Abstract：
:This study was designed to evaluate the synergistic cytotoxicity of herb prescription, Palgin, in adriamycin-treated cancer cells. The combination of Palgin and adriamycin synergistically augmented the cytotoxicity of Chang and HL-60 cells, but not in Hep3B and Alexander cells. The cytotoxicity of two drugs was revealed as apoptosis characterized by nuclear fragmentation. The apoptotic cell death was accompanied by the activation of caspase-3 as well as cleavage of poly(ADP) ribose polymerase (PARP) in Chang cells. Interestingly, a synergistic increase in apoptosis by the combination of two drugs was accompanied by the enhancement of Fas and Fas ligand (FasL) expression in Chang cells. Taken together, the combination of Palgin and adriamycin significantly augmented the apoptotic cytotoxicity of Fas-positive cells, such as Chang and HL-60 cells, via activation of caspase signaling pathway. This notion will provide a new trial to treat cancer patients in clinical fields as a complementary treatment of Western and Oriental medicine.
journal_name
Life Scijournal_title
Life sciencesauthors
Lim YS,So HS,Kim MS,Moon G,Won JH,Baek SW,Moon SR,Yang SH,Kim BJ,Ko CB,Park Rdoi
10.1016/s0024-3205(02)02039-8subject
Has Abstractpub_date
2002-10-04 00:00:00pages
2391-401issue
20eissn
0024-3205issn
1879-0631pii
S0024320502020398journal_volume
71pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(99)00292-1
更新日期：1999-01-01 00:00:00
abstract：:The localization of vasoactive intestinal polypeptide (VIP) in the male genitourinary tract was investigated in the rabbit and man by means of radioimmunoassay and immunohistochemistry. In addition, the in vitro effect of VIP upon penile smooth muscle from man, the Vervet monkey, and the rabbit was investigated. Signi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(83)80013-7
更新日期：1983-07-25 00:00:00
abstract：AIMS:Fcγ receptor I (FcγRI/CD64) that is restrictedly expressed on monocytes and macrophages, acts as the single high-affinity receptor of immunoglobulin G (IgG) in human. The expression of FcγRI is positively correlated with immune inflammation. The primary aim of this study was to explore the effects of FcγRI express...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.06.015
更新日期：2018-08-15 00:00:00
abstract：:Atherosclerosis (AS) is a chronic inflammatory disease that results from Oxidized low-density lipoprotein (Ox-LDL) induced endothelial dysfunction. Cytoplasmic polyadenylation element binding protein 1 (CPEB1) is closely related to the development of epithelial cells, but the role of CPEB1 in AS remains unknown. The R...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116874
更新日期：2019-12-15 00:00:00
abstract：AIMS:Solid lipid nanoparticles (SLNs) conjugated with surface 83-14 monoclonal antibody (8314MAb) and anti-epithelial growth factor receptor (AEGFR) were synthesized and applied to permeate the blood-brain barrier (BBB) and inhibit the growth of glioblastoma multiforme (GBM). MAIN METHODS:8314MAb and AEGFR were crossl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.01.025
更新日期：2016-02-01 00:00:00
abstract：AIMS:Nanoparticles (NPs)-based drugs have been recently introduced to improve the efficacy of current therapeutic strategies for the treatment of cancer; however, the molecular mechanisms by which a NP interacts with cellular systems still need to be delineated. Here, we utilize the autophagic potential of TiO2 NPs for...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117466
更新日期：2020-05-01 00:00:00
abstract：AIMS:Aging and drug-induced side effects may contribute to deteriorate mitochondrial bioenergetics in many tissues, including kidney and liver. One possibility is that the combination of both aging and drug toxicity accelerates the process of mitochondrial degradation, leading to progressive bioenergetic disruption. We...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.07.004
更新日期：2013-09-03 00:00:00
abstract：:The effects of opioids on human subjective olfactory function have rarely been investigated. This is despite the fact that opioid receptors are widely distributed throughout the olfactory systems. Using an established validated test of subjective olfactory function, olfactory threshold, odor discrimination and odor id...
journal_title：Life sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0024-3205(01)01305-4
更新日期：2001-09-28 00:00:00
abstract：AIMS:Oxidative stress emerges after reperfusion of an organ following an ischemic period and results in tissue damage. In the heart, an amplified generation of reactive oxygen species and a significant Ca(2+) accumulation cause ventricular arrhythmias and mitochondrial dysfunction. This occurs in consequence of increas...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2013.12.026
更新日期：2014-02-06 00:00:00
abstract：:To investigate the difference of metabolic pharmacokinetics between pure glycyrrhizin (GZ) and GZ in licorice decoction, six New Zealand White rabbits were orally given pure GZ and licorice decoction containing equivalent content of GZ in a randomized crossover design. HPLC methods were used for the quantitation of GZ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.020
更新日期：2005-01-21 00:00:00
abstract：:We investigated the effects of the chronic administration of hesperetin on the activation of the antioxidant defence system in mice in which oxidative stress had been induced by 7,12-dimethylbenz(a)anthracene (DMBA). Mice were divided randomly into three treatment groups. Hesperetin was administered orally to two of t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.03.002
更新日期：2008-05-23 00:00:00
abstract：:Lipopolysaccharide (LPS) has been known to induce endotoxin shock via production of inflammatory modulators such as tumor necrosis factor alpha (TNF-alpha), or nitric oxide (NO). In this study, we have examined the effect of naringin (NG), one of the flavonoids, on LPS-induced endotoxin shock in mice and NO production...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.04.051
更新日期：2006-01-11 00:00:00
abstract：:Increased levels of particulate matter (PM) air pollutants in East Asia have resulted in detrimental health impacts increasing morbidity and mortality. Epidemiological studies suggest a possible relation between the cutaneous exposure of PM and increased oxidative stress and inflammation which lead to skin lesions. Th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116714
更新日期：2019-09-15 00:00:00
abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90092-1
更新日期：1989-01-01 00:00:00
abstract：AIMS:Lipid soluble vitamin E plays a role in several physiological mechanisms, however, the mechanism of this action is controversial. We investigated how tocopherol (α-tocopherol acid succinate) influences the effects of cyclooxygenase inhibitors (COXi) in the smooth muscles. MAIN METHODS:The contractility of the sam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.11.048
更新日期：2018-01-01 00:00:00
abstract：:The molecular dynamics (MD) simulations study in the formation of the complex between compound SWR-0342SA and beta-ARs suggested that upon binding SWR-0342SA stimulates receptor activation through residues network (Asp104, Leu335 in beta(1)-AR; Asp117, Ser209, Leu303, Ser191 in beta(3)-AR) in an active conformation st...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.09.023
更新日期：2006-03-20 00:00:00
abstract：:The role of endothelium-derived nitric oxide (NO) to cause smooth muscle phospholamban (PLB) phosphorylation was studied in the isolated perfused rat aorta precontracted with norepinephrine using a back-phosphorylation technique. NO-induced relaxation was associated with increased PLB-phosphorylation while norepinephr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90357-u
更新日期：1992-01-01 00:00:00
abstract：:We investigated whether nitric oxide (NO) exposure alters the balance between NO and endothelium-derived hyperpolarizing factor (EDHF) released from rat renal arteries. To produce states of acutely or chronically excessive NO, lipopolysaccharide (LPS) was administered intraperitoneally to rats in a single dose of 4 mg...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.10.019
更新日期：2004-04-16 00:00:00
abstract：AIMS:This study was aimed to investigate the effect of Lycium barbarum polysaccharides (LBP) on renal function and inflammatory reaction in rabbits with diabetic nephropathy. MAIN METHODS:Diabetes was induced by injecting alloxan (ALX). Japanese male white rabbits were randomly assigned into 5 groups: normal control g...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.05.045
更新日期：2016-07-15 00:00:00
abstract：:Cold acclimation increases the thermogenic capacity of brown adipose tissue (BAT) and this is associated with both a general hypertrophy of the tissue and a selective increase in the proportion of a specific 32,000 molecular weight, GDP-binding protein in the mitochondrial membrane. This protein regulates the activity...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90081-x
更新日期：1984-03-19 00:00:00
abstract：AIM:Preparation of pegylated gold nanorods (PEG-AuNRs) that are capable of converting near infrared (NIR) light into heat. Evaluation of cancer therapeutic efficacy and long-term toxicity of the proposed photothermal therapy in comparison with other conventional modalities. MATERIALS AND METHODS:Prepared PEG-AuNRs wer...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118108
更新日期：2020-09-15 00:00:00
abstract：AIMS:Oxidative stress and inflammatory response are major factors causing several tissue injuries in intestinal ischemia and reperfusion (I/R). Agmatine has been reported to attenuate I/R injury of various organs. The present study aims to analyze the possible protective effects of agmatine on intestinal I/R injury in ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.08.032
更新日期：2017-11-15 00:00:00
abstract：:The effects of a newly synthesized compound, 7-(3-[4-(2,3-dimethylphenyl)piperazinyl]propoxy)-2(1H)-quinolinone (OPC-4392), on tyrosine hydroxylation in situ and in vitro were studied using rat striatal slices and tyrosine hydroxylase (TH) purified from bovine adrenal medulla, respectively. OPC-4392 dose-dependently i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90644-3
更新日期：1988-01-01 00:00:00
abstract：:Meso-dimercaptosuccinic acid (DMSA) and the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS) are analogous in chemical structure to dimercaprol (BAL, British Anti-Lewisite). Dimercaprol was among the first therapeutically useful metal chelating agents and was developed originally as an anti-lewisite agent. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90108-4
更新日期：1982-11-08 00:00:00
abstract：AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.01.016
更新日期：2009-04-10 00:00:00
abstract：OBJECTIVE:Stem cell transplantation is a promising tool to treat burn injuries. However, the inflammatory microenvironment in damaged skin limits the efficiency of stem cell-based therapy via poorly understood mechanisms. The aim of our study is to explore the contribution and mechanism of Sirtuin-1 (Sirt1) in TNFα-med...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.10.003
更新日期：2018-11-01 00:00:00
abstract：:The leukotriene (LT) synthesis inhibitors BAY x1005 and MK-886 were evaluated in human lung parenchyma challenged with an anti-IgE. The anti-IgE-induced LTE4 release was time- and dose-dependent. Treatment of the parenchyma with indomethacin (3 microM) prior to anti-IgE challenge inhibited the 6-keto prostaglandin F1 ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00426-2
更新日期：1996-01-01 00:00:00
abstract：:In murine splenocytes, a primary antigen-specific antibody response is stimulated by 2-O-alpha-D-glucopyranosyl-L-ascorbic acid (AA-2G), a stable form of ascorbate, as described in our previous paper. We examined here the effect of nerve growth factor (NGF) on the antigen-specific antibody production in vitro augmente...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00561-9
更新日期：1996-01-01 00:00:00
abstract：AIMS:Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown. MAIN METHODS:Expression of NRSF in n...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.10.070
更新日期：2018-12-15 00:00:00
abstract：AIMS:Benzodiazepines (BZDs) produce various pharmacological actions by binding to and allosterically regulating GABAA receptors. Several in vitro studies have demonstrated diazepam, the prototypic BZD, produces a high-dose action that cannot be countered with the classical BZD-binding site antagonist flumazenil. Here, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117033
更新日期：2019-12-15 00:00:00
