Abstract：
:Exposure of rats to an acute, uncontrollable stressor can increase brain norepinephrine (NE) turnover and decrease locomotor and exploratory behavior. We examined the ability of exogenous tyrosine, NE's amino acid precursor, to protect rats from developing these neurochemical and behavioral changes when stressed. Animals pretreated with saline or tyrosine (200 mg/kg, i.p.) were subjected to tail shock (15 v, 2 mA, 5 sec/30 sec) or to no shock during a 60-min period. Exposure to shock depleted NE and increased its turnover [as indicated by altered NE and 3-methoxy-4-hydroxy-phenylene-glycol sulfate levels (MHPG-SO4)] within the locus coeruleus, the hippocampus and the hypothalamus. Behavioral deficits were observed using measures of locomotion, standing on hind legs, and hole-poking in an open-field apparatus. Animals given tyrosine before shock displayed neither shock-induced NE depletion nor the deficits in locomotion and hole-poking; brain MHPG-SO4 levels tended to be greater than after shock alone. These observations suggest that the stress caused NE to be released from some neurons more rapidly than it could be restored by synthesis or reuptake, thereby impairing noradrenergic transmission and NE-dependent exploratory behaviors. Tyrosine administration presumably enhanced the transmitter's synthesis in stressed animals, thereby preventing both the neurochemical and the behavioral deficits.
journal_name
Life Scijournal_title
Life sciencesauthors
Reinstein DK,Lehnert H,Scott NA,Wurtman RJdoi
10.1016/0024-3205(84)90209-1subject
Has Abstractpub_date
1984-06-04 00:00:00pages
2225-31issue
23eissn
0024-3205issn
1879-0631pii
0024-3205(84)90209-1journal_volume
34pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:Memory impairment induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) in rats is associated with impaired brain glucose and energy metabolism, oxidative stress and impaired cholinergic neurotransmission. Treatment with antioxidants and cholinergic agonists has been reported to produce beneficial...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2006.07.018
更新日期：2006-11-02 00:00:00
abstract：AIM:Myocardial infarction (MI), an important cause of morbidity and mortality, can be followed by left ventricular dysfunction and cardiomyocyte loss. Cardiac repair mechanisms may subsequently improve left ventricular function. Exercise training has been suggested to have cardioprotective effects against MI damage, bu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.02.045
更新日期：2019-03-15 00:00:00
abstract：AIMS:Extensive evidence supports a role for voltage-gated calcium channels (VGCC) and TRPV1 receptors in pain transmission and modulation. We investigated the profile of analgesic interaction between Phα1β toxin (a VGCC blocker) and SB366791 (selective TRPV1 antagonist) in a model of acute pain induced by capsaicin. Ch...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.06.018
更新日期：2017-08-01 00:00:00
abstract：AIMS:The mechanism of cough hypersensitivity induced by particulate matter 2.5 (PM2.5) remains elusive. The current study was designed to explore the effect of transient receptor potential vanilloid-1 (TRPV1) on cough hypersensitivity in airway and central nervous system. MAIN METHODS:The PM2.5-induced chronic cough m...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.02.064
更新日期：2016-04-15 00:00:00
abstract：AIMS:A growing body of evidence shows the cardiovascular benefits of fish oil ingredients, including eicosapentaenoic acid (EPA), in humans and experimental animals. However, the effects of EPA on endothelin (ET)-1-induced cardiomyocyte hypertrophy and the involved signaling cascade are largely unknown. A previous stud...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.04.025
更新日期：2014-11-24 00:00:00
abstract：:Linear sucrose density gradient centrifugation of a crude synaptosomal-mitochondrial preparation of rat striatum was performed at 82,500g for 7.5, 15 and 30 min and 1, 4 and 20 h. After centrifugation various marker enzyme activities were measured throughout the gradients, viz. tyrosine hydroxylase (TH) and DOPA decar...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90248-5
更新日期：1983-08-15 00:00:00
abstract：AIM:We previously reported the possible involvement of mucosal nitric oxide (NO)-triggered 5-HT release in luminal glutamate sensing by the gastric vagus nerve, and we proposed that the stomach, like the duodenum, could "taste" luminal nutrients. Nitric oxide synthase (NOS) is widely distributed in the gastric mucosa, ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2009.10.009
更新日期：2009-12-16 00:00:00
abstract：AIMS:Head and neck squamous cell carcinoma (HNSCC) is an highly aggressive tumor with heterogeneous prognosis. We here report that immune-related genes (IRGs) could effectively distinguish prognostically different HNSCC patients. MATERIALS AND METHODS:MRNA levels of 1333 IRGs that from ImmPort database in HNSCC sample...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117906
更新日期：2020-09-01 00:00:00
abstract：AIMS:GnRH-DFF40 (gonadotropin releasing hormone-DNA fragmentation factor 40) humanized recombinant immunotoxin serves as a prospective candidate for targeted therapy of malignancies with over-expressed gonadotropin releasing hormone receptor (GnRHR). In this study, we attempted to generate a GnRH-based chimeric protein...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118866
更新日期：2021-01-15 00:00:00
abstract：AIMS:We elucidated the therapeutic potential of human umbilical vein endothelial cells (HUVECs) for ameliorating progressive heart failure in a myocardial infarction (MI) rat model. MAIN METHODS:MI was induced by ligation of left anterior descending artery, and HUVEC was transplanted 1week after MI. Cardiac function w...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2014.02.009
更新日期：2014-04-17 00:00:00
abstract：AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.03.053
更新日期：2016-05-01 00:00:00
abstract：:The effect of gamma-aminobutyric acid (GABA) on the binding of PK 8165, a quinoline derivative, and CGS 8216, a pyrazoloquinoline, was assessed in two different regions of the rat brain. PK 8165, a compound with reported anxiolytic properties, inhibited [3H]-propyl beta-carboline-3-carboxylate labeled receptors in the...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90403-9
更新日期：1982-07-05 00:00:00
abstract：:Testosterone propionate, cortisone, or sesame oil vehicle were given to rats during the last week of pregnancy so that effects of the hormones on anogenital distance, breeding capacity and vaginal opening of the female progeny could be contrasted. Testosterone significantly increased anogenital distance and delayed va...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90248-n
更新日期：1992-01-01 00:00:00
abstract：:The phenomenon has raised the concerns about the safety of an extended manned mission into deep space due to the high potential for exposure to high-LET radiation during space missions. Heavy ions such as (56)Fe are main radiation sources in deep space, which could pose a significant hazard to space flight crews durin...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.05.043
更新日期：2016-07-15 00:00:00
abstract：AIM:Ischemia/reperfusion (I/R) injury is the major cause of neurological deficit following stroke. Our previous study showed neuroprotective effects of hispidulin against cerebral ischemia reperfusion injury (IRI). In this study, we further examined the involvement of pyroptosis in this neuroprotective function. MATER...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116599
更新日期：2019-09-01 00:00:00
abstract：AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.07.011
更新日期：2011-09-12 00:00:00
abstract：:Microiontophoretic study was performed to elucidate dopaminergic mechanism in the nucleus accumbens (Acc) of rats anesthetized with chloral hydrate. Iontophoretically applied dopamine produced an inhibition of glutamate-induced firing in 28 (62%) out of 45 Acc neurons tested. The dopamine-induced inhibition of 14 Acc ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90356-9
更新日期：1983-06-06 00:00:00
abstract：:Opiate antagonists have been shown to reliably attenuate drinking behavior. Recent research points to a central site of action for this antidipsogenic effect. To pursue this issue of site specificity, naloxone, a specific opiate antagonist, was delivered into a number of discrete subcortical areas in 23 hour water-dep...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(83)90786-5
更新日期：1983-08-22 00:00:00
abstract：:SR 142801 is the first potent and selective non-peptide antagonist of the tachykinin NK3 receptor. It inhibited [MePhe7]NKB binding to its receptor from various species, including humans. SR 142801 was a competitive antagonist of [MePhe7]NKB-mediated contractions of guinea-pig ileum and inhibited the acetylcholine rel...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(94)00413-m
更新日期：1995-01-01 00:00:00
abstract：:Recent evidence suggests that the Type 1 opiate receptor (in rat striatal patches) is a mobile receptor which is able to adopt a mu, delta, or kappa opiate receptor ligand selectivity pattern under appropriate conditions. In this paper, we have investigated such a possibility for Type 2 opiate receptors which are visu...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90183-7
更新日期：1982-10-18 00:00:00
abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.09.023
更新日期：2005-02-25 00:00:00
abstract：:Ocimum sanctum, the Indian holy basil, has significant ability to scavenge highly reactive free radicals. Shade dried leaf powder of the plant was extracted with water and alcohol, and then fractionated with different solvents. Both extracts and their fractions have in vitro anti-lipidperoxidative activity at very low...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2004.05.036
更新日期：2004-11-19 00:00:00
abstract：:This experiment was designed to assess the role of the septo-hippocampal cholinergic (ACh) system in the deleterious effects produced by systemic benzodiazepine injection on learning processes in rats. Retention of a step through passive avoidance task was analysed after systemic injection of increasing doses of eithe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00092-2
更新日期：1999-01-01 00:00:00
abstract：:Fissistigma oldhamii (Hemsl.) Merr [F. oldhamii], a traditional Chinese herb medicine, is widely used for treating rheumatoid arthritis (RA) in China. Following bioactivity-guided isolation, a representative immunosuppressive compound with low cytotoxicity, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenam...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.10.004
更新日期：2007-12-14 00:00:00
abstract：AIMS:Although approving new anticonvulsants was a major breakthrough in the field of epilepsy control, so far we have met limited success in almost one third of patients suffering from epilepsy and a definite and reliable method is yet to be found. Levosimendan demonstrated neuroprotective effects and reduced mortality...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2016.11.006
更新日期：2017-01-01 00:00:00
abstract：:New types of alpha1-adrenoceptor antagonists (tamsulosin, KMD-3213 and JTH-601) are currently receiving a great deal of attention, especially in terms of developing effective therapeutic agents to treat bladder outlet obstruction with less side effects, such as postural hypotension, in patients with benign prostatic h...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(98)00111-8
更新日期：1998-01-01 00:00:00
abstract：:The plasma concentration of the dopamine (DA) metabolite, homovanillic acid (HVA), is used as an indicator of central nervous system dopaminergic activity. Using percutaneously inserted catheters we were able to obtain blood samples simultaneously from the right and left internal jugular veins. Veno-arterial HVA plasm...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90593-z
更新日期：1991-01-01 00:00:00
abstract：AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2011.04.010
更新日期：2011-06-20 00:00:00
abstract：:Retinoic acids and their cognate nuclear receptors exert a substantial regulatory role in cell growth and development as well as in the neuroendocrine system. These effects are primarily mediated by all-trans retinoic acid receptors (RARs), members of the steroid/thyroid hormone receptor superfamily of ligand inducibl...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(00)00496-3
更新日期：2000-03-24 00:00:00
abstract：:Immunoreactive (ir) beta-endorphin (b-END) and dynorphin (DYN) in rat brain and pituitary were measured after food and water deprivation and from brains taken during either day or night. In other rats, eating and drinking were measured following lesions in the arcuate n. Ir-DYN levels are higher in hypothalamus and lo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(82)90221-1
更新日期：1982-10-18 00:00:00
