当前位置： SCI文献检索 > LIFE SCIENCES期刊下所有文献 > Leukotriene synthesis inhibition and anti-ige challenge of human lung parenchyma.

Leukotriene synthesis inhibition and anti-ige challenge of human lung parenchyma.

Abstract：

:The leukotriene (LT) synthesis inhibitors BAY x1005 and MK-886 were evaluated in human lung parenchyma challenged with an anti-IgE. The anti-IgE-induced LTE4 release was time- and dose-dependent. Treatment of the parenchyma with indomethacin (3 microM) prior to anti-IgE challenge inhibited the 6-keto prostaglandin F1 alpha (6-keto PGF1 alpha) release and enhanced (36%) the quantities of LTE4 detected during IgE-stimulations. BAY x1005 and MK-886 were assessed in the presence of indomethacin (3 microM) and the IC50 values for both inhibitors were similar (0.13 microM). BAY x1005 (1 microM) produced the same percent of inhibition of anti-IgE-induced LTE4 release in the presence or absence of indomethacin. BAY x1005 (1 microM) did not alter the 6-keto PGF1 alpha release during anti-IgE challenge. The results indicate that BAY x1005 and MK-886 are potent inhibitors of LT synthesis when human lung parenchyma were stimulated by an anti-IgE.

journal_name

Life Sci

journal_title

Life sciences

authors

Gorenne I,Alaoui HS,Gascard JP,Labat C,Norel X,De Montpreville V,Brink C

doi

10.1016/0024-3205(96)00426-2

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

PL213-9

issue

13

eissn

0024-3205

issn

1879-0631

pii

0024320596004262

journal_volume

59

pub_type

杂志文章

相关文献

LIFE SCIENCES文献大全
  • Excitatory amino acids and monoamines in parahippocampal gyrus and frontal cortical pole of adults with Down syndrome.

    abstract：:Aspartate (ASP), glutamate (GLU), noradrenaline (NA), dopamine (DA) and its acidic metabolites DOPAC and HVA, serotonin (5-HT) and its metabolite 5-HIAA were simultaneously investigated in post-mortem tissue samples from right parahippocampal gyrus (temporal cortex) and frontal cortical pole (frontal cortex) of adults...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(97)00067-2

    authors： Risser D,Lubec G,Cairns N,Herrera-Marschitz M

    更新日期：1997-01-01 00:00:00

  • Chronopharmacological study of furosemide; (V). Influence of pretreatment with 6-hydroxydopamine.

    abstract：:Our previous indirect evidences suggested that the adrenergic nervous system is involved in the mechanisms responsible for the time-dependent changes in the effects of furosemide in Wistar rats. In the present study, the role of this system was examined more directly by means of 6-hydroxydopamine-induced sympathectomy...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(90)90111-4

    authors： Fujimura A,Ebihara A

    更新日期：1990-01-01 00:00:00

  • Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways.

    abstract：:The pathogenesis of abdominal aortic aneurysm remains unclear. The aim of the present study was to establish whether isoleucyl-tRNA synthetase (Iars) regulates the differentiation and apoptosis of vascular smooth muscle cells (VSMCs) during the development of abdominal aortic aneurysm (AAA). In addition, the contribut...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.03.052

    authors： Li B,Wang Z,Chen R,Hong J,Wu Q,Hu J,Hu Z,Zhang M

    更新日期：2019-05-01 00:00:00

  • Metformin therapy confers cardioprotection against the remodeling of gap junction in tachycardia-induced atrial fibrillation dog model.

    abstract：OBJECTIVE:Metformin, introduced in 1957, is widely used as an anti-diabetic drug and has considerable benefits in cardiovascular disease reportedly, dependent or independent on its glucose-lowering effects. Aim of this study was to investigate the effect of metformin on gap junction and the inducibility of AF. METHODS...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.117759

    authors： Li J,Li B,Bai F,Ma Y,Liu N,Liu Y,Wang Y,Liu Q

    更新日期：2020-08-01 00:00:00

  • Expression of the cytochrome P450 epoxygenase CYP2J2 in human monocytic leukocytes.

    abstract：:CYP2J2 is one of the cytochrome P450 epoxygenases involved in the metabolism of arachidonic acid. CYP2J2 has been identified in several tissues, especially cardiovascular tissues. CYP2J2 has cardiovascular effects, as epoxyeicosatrienoic acid, one of its metabolites, has anti-inflammatory and vasodilative activities. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2008.06.026

    authors： Nakayama K,Nitto T,Inoue T,Node K

    更新日期：2008-08-29 00:00:00

  • Design and screening of a novel neuropilin-1 targeted penetrating peptide for anti-angiogenic therapy in glioma.

    abstract：AIMS:This study aimed to design and screen a dual functional fusion peptide that could penetrate the blood-brain barrier and target neuropilin 1 (NRP1) overexpressed in vascular endothelial cells for the anti-angiogenesis of glioma treatment. MAIN METHODS:At the cellular level, the in vitro anti-angiogenic activity of...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2021.119113

    authors： Zhao L,Chen H,Lu L,Zhao C,Malichewe CV,Wang L,Guo X,Zhang X

    更新日期：2021-01-27 00:00:00

  • Physiological stress response to video-game playing: the contribution of built-in music.

    abstract：:Recent studies on video game playing have uncovered a wide range of measurable physiological effects on the organism, such as increases in cardiovascular activity and breathing responses. However, the exact source of these effects remains unclear. Given the well-known effects of sound on physiological activity, especi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.11.011

    authors： Hébert S,Béland R,Dionne-Fournelle O,Crête M,Lupien SJ

    更新日期：2005-04-01 00:00:00

  • Berberine produces antidepressant-like effects in the forced swim test and in the tail suspension test in mice.

    abstract：:This study investigated the effect of berberine (BER) in the mouse forced swim test (FST) and in the tail suspension test (TST), two models predictive of antidepressant activity. We also investigated the antidepressant-like mechanism of BER by the combination of the desipramine [DES, an inhibitor of reuptake of noradr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.08.003

    authors： Peng WH,Lo KL,Lee YH,Hung TH,Lin YC

    更新日期：2007-08-23 00:00:00

  • Phosphoesterase complex modulates microflora and chronic inflammation in rats with alcoholic fatty liver disease.

    abstract：:Phosphoesterase complex (Pho), a major active component of barley malt, has been demonstrated to be clinically effective in relieving alcoholic fatty liver disease (AFLD), and several lines of evidence have suggested that microbial dysbiosis, caused by chronic alcohol overconsumption, plays a key role in the progressi...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2020.118509

    authors： Ma D,Hu J,Xu W,Wang Y,Wang J,Li L,Wang S,Zhou H,Li Y,Liu L

    更新日期：2020-12-01 00:00:00

  • Ethanol and caffeine consumption modulates the expression of miRNAs in the cerebellum and plasma of UChB rats.

    abstract：AIMS:The present study aimed to verify changes in cerebellar and plasmatic expression of miRNAs after the chronic consumption of ethanol and caffeine in the UChB rat, an experimental model for alcoholism. MATERIAL AND METHODS:Male rats at 5 months of age, were divided into the following groups (n = 10/group): 1. Ethan...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.05.016

    authors： Rossetto IMU,Cagnon VHA,Lizarte FSN,Tirapelli LF,Tirapelli DPC,Arantes RMS,Chuffa LGA,Martinez FE,Martinez M

    更新日期：2019-07-15 00:00:00

  • Involvement of MAPK signaling pathway in the osteogenic gene expressions of Cervi Pantotrichum Cornu in MG-63 human osteoblast-like cells.

    abstract：AIMS:The purposes of this study were to determine whether Cervi Pantotrichum Cornu (CPC) has osteogenic activities in human osteoblastic MG-63 cells and to investigate the underlying molecular mechanism. MAIN METHODS:The effects of CPC on alkaline phosphatase activity, collagen synthesis, and calcium deposits were mea...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2013.11.002

    authors： Kim JH,Jung TY,Seo J,Lee S,Kim MG,Leem KH,Lim SC

    更新日期：2014-01-14 00:00:00

  • Study of bone repair mediated by recombination BMP-2/ recombination CXC chemokine Ligand-13-loaded hollow hydroxyapatite microspheres/chitosan composite.

    abstract：AIMS:The present study aimed to investigate the mechanism of bone repair mediated by recombination BMP-2 (rhBMP-2)/recombination CXC chemokine ligand-13 (rhCXCL13)-loaded hollow hydroxyapatite (HA) microspheres/chitosan (CS) composite. MATERIALS AND METHODS:Firstly, the biological activity of rhBMP-2 and rhCXCL13 rele...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2019.116743

    authors： Zeng J,Xiong S,Ding L,Zhou J,Li J,Qiu P,Liao X,Xiong L,Long Z,Liu S

    更新日期：2019-10-01 00:00:00

  • Plasma levels and biochemical characterisation of circulating met-enkephalin in canine endotoxin shock.

    abstract：:Endogenous opioid peptides have been implicated in the pathophysiology of shock (1-5). In anaesthetised mongrel dogs, administration of E coli endotoxin caused a rise in plasma met-enkephalin-like immunoreactivity (MLI). Biochemical characterisation of MLI by gel filtration chromatography revealed various molecular fo...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(84)90063-8

    authors： Evans SF,Medbak S,Hinds CJ,Tomlin SJ,Varley JG,Rees LH

    更新日期：1984-04-09 00:00:00

  • Essential oils components as a new path to understand ion channel molecular pharmacology.

    abstract：:The discovery and development of new drugs targeting voltage-gated ion channels are important for treating a variety of medical conditions and diseases. Ion channels are molecular nanostructures expressed ubiquitously throughout the whole body, and are involved in many basic physiological processes. Over the years, na...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2011.04.020

    authors： de Araújo DA,Freitas C,Cruz JS

    更新日期：2011-10-10 00:00:00

  • Splenocyte blastogenesis suppressed in rats implanted with an osmotic pump.

    abstract：:Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(92)90291-v

    authors： Pross S,Newton C,Widen R,Klein TW,Friedman H,Spitzer JA

    更新日期：1992-01-01 00:00:00

  • Sodium spirulan as a potent inhibitor of arterial smooth muscle cell proliferation in vitro.

    abstract：:Sodium spirulan (Na-SP) is a sulfated polysaccharide with M(r) approximately 220,000 isolated from the blue-green alga Spirulina platensis. The polysaccharide consists of two types of disaccharide repeating units, O-hexuronosyl-rhamnose (aldobiuronic acid) and O-rhamnosyl-3-O-methylrhamnose (acofriose) with sulfate gr...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.09.061

    authors： Kaji T,Okabe M,Shimada S,Yamamoto C,Fujiwara Y,Lee JB,Hayashi T

    更新日期：2004-03-26 00:00:00

  • The effect of taurine on cholesterol degradation in mice fed a high-cholesterol diet.

    abstract：:The hypocholesterolemic effect of taurine was examined in mice fed a high-cholesterol diet containing 1% cholesterol and 0.25% sodium cholate. Male C57BL/6 mice were divided into 3 groups: control group (HC), 1% taurine-supplemented group (HCT+), and taurine-deficient group (HCT-) produced by supplying 0.5% guanidinoe...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2003.08.041

    authors： Chen W,Matuda K,Nishimura N,Yokogoshi H

    更新日期：2004-02-27 00:00:00

  • Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.

    abstract：:The heterogeneity of muscarine receptors was examined in two brain regions (cerebral cortex and cerebellum) and in some parasympathetically innervated peripheral tissues (heart, salivary gland and intraorbital lacrimal gland), by in vitro binding techniques. As a tool, we used a new antimuscarinic compound, AF-DX 116 ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90409-1

    authors： Hammer R,Giraldo E,Schiavi GB,Monferini E,Ladinsky H

    更新日期：1986-05-05 00:00:00

  • Enhanced secretion of tissue plasminogen activator by simultaneous use of retinoic acid and ascorbic acid from tissue cultured gastroepiploic artery.

    abstract：:Tissue-type plasminogen activator (tPA) is a key enzyme in the fibrinolysis system and the regulation of its expression has been extensively studied in cultured vascular endothelial cells. Many kinds of supplements including growth factors are needed, however, to keep endothelial cells viable, which leads the culture ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(01)01513-2

    authors： Yoshino A,Suzuki K,Urano T,Aoki K,Takada Y,Kazui T,Takada A

    更新日期：2002-02-08 00:00:00

  • Pharmacological characterisation of voltage-dependent Ca2+ channels in isolated ganglia from the myenteric plexus.

    abstract：:Voltage-dependent Ca2+ channels of fura-2-loaded ganglionic cells from the myenteric plexus of newborn rats were pharmacologically characterised. In contrast to completely dissociated myenteric cells, intact ganglia showed a stronger loading with the Ca2+-sensitive dye and a reproducible stimulation of the fura-2 sign...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2004.12.053

    authors： Schäufele N,Diener M

    更新日期：2005-09-30 00:00:00

  • Thiol group may be involved in the irreversible blockade of presynaptic alpha 2-adrenoreceptors by pyrextramine and benextramine in the isolated guinea pig ileum.

    abstract：:This study, conducted on isolated guinea pig ileum, was designed to establish the mechanism of presynaptic alpha 2-adrenoreceptor blockade by the tetramine disulfides, benextramine and pyrextramine. At 1 microM these drugs irreversibly blocked norepinephrine (NE)-induced inhibition of the twitch response to electrical...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(86)90407-8

    authors： Brasili L,Cassinelli A,Angeli P,Melchiorre C

    更新日期：1986-05-05 00:00:00

  • Captopril attenuates reflex adrenergic response in essential hypertension.

    abstract：:An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension. Captopril produced a fall in mean arterial pre...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90415-8

    authors： Mohara O,Masuyama Y

    更新日期：1991-01-01 00:00:00

  • Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats.

    abstract：:alpha-lactorphin (Tyr-Gly-Leu-Phe) lowers blood pressure in conscious adult SHR. This tetrapeptide is originally released from milk protein alpha-lactalbumin by enzymatic hydrolysis. In order to evaluate the antihypertensive mechanisms of alpha-lactorphin, the effects of the tetrapeptide on vascular function were inve...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(02)01793-9

    authors： Sipola M,Finckenberg P,Vapaatalo H,Pihlanto-Leppälä A,Korhonen H,Korpela R,Nurminen ML

    更新日期：2002-08-02 00:00:00

  • Low pH medium induces calcium dependent release of CGRP from sensory nerves of guinea-pig dural venous sinuses.

    abstract：:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH m...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(91)90263-b

    authors： Fanciullacci M,Tramontana M,Del Bianco E,Alessandri M,Geppetti P

    更新日期：1991-01-01 00:00:00

  • Type II diabetes promotes a myofibroblast phenotype in cardiac fibroblasts.

    abstract：AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2013.01.003

    authors： Fowlkes V,Clark J,Fix C,Law BA,Morales MO,Qiao X,Ako-Asare K,Goldsmith JG,Carver W,Murray DB,Goldsmith EC

    更新日期：2013-03-28 00:00:00

  • Expression of steroidogenic acute regulatory protein (StAR) and LH receptor in MA-10 cells.

    abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/s0024-3205(03)00698-2

    authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

    更新日期：2003-10-17 00:00:00

  • Endomorphin 1[psi] and endomorphin 2[psi], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception.

    abstract：:Endomorphin 1 (EM1) and endomorphin 2 (EM2) are highly potent and selective mu-opioid receptor agonists and have significant antinociceptive action. In the mu-selective pocket of endomorphins (EMs), Pro2 residue is a spacer and directs the Tyr1 and Trp3/Phe3 side chains into the required orientation. The present work ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2005.03.005

    authors： Zhao QY,Chen Q,Yang DJ,Feng Y,Long Y,Wang P,Wang R

    更新日期：2005-07-22 00:00:00

  • New insights on possible vaccine development against SARS-CoV-2.

    abstract：:In December 2019, a novel virus, namely COVID-19 caused by SARS-CoV-2, developed from Wuhan, (Hubei territory of China) used its viral spike glycoprotein receptor-binding domain (RBD) for the entrance into a host cell by binding with ACE-2 receptor and cause acute respiratory distress syndrome (ARDS). Data revealed th...

    journal_title：Life sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.lfs.2020.118421

    authors： Chaudhry SN,Hazafa A,Mumtaz M,Kalsoom U,Abbas S,Kainaat A,Bilal S,Zafar N,Siddique A,Zafar A

    更新日期：2020-11-01 00:00:00

  • Characterization of the hepatic alpha 1B-adrenoceptors of rats, mice and hamsters.

    abstract：:The alpha 1-adrenoceptors present in liver membranes from rats, hamsters and mice were characterized using [3H]prazosin. In the liver membranes from the three species a relatively large number of receptors was observed (500-900 fmol/mg of protein) and the affinities for [3H]prazosin were very similar (0.2-0.3 nM). Mem...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/0024-3205(94)90134-1

    authors： García-Sáinz JA,Casas-González P,Romero-Avila MT,González-Espinosa C

    更新日期：1994-01-01 00:00:00

  • Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium.

    abstract：:Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that emodin protects against myocardial ischemia/reperfusion injury. However, its mechanism underlying its effects remains unknown. ...

    journal_title：Life sciences

    pub_type： 杂志文章

    doi：10.1016/j.lfs.2007.08.040

    authors： Wu Y,Tu X,Lin G,Xia H,Huang H,Wan J,Cheng Z,Liu M,Chen G,Zhang H,Fu J,Liu Q,Liu DX

    更新日期：2007-10-13 00:00:00