Abstract：
:Proteinase inhibitors were tested for their ability to inhibit prolactin (PRL) and growth hormone (GH) release by cultured anterior pituitary cells of the rat. Inhibitors of microbial origin (chymostatin, elastatinal, leupeptin) had either no or a moderate effect on hormone release while some tripeptide aldehydes, especially those with lysine at their C terminus, inhibited markedly PRL and to a lesser extent GH release. Boc-DPhe-Phe-lysinal was the most effective on lactotrophs inhibiting PRL release more than 50% at 10(-4) M. The site(s) of action of tripeptide aldehydes remain to be elucidated.
journal_name
Life Scijournal_title
Life sciencesauthors
Rappay G,Makara GB,Bajusz S,Nagy Idoi
10.1016/0024-3205(85)90636-8subject
Has Abstractpub_date
1985-02-11 00:00:00pages
549-55issue
6eissn
0024-3205issn
1879-0631pii
0024-3205(85)90636-8journal_volume
36pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract：:We report the presence of p-fluorophenylglycine (p-FPG) in the urine of six baboons treated with HPTP, the tetrahydropyridine dehydration product of haloperidol (HP). Oxidative N-dealkylation, the major metabolic pathway of HP, gives rise to 3-(4-fluorobenzoyl)propionic acid (p-FBPA). Subsequent beta-oxidation of p-FB...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00274-x
更新日期：1999-01-01 00:00:00
abstract：AIMS:Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. However, the underlying molecular mechanism...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2019.116966
更新日期：2019-12-15 00:00:00
abstract：AIMS:Reactive oxygen species (ROS) are generated in the ischaemic myocardium especially during early reperfusion and affect myocardial function and viability. Monoterpenes have been proposed to play beneficial roles in diverse physiological systems; however, the mechanisms of action remain largely unknown. This study a...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2017.01.008
更新日期：2017-03-01 00:00:00
abstract：AIMS:Data suggest pharmacological treatment of depression with selective serotonin reuptake inhibitors (SSRI) may impair bone health. Our group has previously modeled compromised craniofacial healing after treatment with sertraline, a commonly prescribed SSRI, and hypothesized potential culprits: alterations in bone ce...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.117827
更新日期：2020-08-15 00:00:00
abstract：:Carbachol (CCH), serotonin (5HT), divalent ionophore A23187, cAMP, and certain neuropeptides, i.e. substance P (SP), inhibit the initial rate of uptake (influx) of 22Na into isolated chicken villus enterocytes. All these agents also increase cytosolic Ca. However, the increases stimulated by CCH, 5HT, and cAMP are not...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(90)90506-m
更新日期：1990-01-01 00:00:00
abstract：:The role of p44/42 mitogen-activated protein kinase (MAPK) in the expression of intercellular adhesion molecule-1 (ICAM-1) in NCI-H292 cells, a human bronchial epithelial cell line, was analyzed. Treatment with the protein kinase C (PKC) activator 12-O-tetradecanoylphorbol 13-acetate (TPA) (16.2 nM) or interferon-gamm...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2003.12.016
更新日期：2004-06-11 00:00:00
abstract：:The potencies of several opioid agonists are reduced in diabetic animals and in animals made hyperglycemic via injections of glucose. In this report we examined the effects of streptozotocin-induced diabetes on the feeding responses to centrally administered opioid agonists with differing receptor selectivities. The s...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(89)90432-3
更新日期：1989-01-01 00:00:00
abstract：AIMS:Wistar-Kyoto rats (HA-WKY) kept in the author's laboratory showed higher levels of serum adiponectin (approximately 4-fold) compared with Wistar-Kyoto/Izm rats (WKY/Izm), a WKY standard strain, at 6weeks old. In a preliminary study, HA-WKY but not WKY/Izm showed hyperinsulinemia and severe hypercholesterolemia whe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2010.01.003
更新日期：2010-02-27 00:00:00
abstract：:Deficiencies in cellular cyclic AMP (cAMP) and nitric oxide (NO) production are thought to be involved in the pathogenesis of diabetic neuropathy. We used a human neuroblastoma cell line, SH-SY5Y, to investigate the effect of cilostazol, a specific cAMP phosphodiesterase inhibitor, on NO production and Na+, K+-ATPase ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00379-3
更新日期：1999-01-01 00:00:00
abstract：:Multiple classes of cell surface receptors and ion channels participate in the detection of changes in environmental stimuli, and thereby influence animal behavior. Among the many classes of ion channels, Transient Receptor Potential (TRP) cation channels are notable in contributing to virtually every sensory modality...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2012.07.029
更新日期：2013-03-19 00:00:00
abstract：:To evaluate the relative contributions of the ovarian inhibin and estradiol-17 beta (E) on the regulation of FSH secretion, inhibin and E in ovarian venous plasma (OVP) and FSH and LH in peripheral plasma were simultaneously measured using superovulating rats with special reference to follicular maturation. By the tra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(86)90445-5
更新日期：1986-07-14 00:00:00
abstract：:The ability of metformin (MF) to acutely relax phenylephrine (PE)-induced contraction in the isolated rat tail artery is reported to be accompanied by repolarization of the arterial smooth muscle cell (SMC) membranes. These membranes contain potassium (K) channels which if opened could mediate such repolarization and ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00522-6
更新日期：1999-10-29 00:00:00
abstract：:We studied effects of tyrphostin A23 (an inhibitor of protein tyrosine kinase; PTK) and tyrphostin A63 (an inactive analog of tyrphostin A23) on forskolin-activated cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channels and Cl(-) secretion in renal epithelial A6 cells. Tyrphostin A23 and A63 had no ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01824-6
更新日期：2002-07-26 00:00:00
abstract：:Female white-footed mice (Peromyscus leucopus) were injected twice daily with 5, 10, 50, 100 micrograms melatonin (MEL) or saline. Injections were given for 7 weeks at 2 and 12 hours after lights-on under a long day (LD 16:8) photoperiod. Afternoon administration of MEL induced gonadal regression, although a dose of 5...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90549-1
更新日期：1985-08-26 00:00:00
abstract：:Fluorescence spectroscopy was used to examine the biophysical characteristics of human platelet membranes as a function of subject age. The structural order of membrane lipid domains was determined with the use of 1,6-diphenyl-1,3,5-hexatriene (DPH), a fluorescent probe that preferentially localizes in the hydrocarbon...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(85)90079-7
更新日期：1985-10-14 00:00:00
abstract：:Intracellular calcium plays an important role on the pathogenesis of hypoxia-induced cellular injury. Calbindin-D(28k), a cytosolic vitamin D-dependent calcium binding protein, can serve as a buffer to limit a surge in intracellular Ca2+ concentration ([Ca2+]i) induced by various stimulations. To evaluate the possible...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(02)01710-1
更新日期：2002-06-21 00:00:00
abstract：:Cerebroventricular perfusate (CVP) from rats subjected to endotoxic shock was infused into the lateral ventricle of the naive rat. This procedure produced a hypotensive response in the recipient rat which could be reversed by the intravenous injection of the opioid antagonist naltrexone. The degree of endotoxemic hypo...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90053-r
更新日期：1992-01-01 00:00:00
abstract：:6-mercaptopurine (6-MP) has been used clinically for 40 years to maintain remission in patients with acute lymphoblastic leukemia (ALL). However, central nervous system (CNS) relapses frequently occur in patients with ALL who continuously receive anticancer drugs, including 6-MP, during remission maintenance therapy. ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00637-2
更新日期：2000-01-01 00:00:00
abstract：:Endothelin-1 (ET-1) is produced from its precursor, big endothelin-1 (BigET-1), by a putative endothelin-converting enzyme (ECE), but it is not known whether the enzyme is present in the brain. This study was conducted to examine the central hemodynamic effects of BigET-1 and to indirectly determine the presence of an...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90491-s
更新日期：1991-01-01 00:00:00
abstract：AIMS:To evaluate potential agents of therapeutic value in tissue inflammation, we studied norcantharidin (NCTD) and its derivatives for their effects on immune responses of human peripheral blood mononuclear cells (PBMC) in vitro. MAIN METHODS:PBMC proliferation was evaluated by tritiated thymidine uptake method. The ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2008.11.020
更新日期：2009-02-13 00:00:00
abstract：:The objective of this study was to investigate whether age induces changes on vasodilator response induced by cromakalim, an ATP-sensitive K+ (K(ATP)) channel opener, as well as the underlying mechanism involved in this possible alteration. For this purpose, aortic segments from young (3-5 months) and old (3 years) ra...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)80003-4
更新日期：1998-01-01 00:00:00
abstract：:SARS-CoV-2 infection or COVID-19 has become a worldwide pandemic; however, effective treatment for COVID-19 remains to be established. Along with acute respiratory distress syndrome (ARDS), new and old cardiovascular injuries are important causes of significant morbidity and mortality in COVID-19. Exploring new approa...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2021.119130
更新日期：2021-01-26 00:00:00
abstract：:The antiarrhythmic and cardioprotective drug stobadine, possessing antioxidant and neuroprotective properties, was studied as to its in vitro effect on aggregation of human blood platelets. Pretreatment of platelets with stobadine for 30 s inhibited stimulated platelet aggregation in a dose-dependent way. Depending on...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/s0024-3205(99)00460-9
更新日期：1999-01-01 00:00:00
abstract：:Anorexia is induced by injection of alpha 1-adrenergic receptor agonists into the hypothalamic paraventricular nucleus (PVN) in rats. Of the agonists tested to date, cirazoline is the most potent when administered either into the PVN or systemically. The present experiments assess the effects of systemically administe...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(92)90057-v
更新日期：1992-01-01 00:00:00
abstract：:Previous investigations showed that chronic metabolic acidosis (CMA) increased the paracellular permeability of ion and neutral hydrophilic molecules in the duodenum of rats and small intestinal-like cell lines. Since proteins of the claudin family have been known to regulate the paracellular transport in several epit...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2007.01.063
更新日期：2007-04-17 00:00:00
abstract：:Cancer is a disease of high complexity. Resistance to therapy is a major challenge in cancer targeted therapies. Overcoming this resistance requires a deep knowledge of the cellular interactions within tumor. Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) are the main anti-cancer immune cells, while T re...
journal_title：Life sciences
pub_type： 杂志文章,评审
doi：10.1016/j.lfs.2019.116960
更新日期：2019-12-01 00:00:00
abstract：AIMS:Dorsal root ganglia contain heterogeneous populations of primary afferent neurons that transmit various sensory stimuli. This functional diversity may be correlated with differential expression of voltage-gated K(+) (Kv) channels. Here, we examine cellular distributions of Kv4 pore-forming and ancillary subunits t...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2012.07.007
更新日期：2012-09-17 00:00:00
abstract：:Regulation of glucose-induced oscillations in intracellular Ca2+ concentration ([Ca2+]i) was investigated by using a novel technique, electroporation from an electrolyte-filled capillary, to deliver energy metabolites to the intracellular compartment of mouse islets. Intracellular application of ATP resulted in a nife...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2005.05.053
更新日期：2005-10-21 00:00:00
abstract：:Changes in neuroendocrine function have been shown to occur in diabetic animals. The aim of the present study was to examine both the prolactin (PRL) and corticosterone (CORT) responses to a short period of restraint stress after the animals had been made diabetic for six weeks. The streptozotocin - induced diabetic r...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/0024-3205(91)90035-a
更新日期：1991-01-01 00:00:00
abstract：AIMS:Investigate the involvement of the histaminergic projections from tuberomammillary nucleus (TMN) to the spinal cord in the modulation of nociception and peripheral edema in a model of monoarthritis. MAIN METHODS:Subacute monoarthritis was induced by an intraarticular injection of carrageenan followed by LPS 72 h ...
journal_title：Life sciences
pub_type： 杂志文章
doi：10.1016/j.lfs.2020.118521
更新日期：2020-12-01 00:00:00
