Effect of exogenous ascorbic acid intake on biosynthesis of ascorbic acid in mice.

abstract：:A review of the rapidly accumulating data in the literature continues to support the notion that catecholamines regulate ovarian function, and extends the complexity of catecholaminergic effects on the ovary via interactions with pituitary and adrenal hormones. It is clear that catecholamines affect growth and differe...

journal_title：Life sciences

authors： Spicer LJ

更新日期：1986-11-10 00:00:00

abstract：:Gluten exorphin B5 (GE-B5) is a food-derived opioid peptide identified in digests of wheat gluten. We have recently shown that GE-B5 stimulates prolactin (PRL) secretion in rats; this effect is abolished by preadministration of the opioid receptor antagonist naloxone. However, since the structure of naloxone allows it...

journal_title：Life sciences

authors： Fanciulli G,Dettori A,Demontis MP,Tomasi PA,Anania V,Delitala G

更新日期：2005-02-25 00:00:00

abstract：:The aim of the present work was to study the effects of various durations of fasting (12, 24 and 72 hours) on brown adipose tissue (BAT) thermogenic parameters--cytrochrome-c-oxidase (COX) activity, GDP-binding activity and uncoupling protein (UCP1) content--and also on morphological features of different mitochondria...

journal_title：Life sciences

authors： Gianotti M,Clapés J,Lladó I,Palou A

更新日期：1998-01-01 00:00:00

abstract：AIMS:The purpose of this study was to determine a relatively short-term effect of feeding an α-linolenic acid (ALA, n-3)-restricted, linoleic acid (LA, n-6)-adequate diet on neurotrophin contents and protein kinase activities in brain regions of the mouse. MAIN METHODS:After feeding mice a safflower oil (SAF) diet (AL...

journal_title：Life sciences

authors： Miyazawa D,Yasui Y,Yamada K,Ohara N,Okuyama H

更新日期：2010-10-09 00:00:00

abstract：:Stem cells have potential to develop into numerous cell types, thus they are good cell source for tissue engineering. As an external physical signal, material stiffness is capable of regulating stem cell fate. Biomaterial stiffness is an important parameter in tissue engineering. We summarize main measurements of mate...

journal_title：Life sciences

authors： Lv H,Wang H,Zhang Z,Yang W,Liu W,Li Y,Li L

更新日期：2017-06-01 00:00:00

abstract：:Cancer cachexia characterized by a chronic wasting syndrome, involves skeletal muscle loss and adipose tissue loss and resistance to conventional nutritional support. Cachexia is responsible for the reduction in quality and length of life of cancer patients. It also decreases the muscle strength of the patients. The p...

journal_title：Life sciences

authors： Patel HJ,Patel BM

更新日期：2017-02-01 00:00:00

abstract：:The adverse effects of prenatal nicotine and alcohol exposure on human reproductive outcomes are a major scientific and public health concern. In the United States, substantial percentage of women (20-25%) of childbearing age currently smoke cigarettes and consume alcohol, and only a small percentage of these individu...

journal_title：Life sciences

authors： Bhattacharya D,Majrashi M,Ramesh S,Govindarajulu M,Bloemer J,Fujihashi A,Crump BR,Hightower H,Bhattacharya S,Moore T,Suppiramaniam V,Dhanasekaran M

更新日期：2018-02-01 00:00:00

abstract：:Danshen, a Chinese herbal medicine has been widely used for the treatment of cardiovascular diseases. Magnesium tanshinoate B (MTB) is an active compound purified from Danshen. The objective of this study was to investigate the effect of MTB on the susceptibility of low density lipoproteins (LDL) to oxidative modifica...

journal_title：Life sciences

authors： O K,Lynn EG,Vazhappilly R,Au-Yeung KK,Zhu DY,Siow YL

更新日期：2001-01-12 00:00:00

abstract：:Phospholipase C (PLC), an enzyme involved in the hydrolysis of membrane phospholipid- phosphatidylinositol-bisphosphate to inositol triphosphate and diacylglycerol, and Phorbol 12, myristate 13, acetate (PMA), a tumor promoting agent, could significantly stimulate testosterone (T) secretion from Leydig cells. Arachido...

journal_title：Life sciences

authors： Didolkar AK,Sundaram K

更新日期：1987-07-27 00:00:00

abstract：:Alzheimer's disease (AD) as a dementia and neurodegenerative disease, is mostly prevalent among people more than 65 years. AD is mostly manifested in the form of degraded mental function, such as losing memory and impaired cognitive function. Due to inefficiency of traditional pharmacological therapeutic approaches wi...

journal_title：Life sciences

authors： Chakari-Khiavi F,Dolati S,Chakari-Khiavi A,Abbaszadeh H,Aghebati-Maleki L,Pourlak T,Mehdizadeh A,Yousefi M

更新日期：2019-08-15 00:00:00

abstract：:We determined by PCR the number of (A-C)n repeats in the 2. 1 kb upstream of the aldose reductase (AR2) gene in healthy control subjects and in patients with NIDDM in Japanese. Sixty-one patients were recruited based on the severity of retinopathy and subdivided into two groups with proliferative retinopathy and witho...

journal_title：Life sciences

authors： Ikegishi Y,Tawata M,Aida K,Onaya T

更新日期：1999-01-01 00:00:00

abstract：:This study was performed in order to investigate the type of T cells recruited to the blood in response to an acute bout of exercise with regard to mean lengths of telomeric terminal restriction fragments (TRF) and surface activation markers and with special emphasis on age-associated differences. Ten elderly and ten ...

journal_title：Life sciences

authors： Bruunsgaard H,Jensen MS,Schjerling P,Halkjaer-Kristensen J,Ogawa K,Skinhøj P,Pedersen BK

更新日期：1999-01-01 00:00:00

abstract：AIMS:The present study aimed to verify changes in cerebellar and plasmatic expression of miRNAs after the chronic consumption of ethanol and caffeine in the UChB rat, an experimental model for alcoholism. MATERIAL AND METHODS:Male rats at 5 months of age, were divided into the following groups (n = 10/group): 1. Ethan...

journal_title：Life sciences

authors： Rossetto IMU,Cagnon VHA,Lizarte FSN,Tirapelli LF,Tirapelli DPC,Arantes RMS,Chuffa LGA,Martinez FE,Martinez M

更新日期：2019-07-15 00:00:00

abstract：:Metalloproteinases (MMP), particularly MMP-9 produced by the intratumor monocyte/macrophages, play an important role in tumor invasion and metastases. Recent clinical trials in patients with primary breast cancer suggest that bisphosphonates (BP), above all clodronate, may reduce bone metastases. The aim of the presen...

journal_title：Life sciences

authors： Valleala H,Hanemaaijer R,Mandelin J,Salminen A,Teronen O,Mönkkönen J,Konttinen YT

更新日期：2003-09-26 00:00:00

abstract：:A fostering/crossfostering analysis of the effects of maternal ethanol exposure on jejunal and ileal folate absorption was performed. Male and female rats were randomized into two groups. In the first group, ethanol-treated rats received ad libitum 5, 10 and 15% ethanol in the drinking fluid during three successive we...

journal_title：Life sciences

authors： Murillo-Fuentes ML,Murillo ML,Carreras O

更新日期：2003-09-12 00:00:00

abstract：:Phenylephrine effect on liver and kidney cortex mitochondrial pyruvate concentration was investigated. While in liver the alpha 1-adrenergic agent produced a decrease in pyruvate content, a significant increase was observed in kidney, even in the presence of 0.5 mM alpha-cyano-4-hydroxy-cinnamate. These changes were n...

journal_title：Life sciences

authors： Oliver J,Sola MM,Salto R,Vargas AM

更新日期：1990-01-01 00:00:00

abstract：:Low pH medium has been shown to activate the 'efferent' function of capsaicin-sensitive primary sensory neurons. Calcitonin gene-related peptide (CGRP) is released from capsaicin-sensitive afferents of guinea-pig superior sagittal and transverse sinuses (SSTS), by capsaicin or bradykinin. Here, we report that low pH m...

journal_title：Life sciences

authors： Fanciullacci M,Tramontana M,Del Bianco E,Alessandri M,Geppetti P

更新日期：1991-01-01 00:00:00

abstract：:An improved two-dimensional HPTLC procedure was developed for separating phospholipids including individual phosphoinositides, phosphatidic acids and plasmalogens. This procedure was used to examine the time course for uptake of label by phospholipids in brain subcellular membranes after intracerebral injection of [ga...

journal_title：Life sciences

authors： Sun GY,Lin TN

更新日期：1989-01-01 00:00:00

abstract：:The [R] and [S] enantiomers of the enkephalinase A inhibitor [R,S]-thiorphan have been prepared by asymmetric synthesis. The [S] isomer is principally responsible for the angiotensin converting enzyme inhibitory activity of [R,S]-thiorphan, whereas there were only small differences in the ability of the [R] and [S] is...

journal_title：Life sciences

authors： Scott WL,Mendelsohn LG,Cohen ML,Evans DA,Frederickson RC

更新日期：1985-04-01 00:00:00

abstract：AIM:Despite recent advances in therapeutic strategies, cancer is still a leading cause of mortality worldwide. Mitochondrial dysfunction is implicated in cancer initiation and metastasis, and even in chemo- and radio-resistance. However, the precise role of mitochondria in cancer is crosstalk and controversial. This st...

journal_title：Life sciences

authors： Kheirandish-Rostami M,Roudkenar MH,Jahanian-Najafabadi A,Tomita K,Kuwahara Y,Sato T,Roushandeh AM

更新日期：2020-03-01 00:00:00

abstract：:The nonsteroidal anti-inflammatory drug zomepirac (ZP) is metabolised to a chemically reactive acyl glucuronide conjugate (ZAG) which can form covalent adducts with proteins. In vivo, such adducts could initiate immune or toxic responses. In rats given ZP, the major band detected in liver homogenates by immunoblotting...

journal_title：Life sciences

authors： Wang M,Gorrell MD,McGaughan GW,Dickinson RG

更新日期：2001-01-05 00:00:00

abstract：:It has been shown that some cytochrome P450-dependent enzyme activities could present daily fluctuations, particularly CYP3A isoenzymes which are enhanced during the dark period. The aim of this study was to investigate whether age and photoperiodic conditions at different circadian stages could influence these fluctu...

journal_title：Life sciences

authors： Martin C,Dutertre-Catella H,Radionoff M,Debray M,Benstaali C,Rat P,Thevenin M,Touitou Y,Warnet JM

更新日期：2003-06-06 00:00:00

abstract：:Since the discovery of leptin in 1994 by Zhang et al., there have been a number of reports showing its implication in the development of a wide range of cardiovascular diseases. However, there exists some controversy about how leptin can induce or preserve cardiovascular function, as different authors have found contr...

journal_title：Life sciences

authors： Feijóo-Bandín S,Portolés M,Roselló-Lletí E,Rivera M,González-Juanatey JR,Lago F

更新日期：2015-11-01 00:00:00

abstract：:The purpose of this study was to investigate the effect of T3 on amino acid accumulation and on the membrane potential of Sertoli cells of immature rat testes. Testes of pre-pubertal and pubertal rats were pre-incubated (30 min) in Krebs-Ringer bicarbonate buffer and incubated in the presence of [14C]methylaminoisobut...

journal_title：Life sciences

authors： Silva FR,Leite LD,Barreto KP,D'Agostini C,Zamoner A

更新日期：2001-07-13 00:00:00

abstract：:The objective of this study was to understand the mechanism of action of nitric oxide (NO) in the heart by determining whether nitric oxide (NO) released from sodium nitroprusside (SNP) induces p38 mitogen activated protein kinase (p38 MAPK) phosphorylation and whether this is mediated through a cyclic GMP (cGMP)/prot...

journal_title：Life sciences

authors： Rabkin SW,Klassen SS,Tsang MY

更新日期：2007-08-02 00:00:00

abstract：:The beta-endorphin, met5-enkephalin-arg6-phe7 (MEAP) and met5-enkephalin (ME) changes related to age and diurnal rhythms were studied in various regions of rat brain and in the pituitary by specific radioimmunoassays. The contents of MEAP, met5-enkephalin and beta-endorphin were higher in the pituitary of old rats (18...

journal_title：Life sciences

authors： Tang F,Tang J,Chou J,Costa E

更新日期：1984-08-27 00:00:00

abstract：AIMS:To determine whether ginsenoside Rg1 is involved in scratch wound healing through altered expression of related molecules in astrocytes and improved functional recovery after spinal cord injury (SCI). MATERIALS AND METHODS:Astrocytes were isolated from rats, followed by Rg1 treatment. The wound healing test was p...

journal_title：Life sciences

authors： Xu L,Tang YY,Ben XL,Cheng MH,Guo WX,Liu Y,Lu ZF,Deng JL

更新日期：2020-07-01 00:00:00

abstract：AIMS:The aim of this study is to investigate the expression and cytoprotective function of a 72-kDa heat shock protein (HSP72) using a reflux esophagitis model in rats. MAIN METHODS:Expression of HSP60, HSP72, and HSP90 in rat esophageal mucosa was evaluated by Western blot analysis before and after hyperthermia (42.5...

journal_title：Life sciences

authors： Izumi Y,Otaka M,Takahashi T,Takada M,Shimada Y,Asaoka D,Nagahara A,Itoh H,Watanabe S

更新日期：2009-04-10 00:00:00

abstract：:This study was conducted to investigate SAFB-induced apoptosis of mast cells as it pertains to both its basic drug mechanism and the potential therapeutics of the pathologic conditions accompanying mast cell proliferation. SAFB induced many apoptotic manifestations as evidenced by changes in cell morphology, generatio...

journal_title：Life sciences

authors： Park HI,Jeong MH,Lim YJ,Park BS,Kim GC,Lee YM,Kim HM,Yoo KS,Yoo YH

更新日期：2001-06-22 00:00:00

abstract：:After their discovery, the two known cannabinoid receptors, CB(1) and CB(2), have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G(i/o) proteins, negatively modulate cyclic AMP levels, and ac...

journal_title：Life sciences

authors： Demuth DG,Molleman A

更新日期：2006-01-02 00:00:00