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Antinociceptive effect of nifedipine and verapamil tested on rats chronically exposed to nicotine and after its withdrawal.

Abstract：

:Antinociceptive effect of nifedipine (15 mg/kg i.p.) and verapamil (10 mg/kg s.c.) was examined in rats chronically exposed to nicotine (6 mg/kg/day via Alzet osmotic pump for 28 days) and after nicotine withdrawal. Sham operated rats served as control for testing DMSO (dimethylsulfoxide, a solvent for nifedipine), nifedipine and verapamil alone. Nociception was measured by the tail-flick technique. Nifedipine, but not verapamil, injected to control rats produced a ceiling tail-flick latency (20 sec) 30 min after the injection, lasting for 10 min. In rats exposed to chronic nicotine for 3 days, nifedipine treatment exhibited ceiling tail-flick latency within 10 min lasting for 80 min. Tested in rats exposed to nicotine for 3 weeks, nifedipine treatment produced this effect 25 min after the injection lasting for 60 min. Nicotine withdrawal abolished this effect. Verapamil did not exhibit any significant changes in tail-flick latencies. These data support our hypothesis that smoking patients treated with nifedipine could be at a potential risk in developing a high pain threshold and missing the first sign of heart attack--a chest pain.

journal_name

Life Sci

journal_title

Life sciences

authors

Zbuzek VK,Cohen B,Wu W

doi

10.1016/s0024-3205(97)00107-0

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

1651-8

issue

19

eissn

0024-3205

issn

1879-0631

pii

S0024320597001070

journal_volume

60

pub_type

杂志文章

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