No evidence for a peripheral effect of L-DOPA on plasma prolactin in the rat.

abstract：:The present study was undertaken to evaluate the cardioprotective potential of Curcuma longa (Turmeric) in the ischemia-reperfusion (I/R) model of myocardial infarction (MI). Wistar rats were divided into three groups and received saline orally (sham, control I/R group) and Curcuma longa 100 mg/kg (CL-100 treated grou...

journal_title：Life sciences

authors： Mohanty I,Singh Arya D,Dinda A,Joshi S,Talwar KK,Gupta SK

更新日期：2004-08-20 00:00:00

abstract：:It was recently reported that vitamin C (500 mg/day for 6 weeks) administered as a dietary supplement to healthy humans exhibits a prooxidant, as well as an antioxidant effect in vivo. Here we show that high intakes of vitamin C (500 mg/kg b.w. for 4 days) in the rat are able to markedly induce hepatic cytochrome P450...

journal_title：Life sciences

authors： Paolini M,Pozzetti L,Pedulli GF,Marchesi E,Cantelli-Forti G

更新日期：1999-01-01 00:00:00

abstract：HEADING AIMS:MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it func...

journal_title：Life sciences

authors： Zhang J,Hua X,Qi N,Han G,Yu J,Yu Y,Wei X,Li H,Chen X,Leng C,Liu Q,Lu Y,Li Y

更新日期：2020-08-01 00:00:00

abstract：AIMS:Second-generation antipsychotic drugs (SGAs) have a high risk for serious metabolic side-effects including dyslipidemia. This study aimed to investigate the acute effects of oral olanzapine treatment on the expression of genes for fatty acid and cholesterol biosynthesis in rats. MAIN METHODS:Female Sprague-Dawley...

journal_title：Life sciences

authors： Liu X,Deng C,Cao S,Gong J,Wang BC,Hu CH

更新日期：2015-05-01 00:00:00

abstract：:Alzheimer's disease (AD) involves selective loss of muscarinic m2, but not m1, subtype neuroreceptors in the posterior parietal cortex of the human brain. Emission tomographic study of the loss of m2 receptors in AD is limited by the fact that there is currently no available m2-selective radioligand which can penetrat...

journal_title：Life sciences

authors： Gitler MS,Cohen VI,De la Cruz R,Boulay SF,Jin B,Zeeberg BR,Reba RC

更新日期：1993-01-01 00:00:00

abstract：:Early induction of VEGF was studied in liver, kidney and lung of spontaneously diabetic rats. Western blot analysis, northern hybridization were applied to show the expression of VEGF in different organs. Radiolabelled hypoxia responsive element (HRE) and cAMP responsive element (CRE) oligonucleotides were assayed by ...

journal_title：Life sciences

authors： Braun L,Kardon T,Reisz-Porszasz ZS,Banhegyi G,Mandl J

更新日期：2001-10-12 00:00:00

abstract：:To study the effects of volume overload and renal failure on plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH), we measured levels of this hormone in normal subjects, in patients with advanced chronic renal failure (CRF) with and without clinically evident volume overload, and in patients with end-st...

journal_title：Life sciences

authors： Shenker Y,Port FK,Swartz RD,Gross MD,Grekin RJ

更新日期：1987-09-28 00:00:00

abstract：:Effects of hexamethonium (C6) on the excitability of sympathetic ganglion cells were examined by means of intracellular recording. When DC currents were injected, high concentrations of C6 significantly augmented the repetitive firing of the cells without any change in threshold voltage for initiation of the spike. Th...

journal_title：Life sciences

authors： Kawai T,Oka J,Watanabe M

更新日期：1985-06-17 00:00:00

abstract：:Tricyclic antidepressant drugs bind to histamine receptors in rodent and other mammalian tissues. However, a readily accessible, normal human tissue for studies of these drugs has not been available. We showed that freshly isolated human leukocytes can be used for this purpose. Following isolation by dextran sedimenta...

journal_title：Life sciences

authors： Sadava D,Wilmington K

更新日期：1984-12-17 00:00:00

abstract：:The substituted glucopyranose ring structure 2-hydroxypropyl-beta-cyclodextrin (CDEX) increases the solubility of molecules by inclusion of the agent in the lipophilic interior of the ring. This property is of particular use for the administration of molecules by the intracerebral (ICV) or intrathecal (IT) routes. In ...

journal_title：Life sciences

authors： Yaksh TL,Jang JD,Nishiuchi Y,Braun KP,Ro SG,Goodman M

更新日期：1991-01-01 00:00:00

abstract：:Exposure of rats to an acute, uncontrollable stressor can increase brain norepinephrine (NE) turnover and decrease locomotor and exploratory behavior. We examined the ability of exogenous tyrosine, NE's amino acid precursor, to protect rats from developing these neurochemical and behavioral changes when stressed. Anim...

journal_title：Life sciences

authors： Reinstein DK,Lehnert H,Scott NA,Wurtman RJ

更新日期：1984-06-04 00:00:00

abstract：:Actinomycin D was found to block binding of a monoclonal antibody to nucleolar phosphoprotein 37/5.2 (B23) when incubated either simultaneously with or prior to addition of the antibody. Daunorubicin had no significant blocking activity of this antigen-antibody reaction. In comparative studies with a monoclonal antibo...

journal_title：Life sciences

authors： Busch RK,Chan PK,Busch H

更新日期：1984-10-22 00:00:00

abstract：:The presence of met5-enkephalin-arg6-phe7 (YGGFMRF) and opiate receptors in rat, guinea pig and human lung was investigated with specific and sensitive radio immuno- and radio-receptor assays. 1) High and low molecular weight YGGFMRF-like immunoreactivity were detected in lung extracts using Bio-Gel P-2 column chromat...

journal_title：Life sciences

authors： Tang J,Chou J,Zhang AZ,Yang HY,Costa E

更新日期：1983-05-16 00:00:00

abstract：AIMS:Several lines of evidence support the hypothesis that the oxidation of low density lipoprotein (LDL) may play a crucial role in the initiation and progression of atherosclerosis. Various studies have shown a positive effect of antioxidant compounds on oxidative modification of LDL and atherogenesis. In view of thi...

journal_title：Life sciences

authors： de Lima Portella R,Barcelos RP,de Bem AF,Carratu VS,Bresolin L,da Rocha JB,Soares FA

更新日期：2008-12-19 00:00:00

abstract：:Ornithine decarboxylase (ODC) activity increases during many growth responses. Some cells and tissues in culture also exhibit elevated enzyme activity with decreasing osmolality of the culture medium. We have found that this also occurs with uterine tissue from ovariectomized rats. Organ culture incubation under hypot...

journal_title：Life sciences

authors： Webster RA,Zaloudek CJ,Inman BC

更新日期：1984-03-26 00:00:00

abstract：:The beta adrenoceptor antagonist radioligand [3H] dihydroalprenolol (DHA) has been used to characterise beta adrenoceptors in membranes prepared from rat renal glomeruli. Association of the ligand was rapid and had reached equilibrium within 10 mins at 37 degrees C. Dissociation occurred in two distinct phases, a rapi...

journal_title：Life sciences

authors： McPherson GA,Summers RJ

更新日期：1983-07-04 00:00:00

abstract：:Homocysteine (Hcy), an intermediate in methionine metabolism, has been proposed to be involved in hepatic fibrogenesis. Impaired liver function can alter Hcy metabolism. The aim of the present study was to determine plasma Hcy alterations in acute obstructive cholestasis and the subsequent biliary cirrhosis. Cholestas...

journal_title：Life sciences

authors： Ebrahimkhani MR,Sadeghipour H,Dehghani M,Kiani S,Payabvash S,Riazi K,Honar H,Pasalar P,Mirazi N,Amanlou M,Farsam H,Dehpour AR

更新日期：2005-04-08 00:00:00

abstract：:Two alpha-adrenoceptor antagonists, phentolamine and 2-(beta-(4-hydroxyphenyl)-ethylaminomethyl)-tetralone (BE 2254) which are phenolic derivatives were radioiodinated after chloramine-T oxidation of Na125I and the labelled material isolated by chromatography. 125I-phentolamine does not bind selectively to alpha-adren...

journal_title：Life sciences

authors： Adams A,Jarrott B

更新日期：1982-03-15 00:00:00

abstract：AIMS:In this study, we used a cross-junction microfluidic device for preparation of alendronate-loaded chitosan nanoparticles with desired characteristics to introduce a suitable element for bone tissue engineering scaffolds. MAIN METHODS:By controlling the reaction condition in microfluidic device, six types of alend...

journal_title：Life sciences

authors： Moradikhah F,Doosti-Telgerd M,Shabani I,Soheili S,Dolatyar B,Seyedjafari E

更新日期：2020-08-01 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：:The effects of nineteen AHPA* derivatives were examined on morphine analgesia by tail-flick test in rats and on enkephalinase inhibition which was based on the formation of tyrosyl-glycyl-glycine from met-enkephalin. The correlation between the enhancement of morphine analgesia in vivo and enkephalinase inhibition in ...

journal_title：Life sciences

authors： Hachisu M,Nakamura T,Kawashima H,Shitoh K,Fukatsu S,Koeda T,Sekizawa Y,Munakata M,Kawamura K,Umezawa H,Takeuchi T,Aoyagi T

更新日期：1982-05-17 00:00:00

abstract：:The present study is undertaken to investigate whether the phospholipase A(2) (PLA(2)) influences mRNA nucleocytoplasmic transport evaluated by nucleoside triphosphatase (NTPase) activity and mRNA export in isolated hepatic nuclear envelope. Isolated hepatic nuclei from rat liver were exposed to PLA(2) (10(-5) approxi...

journal_title：Life sciences

authors： Li JX,Li ZQ,Pang YZ,Tang CS

更新日期：2003-07-11 00:00:00

abstract：:The analgesic buprenorphine hydrochloride (Bph) induced apoptosis-like cell death in the caspase-3-deficient human breast cancer cell line, MCF-7. This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6. Bph caused the release of ...

journal_title：Life sciences

authors： Kugawa F,Matsumoto K,Aoki M

更新日期：2004-06-04 00:00:00

abstract：AIMS:To better understand mechanisms whereby Ajulemic acid (AjA), a synthetic antiinflammatory cannabinoid, promotes resolution of acute and chronic inflammation in animal models, we investigated its influence on cyclooxygenase 2 (COX2) expression and eicosanoid production in human fibroblast-like synovial cells (FLS)....

journal_title：Life sciences

authors： Stebulis JA,Johnson DR,Rossetti RG,Burstein SH,Zurier RB

更新日期：2008-11-07 00:00:00

abstract：:We determined whether two naturally occurring steroids, cortisol and 17beta-estradiol (E2), can rapidly modulate the activity of an important membrane protein, human erythrocyte (RBC) Na+,K+-ATPase, an enzyme that does not bind either hormone directly. We also determined the membrane binding locations for cortisol and...

journal_title：Life sciences

authors： Golden GA,Mason RP,Tulenko TN,Zubenko GS,Rubin RT

更新日期：1999-01-01 00:00:00

abstract：:Sphinganine (SP) pre-treatment potentiated the retinoic acid (RA)-induced (4-96h exposures) differentiation and increase of alkaline phosphatase (ALP) activity. A higher percentage of SP pre-treated cells in RA exposures resembled mature myelocytes or granulocytes; greater increase in ALP activity was observed. In cel...

journal_title：Life sciences

authors： Wei LL,Hui EK,Wei JS,Tzeng WF,Yung BY

更新日期：1993-01-01 00:00:00

abstract：:Previously we have reported a decreased GABAB receptor expression in brain of spontaneously hepertensive rats (SHR). Moreover, decreased receptor numbers were accompanied by depressed stimulation of cAMP formation. We have now quantified Gi alpha protein by immunoblotting in cerebral membranes from 11-week-old normote...

journal_title：Life sciences

authors： Ichida T,Takeda K,Sasaki S,Nakagawa M,Kuriyama K

更新日期：1996-01-01 00:00:00

abstract：AIM:The present study aimed to understand the relationship between pharmacological activation of mGlu4 receptors and regulation of its gene in the hippocampus. MAIN METHODS:The expression level of the GRM4 gene, encoding mGluR4 receptors, was studied in the hippocampus and frontal cortex of rats after pharmacological ...

journal_title：Life sciences

authors： Pershina EV,Arkhipov VI

更新日期：2016-05-15 00:00:00

abstract：:The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely us...

journal_title：Life sciences

authors： Sadeghi S,Soudi S,Shafiee A,Hashemi SM

更新日期：2020-12-01 00:00:00

abstract：:Addition of synthesized atriopeptin II (AP-2), a 23 amino acid peptide of rat atria, to rat thoracic aorta smooth muscle cells results in the stimulation of cyclic GMP production by the cells. The EC50 for the effect is 81 nM and a 7 fold increase occurs at 10 microM AP-2. Cyclic GMP levels increased within 15 seconds...

journal_title：Life sciences

authors： Harris DW,Baker CA,Saneii HH,Johnson GA

更新日期：1985-08-19 00:00:00