Abstract：
:In vitro effects of medicinal plant extracts from the pericarpium of Citrus reticulata (cv Jiao Gan) (PCRJ) on the growth and differentiation of a recently characterized murine myeloid leukemic cell clone WEHI 3B (JCS) were investigated. Extracts of PCRJ not only inhibited the proliferation of JCS cells in a dose dependent manner, but also induced differentiation of JCS cells into macrophages and granulocytes. Morphological differentiation of PCRJ treated JCS cells was associated with an increase in phagocytic activity of the cells. Furthermore, both in vitro clonogenicity and in vivo growth of PCRJ treated JCS leukemic cells in syngeneic BALB/c mice were significantly reduced. The survival rate of mice receiving PCRJ treated JCS tumour cells was also increased. Using 1H-NMR, 13C-NMR, and GC/MS, two active components isolated from PCRJ were identified as nobiletin and tangeretin.
journal_name
Life Scijournal_title
Life sciencesauthors
Mak NK,Wong-Leung YL,Chan SC,Wen J,Leung KN,Fung MCdoi
10.1016/0024-3205(96)00088-4subject
Has Abstractpub_date
1996-01-01 00:00:00pages
1269-76issue
15eissn
0024-3205issn
1879-0631pii
0024320596000884journal_volume
58pub_type
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