Centrally acting endogenous hypotensive substances in rats subjected to endotoxic shock.

abstract：:Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...

journal_title：Life sciences

authors： Roy M,Sen S,Chakraborti AS

更新日期：2008-05-23 00:00:00

abstract：:In the field of estrogen therapy breast cancer risk is one of the most controversially discussed topic. Actually, the as yet largest placebo-controlled study, the Women's Health Initiative, rather showed a risk reduction, in contrast to observational studies. In the present study we have investigated the effect of est...

journal_title：Life sciences

authors： Seeger H,Wallwiener D,Mueck AO

更新日期：2006-02-23 00:00:00

abstract：:When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...

journal_title：Life sciences

authors： Herrera-Marschitz M,Hökfelt T,Ungerstedt U,Terenius L

更新日期：1983-01-01 00:00:00

abstract：:The drug transporter, multidrug resistance-associated protein 2 (ABCC2/Mrp2), is known to play important roles in excretion of various drugs. In the present study, we investigated whether Mrp2 is involved in the transport of micafungin, a newly developed antifungal agent. When Sprague-Dawley rats received an intraveno...

journal_title：Life sciences

authors： Abe F,Ueyama J,Kimata A,Kato M,Hayashi T,Nadai M,Saito H,Takeyama N,Noguchi H,Hasegawa T

更新日期：2008-08-15 00:00:00

abstract：AIMS:We have shown that diabetes causes cerebrovascular remodeling in part by the activation of the endothelin (ET-1) system in a glucose-dependent manner. We also reported increased yet dysfunctional cerebral angiogenesis in diabetes. Here, we tested the hypothesis that dual ET-1 receptor antagonism or glycemic contro...

journal_title：Life sciences

authors： Abdelsaid M,Kaczmarek J,Coucha M,Ergul A

更新日期：2014-11-24 00:00:00

abstract：:Hyaluronic acid (HA), a major glycosaminoglycan component of the extracellular matrix, has regulatory influences on cells and cellular activities. To explore the effects of a high concentration (1 mg/mL) of high molecular weight HA (500-730 kD) on U937 macrophage growth dynamics, three factors that influence overall c...

journal_title：Life sciences

authors： Sheehan KM,DeLott LB,West RA,Bonnema JD,DeHeer DH

更新日期：2004-11-12 00:00:00

abstract：AIMS:The rational basis that explains the benefits of exercise therapy on Chagas cardiomyopathy (ChC) is poorly understood. This study investigated the impact of an exercise program on exercise performance, heart parasitism, immunoinflammatory response, fibrogenesis, oxidative damage, and cardiomyocytes contractility i...

journal_title：Life sciences

authors： Novaes RD,Gonçalves RV,Penitente AR,Bozi LH,Neves CA,Maldonado IR,Natali AJ,Talvani A

更新日期：2016-05-01 00:00:00

abstract：:The plasma membrane ATPase on the human umbilical vein endothelial cell line (ECV304) was demonstrated to be an ecto-enzyme. Hydrolysis of ATP was measured by monitoring the appearance of inorganic phosphorus. Hydrolysis of extracellular ATP was insensitive to oligomycin, vanadate, ouabain and N-ethylmaleimide, compou...

journal_title：Life sciences

authors： Meghji P,Burnstock G

更新日期：1995-01-01 00:00:00

abstract：:Although lipid peroxidation of biological samples may be assessed by different chemical and physical methods, those based on the measurement of malondialdehyde formed from the breakdown of endoperoxides during the last stages of the oxidation of a polyunsaturated fatty acid, appear as the most widely used. Among the v...

journal_title：Life sciences

authors： Valenzuela A

更新日期：1991-01-01 00:00:00

abstract：AIMS:We have developed biochemical and cell based assays to characterize small therapeutic molecules that inhibit the DNA damage checkpoint enzyme, Chk1 (Checkpoint kinase 1). MAIN METHODS:To prepare a screen of large chemical libraries, we purified the full-length and the catalytic domain versions of human Chk1. We c...

journal_title：Life sciences

authors： Ferry G,Studeny A,Bossard C,Kubara PM,Zeyer D,Renaud JP,Casara P,de Nanteuil G,Wierzbicki M,Pfeiffer B,Prudhomme M,Leonce S,Pierré A,Boutin JA,Golsteyn RM

更新日期：2011-08-15 00:00:00

abstract：AIMS:Steroid hormones and steroid receptors (SRs) play a crucial role in spermatogenesis. Steroid receptor coregulators are the major determinants of SR functioning, and any alteration in their expression is known to be associated with impaired spermatogenesis. Since Bisphenol A (BPA) exposure leads to an impairment of...

journal_title：Life sciences

authors： Salian S,Doshi T,Vanage G

更新日期：2009-07-03 00:00:00

abstract：:The effect of chronic cigarette smoke exposure on the activity of rat trachea and lung ornithine decarboxylase (ODC) and s-adenosyl-methionine decarboxylase (AdoMet-DC) was determined. Male rats were exposed once daily for 10 min to mainstream (MS) or different sidestream (SS) dilutions of fresh Kentucky 2R1 cigarette...

journal_title：Life sciences

authors： Olson JW

更新日期：1985-12-09 00:00:00

abstract：OBJECTIVE:To investigate the protective efficacies and potent mechanisms of combination therapy with semaglutide and rosiglitazone (RSG) on the high-glucose incubated human ARPE-19 cells and diabetic retinopathy (DR) model rats. MAIN METHODS:The CCK-8 methods were used to evaluate the protective effects of semaglutide...

journal_title：Life sciences

authors： Yang X,Wu S,Feng Z,Yi G,Zheng Y,Xia Z

更新日期：2021-01-05 00:00:00

abstract：BACKGROUND AND AIMS:Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it is not clearly known whether or not DPSCs maintain their immunosuppressive effects after differentiation. In the present study, we examined t...

journal_title：Life sciences

authors： Hossein-Khannazer N,Hashemi SM,Namaki S,Ghanbarian H,Sattari M,Khojasteh A

更新日期：2019-01-01 00:00:00

abstract：:An attenuation of adrenergic activity during the inhibition of endogenous angiotensin II formation was evaluated by determining plasma norepinephrine concentration after a single oral administration of captopril compared to that after nifedipine in essential hypertension. Captopril produced a fall in mean arterial pre...

journal_title：Life sciences

authors： Mohara O,Masuyama Y

更新日期：1991-01-01 00:00:00

abstract：AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...

journal_title：Life sciences

authors： Msoka TF,Van Guilder GP,van Furth M,Smulders Y,Meek SJ,Bartlett JA,Vissoci JRN,van Agtmael MA

更新日期：2019-10-15 00:00:00

abstract：:Calcium entry from extracellular space to acetylcholine (ACh)-sensitive internal stores was investigated in beta-escin permeabilized bovine tracheal smooth muscle. Cyclopiazonic acid (CPA), a selective inhibitor of the sarcoplasmic reticulum (SR) calcium pump, and nifedipine, both inhibited the refilling, and inhibiti...

journal_title：Life sciences

authors： Qian Y,Bourreau JP

更新日期：1999-01-01 00:00:00

abstract：AIMS:Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicin...

journal_title：Life sciences

authors： Makarević J,Tsaur I,Juengel E,Borgmann H,Nelson K,Thomas C,Bartsch G,Haferkamp A,Blaheta RA

更新日期：2016-02-15 00:00:00

abstract：:The extract of Crataegus, a mixture of flavonoids and procyanidins extracted from hawthorn, Crataegus oxyacantha, L. and C. monogyna Jacq., relaxed vascular tone or increased production of cyclic GMP in the rat aorta, but flavonoid components of Crataegus extract, hyperoside, rutin and vitexin, did not affect the vasc...

journal_title：Life sciences

authors： Kim SH,Kang KW,Kim KW,Kim ND

更新日期：2000-01-01 00:00:00

abstract：:Previous studies from this laboratory have shown that rats with experimental cirrhosis of the liver induced by the combined administration of oral phenobarbital and inhaled carbon tetrachloride show an hyperdynamic status with enhanced cardiac output (CO), and decreased mean arterial pressure (MAP) and peripheral vasc...

journal_title：Life sciences

authors： Villamediana LM,Sanz E,Fernandez-Gallardo S,Caramelo C,Sanchez Crespo M,Braquet P,Lopez-Novoa JM

更新日期：1986-07-21 00:00:00

abstract：:Plasma opioid levels were determined in 9 obese non-diabetic subjects, their 8 age matched controls, and in 29 diabetic patients; 10 maintained on diet alone, 6 on an oral hypoglycemic agent (chlorpropamide) and 13 treated with insulin. Five age matched controls for the diabetic groups were also studied for comparison...

journal_title：Life sciences

authors： Awoke S,Voyles NR,Bhathena SJ,Tanenberg RJ,Recant L

更新日期：1984-05-21 00:00:00

abstract：:Adrenals of young adult male mice kept on a LD 12:12 lighting regimen for three weeks prior to study and harvested at four different circadian stages were incubated for 2 hours with 0.4 IU synthetic ACTH in 2 ml Krebs-Ringer buffer (KR), or with 50, 150, and 450 microM of melatonin in KR containing 0.4 IU ACTH. The ad...

journal_title：Life sciences

authors： Haus E,Nicolau GY,Ghinea E,Dumitriu L,Petrescu E,Sackett-Lundeen L

更新日期：1996-01-01 00:00:00

abstract：AIMS:The present study was to investigate the effect of hydrogen peroxide (H2O2) on bone marrow stem cells and their endothelial differentiation and the underlying mechanisms in vitro. MAIN METHODS:Rat bone marrow multipotent adult progenitor cells (MAPCs) were used as the source of bone marrow stem cells, and treated...

journal_title：Life sciences

authors： Xiao Y,Li X,Cui Y,Zhang J,Liu L,Xie X,Hao H,He G,Kander MC,Chen M,Liu Z,Verfaillie CM,Zhu H,Lei M,Liu Z

更新日期：2014-09-01 00:00:00

abstract：:Sleep-disordered breathing is characterized by disruptions of normal breathing patterns during sleep. Obesity is closely related to hypoventilation or apnea and becomes a primary risk factor for sleep-disordered breathing. Leptin, a peptide secreted by adipose tissue, has been implicated in central control of breathin...

journal_title：Life sciences

authors： Wei Z,Hao Y,Yu H,Shi L,Jing X,Zhang X,Liu N,Li T,Zhang X,Yuan F

更新日期：2020-09-15 00:00:00

abstract：:LH stimulation is mediated by its own receptor at the first step of the cascade, after which intracellular cAMP increases to stimulate the transcription of steroidogenic acute regulatory protein (StAR) in mouse MA-10 Leydig tumor cells. StAR mediates the rate-limiting step of steroidogenesis, which is the transfer of ...

journal_title：Life sciences

authors： Tsuchiya M,Inoue K,Matsuda H,Nakamura K,Mizutani T,Miyamoto K,Minegishi T

更新日期：2003-10-17 00:00:00

abstract：:To investigate the properties of the gamma-aminobutyric acid (GABA) synthesizing enzyme, glutamate decarboxylase (GAD), in the brain and the pancreatic islets of the rat, GABA concentration in the brain and the pancreatic islets was measured after administration of 3-mercaptopropionic acid (3-MP) at 25 mg/kg intraperi...

journal_title：Life sciences

authors： Katoh J,Taniguchi H,Ogura M,Miyamoto K,Kasuga M,Okada Y

更新日期：1994-01-01 00:00:00

abstract：AIMS:To investigate the effects of malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) on cognitive dysfunction, the expression of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β and amyloid β peptide (Aβ) in the hippocampus, as well as dendritic pathology in the hippocampal CA1 region in sepsis-associate...

journal_title：Life sciences

authors： Zhong J,Guo C,Hou W,Shen N,Miao C

更新日期：2019-10-15 00:00:00

abstract：AIMS:We investigated whether cAMP-mediated protein kinase A(PKA) and Epac1/Rap1 pathways differentially affect brain tumor cell death using 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone(rolipram), specific phosphodiesterase type IV(PDE IV) inhibitor. MAIN METHODS:A172 and U87MG human glioblastoma cells were used....

journal_title：Life sciences

authors： Moon EY,Lee GH,Lee MS,Kim HM,Lee JW

更新日期：2012-02-27 00:00:00

abstract：:The level of hepatic lipidperoxides in chick embryos was determined during cataract formation resulting from glucocorticoid treatment. When 15 day old chick embryos were administered 0.25 mumol of hydrocortisone acetate their hepatic lipidperoxide level, determined by thio-barbituric acid, increased after a lag time o...

journal_title：Life sciences

authors： Nishigori H,Lee JW,Iwamoto Y,Hayashi R,Maruyama K,Iwatsuru M

更新日期：1984-08-27 00:00:00

abstract：:The potential for a drug interaction between cyclosporin A and phenytoin was investigated in rats. Rats were treated daily for 14 days with cyclosporin A (50 mg/Kg, s.c.) and on the day of the experiment phenytoin (10 mg/Kg) was administered intravenously. The mean residence time, the elimination half-life and the vol...

journal_title：Life sciences

authors： Wasfi IA,Tanira MO

更新日期：1993-01-01 00:00:00