Abstract：
:Cardiovascular risk factors associated with hypertension include alterations in arterial compliance and an increased tendency to thrombosis. In this study we examined the relationship between arterial compliance and endothelial derived components of the hemostatic system: von Willebrand factor (vWF) and tissue plasminogen activator (t-PA). Ten males (4 normal and 6 untreated hypertensives, 41 +/- 12 years) were studied. Compliance of proximal (large vessel) and distal (small vessel) arteries was measured by intraarterial pulse wave analysis; left ventricular wall thickness by echocardiography; and vWF and t-PA by immunoassay of plasma obtained before and immediately after maximum treadmill exercise. Baseline t-PA and vWF correlated inversely with distal compliance (r = -0.74, p = 0.01; r = -0.56, p = 0.09). Exercise strengthened the relationship between vWF and both distal compliance (r = -0.56 to r = -0.86) and proximal compliance (r = -0.44 to r = -0.70). Moreover, post-exercise levels of vWF and t-PA were each significantly related to left ventricular posterior wall and septal thickness. Of note, these protein concentrations correlated more strongly with arterial compliance and left ventricular wall thickness than with blood pressure. Thus, arterial compliance and left ventricular wall thickness appear to be more powerful than blood pressure as predictors of the endothelial release of vWF and t-PA in response to exercise. These findings indicate that some of the key cardiac and arterial characteristics of hypertension might be linked to increased endothelial reactivity to hemodynamic stress.
journal_name
Life Scijournal_title
Life sciencesauthors
Smith DH,Vaziri ND,Winer RL,Neutel JM,Graettinger WF,Gonzales E,Weber MAdoi
10.1016/0024-3205(93)90192-6subject
Has Abstractpub_date
1993-01-01 00:00:00pages
1005-11issue
12eissn
0024-3205issn
1879-0631pii
0024-3205(93)90192-6journal_volume
52pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose depe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(96)00088-4
更新日期：1996-01-01 00:00:00
abstract：:The purpose of this study was to evaluate the induction of oxidative stress in heart and erythrocytes from rats with abdominal aorta coarctation (Coa) compared with sham-operated normotensive controls (Sham). The group of Coa animals developed myocardial hypertrophy, showing heart homogenates markedly increased levels...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.02.004
更新日期：2006-07-04 00:00:00
abstract：:The in vivo dipyridamole treatment for 16 days produced a significant decrease in chick plasma cholesterol, mainly due to the esterified form. This effect was especially patent in the VLDL + LDL fraction. Similar results were observed in triglyceride content. To our knowledge, this is the first report on this hypolipi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90574-u
更新日期：1991-01-01 00:00:00
abstract：:The effects of t-butylhydroperoxide (TBH) and cigarette smoke on lung mechanics (CDYN and RL) and glutathione status (GSH) were studied using an isolated perfused and ventilated rat lung preparation. TBH (200, 400, 1000 microM) infused via the pulmonary circulation caused a dose-related bronchoconstriction. The lung G...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90054-9
更新日期：1988-01-01 00:00:00
abstract：AIMS:Salivary gland dysfunction is a common complication of diabetes mellitus (DM). Long non-coding RNA (lncRNA) is evidenced to involve in the functional regulation of salivary gland, however, its role in DM-impaired gland is unknown. Therefore, this study aimed to investigate the expression profiles and functional ne...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.119009
更新日期：2021-01-04 00:00:00
abstract：:Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that emodin protects against myocardial ischemia/reperfusion injury. However, its mechanism underlying its effects remains unknown. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.08.040
更新日期：2007-10-13 00:00:00
abstract：AIMS:A bridging ligand 2,4,6-pyridine tricarboxylic acid (H(3)ptc) and its manganese(II) complex [Mn(Hptc)(phen)(OH)]n(Hptc=2,4,6-pyridine tricarboxylic acid, phen=1,10-phenanthroline) have been synthesized and characterized. MAIN METHODS:The interaction with DNA (HeLa and KB) was carried out by fluorescence spectrum ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.01.006
更新日期：2012-04-09 00:00:00
abstract：AIMS:Intra-platelet 5-HT (IP 5-HT) and YAP exhibit an important role in hepatocellular carcinoma (HCC). The aim of the study was to investigate whether IP 5-HT and YAP could affect the progression and prognosis of HCC. METHODS:5-HT level and YAP expression were measured and were compared between HCC patients and contr...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119140
更新日期：2021-01-29 00:00:00
abstract：AIMS:The present study evaluated the carvacrol (CARV) effect on hyperalgesia and nociception induced by sarcoma 180 (S180) in mice. MAIN METHODS:Carvacrol treatment (12.5-50mg/kgs.c.) once daily for 15days was started 24h after injection of the sarcoma cells in the hind paw (s.c.). Mice were evaluated for mechanical s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.08.020
更新日期：2014-10-22 00:00:00
abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(84)90551-4
更新日期：1984-03-26 00:00:00
abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.08.005
更新日期：2014-10-02 00:00:00
abstract：:Although the understanding of migraine pathophysiology is still incomplete, there seems to be little doubt that dilatation of cranial blood vessels, including meningeal arteries, is involved in the headache phase of migraine. Since calcitonin gene-related peptide (CGRP) has been implicated in this vasodilatation, the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.01.003
更新日期：2006-06-13 00:00:00
abstract：HEADING AIMS:Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdomi...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117533
更新日期：2020-07-15 00:00:00
abstract：:As a step in the purification and characterization of the glucose transporter from rat skeletal muscle, we have reconstituted glucose transport activity in liposomes. Plasma membranes were prepared from skeletal muscle which display D-glucose reversible binding of cytochalasin B (10 pmol sites/mg protein; KD = 0.3 mic...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(87)90503-0
更新日期：1987-06-15 00:00:00
abstract：:Angiogenesis-targeted therapy of cancer is considered a promising strategy for therapeutic management of cancer progression. Over the last two decades, a few anti-angiogenesis monoclonal antibodies (mAbs) blocking VEGF signaling have been developed and approved by the FDA. The most widely used anti-angiogenesis drug i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.117018
更新日期：2019-12-15 00:00:00
abstract：:3H-Flunitrazepam (FNZP) binding was examined in a crude membrane fraction obtained from rat interscapular brown adipose tissue (IBAT). A single population of binding sites was apparent with dissociation constant (KD) = 0.47 +/- 0.04 microM and maximal number of binding sites (Bmax) = 31 +/- 5 pmol.mg prot-1. From the ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(88)90077-x
更新日期：1988-01-01 00:00:00
abstract：:Benzo(a)pyrene induces cytochrome P-450 1A1 (CYP1A1) expression in rat polymorphonuclear leukocytes (PMNs) that upregulates expression of inducible nitric oxide synthase (iNOS). In the present study, the involvement of secondary signaling molecules in CYP1A1-mediated augmentation of iNOS expression in benzo(a)pyrene-t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.09.032
更新日期：2007-11-30 00:00:00
abstract：:Leukocyte interactions with endothelial cell monolayers (ECM) and smooth muscle cells (SMC) play an important role during inflammatory processes. Several studies describe an inhibitory effect of dexamethasone on polymorphonuclear leukocytes (PMNL), endothelial cell function, and interleukin-1 (IL-1) release. Aim of th...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00609-2
更新日期：1999-01-01 00:00:00
abstract：AIMS:it has been suggested that Chromium (Cr), one of the essential minerals, can be beneficial to type 2 diabetic patients because it lowers blood glucose levels by improving various steps in insulin action. A few studies reported that Cr might also have some beneficial effects in people with type 1 diabetes mellitus ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.08.001
更新日期：2010-09-25 00:00:00
abstract：:In experienced marijuana smokers, marijuana smoking was accompanied by a significant bilateral increase in cerebral blood flow (CBF) especially in the frontal regions and cerebral blood velocity. The post-marijuana CBF increase could not be explained on the basis on changes in general circulation or respiration. Simil...
journal_title：Life sciences
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0024-3205(93)90239-y
更新日期：1993-01-01 00:00:00
abstract：:Restraint stress is known to induce gastric ulcers in rats. Peripheral sympathetic activity and catecholamines are involved in the pathogenesis of these gastric ulcers. The aim of the present study was to evaluate the effects of restraint on mucosal and muscle catecholamine concentrations in the glandular stomach of r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90434-s
更新日期：1990-01-01 00:00:00
abstract：:The pure estrogen antagonist ICI-182780, at doses above 50 micrograms/kg, effectively inhibited the initiation of embryo implantation in rats when administered on day 4 of pregnancy (day 1 = sperm positive). The same dose inhibited the implantation initiating effect of intravenous 25 ng of estradiol-17 beta in delayed...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(93)90186-7
更新日期：1993-01-01 00:00:00
abstract：:Previous studies showed that acute treatment with aminophylline (AMPY) significantly elevated maximum thermogenesis and improved cold tolerance in rats and man in severe cold. However, the exact mechanism by which AMPY enhances thermogenesis was unknown. Rats receiving enprofylline (ENPRO) (1.5 and 15 mg/kg, i.p.), a ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90491-8
更新日期：1989-01-01 00:00:00
abstract：:The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus in vitro has been investigated. Of the compounds tested, only trans-[(NO)(P(OEt)3)(NH3)4Ru](PF6)3 (1-2.5 mM) exerted a strong facilitatory action on the population spik...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(01)00951-1
更新日期：2001-02-16 00:00:00
abstract：:These experiments were designed to test the hypothesis that cyclosporine A (CSA) inhibits renin secretion and stimulates renal prostaglandin E2 (PGE2) release in vitro. In rat renal cortical slices incubated at 37 degrees C in a buffered and oxygenated physiological saline solution containing 4 mM KCl, CSA concentrati...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90187-v
更新日期：1990-01-01 00:00:00
abstract：AIMS:Multiple sclerosis (MS) is one of the commonest neurologic disorders globally. LncRNA OIP5-AS1 has been found to be implicated in the etiology of MS. This study was to explore the roles and molecular mechanisms of OIP5-AS1 in the development of MS. MATERIALS AND METHODS:RT-qPCR assay was used to measure expressio...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2021.119108
更新日期：2021-01-27 00:00:00
abstract：AIMS:Transforming growth factor-β1 (TGF-β1) plays a significant role in epithelial-mesenchymal transition (EMT). Furthermore, endoplasmic reticulum (ER) stress also can induce EMT. However, the relationship among TGF-β1, ER stress and EMT in podocytes is still unclear. Consequently, this study examines the crosstalk ef...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2018.07.050
更新日期：2018-09-15 00:00:00
abstract：:To study the source of immunoreactive epidermal growth factor (ir-EGF) released by thrombin formation we removed 99.9% of the leukocytes normally present in platelet-rich plasma and induced coagulation with 30 mM of Ca2+. The absence of leukocytes did not reduce the amount of ir-EGF released; thus platelets are most l...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90642-o
更新日期：1991-01-01 00:00:00
abstract：AIMS:Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised ra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.11.003
更新日期：2010-01-02 00:00:00
abstract：:Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90622-7
更新日期：1983-08-29 00:00:00
