Abstract：
:When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, while Leu-enkephalin did not elicit any significant response at the doses tested. D-amphetamine, injected subcutaneously 60 min after dynorphin, significantly enhanced the contralateral rotation induced by the intranigral administration of dynorphin. Experiments with dynorphin injections combined with D-amphetamine suggest that the dynorphin effects are mediated by neuronal loops involving dynorphin dopamine interactions.
journal_name
Life Scijournal_title
Life sciencesauthors
Herrera-Marschitz M,Hökfelt T,Ungerstedt U,Terenius Ldoi
10.1016/0024-3205(83)90563-5subject
Has Abstractpub_date
1983-01-01 00:00:00pages
555-8eissn
0024-3205issn
1879-0631journal_volume
33 Suppl 1pub_type
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