Abstract：
:[3H] Dynorphin can be shown to bind to the brains of both rat and guinea pigs with approximately 50% specific binding. Characterization of the binding in terms of multiple opiate receptor types supports the kappa selectivity of dynorphin in guinea pig. However, in rat brain, a substantial proportion of the [3H] dynorphin binding is displaced by morphine, suggesting a mu as well as kappa component. Consequently, in rat, dynorphin may show effects at both mu and kappa receptors in vivo.
journal_name
Life Scijournal_title
Life sciencesauthors
Young E,Walker JM,Houghten R,Akil Hdoi
10.1016/0024-3205(83)90499-xsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
287-90eissn
0024-3205issn
1879-0631pii
0024-3205(83)90499-Xjournal_volume
33 Suppl 1pub_type
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