Glutamate metabotropic receptors modulate the expression of in vitro epileptiform activity in rat hippocampal slices.

abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...

journal_title：Life sciences

authors： Brtko J,Knopp J,Kvetnanský R

更新日期：2000-03-24 00:00:00

abstract：:After their discovery, the two known cannabinoid receptors, CB(1) and CB(2), have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G(i/o) proteins, negatively modulate cyclic AMP levels, and ac...

journal_title：Life sciences

authors： Demuth DG,Molleman A

更新日期：2006-01-02 00:00:00

abstract：AIMS:Uric acid nephropathy (UAN) is due to excessive uric acid, which leads to hyperuricemia and kidney damage via the deposition of urate microcrystals in the kidneys. Iridoid glycosides of Paederia scandens (IGPS) is a major active component isolated from the traditional Chinese herb P. scandens (LOUR.) MERRILL (Rubi...

journal_title：Life sciences

authors： Zhu W,Pang M,Dong L,Huang X,Wang S,Zhou L

更新日期：2012-10-05 00:00:00

abstract：AIMS:The goal of the current study was to evaluate the impact of maternal sodium intake during gestation on the systemic and renal renin-angiotensin-aldosterone-system (RAAS) of the adult offspring. MAIN METHODS:Female Wistar rats were fed high- (HSD-8.0% NaCl) or normal-sodium diets (NSD-1.3% NaCl) from 8 weeks of ag...

journal_title：Life sciences

authors： Ramos DR,Costa NL,Jang KL,Oliveira IB,da Silva AA,Heimann JC,Furukawa LN

更新日期：2012-05-22 00:00:00

abstract：AIMS:We investigated whether cAMP-mediated protein kinase A(PKA) and Epac1/Rap1 pathways differentially affect brain tumor cell death using 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone(rolipram), specific phosphodiesterase type IV(PDE IV) inhibitor. MAIN METHODS:A172 and U87MG human glioblastoma cells were used....

journal_title：Life sciences

authors： Moon EY,Lee GH,Lee MS,Kim HM,Lee JW

更新日期：2012-02-27 00:00:00

abstract：:Liver sections removed from phenobarbital induced rats 24 to 48 hours after a 2 hour exposure to 1.0% halothane with 10% oxygen and subjected to immunocytochemical treatment showed evidence of centrilobular damage as well as evidence of the production of a protein which has immunoreactivity with anti HSP 72 antibodies...

journal_title：Life sciences

authors： Van Dyke RA,Mostafapour S,Marsh HM,Li Y,Chopp M

更新日期：1992-01-01 00:00:00

abstract：:Gradual increases in the electrical stimulation of the inferior colliculus produces progressive aversive responses from vigilance, through freezing, until escape. These responses are probably mediated by excitatory amino acids (EAA) mechanisms as microinjection of glutamate into the inferior colliculus can trigger fre...

journal_title：Life sciences

authors： Nobre MJ,Borelli KG,Brandão ML

更新日期：2002-11-08 00:00:00

abstract：AIMS:Endurance exercise causes fatigue due to mitochondrial dysfunction and oxidative stress. In order to find an effective strategy to prevent fatigue or enhance recovery, the effects of a combination of mitochondrial targeting nutrients on physical activity, mitochondrial function and oxidative stress in exercised ra...

journal_title：Life sciences

authors： Sun L,Shen W,Liu Z,Guan S,Liu J,Ding S

更新日期：2010-01-02 00:00:00

abstract：HEADING AIMS:MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it func...

journal_title：Life sciences

authors： Zhang J,Hua X,Qi N,Han G,Yu J,Yu Y,Wei X,Li H,Chen X,Leng C,Liu Q,Lu Y,Li Y

更新日期：2020-08-01 00:00:00

abstract：:MSG (4 mg/g BW) or the equivalent molar ratio of NaCl were injected subcutaneously into chicks from four populations of chickens derived from a double selection experiment [(1) low exponential growth rate (EGR) to 14 days of age (14L), (2) high EGR to 14 days of age (14H), (3) low EGR to 42 days of age (42L) and high ...

journal_title：Life sciences

authors： Sizemore FG,Barbato GF

更新日期：1991-01-01 00:00:00

abstract：:The cytokeratins from human bladder and esophageal epithelia were separated using chromatographic techniques. The cytokeratins were first extracted from fresh autopsy tissue using high and low salt buffers. Urea, 8.0-9.5 M, was used to solubilize the resulting cytokeratin pellet. Imidazole was found to increase the so...

journal_title：Life sciences

authors： Meiklejohn B,Nagle RB,McDaniel KM,Wilson GS

更新日期：1990-01-01 00:00:00

abstract：:Kinetics of activation of the NADPH oxidase in a fully soluble cell-free system from phorbol myristate acetate (PMA)-stimulated human neutrophils were investigated. In a cell-free system in which Mg2+ and sodium dodecyl sulfate, an anionic detergent required for the activation of NADPH oxidase are contained, cytosol p...

journal_title：Life sciences

authors： Umeki S

更新日期：1990-01-01 00:00:00

abstract：AIMS:This study was performed to examine whether hypertension affects the sympathetic transmission to resistance vessels of pithed rats via inhibitory presynaptic cannabinoid CB1 receptors and whether endocannabinoids are involved in this response. MATERIALS AND METHODS:We compared uninephrectomised rats rendered hype...

journal_title：Life sciences

authors： Toczek M,Schlicker E,Grzęda E,Malinowska B

更新日期：2015-10-01 00:00:00

abstract：:The aim of this study was to assess the anxiolytic effect of berberine (abbrev. BER) using two experimental anxiety models in the mouse. In the black and white test of anxiety, berberine (100, 500 mg/kg) produced an increase in the first time entry, time spent in the white section, and total changes between two compar...

journal_title：Life sciences

authors： Peng WH,Wu CR,Chen CS,Chen CF,Leu ZC,Hsieh MT

更新日期：2004-10-01 00:00:00

abstract：:Melanin in the skin determines the skin color, and decreased melanin causes many hypopigmentation disorders and increased damage to skin by ultraviolet B (UVB) light irradiation. Here, we stimulate melanogenesis in B16F10 melanoma cells by using specific frequencies of ELF-EMFs. In this study, we focus on the melanoge...

journal_title：Life sciences

authors： Kim YM,Cho SE,Seo YK

更新日期：2016-10-01 00:00:00

abstract：:The ileal Na+/bile acid cotransporter (IBAT) maintains the reabsorption of bile acids from the intestine in the enterohepatic circulation of bile acids. In the present study, we showed that S-8921 could dose-dependently inhibit the uptake of [3H] taurocholate in the COS7 cell line which constitutively expresses hamste...

journal_title：Life sciences

authors： Hara S,Higaki J,Higashino K,Iwai M,Takasu N,Miyata K,Tonda K,Nagata K,Goh Y,Mizui T

更新日期：1997-01-01 00:00:00

abstract：:Male and female rats with two permanently indwelling intravenous catheters were infused for 2 hours with ovine prolactin. During equilibrium conditions the effects of intravenously injected L-DOPA and benzerazide (a blocker of dopa-decarboxylase) on steady state levels of ovine prolactin were measured. A dose of 4.5 m...

journal_title：Life sciences

authors： Mattheij JA,Brouwer GM,Hanstede JG,Swarts JJ

更新日期：1982-08-30 00:00:00

abstract：AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...

journal_title：Life sciences

authors： Grover GJ,Koetzner L,Wicks J,Gahler RJ,Lyon MR,Reimer RA,Wood S

更新日期：2011-02-28 00:00:00

abstract：:Comparison of neuronal and non-neuronal membrane transport of, and neuroexcitation by, the dicarboxylic amino acids bring out provocative similarities in structural selectivity, and hence in the strategies for studying them. Parallel anomalies in stereoselectivity show for both phenomena that the recognition sites are...

journal_title：Life sciences

authors： Christensen HN,Makowske M

更新日期：1983-12-05 00:00:00

abstract：:Specific binding sites for atrial natriuretic peptide have been identified in membrane of the phaeochromocytoma cell line PC12. Scatchard analysis of binding studies revealed a Kd of 794 pM and a density (Bmax) of 254 fmol/mg protein. Hormones unrelated to ANP such as angiotensin II, bradykinin and arginine-8-vasopres...

journal_title：Life sciences

authors： Boumezrag A,Lyall F,Dow JA

更新日期：1988-01-01 00:00:00

abstract：:Previous studies with N-terminal fragments of substance P (SP) have suggested the existence of two separate SP receptor populations. SP1 receptors are found in guinea pig ilea and rat colons. SP2 receptors are found in mouse spinal cords and rat salivary glands. We have now found that substitution of Gly9 in substance...

journal_title：Life sciences

authors： Piercey MF,Dobry-Schreur PJ,Masiques N,Schroeder LA

更新日期：1985-02-25 00:00:00

abstract：:The relative efficiencies of microdialysis probes were determined both in vitro and in vivo using tritiated water. Tritiated water (THO) freely distributes throughout the fluid spaces of an experimental animal and, at equilibrium, the brain extracellular concentration of THO is the same as the plasma concentration. Mi...

journal_title：Life sciences

authors： Alexander GM,Grothusen JR,Schwartzman RJ

更新日期：1988-01-01 00:00:00

abstract：:Platelets from normal and malignant hyperthermia (MH)-susceptible pigs were evaluated for differences in 45calcium uptake in the absence or presence of caffeine (2-16 mM), halothane (0.05-0.5%), or halothane and caffeine together. There were no statistically significant differences in basal or halothane-inhibited calc...

journal_title：Life sciences

authors： Miller KE,Brooks RR,Bonk KR,Carpenter JF

更新日期：1991-01-01 00:00:00

abstract：AIMS:TsTX-I scorpion toxin, also known as γ-toxin, is a β-toxin which binds to site 4 of the sodium channel, shifting its activation potential. There are few studies about its pharmacological action in the central nervous system. The objective of this work was to determine the electroencephalographic, behavioral and hi...

journal_title：Life sciences

authors： Teixeira VF,Conceição IM,Lebrun I,Nencioni AL,Coronado Dorce VA

更新日期：2010-10-09 00:00:00

abstract：:It has been suggested that dopamine might play a role in the regulation of the immune system. In this study, reverse transcriptase-polymerase chain reaction (RT-PCR) was used to investigate the expression of mRNA for the different subtypes of dopamine receptors in the rat lymphocytes. D1, D3 and D5 receptor mRNAs were...

journal_title：Life sciences

authors： Caronti B,Calderaro C,Passarelli F,Palladini G,Pontieri FE

更新日期：1998-01-01 00:00:00

abstract：:In the biosynthesis of adrenomedullin (AM), glycine-extended AM, an intermediate form (iAM) processed from proAM is converted to AM[1-52]-NH2, the bioactive mature form of AM (mAM), by enzymatic amidation. We earlier showed that both molecular forms of AM circulate in human plasma. In the present study, to investigate...

journal_title：Life sciences

authors： Hirayama N,Kitamura K,Imamura T,Kato J,Koiwaya Y,Eto T

更新日期：1999-01-01 00:00:00

abstract：:Despite the recent scientific advances made in cancer diagnostics and therapeutics, cancer still remains the second leading cause of death worldwide. Thus, there is a need to identify new potential biomarkers/molecular targets to improve the diagnosis and treatment of cancer patients. In this regard, long non-coding R...

journal_title：Life sciences

authors： Sharma U,Barwal TS,Malhotra A,Pant N,Vivek,Dey D,Gautam A,Tuli HS,Vasquez KM,Jain A

更新日期：2020-09-15 00:00:00

abstract：:Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO...

journal_title：Life sciences

authors： Matsui M,Yamada S,Oki T,Manabe T,Taketo MM,Ehlert FJ

更新日期：2004-11-05 00:00:00

abstract：:Nitric oxide (NO) is the mediator of ischemic preconditioning against myocardial infarction. Desflurane produces anesthetic preconditioning to protect the myocardium against infarction. In the model of myocardial ischemia-reperfusion injury in rabbits, we evaluated desflurane-induced ischemic preconditioning and studi...

journal_title：Life sciences

authors： Tsai SK,Lin SM,Huang CH,Hung WC,Chih CL,Huang SS

更新日期：2004-12-24 00:00:00

abstract：AIMS:Ginsenoside-Rg1 (G-Rg1), a saponin that is a primary component of ginseng, is very useful and important in traditional Chinese medicine for stroke. The objective of this study was to explore the mechanisms underlying the neuroprotective effect of G-Rg1 on focal cerebral ischemia/reperfusion. MAIN METHODS:Focal ce...

journal_title：Life sciences

authors： Xie CL,Li JH,Wang WW,Zheng GQ,Wang LX

更新日期：2015-01-15 00:00:00