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Nitric oxide-active compounds modulate the intensity of glutamate-evoked responses in the globus pallidus of the rat.

Abstract：

AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG), a NO donor, and Nω-nitro-l-arginine methyl ester (L-NAME), a NOS inhibitor. KEY FINDINGS:Most GP cells were excited by SNOG whereas administration of L-NAME induced decrease of GP neurons activity. Nearly all neurons responding to SNOG and/or L-NAME showed significant modulation of their excitatory responses to the administration of iontophoretic GLU. In these cells, the changes induced by NO-active drugs in the magnitude of GLU-evoked responses were used as indicators of NO modulation. In fact, when a NO-active drug was co-iontophoresed with GLU, significant changes in GLU-induced responses were observed: generally, increased magnitudes of GLU-evoked responses were observed during SNOG ejection, whereas the administration of L-NAME decreased responses to GLU. SIGNIFICANCE:The results suggest that the NO-active drugs modulate the response of GP neurons to glutamatergic transmission. Nitrergic modulation of glutamatergic transmission could play an important role in the control of GP bioelectric activity, considered a fundamental key in the BG function.

journal_name

Life Sci

journal_title

Life sciences

authors

Sardo P,Carletti F,Rizzo V,Lonobile G,Friscia S,Ferraro G

doi

10.1016/j.lfs.2011.04.010

subject

Has Abstract

pub_date

2011-06-20 00:00:00

pages

1113-20

issue

25-26

eissn

0024-3205

issn

1879-0631

pii

S0024-3205(11)00193-7

journal_volume

88

pub_type

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