Effects of antisense oligodeoxynucleotides against opioid receptors on the receptor mRNA contents.

abstract：:Histogranin is a naturally-occurring pentadecapeptide with a structure 80% homologous with that a fragment-(86-100) of histone H4. First isolated from bovine adrenal medulla, the peptide was also shown to be present in the pituitary, brain, adrenal glands, blood plasma, lungs and spleen. At the subcellular level, hist...

journal_title：Life sciences

authors： Lemaire S,Rogers C,Dumont M,Shukla VK,Lapierre C,Prasad J,Lemaire I

更新日期：1995-03-03 00:00:00

abstract：AIM:The effects of local applied NO-active compounds on glutamate (GLU)-evoked responses were investigated in globus pallidus (GP) neurons. MAIN METHODS:Extracellularly recorded single units from anesthetized rats were treated with GLU before and during the microiontophoretic application of S-nitrosoglutathione (SNOG)...

journal_title：Life sciences

authors： Sardo P,Carletti F,Rizzo V,Lonobile G,Friscia S,Ferraro G

更新日期：2011-06-20 00:00:00

abstract：:We studied Na,K-ATPase mRNA expression in cardiomyopathic (Bio 14.6) and normal (F1b) Syrian hamster ventricles. In Northern blot analysis, Na,K-ATPase alpha 1, alpha 2, alpha 3 and beta 1 isoform mRNAs were detected in 3-week-old Bio 14.6 and F1b hamster ventricles. We then investigated the expression of alpha 1 subu...

journal_title：Life sciences

authors： Tsuruya Y,Ikeda U,Yamamoto K,Seino Y,Kanbe T,Shimada K

更新日期：1994-01-01 00:00:00

abstract：AIMS:The present study was designed to compare the effects of a low-fat diet (LF), calorie restriction (CR), quercetin (Que) and exercise (Ex) on hepatic steatosis in a high-fat (HF) diet-induced obesity prone (OP) model in the perspective of microRNA (miR)-dependent thyroid hormone (TH) synthesis and action. MAIN MET...

journal_title：Life sciences

authors： Xia SF,Jiang YY,Qiu YY,Huang W,Wang J

更新日期：2020-02-01 00:00:00

abstract：AIMS:Acetylcholine (ACh) has been shown to increase ion and water excretion in the kidneys, resulting in hypotension. However, no evidence of renal parasympathetic innervation has been shown, and the source of ACh acting on nephrons is still unknown. The aim of the present study was to identify ACh-producing cells in t...

journal_title：Life sciences

authors： Maeda S,Jun JG,Kuwahara-Otani S,Tanaka K,Hayakawa T,Seki M

更新日期：2011-09-12 00:00:00

abstract：AIMS:Stroke-prone spontaneously hypertensive rats (SHRSP) show significantly lower body weight than normotensive Wistar-Kyoto rats (WKY). Our hypotheses are as follows: weight loss of the skeletal muscle is related to hypertension-related diseases, and muscle hypotrophy is useful as a therapeutic target for hypertensio...

journal_title：Life sciences

authors： Inoue T,Hagiyama M,Maenishi O,Kimura M,Mizuguchi N,Mine Y,Kimura R,Chikugo T,Itoh T,Satou T,Ito A

更新日期：2019-11-15 00:00:00

abstract：:Protein binding determination in post heparin plasma samples is complicated by the continued post heparin lipase activity, in vitro, during the binding analysis. The decomposition of lipoproteins and accumulation of nonesterified fatty acids (NEFA) results in artifically elevated free fractions of many drugs. This art...

journal_title：Life sciences

authors： Pearce GA,Brown KF

更新日期：1983-10-10 00:00:00

abstract：AIMS:In our model, we aimed to explore the cytotoxicity of 5-Aza-2'-deoxycytidine (5-Aza-CdR) against the colorectal cell line, Lovo, and further characterize the possible mechanisms. MAIN METHODS:After Lovo cells were treated with 5-Aza-CdR at different concentrations for different periods of time, the cell viability...

journal_title：Life sciences

authors： Deng T,Zhang Y

更新日期：2009-02-27 00:00:00

abstract：AIMS:We previously found that paeoniflorin, a major constituent of Paeonia lactiflora Pall, could induce heat shock proteins (HSPs) in cultured mammalian cells without apparent toxicity (Yan et al. 2004). We here investigated the induction of HSPs by paeoniflorin in mouse stomach and the effect of paeoniflorin on the H...

journal_title：Life sciences

authors： Asai M,Kawashima D,Katagiri K,Takeuchi R,Tohnai G,Ohtsuka K

更新日期：2011-02-14 00:00:00

abstract：AIMS:Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the ...

journal_title：Life sciences

authors： Duerr GD,Feißt A,Halbach K,Verfuerth L,Gestrich C,Wenzel D,Zimmer A,Breuer J,Dewald O

更新日期：2018-12-15 00:00:00

abstract：:YM-09151-2(cis-N-(1-benzyl-2-methylpyrrolidin-3-yl) -5-chloro-2-methoxy-4-methylaminobenzamide) is a new benzamide which has been reported to be an antagonist of dopamine (DA) at D1-type DA receptors. In the present study, we have examined the extent of the interaction of YM-09151-2 with D2-type DA receptors in the an...

journal_title：Life sciences

authors： Meltzer HY,Mikuni M,Simonovic M,Gudelsky GA

更新日期：1983-02-28 00:00:00

abstract：:Nitric oxide (NO) may be an intercellular modulator within the central nervous system. L-arginine, which results in NO synthesis, increased food intake in mice while the inhibitor of NO synthesis, L-NG-nitro arginine (L-NO Arg) inhibited food intake in food deprived mice. L-arginine, but not D-arginine, partially reve...

journal_title：Life sciences

authors： Morley JE,Flood JF

更新日期：1991-01-01 00:00:00

abstract：AIMS:Previous studies demonstrated that the Western diet (WD), which is rich in saturated fat (HFD) and refined sugar (HSU), is related to the impairments of hippocampus-dependent learning and memory and forebrain synaptic plasticity in rodents. The environmental enrichment (EE) has been shown to enhance learning and m...

journal_title：Life sciences

authors： Gergerlioglu HS,Oz M,Demir EA,Nurullahoglu-Atalik KE,Yerlikaya FH

更新日期：2016-03-01 00:00:00

abstract：:We hypothesized that the atheroinhibitory and cardioprotective effects of estrogen may be mediated in part through increased prostacyclin formation by the artery wall. Atherosclerotic abdominal aorta was collected at necropsy from ovariectomized female monkeys fed an atherogenic diet alone or with added Premarin. Basa...

journal_title：Life sciences

authors： O'Sullivan MG,Goodrich JA,Adams MR

更新日期：2001-06-15 00:00:00

abstract：:Opiate binding sites have been characterized on membranes from bovine adrenal medullas and six human pheochromocytomas. In human tumors, large variations in site distribution were observed. Kappa and benzomorphan sites represented the majority of the sites detected. The heterogeneity of the opiate sites on these tissu...

journal_title：Life sciences

authors： Castanas E,Giraud P,Audigier Y,Drissi R,Boudouresque F,Conte-Devolx B,Oliver C

更新日期：1983-01-01 00:00:00

abstract：AIMS:Endoplasmic reticulum stress (ERS) as an emerging factor is involved in insulin resistance (IR), which is the pathological basis of diabetes mellitus. Accumulation of asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase is associated with IR, but the underlying mechanisms have not b...

journal_title：Life sciences

authors： Qiu N,Wei XM,Zhang ZJ,He YL,Zhou XK,Xiong Y

更新日期：2020-11-01 00:00:00

abstract：AIMS:The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. MATERIALS AND METHODS:circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression...

journal_title：Life sciences

authors： Zou J,Liu KC,Wang WP,Xu Y

更新日期：2020-09-01 00:00:00

abstract：:The effects of four anilidopiperidine analgesics, fentanyl, sufentanil, lofentanil and alfentanil on the activity of single neurones in the rat brain stem were examined using the technique of microiontophoresis. Neurones whose discharge rate could be related to respiration and non-respiratory neurones were studied. Al...

journal_title：Life sciences

authors： Hewson G,Bradley PB

更新日期：1982-11-15 00:00:00

abstract：:Human milk was tested in the Ames plate incorporation test using strain TA98. Pools from smokers and non-smokers respectively, as well as individual samples from 14 smokers and 15 controls were tested. No difference was found between milk from smokers and non-smokers in the concentrations and volumes used. Preliminary...

journal_title：Life sciences

authors： Rivrud GN,Hagen I,Børresen AL

更新日期：1987-11-23 00:00:00

abstract：AIMS:The effects of the novel water soluble, viscous fiber complex PolyGlycopleX® [(α-D-glucurono-α-D-manno-β-D-manno-β-D-gluco), (α-L-gulurono-β-D mannurono), β-D-gluco-β-D-mannan (PGX®)] on body weight, food consumption, glucose, insulin, and glucagon-like peptide (GLP-1) levels were determined in Zucker diabetic rat...

journal_title：Life sciences

authors： Grover GJ,Koetzner L,Wicks J,Gahler RJ,Lyon MR,Reimer RA,Wood S

更新日期：2011-02-28 00:00:00

abstract：:Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platf...

journal_title：Life sciences

authors： Zhao S,Chu Y,Zhang Y,Zhou Y,Jiang Z,Wang Z,Mao L,Li K,Sun W,Li P,Jia S,Wang C,Xu A,Loomes K,Tang S,Wu D,Hui X,Nie T

更新日期：2019-04-01 00:00:00

abstract：:The regulation of G protein-coupled receptor expression is important in the physiology of an organism and can occur at any of the steps between gene transcription to turnover of the receptor protein itself. Agonist stimulation causes receptor desensitization, which is characterized by a rapid reduction in response to ...

journal_title：Life sciences

authors： Heck DA,Bylund DB

更新日期：1998-01-01 00:00:00

abstract：:Three neurodegenerative diseases, Huntington's disease (HD), Kennedy's disease (hereditary spinobulbar muscular atrophy, SBMA), and type 1 spinocerebellar ataxia (SCA-1) have been found to share a common genetic defect: an unstable region of repeated CAG trinucleotides which are thought to be translated into a polyglu...

journal_title：Life sciences

authors： Cha JH,Dure LS 4th

更新日期：1994-01-01 00:00:00

abstract：:Hepatic tryptophan 2,3-dioxygenase (TDO) is one of the rate-limiting enzymes in tryptophan catabolism and plays an important role in regulating the physiological flux of tryptophan into relevant metabolic pathways. In this study, we determined the effect of the non-steroidal anti-inflammatory agents, tolmetin and suli...

journal_title：Life sciences

authors： Dairam A,Antunes EM,Saravanan KS,Daya S

更新日期：2006-11-10 00:00:00

abstract：:Effect of mitragynine, an indole alkaloid isolated from Thai medicinal plant kratom (Mitragyna speciosa), on electrically stimulated contraction was studied in the guinea-pig ileum. Mitragynine (1 nM-3 microM) inhibited the ileum contraction elicited by electrical stimulation, and its pD2 value was 6.91 +/- 0.04 (n = ...

journal_title：Life sciences

authors： Watanabe K,Yano S,Horie S,Yamamoto LT

更新日期：1997-01-01 00:00:00

abstract：:The purpose of the this study was to characterize the putative anxiolytic-like effects of the aqueous extract of Albizzia julibrissin stem bark using the elevated plus maze (EPM) in rats. The water extract of Albizzia julibrissin was orally administered at 10, 50, 100 or 200 mg/kg to adult male SD rats, 1 h before beh...

journal_title：Life sciences

authors： Kim WK,Jung JW,Ahn NY,Oh HR,Lee BK,Oh JK,Cheong JH,Chun HS,Ryu JH

更新日期：2004-10-22 00:00:00

abstract：:Asthma is a chronic inflammatory and allergic disease that is mainly characterized by reversible airway obstruction and bronchial hyperresponsiveness. The incidence of asthma is increasing with more than 350 million people worldwide are affected. Up to now, there is no therapeutic option for asthma and most of the pre...

journal_title：Life sciences

authors： Al-Azzam N,Elsalem L

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Cardiac fibrosis is the scarring process occurs commonly with CVDs impairing the function and structure of heart. Herein, we investigated the role of circPAN3 in the pathogenesis of cardiac fibrosis. METHODS:A rat myocardial infarctio...

journal_title：Life sciences

authors： Li F,Long TY,Bi SS,Sheikh SA,Zhang CL

更新日期：2020-09-15 00:00:00

abstract：AIMS:Epidemiological studies report that individuals who exercise are less likely to abuse drugs. Preclinical studies report that exercise, in the form of treadmill or wheel running, reliably decreases the self-administration of psychomotor stimulants and opioids. To date, preclinical studies have only examined the eff...

journal_title：Life sciences

authors： Lacy RT,Strickland JC,Brophy MK,Witte MA,Smith MA

更新日期：2014-10-02 00:00:00

abstract：:Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that peripar...

journal_title：Life sciences

authors： Kristal MB,Thompson AC,Abbott P,Di Pirro JM,Ferguson EJ,Doerr JC

更新日期：1990-01-01 00:00:00