Abstract：
:The present study was performed to determine if the attenuated pressor response to vasopressin in conscious non-estrous female rats is due in part to an enhanced V2-like receptor vasodilator action. In male rats, infusion of vasopressin at a rate of 1 ng.min(-1).kg body weight-1 (wt) resulted in an increase in mean arterial blood pressure (MABP) of about 20 mm Hg. Thirty minutes after beginning the infusion of vasopressin, the iv bolus injection of a non-peptide V2-receptor antagonist, OPC-31260 (2 mg.kg body wt-1), resulted in a further gradual increase in MABP of approximately 8 mm Hg in the next 60 min (p < 0.05). Thus, the pressor response to vasopressin was greater in OPC-31260-treated than in vehicle-treated male rats (p < 0.01). The pressor response to vasopressin 30 min after the start of its infusion was lower (about 8 mm Hg) in non-estrous female rats than in males. During the next 60 min of vasopressin infusion, there was a small further increase (p < 0.05) in MABP in the females given either OPC-31260 or its saline vehicle. In contrast to the male rats, however, there was no difference in MABP between the OPC-31260 and vehicle treated females. Thus, the present study has provided additional evidence for a V2-like receptor related vasodilator effect in male rats. However, since female rats do not appear to express a V2-receptor mediated vasodilator response, the sexually dimorphic pressor response to vasopressin cannot be due to a gender difference in V2-receptor vasodilator activity.
journal_name
Life Scijournal_title
Life sciencesauthors
Wang YX,Crofton JT,Liu H,Sato K,Share Ldoi
10.1016/0024-3205(96)00351-7subject
Has Abstractpub_date
1996-01-01 00:00:00pages
695-703issue
8eissn
0024-3205issn
1879-0631pii
0024320596003517journal_volume
59pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficient red blood cells (RBCs) are known to be more susceptible to oxidant-induced hemolysis. Erythrocytes from G6PD-deficient individuals are significantly more susceptible to Ca(2+)-induced vesiculation than normal control cells. The enhanced susceptibility of G6PD-deficien...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00377-3
更新日期：1996-01-01 00:00:00
abstract：:Rats were administered intravenously liposome-encapsulated or free cobalt, and the organ distribution of the metal was explored using Co57 tracer. Two hours after administration, the cobalt level in the heart was about 40% of the control when given in sphingomyelin (SM)/cholesterol (CH) (1:1 mole ratio) liposomes. The...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90092-1
更新日期：1989-01-01 00:00:00
abstract：AIMS:Luteolin has been shown to be beneficial to cardiovascular tissues and organs. We aimed to study its vasospasmolytic effects against various vasoconstrictors in the isolated rat coronary arteries (RCAs) and its electrophysiological effects on K+ currents via voltage-gated potassium (Kv) channels and inward rectifi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.028
更新日期：2019-03-15 00:00:00
abstract：:This study examined the effects of chronic treatment of a new phosphodiesterase type 5 inhibitor, DA-8159, on endothelial dysfunction in stroke-prone spontaneously hypertensive rats (SHR-SP). Six-week-old male SHR-SP were divided into 4 groups; vehicle control, DA-8159 1, 3, and 10 mg/kg/day. During a 32-week experime...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.06.042
更新日期：2006-02-09 00:00:00
abstract：AIMS:The aim of the present study was to evaluate the oral resveratrol effects associated with diet and physical training changes on anthropometric and biochemical parameters. MAIN METHODS:25 individuals aged from 30 to 60 years old; with Body Mass Index (BMI) ≥ 30 kg/m2 were included in the study. Following the prima...
journal_title：Life sciences
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.lfs.2020.117962
更新日期：2020-09-01 00:00:00
abstract：:Since hypertension may compromise the ability to withstand hypernatremic dehydration, we investigated the impact of two experimental models of hypertension and pharmacologic normalization of blood pressure on the tolerance to chronic hypernatremic dehydration. In DOCA-salt hypertensive animals and the spontaneously-hy...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90450-6
更新日期：1990-01-01 00:00:00
abstract：:Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflamm...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2018.11.009
更新日期：2018-12-15 00:00:00
abstract：:Liver sections removed from phenobarbital induced rats 24 to 48 hours after a 2 hour exposure to 1.0% halothane with 10% oxygen and subjected to immunocytochemical treatment showed evidence of centrilobular damage as well as evidence of the production of a protein which has immunoreactivity with anti HSP 72 antibodies...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90394-5
更新日期：1992-01-01 00:00:00
abstract：AIMS:This study aims to explore factors that influence glucocorticoid (GC)-related genes and receptors/regulatory enzyme expression in intrauterine growth restriction (IUGR) filial rats. MAIN METHODS:An IUGR animal model was established by starvation, and brain tissue was removed after birth. Affymetrix Rat Gene 2.0 S...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.079
更新日期：2016-04-01 00:00:00
abstract：AIMS:We examined the nature of pharmacological interaction after coadministration of melatonin with clonidine or neostigmine on formalin-induced nociception at the spinal level. Further, the role of melatonin receptor subtypes in melatonin-induced antinociception was clarified. MAIN METHODS:Catheters were inserted int...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.09.028
更新日期：2008-12-19 00:00:00
abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119140
更新日期：2021-01-29 00:00:00
abstract：:We investigated the effects of genistein and genistin on proliferation and apoptosis of human ovarian SK-OV-3 cells and explored the mechanism for these effects. SK-OV-3 cells were treated with genistein and genistin at various concentrations (ranging from 1 to 100 muM) either alone or in combination for 24 and 48 h. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.12.031
更新日期：2007-03-20 00:00:00
abstract：:The present investigation was aimed at comparing the influence of the partial dopamine (DA) receptor agonist (-)-3-PPP (preclamol) on prolactin release in acutely hyperprolactinemic but otherwise intact female rats and female rats subjected to chronic DA depletion. One group of animals received daily vehicle injection...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90100-2
更新日期：1988-01-01 00:00:00
abstract：:A modification of beta-adrenoceptor binding has been observed in different human and animal tissues after glucocorticoid administration. In this study we observed that hydrocortisone increased human intact lymphocyte beta-adrenoceptors labelled with 3H-dyhydroalprenolol in vitro, in physiological and pharmacological c...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90528-9
更新日期：1984-12-03 00:00:00
abstract：:We examined the direct effect of magnesium ion on aldosterone production by adrenal cells using collagenase-dispersed zona-glomerulosa cells in rats. The effects of magnesium on aldosterone production stimulated by angiotensin II or ACTH were also investigated. Both magnesium sulphate (MgSO4) and magnesium chloride (M...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90327-5
更新日期：1989-01-01 00:00:00
abstract：:The effect of i.v. injection of various doses of naloxone (NAL) on plasma adrenocorticotropin (ACTH) and prolactin (Prl) in conscious animals bearing an indwelling intrajugular catheter was assessed. The effects were evaluated in animals which were left undisturbed and in others subjected to either restraint or ether ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90426-8
更新日期：1989-01-01 00:00:00
abstract：:The role of alpha 1-adrenoceptors in the mediation of autonomic functions, particularly in the control of the cardiovascular system, is widely known. It has been shown that alpha 1-adrenoceptors localized in human prostate mediate the contraction of prostatic smooth muscles which produces an increase in the intraureth...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/0024-3205(94)90141-4
更新日期：1994-01-01 00:00:00
abstract：:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorp...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90499-x
更新日期：1983-01-01 00:00:00
abstract：:Previously we have reported a decreased GABAB receptor expression in brain of spontaneously hepertensive rats (SHR). Moreover, decreased receptor numbers were accompanied by depressed stimulation of cAMP formation. We have now quantified Gi alpha protein by immunoblotting in cerebral membranes from 11-week-old normote...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(96)00573-5
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Mesenchymal stem cells (MSCs) are widely applied in various clinical disorders, including acute lung injury (ALI). We aimed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs)-derived exosomal microRNA-22-3p (miR-22-3p) on lipopolysaccharid (LPS)-induced ALI via...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.119004
更新日期：2021-01-06 00:00:00
abstract：:Pancreatitis is an inflammatory disease of the pancreas characterized by acinar cell injury and is associated with the abnormal release of trypsin, which results in high mortality due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). The inflammatory response, impaired a...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118641
更新日期：2021-01-01 00:00:00
abstract：:Hepatotoxicity is a common side effect encountered with tamoxifen (TAM) administration. Due to the great value of TAM in breast cancer treatment, hepato-protection is seriously recommended. AIMS:The present study investigated the hepato-protective effect of celecoxib (CX) against TAM-induced hepatotoxicity in rats. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116573
更新日期：2019-08-15 00:00:00
abstract：:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), ni...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(97)00107-0
更新日期：1997-01-01 00:00:00
abstract：AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117323
更新日期：2020-02-15 00:00:00
abstract：:Swim therapy in the form of moderate physical activity has general health benefits. Regular exercise prevents the progression of chronic diseases affecting the different bodily systems. The metabolic alterations associated with following such lifestyle remain not fully understood. The aim of the present study was to e...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118516
更新日期：2020-12-01 00:00:00
abstract：:Examination was made of the effects of 17 synthetic and naturally occurring flavonoids on human lymphocyte proliferation in the presence of concanavalin A as a mitogen. Twelve of the flavonoids examined were mono-hydroxy or methoxy derivatives. The mitogen-induced response of lymphocytes was evaluated from the extent ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90028-3
更新日期：1989-01-01 00:00:00
abstract：:Uncontrolled recreational drugs are proliferating in number and variety. Effects of long-term use are unknown, and regulation is problematic, as efforts to control one chemical often lead to several other structural analogs. Advanced analytical instrumentation and methods are continuing to be developed to identify dru...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2012.10.031
更新日期：2013-03-19 00:00:00
abstract：:Pulmonary fibrosis (PF), which is characterized by excessive matrix formation, may ultimately lead to irreversible lung damage and thus death. Fibroblast activation has been regarded as a central event during PF pathogenesis. In our previous study, we confirmed that the miR-627/high-mobility group box protein 1 (HMGB1...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119085
更新日期：2021-01-20 00:00:00
abstract：AIMS:The potential of human mesenchymal stem cell-like stroma prepared from placental/umbilical cord blood for hematopoietic regeneration by X-irradiated hematopoietic stem cells is herein assessed. MAIN METHODS:Placental/umbilical cord blood-derived mesenchymal stem cell-like stromal cells were applied to a regenerat...
journal_title：Life sciences
pub_type： 杂志文章
doi：
更新日期：2009-04-24 00:00:00
abstract：:A radioimmunoassay for orexin A has been developed. Anti-orexin A antiserum was raised in New Zealand white rabbits immunized with a conjugate of synthetic orexin A with bovine serum albumin. This antibody did not crossreact with orexin B, hypothalamic hormones, pituitary hormones, neuropeptides or gut hormones. Radio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00673-6
更新日期：2000-01-01 00:00:00
