Abstract：
:The effects of three local anesthetics, lidocaine, dibucaine, and tetracaine, on Na+/H+ antiporter activity were examined in brush border membrane-reconstituted vesicles. Lidocaine at 10 microM inhibited H+ efflux in the presence of an inward Na+ gradient, suggesting that this anesthetic specifically inhibits the Na+/H+ antiporter. On the other hand, dibucaine and tetracaine decreased H+ efflux even in the absence of a Na+ gradient.
journal_name
Life Scijournal_title
Life sciencesauthors
Shibamoto S,Hori T,Hayakawa M,Nango M,Cragoe EJ Jr,Oku N,Ito Fdoi
10.1016/0024-3205(90)90172-nsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
1129-33issue
13eissn
0024-3205issn
1879-0631pii
0024-3205(90)90172-Njournal_volume
47pub_type
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