Nicotine and cannabinoids as adjuncts to neuroleptics in the treatment of Tourette syndrome and other motor disorders.

abstract：:NSAIDs can elevate blood pressure through mechanisms such as renal vasoconstriction and sodium retention. These effects are particularly evident in hypertensive individuals. Nitric oxide-releasing NSAID derivatives have been shown to have greatly reduced toxicity in the gastrointestinal tract and kidney. We therefore ...

journal_title：Life sciences

authors： Muscará MN,McKnight W,Del Soldato P,Wallace JL

更新日期：1998-01-01 00:00:00

abstract：:The putative anxiolytic activity of succinic acid was examined in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that diazepam (1.0, 2.0 and 4.0 mg/kg, PO) or succinic acid (3.0 or 6.0 mg/kg,...

journal_title：Life sciences

authors： Chen SW,Xin Q,Kong WX,Min L,Li JF

更新日期：2003-11-07 00:00:00

abstract：:Two recently isolated peptides, endomorphin-1 (Tyr-Pro-Trp-Phe-NH2) and endomorphin-2 (Tyr-Pro-Phe-Phe-NH2), are highly selective micro-opioid receptor agonists with analgesic actions in the tail-flick test. To further assess the analgesic properties of these peptides, the effects of endomorphin-1, endomorphin-2, and ...

journal_title：Life sciences

authors： Soignier RD,Vaccarino AL,Brennan AM,Kastin AJ,Zadina JE

更新日期：2000-07-14 00:00:00

abstract：AIMS:Circular RNAs (circRNAs) have been emerged as novel regulators in multiple tumorigenesis, including melanoma. CircRNA_0084043 was recently demonstrated to be deregulated in human melanoma cells. Nevertheless, its role and mechanism are largely unrevealed in melanoma. MATERIALS AND METHODS:Expression of circ_00840...

journal_title：Life sciences

authors： Chen Z,Chen J,Wa Q,He M,Wang X,Zhou J,Cen Y

更新日期：2020-02-15 00:00:00

abstract：:We recently suggested that peroxisome proliferators (PP)-induced hepatocyte DNA synthesis may be mediated by a specific peroxisome proliferator activated receptor (PPAR). Heterodimers of the PPAR with the retinoid nuclear receptor, RXR, activate transcription after binding to DR1 response elements of the target genes....

journal_title：Life sciences

authors： Ohmura T,Columbano GL,Columbano A,Katyal SL,Locker J,Shinozuka H

更新日期：1996-01-01 00:00:00

abstract：:Single smooth muscle cells from rat tail artery and ventricular myocytes from neonatal rat were isolated by repeated enzyme digestion. The change in cell area as determined photographically was used as an index of cell contraction. The photographic areas of single smooth muscle cells bathed in normal Tyrode solution w...

journal_title：Life sciences

authors： Wang R,Wu L,Karpinski E,Pang PK

更新日期：1993-01-01 00:00:00

abstract：AIMS:Absent in melanoma 2 (AIM2) is a cytosolic DNA sensor which plays an important role in inflammasome formation and is involved in various cellular functions including pyroptosis, fibrosis, and tissue injury. Our study aimed to investigate whether AIM2 plays a role in diabetic cardiomyopathy (DCM) and to explore its...

journal_title：Life sciences

authors： Wang X,Pan J,Liu H,Zhang M,Liu D,Lu L,Tian J,Liu M,Jin T,An F

更新日期：2019-03-15 00:00:00

abstract：:Groups of 35-day-old male C57BL/6 mice were stressed 1 hour per day by immobilization for 1, 2, 3, 5, 8, 11 or 14 consecutive days. Control groups were left undisturbed. The animals were then killed and body weight and the weights of the thymus, spleen and axillary lymph nodes determined. Chronic immobilization stress...

journal_title：Life sciences

authors： Domínguez-Gerpe L,Rey-Méndez M

更新日期：1997-01-01 00:00:00

abstract：:This study investigated the effects of captopril, hydralazine and losartan on the locomotor activity, tailflick and hot plate latencies in spontaneously hypertensive rats (SHR) and their genetic controls the Wistar-Kyoto rat (WKY). The increased hot plate latencies normally exhibited by the spontaneously hypertensive ...

journal_title：Life sciences

authors： Irvine RJ,White JM,Head RJ

更新日期：1995-02-17 00:00:00

abstract：:The effect of silymarin on different functions of mitochondria isolated from rat kidneys was studied. Addition of silymarin to mitochondria oxidizing succinate, induced stimulation of the respiratory State 4; while in mitochondria oxidizing NAD-dependent substrates, the drug produced inhibition of the oxygen consumpti...

journal_title：Life sciences

authors： Chávez E,Bravo C

更新日期：1988-01-01 00:00:00

abstract：AIMS:The mechanisms underlying the changes in blood-brain barrier (BBB) integrity and the generation of seizures in childhood associated with preexisting brain lesions like cortical dysplasia (CD) are poorly understood. We investigated the effects of levetiracetam (LEV) on BBB integrity and the survival during hyperthe...

journal_title：Life sciences

authors： Ahishali B,Kaya M,Orhan N,Arican N,Ekizoglu O,Elmas I,Kucuk M,Kemikler G,Kalayci R,Gurses C

更新日期：2010-11-20 00:00:00

abstract：:Immunotherapy with immune checkpoint inhibitors, such as anti-PD-1 drugs, is an area in increasing development for its efficacy and advantages in the treatment of advanced metastatic melanoma. In fact, immunotherapy has been the target of several and recent studies in different types of cancer, namely in melanoma, a g...

journal_title：Life sciences

authors： Moreira RS,Bicker J,Musicco F,Persichetti A,Pereira AMPT

更新日期：2020-01-01 00:00:00

abstract：:The purpose of this study was to investigate the involvement of calcium in K+ currents and its effects on amino acid accumulation and on the membrane potential regulated by tri-iodo-L-thyronine (T3) in Sertoli cells. Immature rat testes were pre-incubated for 30 min in Krebs-Ringer bicarbonate buffer and incubated for...

journal_title：Life sciences

authors： Volpato KC,Menegaz D,Leite LD,Barreto KP,de Vilhena Garcia E,Silva FR

更新日期：2004-01-23 00:00:00

abstract：:Reportedly, excitatory amino acids are involved in the control of gonadotropin secretion of rats and non-human primates. The aim of this study was to investigate the effect of chronic blockade of NMDA (N-methyl-D-aspartic acid) receptors by the non competitive receptor antagonist MK-801 on gonadotropin secretion and t...

journal_title：Life sciences

authors： Veneroni O,Cocilovo L,Müller EE,Cocchi D

更新日期：1990-01-01 00:00:00

abstract：:Previous investigations showed that chronic metabolic acidosis (CMA) increased the paracellular permeability of ion and neutral hydrophilic molecules in the duodenum of rats and small intestinal-like cell lines. Since proteins of the claudin family have been known to regulate the paracellular transport in several epit...

journal_title：Life sciences

authors： Charoenphandhu N,Wongdee K,Tudpor K,Pandaranandaka J,Krishnamra N

更新日期：2007-04-17 00:00:00

abstract：:Alpha-inhibin-92 (alpha-IB-92) has been characterized from human seminal plasma and found to be active in suppressing FSH release in vitro and in vivo. In order to determine if smaller fragments of this 92 amino acid peptide would still be active to suppress FSH release, we have evaluated 5 of these fragments for thei...

journal_title：Life sciences

authors： Yu WH,Riedel M,Yamashiro D,Ramasharma K,McCann SM

更新日期：1994-01-01 00:00:00

abstract：:Dose-effect curves were obtained for five specific components of stereotyped behavior (locomotor hyperactivity, rearing, sniffing, grooming and oral activity) elicited by the nonselective dopamine agonists N-propylnorapomorphine (NPA; 0.001-4.5 mg/kg) and apomorphine (APO; 0.3-10.0 mg/kg), the selective D2 agonists LY...

journal_title：Life sciences

authors： Meller E,Bordi F,Bohmaker K

更新日期：1988-01-01 00:00:00

abstract：:In vitro competition binding experiments with the selective muscarinic antagonists AF-DX 116 and pirenzepine (PZ) vs 3H-N-methylscopolamine as radioligand revealed a characteristic distribution of muscarinic receptor subtypes in different regions of rat brain. Based on non linear least squares analysis, the binding da...

journal_title：Life sciences

authors： Giraldo E,Hammer R,Ladinsky H

更新日期：1987-03-02 00:00:00

abstract：:Physalis angulata and P. peruviana are herbs widely used in folk medicine. In this study, the aqueous and ethanol extracts prepared from the whole plant of these species were evaluated for their antihepatoma activity. Using XTT assay, three human hepatoma cells, namely Hep G2, Hep 3B and PLC/PRF/5 were tested. The res...

journal_title：Life sciences

authors： Wu SJ,Ng LT,Chen CH,Lin DL,Wang SS,Lin CC

更新日期：2004-03-05 00:00:00

abstract：:Inhaled antimuscarinics, often called anticholinergics in clinical medicine, are established as first line bronchodilators in COPD. Tiotropium has been developed as a new generation antimuscarinic following ipratropium. Tiotropium is a specific, highly potent antimuscarinic, demonstrating very slow dissociation from m...

journal_title：Life sciences

authors： Disse B,Speck GA,Rominger KL,Witek TJ Jr,Hammer R

更新日期：1999-01-01 00:00:00

abstract：:We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabeti...

journal_title：Life sciences

authors： Zarzuelo A,Jiménez I,Gámez MJ,Utrilla P,Fernadez I,Torres MI,Osuna I

更新日期：1996-01-01 00:00:00

abstract：:In order to clarify the role played by interleukin-2 (IL-2) in the regulation of fibroblast function, we investigated the effect of rat IL-2 and human recombinant IL-2 on 3T3 fibroblast proliferation and collagen synthesis. Fibroblasts were incubated with various concentrations of IL-2 for different periods of time. I...

journal_title：Life sciences

authors： Rubinchik E,Levi-Schaffer F

更新日期：1996-01-01 00:00:00

abstract：AIMS:Dietary habits are crucial factors affecting metabolic homeostasis. However, few animal experiments have addressed the effects of long-term feeding with soft food on parameters reflecting systemic health. MAIN METHODS:Using mice, we compared the effects of short (3 days) and long (17 weeks from weaning) feeding p...

journal_title：Life sciences

authors： Tsuchiya M,Niijima-Yaoita F,Yoneda H,Chiba K,Tsuchiya S,Hagiwara Y,Sasaki K,Sugawara S,Endo Y,Tan-No K,Watanabe M

更新日期：2014-05-08 00:00:00

abstract：:Chromatin organization was examined in confluent cultures of embryonic lung fibroblasts in the middle and at the end of their replicative lifespan. Age-related modifications resulted in an unusually wide spacing of the chromatin threads induced by a mild loosening treatment and an increased sensitivity of the nucleoso...

journal_title：Life sciences

authors： Puvion-Dutilleul F,Puvion E,Macieira-Coelho A

更新日期：1983-06-13 00:00:00

abstract：:Endothelins (ET) are 21-amino acid peptides that bind to membrane receptors to initiate a wide range of pathophysiological effects. PD-156707, L-749329, Ro-470203, and A-127722 are potent non-peptide ET receptor antagonists developed recently. When tested in human and rat plasma, both ET-1 and -3 and the four aforemen...

journal_title：Life sciences

authors： Wu-Wong JR,Chiou WJ,Hoffman DJ,Winn M,von Geldern TW,Opgenorth TJ

更新日期：1996-01-01 00:00:00

abstract：:The effects of the mixed class I and II mGLUR agonist (+) 1S,3R-trans-amino-cyclopentane-1,3-dicarboxylic acid (ACPD) and antagonists (+) alpha-methyl-4-carboxyphenylglycine (MCPG) and L-2-amino-3-phosphonopropionic acid (L-AP3) on the basal neuronal excitability and on the expression of in vitro epileptiform activity...

journal_title：Life sciences

authors： Tebano MT,Marinelli S,Sagratella S

更新日期：1997-01-01 00:00:00

abstract：AIM:This study was undertaken to determine the biological activity of a green tea supplement with respect to cells and erythrocyte membranes and the molecular mechanism of that activity. MAIN METHODS:The extract's activity was evaluated on the basis of its hemolytic, antioxidant and antiinflammatory actions. In additi...

journal_title：Life sciences

authors： Cyboran S,Strugała P,Włoch A,Oszmiański J,Kleszczyńska H

更新日期：2015-04-01 00:00:00

abstract：:Morphine and the enkephalin-like peptide FK 33-824 given i.p. to rats potently inhibit gastrointestinal transit of a charcoal test meal, the doses inhibiting transit by 50% being respectively about 10 and 1 microgram/kg. These intestinal effects are opiate-specific, locally elicited and presumably involve the same act...

journal_title：Life sciences

authors： Manara L,Bianchi G,Fiocchi R,Notarnicola A,Peracchia F,Tavani A

更新日期：1982-09-20 00:00:00

abstract：:The effects of the novel anticonvulsant felbamate, which binds to the 5-7 dichlorokynurenic binding sites, were tested towards the CA1 epileptiform activity induced in rat hippocampal slices by kainic acid. The effects of the kynurenic acid derivatives 7-chlorokynurenic acid and 5-7 dichlorokynurenic acid and of the N...

journal_title：Life sciences

authors： Domenici MR,Marinelli S,Sagratella S

更新日期：1996-05-24 00:00:00

abstract：:Uptake of serotonin and 3H-imipramine binding in platelets of depressed patients were investigated simultaneously with changes in clinical state. Both Vmax for serotonin uptake and Bmax for 3H-imipramine binding were significantly lower in unmedicated depressed patients with respect to normal subjects. Successful trea...

journal_title：Life sciences

authors： Suranyi-Cadotte BE,Quirion R,Nair NP,Lafaille F,Schwartz G

更新日期：1985-02-25 00:00:00