Study of bone repair mediated by recombination BMP-2/ recombination CXC chemokine Ligand-13-loaded hollow hydroxyapatite microspheres/chitosan composite.

abstract：:Glycated human serum albumin (glc HSA) and glc proteins in back hairs from diabetic rats were deglycated by incubation with hydrazine or aminoguanidine (guanylhydrazine) at physiological temperature (37 degrees C). Glc HSA decreased by 35% with 0.2 M hydrazine at day 20 and by 56% with 0.1 M aminoguanidine at day 10. ...

journal_title：Life sciences

authors： Kobayashi K,Yoshimoto K,Hirauchi K,Uchida K

更新日期：1993-01-01 00:00:00

abstract：AIMS:Benidipine, a dihydropyridine Ca(2+) channel blocker, has been reported to block T-type Ca(2+) channels; however, the mechanism underlying this effect was unclear. In this study, we characterized the mechanism responsible for this blocking activity. Furthermore, the blocking activity was compared between two enant...

journal_title：Life sciences

authors： Inayoshi A,Sugimoto Y,Funahashi J,Takahashi S,Matsubara M,Kusaka H

更新日期：2011-05-09 00:00:00

abstract：AIMS:We investigated the pathophysiological changes in mice lacking α2-antiplasmin (α2-AP) and plasminogen activator inhibitor type-1 (PAI-1) genes, and elucidated the involvement of these inhibitors for fibrinolysis in immune response. MAIN METHODS:The pathophysiological changes induced by a lack of both α2-AP and PA...

journal_title：Life sciences

authors： Okada K,Ueshima S,Kawao N,Yano M,Tamura Y,Tanaka M,Sakamoto A,Hatano M,Arima M,Miyata S,Nagai N,Tokuhisa T,Matsuo O

更新日期：2013-07-30 00:00:00

abstract：AIMS:Endothelin-1 (ET-1) and endothelin-2 (ET-2; Trp(6)Leu(7)ET-1) are expressed by different cell types, but are considered to display identical pharmacological properties on endothelin receptors. We studied agonist-dependent aspects of endothelin(A) (ET(A))-receptor function and the importance of amino acids 6 and 7 ...

journal_title：Life sciences

authors： Compeer MG,Suylen DP,Hackeng TM,De Mey JG

更新日期：2012-10-15 00:00:00

abstract：:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean ar...

journal_title：Life sciences

authors： Wang YX,Crofton JT,Liu H,Sato K,Share L

更新日期：1996-01-01 00:00:00

abstract：AIMS:Obesity represents a global health problem. Excessive caloric intake promotes the release of inflammatory mediators by hypertrophic adipocytes and obesity-induced inflammation is now recognized as a risk factor for the development of several diseases, such as cardiovascular diseases, insulin resistance, type-II di...

journal_title：Life sciences

authors： Sardi C,Martini E,Mello T,Camelliti S,Sfondrini L,Marcucci F,Kallikourdis M,Sommariva M,Rumio C

更新日期：2021-01-01 00:00:00

abstract：AIMS:Sarcopenia is characterized by muscle mass and strength loss and reduced physical activity. Branched-chain amino acids (BCAAs) were recently described as an activator of protein synthesis via mammalian target of rapamycin (mTOR) signaling for muscle atrophy. In cardiovascular diseases, excessive activation of the ...

journal_title：Life sciences

authors： Yamanashi K,Kinugawa S,Fukushima A,Kakutani N,Takada S,Obata Y,Nakano I,Yokota T,Kitaura Y,Shimomura Y,Anzai T

更新日期：2020-06-01 00:00:00

abstract：:Colorectal cancer remains to be the most prevalent malignancy in humans and 1.5 million men and women living in the United States are diagnosed with colorectal cancer, with a predicted 145,600 new cases to be diagnosed in 2019. Curcuminoids and its synthetic analogs are now of interest due to their bioactive attribute...

journal_title：Life sciences

authors： Selvam C,Prabu SL,Jordan BC,Purushothaman Y,Umamaheswari A,Hosseini Zare MS,Thilagavathi R

更新日期：2019-12-15 00:00:00

abstract：AIMS:Septic shock, the severe form of sepsis, is associated with development of progressive damage in multiple organs. Kidney can be injured and its functions altered by activation of coagulation, vasoactive-peptide and inflammatory processes in sepsis. Endothelin (ET)-1, a potent vasoconstrictor, is implicated in the ...

journal_title：Life sciences

authors： Jesmin S,Shimojo N,Yamaguchi N,Mowa CN,Oki M,Zaedi S,Sultana SN,Rahman A,Islam M,Sawamura A,Gando S,Kawano S,Miyauchi T,Mizutani T

更新日期：2014-05-02 00:00:00

abstract：OBJECTIVE:The present study aimed to investigate the ability of hesperidin to suppress the migration and invasion of A549 cells, and to investigate the role of the SDF-1/CXCR-4 cascade in this suppression. METHODS:We performed a Transwell migration assay to measure the migratory capability of A549 cells treated with 0...

journal_title：Life sciences

authors： Xia R,Xu G,Huang Y,Sheng X,Xu X,Lu H

更新日期：2018-05-15 00:00:00

abstract：:Phospholipid-sensitive Ca2+-dependent protein kinase and its endogenous substrate proteins were examined in acinar cells from rat pancreas. The enzyme was clearly demonstrable by DEAE-cellulose chromatography of acinar cell extract. At least four endogenous substrate proteins (Mr = 38K, 30K, 22K and 15K) for this Ca2+...

journal_title：Life sciences

authors： Wrenn RW

更新日期：1983-05-16 00:00:00

abstract：:The effect of various fractions of black tea [(Camellia Sinensis) (L) O. Kuntze (Theaceae)] on the function of mammalian skeletomotor apparatus was studied. The theaflavin fraction (Tfs) produced a concentration- dependent facilitation of indirect twitch responses of the rat phrenic nerve diaphragm preparation and the...

journal_title：Life sciences

authors： Basu S,Chaudhuri T,Chauhan SP,Das Gupta AK,Chaudhury L,Vedasiromoni JR

更新日期：2005-05-13 00:00:00

abstract：:Dopamine inhibited basal, TRH-, IBMX- and A23187-stimulated prolactin secretion from rat anterior pituitary cells. However, dopamine did not inhibit prolactin secretion stimulated by elevated K+ concentrations. These data are interpreted in terms of dopaminergic inhibition of both cyclic AMP production and Ca2+ influx...

journal_title：Life sciences

authors： Merritt JE,Brown BL

更新日期：1984-08-13 00:00:00

abstract：:The aim of the study was to explore the effect of an acute dose of creatine (Cr) ingestion on serum Cr and serum creatinine (Crn) concentrations. Sixteen healthy subjects ingested a single dose of Cr (20 g) followed by the measurement of serum Cr and Crn concentration for 3 h up to a maximum of 6 h (n=6). In response ...

journal_title：Life sciences

authors： Schedel JM,Tanaka H,Kiyonaga A,Shindo M,Schutz Y

更新日期：1999-10-29 00:00:00

abstract：AIMS:Tianeptine is an atypical antidepressant drug that has a different mechanism of action than other antidepressants. Olanzapine is an atypical antipsychotic drug used for the treatment of schizophrenia. The present study was undertaken to investigate effects of chronic administration of tianeptine or olanzapine on u...

journal_title：Life sciences

authors： Mutlu O,Gumuslu E,Ulak G,Celikyurt IK,Kokturk S,Kır HM,Akar F,Erden F

更新日期：2012-12-17 00:00:00

abstract：:The effect of cadmium (Cd2+) was studied in vitro on the flavokinase (ATP : riboflavin 5'-phosphotransferase, EC 2.7.1.26) activity purified from rat liver. Cadmium inhibited flavokinase activity in a concentration-dependent manner and the effect was completely reversed by increasing concentration of zinc (Zn2+), indi...

journal_title：Life sciences

authors： Bandyopadhyay D,Chatterjee AK,Datta AG

更新日期：1997-01-01 00:00:00

abstract：:In rat prefrontal cortical slices, the excitatory amino acids N-methyl-D-aspartate (NMDA), ibotenate, L-aspartate, quisqualate, kainate and L-glutamate inhibit carbachol-induced phosphoinositide hydrolysis as measured by the accumulation of [3H]inositol-1-phosphate ([3H]IP1). NMDA dose-dependently inhibited the carbac...

journal_title：Life sciences

authors： Noble EP,Sincini E,Bergmann D,ten Bruggencate G

更新日期：1989-01-01 00:00:00

abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...

journal_title：Life sciences

authors： Naderi N,Hemmatinafar M,Gaeini AA,Bahramian A,Ghardashi-Afousi A,Kordi MR,Darbandi-Azar A,Karimzade F,Mohebbi H,Barati M

更新日期：2019-03-15 00:00:00

abstract：:Sepsis is commonly associated with enhanced generation of reactive oxygen metabolites, which lead to multiple organ dysfunction. The aim of this study was to examine the role of melatonin, a potent antioxidant, in protecting the intestinal and bladder tissues against damage in a rat model of sepsis. Sepsis was induced...

journal_title：Life sciences

authors： Paskaloğlu K,Sener G,Kapucu C,Ayanoğlu-Dülger G

更新日期：2004-01-16 00:00:00

abstract：:Three distinct peptidyldipeptidases (exopeptidases releasing carboxyl terminal dipeptide residues) can be solubilized from nerve terminal membrane fractions from whole rat brain or striatum, and separated by ion exchange chromatography. Brain angiotensin-converting enzyme (PDP-1) cleaves Hip-His-Leu, but not 80 nM [3H...

journal_title：Life sciences

authors： Cushman DW,Gordon EM,Wang FL,Cheung HS,Tung R,Delaney NG

更新日期：1983-01-01 00:00:00

abstract：:Ro41-0960 is a potent, fluorine containing COMT inhibitor which has be en reported to cross the blood brain barrier and to inhibit COMT in the brain. It is structurally similar to Ro40-7592 which is currently undergoing clinical trials in Parkinson's disease. Positron emission tomographic (PET) studies in baboon using...

journal_title：Life sciences

authors： Ding YS,Gatley SJ,Fowler JS,Chen R,Volkow ND,Logan J,Shea CE,Sugano Y,Koomen J

更新日期：1996-01-01 00:00:00

abstract：:Specific binding sites for atrial natriuretic peptide have been identified in membrane of the phaeochromocytoma cell line PC12. Scatchard analysis of binding studies revealed a Kd of 794 pM and a density (Bmax) of 254 fmol/mg protein. Hormones unrelated to ANP such as angiotensin II, bradykinin and arginine-8-vasopres...

journal_title：Life sciences

authors： Boumezrag A,Lyall F,Dow JA

更新日期：1988-01-01 00:00:00

abstract：:To examine the direct effects of tributyltin acetate (TBTA) on osteoclasts and osteoblasts, teleost scale, which has both osteoclasts and osteoblasts and is similar to mammalian membrane bone, was used in the present study. The activities of tartrate-resistant acid phosphatase and alkaline-phosphatase, as respective i...

journal_title：Life sciences

authors： Suzuki N,Tabata MJ,Kambegawa A,Srivastav AK,Shimada A,Takeda H,Kobayashi M,Wada S,Katsumata T,Hattori A

更新日期：2006-04-18 00:00:00

abstract：:Progressive lysis of bone in loose total hip replacement has been ascribed to the capacity of the synovial-like membrane present at the bone interface to produce prostaglandin E2 and cytokines such as tumor necrosis factor (TNF alpha). Phospholipase A2 (PLA2) produces rate limiting precursor i.e. arachidonic acid in t...

journal_title：Life sciences

authors： Cirino G,Misasi M,Loffredo A,Sorrentino L,Caivano P,Bucci M,Cicala C

更新日期：1996-01-01 00:00:00

abstract：:CYP3A4, the predominant cytochrome P450 (CYP) expressed in human liver, contributes to the metabolism of approximately half the drugs in use today. In general, human-derived cell lines fail to express CYPs. It was previously shown that CYP3A4 mRNA and CYP3A immunoreactive protein are induced by 1alpha,25-dyhydroxyvita...

journal_title：Life sciences

authors： Elizondo G,Medina-Díaz IM

更新日期：2003-05-30 00:00:00

abstract：OBJECTIVE:To estimate the alterations of paraoxonase 1 (PON1) and high-density lipoprotein (HDL) in rheumatoid arthritis (RA). DESIGN AND METHODS:We investigated the serum enzyme activity and concentration of PON1 and their relationship with serum lipids, high-density lipoprotein (HDL) parameters, and acute phase reac...

journal_title：Life sciences

authors： Tanimoto N,Kumon Y,Suehiro T,Ohkubo S,Ikeda Y,Nishiya K,Hashimoto K

更新日期：2003-05-09 00:00:00

abstract：AIMS:Evidence has indicated U50,488H, a selective κ-opioid receptor (κ-OR) agonist, administered before ischemia attenuates apoptosis and infarction during ischemia and reperfusion (I/R). However, it remains unclear whether U50,488H postconditioning reduces apoptosis during I/R. This study was designed, therefore, to t...

journal_title：Life sciences

authors： Tong G,Sun Z,Wei X,Gu C,Kaye AD,Wang Y,Li J,Zhang Q,Guo H,Yu S,Yi D,Pei J

更新日期：2011-01-03 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：:Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds...

journal_title：Life sciences

authors： Harris DW,Baker CA,Saneii HH,Johnson GA

更新日期：1985-08-19 00:00:00

abstract：UNLABELLED:Based on preclinical findings, cellular therapy has become a promising therapeutic approach for neonatal hypoxia-ischemia (HI). However, before translation into the clinical setting, new and effective routes of cell delivery must be determined. Intra-arterial (IA) delivery is an attractive route of cellular ...

journal_title：Life sciences

authors： Greggio S,de Paula S,Azevedo PN,Venturin GT,Dacosta JC

更新日期：2014-02-06 00:00:00