Abstract:
:To clarify the mechanism of meconium-induced cellular injury, we examined the effect of meconium on the alveolar macrophages (AM) and bronchial epithelial cells (AK-D). Meconium obtained from healthy newborns was added to culture medium of AM and/or AK-D, which were cultured for 1 hour. Superoxide anion production of AM and the expression of intercellular adhesion molecule-1 (ICAM-1) on AK-D stimulated by meconium or oxygen radicals were determined. As a result, superoxide anion production of AM significantly increased when AM was cultured with meconium. Expression of ICAM-1 on AK-D appeared when AK-D was stimulated by hydroxyl radical but did not when AK-D was cultured with meconium. These results suggest that meconium-induced lung injury may occur through an activation of alveolar macrophages and the macrophage-epithelial cell axis may be important for the pathogenesis of meconium aspiration syndrome.
journal_name
Life Scijournal_title
Life sciencesauthors
Kojima T,Hattori K,Fujiwara T,Sasai-Takedatsu M,Kobayashi Ydoi
10.1016/0024-3205(94)90026-4subject
Has Abstractpub_date
1994-01-01 00:00:00pages
1559-62issue
21eissn
0024-3205issn
1879-0631pii
0024-3205(94)90026-4journal_volume
54pub_type
杂志文章相关文献
LIFE SCIENCES文献大全abstract:AIMS:We performed a systematic review and meta-analysis on the effect of HIV infection and antiretroviral therapy (ART) on carotid intima-media thickness (cIMT) to elucidate the role of HIV infection and ART. Also, an analysis on the role of ethnicity and gender on cIMT in HIV-infected populations was performed. MAIN ...
journal_title:Life sciences
pub_type: 杂志文章,meta分析
doi:10.1016/j.lfs.2019.116851
更新日期:2019-10-15 00:00:00
abstract::The effects of thioperamide, an H3 antagonist, and histamine H1 and H2 antagonists (s.c.) on morphine (s.c. or i.c.v.)- and U-50,488H (i.c.v.)-induced antinociception in male ddY mice were examined using the hot-plate (55 degrees C) test. Thioperamide significantly inhibited morphine-induced antinociception, but not U...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(94)00589-3
更新日期:1994-01-01 00:00:00
abstract::Rats implanted subcutaneously with an empty osmotic pump connected by a polyethylene catheter to a jugular vein for 5 to 10 days evinced a decreased splenocyte responsiveness to blastogenic stimulation in vitro to bacterial lipopolysaccharide, a known B cell stimulator, as well as to the plant mitogens pokeweed mitoge...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90291-v
更新日期:1992-01-01 00:00:00
abstract:AIMS:Oxidative stress and inflammatory response are major factors causing several tissue injuries in intestinal ischemia and reperfusion (I/R). Agmatine has been reported to attenuate I/R injury of various organs. The present study aims to analyze the possible protective effects of agmatine on intestinal I/R injury in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2017.08.032
更新日期:2017-11-15 00:00:00
abstract::Hypotensive responses to tryptophan and 5-hydroxytryptophan infusions were studied in normotensive male Sprague-Dawley rats. Results showed that 5-hydroxytryptophan but not tryptophan lowered pressure in a dose dependent way in direct relation to the production of brain serotonin and 5-HIAA. Intrinsic release of serot...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(85)90220-6
更新日期:1985-11-11 00:00:00
abstract::Red wine, at a final dilution of 1/50, caused release of [14C]5-hydroxytryptamine (5-HT) from preloaded platelets, an effect which was not observed with any white wines or beers tested. Since 5-HT, is probably released from body stores during migraine attacks and red wine is known to provoke migraine episodes in susce...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90265-d
更新日期:1991-01-01 00:00:00
abstract::Decreased heart rate variability (HRV) and heart rate turbulence (HRT) are independent predictors of mortality after acute myocardial infarction (AMI). There are no previous studies on the relationship between warm-up phenomenon and cardiac autonomic control in stable coronary artery disease (CAD). We investigated the...
journal_title:Life sciences
pub_type: 临床试验,杂志文章
doi:10.1016/j.lfs.2004.06.033
更新日期:2005-03-25 00:00:00
abstract::Daily s.c. injection of (-)deprenyl (2.0 mg/kg/day) for three weeks in young male rats caused a threefold increase in superoxide dismutase (SOD) activity in the striatum of the brain compared with the value in saline-injected control rats. Furthermore, the activity of catalase (but not of glutathione peroxidase) was a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(91)90466-o
更新日期:1991-01-01 00:00:00
abstract::The influence of different, nitric oxide-containing ruthenium complexes on the evoked potentials recorded from the CA1 region of the mouse hippocampus in vitro has been investigated. Of the compounds tested, only trans-[(NO)(P(OEt)3)(NH3)4Ru](PF6)3 (1-2.5 mM) exerted a strong facilitatory action on the population spik...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)00951-1
更新日期:2001-02-16 00:00:00
abstract::Intravenous (640 micrograms/kg) or intracerebroventricular (0.5 and 1 microgram) injection of Escherichia coli endotoxin (LPS) causes inhibition of water intake induced by 24 hour period of water deprivation in the rat. Tumor necrosis factor alpha (TNF-alpha; 20 and 40 ng/rat) given into the lateral cerebral ventricle...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90154-h
更新日期:1992-01-01 00:00:00
abstract::When injected into the substantia nigra reticulata of naive rats, dynorphin-(1-17) caused a dose dependent contralateral rotation which was inhibited by naloxone in a dose dependent manner. Met-enkephalin injected in the same coordinates as the ones used with dynorphin also induced rotation but of lower intensity, whi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90563-5
更新日期:1983-01-01 00:00:00
abstract::Many hormones are known to induce the activity of ornithine decarboxylase (ODC), the first and rate-limiting enzyme for polyamine biosynthesis, in their target tissues. Using ovariectomized rats, we have compared the effects of sex hormones on ODC activity in the uterus and the kidney which contain estrogen and androg...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(90)90219-h
更新日期:1990-01-01 00:00:00
abstract:AIMS:Normal human cells in culture progressively lose their capacity for replication, ending in an irreversible arrested state known as replicative senescence. Senescence has been functionally associated to the process of organismal ageing and is also considered a major tumor-suppressing mechanism. Although a great dea...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.11.009
更新日期:2009-01-16 00:00:00
abstract::Glycation-modified hemoglobin in diabetes mellitus has been suggested to be a source of enhanced catalytic iron and free radicals causing pathological complications. The present study aims to verify this idea in experimental diabetes. Pelargonidin, an anthocyanidin, has been tested for its antidiabetic potential with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2008.03.011
更新日期:2008-05-23 00:00:00
abstract::The present study investigated the effects of nitric oxide synthase (NOS) inhibitors on the seizure threshold of DMCM in mice. The seizure threshold of DMCM was evaluated using an intravenous infusion technique. The threshold of DMCM was significantly decreased by pretreatment with N-nitro-L-arginine (NOARG; 8 mg/kg) ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00226-9
更新日期:1997-01-01 00:00:00
abstract::The role of serotonin (5-HT) in the regulation of steroidogenesis in the ovary via 5-HT2 receptor was studied in normal cycling rats and their preovulatory follicles. Oral administration of ketanserin (KET), a selective 5-HT2 antagonist, at 10 mg/kg BW at 1100h on the day of proestrus resulted in a marked decrease in ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(93)90713-d
更新日期:1993-01-01 00:00:00
abstract::Rabbits were made reticulocytotic by repeated bleeding or by injection of phenylhydrazine. Up to reticulocyte levels of 70%, the baseline activity of magnesium-dependent calcium-stimulated adenosine triphosphatase ( ( Ca + Mg)-ATPase, EC 3.6.1.3.) of the red cell plasma membrane was not significantly changed. Maximal ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90622-7
更新日期:1983-08-29 00:00:00
abstract::Alpha-lipoic acid (ALA), a potent biological antioxidant, improves insulin action of skeletal muscle glucose transport and metabolism in both human and animal models of insulin resistance. In order to obtain further insight into the potential intracellular mechanisms for the action of ALA on insulin-stimulated glucose...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(97)00562-6
更新日期:1997-01-01 00:00:00
abstract::The analgesic effects of bestatin and thiorphan, two enzymatic inhibitors protecting endogenous enkephalins from their degradation, and those of DAGO and deltakephalin, respectively mu and delta opioid peptides, are assessed on the electrical stimulation test of the mouse tail. The relative analgesic potency of DAGO a...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(83)90595-7
更新日期:1983-01-01 00:00:00
abstract:AIMS:Ventilatory disturbance is a fatal side-effect of opioid analgesics. Separation of analgesia from ventilatory depression is important for therapeutic use of opioids. It has been suggested that opioid-induced ventilatory depression results from a decrease in adenosine 3',5'-cyclic monophosphate content in the respi...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.02.006
更新日期:2015-04-15 00:00:00
abstract::It was demonstrated in the previous study that the microinjection of antisense oligodeoxynucleotide (AS ODN) against mu-opioid receptor (MOR) into periaqueductal gray (PAG) of rat brain selectively decreased the MOR mRNA content in PAG, and the decrease in MOR mRNA content was enhanced by pretreatment of the PAG with ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(01)01009-8
更新日期:2001-04-06 00:00:00
abstract:AIMS:The antihypertensive mechanism (s) of the epigallocatechin-3-gallate (EGCG), a major effective component in green tea, might associate with microRNAs (miRNAs). Here, we aimed to investigate which microRNA in aorta of spontaneously hypertensive rats (SHRs) were modulated by administration of EGCG and its mechanism....
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2018.04.041
更新日期:2018-06-15 00:00:00
abstract::Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects ...
journal_title:Life sciences
pub_type: 杂志文章,评审
doi:10.1016/j.lfs.2018.10.044
更新日期:2018-12-01 00:00:00
abstract:AIMS:Cardiovascular disease is the leading cause of death for individuals diagnosed with type II diabetes mellitus (DM). Changes in cardiac function, left ventricular wall thickness and fibrosis have all been described in patients and animal models of diabetes; however, the factors mediating increased matrix deposition...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2013.01.003
更新日期:2013-03-28 00:00:00
abstract::A novel bioactive lipid, cyclic phosphatidic acid (cPA), was identified in lipids bound to human serum albumin. A cPA fraction was extracted and purified from human serum albumin by use of a combination of preparative TLC and HPLC. Electrospray ionization mass spectrometry of the purified fraction showed molecular ion...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/s0024-3205(99)00483-x
更新日期:1999-01-01 00:00:00
abstract::Dehydroepiandrosterone (DHEA), the major secretory product of the human adrenal cortex, significantly declines with advanced age. We have previously demonstrated that DHEA prevents the reduction in non-amyloidogenic APP processing, following prolonged stimulation of the muscarinic receptor, in PC12 cells that express ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(96)00496-1
更新日期:1996-01-01 00:00:00
abstract:AIMS:In this study, we investigated the effects of Bax-inhibiting peptide (Bip)-V5, an anti-apoptosis membrane-permeable peptide, on the 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) model rats. MATERIALS AND METHODS:Rats were randomly divided into five groups: Control, 6-OHDA only, Vehicle+6-OHDA, zVAD+...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2015.11.019
更新日期:2016-01-01 00:00:00
abstract::The systemic administration of neurotensin (NT) dose-dependently increased plasma adrenocorticotropin (ACTH) concentration in rats, and this effect was annulled by (alpha-helical)-CRH9-41, an antagonist of corticotropin-releasing hormone (CRH). The systemic administration of [D-Trp11]-neurotensin (NT-A), a specific NT...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/0024-3205(92)90250-s
更新日期:1992-01-01 00:00:00
abstract::Acute myocardial infarction (AMI) is associated with inflammation and apoptosis. Emodin plays an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that emodin protects against myocardial ischemia/reperfusion injury. However, its mechanism underlying its effects remains unknown. ...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2007.08.040
更新日期:2007-10-13 00:00:00
abstract:AIMS:To examine the effects of metoprolol on expression of myocardial inflammatory cytokines and myocardial function in rats following coronary microembolization (CME). MAIN METHODS:Male rats were randomly assigned to receive either sham-operation (control group), CME plus saline (CME group), or CME plus metoprolol (m...
journal_title:Life sciences
pub_type: 杂志文章
doi:10.1016/j.lfs.2011.03.012
更新日期:2011-06-06 00:00:00