:Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a cell adhesion and signaling receptor that is expressed on hematopoietic and endothelial cells. PECAM-1 is vital to the regulation of inflammatory responses, as it has been shown to serve a variety of pro-inflammatory and anti-inflammatory functions. Pr...

journal_title：Life sciences

authors： Privratsky JR,Newman DK,Newman PJ

更新日期：2010-07-17 00:00:00

abstract：:The intracellular ionic content of human erythrocytes may be altered by hyperglycaemia. Despite this, very little is known about the cellular mechanisms linking glucose and cellular magnesium homeostasis. We measured intracellular ionized magnesium in human lymphocytes, by means of a fluorimetric technique, total intr...

journal_title：Life sciences

authors： Delva P,Degan M,Pastori C,Faccini G,Lechi A

更新日期：2002-09-20 00:00:00

abstract：:Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...

journal_title：Life sciences

authors： Kubota K,Matsuoka Y,Sakuma M,Satoh S,Uruno T,Sunagane N

更新日期：1982-09-20 00:00:00

abstract：:The N-terminus portion of the POMC leader sequence (signal peptide) was synthesized, and an antiserum was raised against it. A radioimmunoassay was developed which is effective at a dilution of 1:500,000, and sensitive at less than 1 fmole/tube. Since leader sequences often exhibit structural homologies, and since syn...

journal_title：Life sciences

authors： Akil H,Shiomi H,Thompson R,Lax S,Coy D,Watson S

更新日期：1982-11-15 00:00:00

abstract：:The effects of longer lasting blood pressure changes on the release of endogenous catecholamines (CA) in limbic and hypothalamic areas were studied in anaesthetized rats. For this purpose the central nucleus of the amygdala (AC), ventral hippocampus (VH) and medial hypothalamus (MH) were simultaneously superfused thro...

journal_title：Life sciences

authors： Dietl H

更新日期：1987-07-13 00:00:00