Abstract：
:Groups of 35-day-old male C57BL/6 mice were stressed 1 hour per day by immobilization for 1, 2, 3, 5, 8, 11 or 14 consecutive days. Control groups were left undisturbed. The animals were then killed and body weight and the weights of the thymus, spleen and axillary lymph nodes determined. Chronic immobilization stress caused involution of the thymus, spleen and lymph nodes to an extent depending on the number of days of stress. The thymus showed the fastest response: thymus weight was significantly lower in stressed animals than in controls by the third day of stress while significant effects on spleen and lymph node weight were not observed until day 5. Fast recovery of lymphoid organ weight was observed after the stress period. The thymus recovered most quickly: control values were re-attained approximately 8 days after cessation of stress, and indeed by day 20 thymus weight was about 12% higher than in normal animals. The spleen and lymph nodes recuperated weight more slowly, re-attaining control values after about 20 days.
journal_name
Life Scijournal_title
Life sciencesauthors
Domínguez-Gerpe L,Rey-Méndez Mdoi
10.1016/s0024-3205(97)00606-1subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1019-27issue
10eissn
0024-3205issn
1879-0631pii
S0024320597006061journal_volume
61pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Several neuronal cell lines were screened for endogenous expression of neuronal nitric oxide synthase (nNOS) protein using Western blot analysis. Detectable levels of the nNOS protein were evident in the SK-N-SH, SH-SY5Y, and N1E-115 neuroblastoma cell lines, as well as the NG108-15 neuroblastoma x glioma hybrid. Only...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01732-0
更新日期：2002-07-05 00:00:00
abstract：:Angiotensin-converting enzyme 2 (ACE 2) is a membrane-bound enzyme that cleaves angiotensin II (Ang II) into angiotensin (1-7). It also serves as an important binding site for SARS-CoV-2, thereby, facilitating viral entry into target host cells. ACE 2 is abundantly present in the intestine, kidney, heart, lungs, and f...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.118676
更新日期：2021-01-01 00:00:00
abstract：:In this study, we have focused our investigation of the facts whether co-administration of a NMDA antagonist dextromethorphan (DM) with morphine during pregnancy and throughout lactation could prevent the adverse effects associated with chronic morphine administration in rat offspring. Adult female Sprague-Dawley rats...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)01316-9
更新日期：2001-10-05 00:00:00
abstract：:The effect of the three forms (CANP1, CANP2 & CANP3) of calf brain calcium activated neutral protease (CANP) on the hydrolysis of purified neurofilament triplet proteins was investigated. It was observed that: each of the purified neurofilament proteins, was hydrolyzed slowly by CANP2 whereas the hydrolysis of 150 KDa...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90331-0
更新日期：1986-10-13 00:00:00
abstract：:Interleukin-18 (IL-18) is a novel proinflammatory cytokine that was recently found in synovial fluids and synovial tissues from patients with rheumatoid arthritis (RA). To investigate the role of IL-18 in rheumatoid synovitis, the levels of IL-18 and serum amyloid A (SAA) were measured in synovial fluids from 24 patie...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.08.025
更新日期：2004-02-13 00:00:00
abstract：:To study the effects of volume overload and renal failure on plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH), we measured levels of this hormone in normal subjects, in patients with advanced chronic renal failure (CRF) with and without clinically evident volume overload, and in patients with end-st...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90732-6
更新日期：1987-09-28 00:00:00
abstract：:Abdominal aortic coarctation above the renal arteries leads to severe hypertension above the stenotic site and provides a model for simultaneous testing of the effects of increased and decreased pressure and consequently shear stress in the same animal. The effects of increased pressure, per se, on oxidative stress an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.10.014
更新日期：2005-01-07 00:00:00
abstract：:In the present study the formation of thrombin-antithrombin-complexes (TAT) during incubation of thrombin (0.89, 4.5, 8.9 nmol/l) and antithrombin (4.6 micromol/l) on the surface of cultured human EC, derived from different parts of the circulation, and on the surface of human vessel segments was studied. In the absen...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00416-0
更新日期：1998-01-01 00:00:00
abstract：AIMS:This study investigates the effect of a new combination of glucosamine hydrochloride, chondroitin sulfate, methylsulfonylmethane, Harpagophytum procumbens root extract (standardized to 3% harpagoside) and bromelain extract (GCMHB) on formalin-induced damage to cartilage tissue in the rat knee joint and evaluates t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2015.03.012
更新日期：2015-06-01 00:00:00
abstract：:miRNAs are a group of non-coding RNAs that have regulatory functions in post-transcriptional gene expression. These molecules play a fundamental role in cellular processes, for instance cell proliferation, apoptosis, migration, and invasion. Scientific investigations have previously established that miRNAs can either ...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2020.117865
更新日期：2020-09-01 00:00:00
abstract：:Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasmin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90192-6
更新日期：1993-01-01 00:00:00
abstract：:It has been previously shown that treatment of newborn rats with the polyamines putrescine, spermidine and spermine can rescue sympathetic neurons from naturally occurring cell death and from induced death after axotomy or immunosympathectomy. The present study demonstrates that polyamine treatment can also prevent th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90409-8
更新日期：1989-01-01 00:00:00
abstract：:The neuropeptide substance P (SP) is a mediator of neurogenic inflammation. Also, beta-amyloid protein (beta AP) can directly activate the cell types involved in inflammatory processes. The relationship between SP and beta AP on their biological actions has attracted much interest. SP is trophic in neuronal cells and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(95)00235-x
更新日期：1995-01-01 00:00:00
abstract：:This study examined the effect of nitric oxide (NO) on the cytosolic free Ca(2+) concentration ([Ca(2+)](c)) of alpha-cells isolated from rat pancreatic islets. When extracellular glucose was reduced from 7 to 0 mM, about half of the alpha-cells displayed [Ca(2+)](c) oscillations. Nicardipine, a Ca(2+) channel blocker...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01608-9
更新日期：2002-05-24 00:00:00
abstract：:To characterize the pharmacokinetics of protein-free granisetron in blood and brain we implanted microdialysis probes into the jugular vein and cerebral frontal cortex of the rat. Granisetron (3 or 6 mg/kg, i.v., n=6) was then administered, and microdialysates from blood and brain were collected from both sites and as...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00143-5
更新日期：1999-01-01 00:00:00
abstract：:The application of acetic acid to the hind leg of a frog will induce a spinally mediated wiping reflex only if the acetic acid concentration is above a certain threshold. By using this reflex as the basis of a test for nociception, we show that morphine sulfate is a potent analgesic in the frog when injected into the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90333-8
更新日期：1983-11-21 00:00:00
abstract：:The effects of chronic treatment with piracetam (100 mg/Kg) plus choline (100 mg/Kg) on rabbits' hippocampal electrical activity and behavior have been studied. Animals were exposed to a neutral environment, in the absence of any external stimulus, and then to an object and a stuffed sparrow-hawk. Results show a drug ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90189-9
更新日期：1984-09-10 00:00:00
abstract：:It has been shown that the main psychoactive component of marihuana, delta9-tetrahydrocannabinol (THC) has mainly inhibitory effects on the regulation of reproduction. Recently, the purification and availability of the endogenous ligand of the cannabinoid receptor, arachidonyl ethanolamide, anandamide, (ANA) and its s...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/s0024-3205(99)00292-1
更新日期：1999-01-01 00:00:00
abstract：:Using hot plate method, analgesia induced by noncatecholic phenylethylamines, phenethylamine, phenylethanolamine and amphetamine, was inhibited by naloxone, reserpine, apomorphine and p-chlorophenylalanine, while potentiated by haloperidol. These results suggest that phenylethylamines induced analgesia involves centra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90347-2
更新日期：1982-09-20 00:00:00
abstract：AIMS:Individual susceptibility to develop obesity may impact the development of cardio-metabolic risk factors that lead to obesity-related comorbid conditions. Obesity-prone Osborne-Mendel (OM) rats expressed higher levels of visceral adipose inflammation than obesity-resistant, S5B/Pl (S5B) rats. However, the consumpt...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.03.022
更新日期：2019-04-15 00:00:00
abstract：:A sensitive method for quantitation of beta-endorphin in biological fluids and tissues using ELISA methodology has been developed. This assay is sensitive to as low as 30 picograms of beta-endorphin per measurement and can be carried out in approximately 5 hours. The determination of antibody titer levels to beta-endo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90461-7
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:The present study aimed to investigate the ability of hesperidin to suppress the migration and invasion of A549 cells, and to investigate the role of the SDF-1/CXCR-4 cascade in this suppression. METHODS:We performed a Transwell migration assay to measure the migratory capability of A549 cells treated with 0...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.03.046
更新日期：2018-05-15 00:00:00
abstract：BACKGROUND/AIMS:Previous studies have demonstrated that Galactooligosaccharides (GOS), known as "bifidus factor", has anti-inflammatory effects. Colitis, a kind of colonic inflammatory damage could be induced by different chemicals. The pathogenesis and mechanism of colitis remains unclear, and may be related to intest...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117220
更新日期：2020-02-01 00:00:00
abstract：:The pupillary effects of intravenous buprenorphine were studied in eight nondependent male subjects who reported previous opiate use. Buprenorphine (0.3, 0.6, and 1.2 mg) decreased pupil size, the amplitude of the light reflex, and the velocities of constriction and dilation. Significant pupillary effects occurred wit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90026-8
更新日期：1991-01-01 00:00:00
abstract：:The effects of C-reactive protein (CRP), the prototypical acute-phase reactant were studied on human polymorphonuclear leukocytes (PMNL) challenged with N-formyl-methionyl-leucyl-phenylalanine (fMLP) and platelet-activating factor (PAF). CRP at 8-64 micrograms/ml concentrations inhibited degranulation and superoxide p...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90613-9
更新日期：1989-01-01 00:00:00
abstract：:Binding studies conducted on membrane preparation from human platelets using (3H) Ro5-4864 and (3H) diazepam showed specific and saturable binding. Scatchard analysis revealed a single class of binding sites with KD = 10.8 +/- 0.9 nM and Bmax = 775 +/- 105 fmol/mg protein for (3H) Ro5-4864 and KD = 10.5 +/- 1.1 nM and...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90556-3
更新日期：1984-11-12 00:00:00
abstract：OBJECTIVE:To investigate the expression and time-dependent manner of bradykinin (BK) as well as its receptors (Bradykinin receptors 1 and 2, B1R and B2R) in spinal cord ischemia-reperfusion injury (SCII) in rat model. METHODS:Sprague-Dawley (SD) rats were subjected to 1 h of infra-renal abdominal aorta occlusion and r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.12.034
更新日期：2019-02-01 00:00:00
abstract：:The biochemical integrity of hepatocellular mitochondria was investigated in rats treated with small doses of human recombinant tumor necrosis factor-alpha (Hur-TNF;50-100 micrograms/kg/d injected intraperitoneally for 5 d) by measuring the activities of three mitochondrial enzymes, glutamate dehydrogenase, succinate ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00495-e
更新日期：1995-01-01 00:00:00
abstract：:Epinephrine (E) infusions raise blood pressure and there is an excess incidence of hypertension among males and blacks. However, reports of E levels by ethnicity, gender, and blood pressure status are inconsistent. Insensitive assays, variability in plasma E levels within individuals, and the small size of most studie...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00568-3
更新日期：2000-05-05 00:00:00
abstract：:We have used the antibiotic gradient-plate technique to generate antifungal producing Actinomadura strains that synthesize enhanced quantities of component 3A of a macrocyclic lactam antifungal compound Sch 38516. Seventy-nine colonies were selected from a mixture of rifampicin and spectinomycin gradient plates. The t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90336-n
更新日期：1992-01-01 00:00:00
